294 related articles for article (PubMed ID: 22705949)
1. Selective binding of nuclear alpha-synuclein to the PGC1alpha promoter under conditions of oxidative stress may contribute to losses in mitochondrial function: implications for Parkinson's disease.
Siddiqui A; Chinta SJ; Mallajosyula JK; Rajagopolan S; Hanson I; Rane A; Melov S; Andersen JK
Free Radic Biol Med; 2012 Aug; 53(4):993-1003. PubMed ID: 22705949
[TBL] [Abstract][Full Text] [Related]
2. Mitochondrial Quality Control via the PGC1α-TFEB Signaling Pathway Is Compromised by Parkin Q311X Mutation But Independently Restored by Rapamycin.
Siddiqui A; Bhaumik D; Chinta SJ; Rane A; Rajagopalan S; Lieu CA; Lithgow GJ; Andersen JK
J Neurosci; 2015 Sep; 35(37):12833-44. PubMed ID: 26377470
[TBL] [Abstract][Full Text] [Related]
3. Region specific mitochondrial impairment in mice with widespread overexpression of alpha-synuclein.
Subramaniam SR; Vergnes L; Franich NR; Reue K; Chesselet MF
Neurobiol Dis; 2014 Oct; 70():204-13. PubMed ID: 25016198
[TBL] [Abstract][Full Text] [Related]
4. Synergistic anti-Parkinsonism activity of high doses of B vitamins in a chronic cellular model.
Jia H; Liu Z; Li X; Feng Z; Hao J; Li X; Shen W; Zhang H; Liu J
Neurobiol Aging; 2010 Apr; 31(4):636-46. PubMed ID: 18639366
[TBL] [Abstract][Full Text] [Related]
5. Isogenic human iPSC Parkinson's model shows nitrosative stress-induced dysfunction in MEF2-PGC1α transcription.
Ryan SD; Dolatabadi N; Chan SF; Zhang X; Akhtar MW; Parker J; Soldner F; Sunico CR; Nagar S; Talantova M; Lee B; Lopez K; Nutter A; Shan B; Molokanova E; Zhang Y; Han X; Nakamura T; Masliah E; Yates JR; Nakanishi N; Andreyev AY; Okamoto S; Jaenisch R; Ambasudhan R; Lipton SA
Cell; 2013 Dec; 155(6):1351-64. PubMed ID: 24290359
[TBL] [Abstract][Full Text] [Related]
6. REST Protects Dopaminergic Neurons from Mitochondrial and α-Synuclein Oligomer Pathology in an Alpha Synuclein Overexpressing BAC-Transgenic Mouse Model.
Ryan BJ; Bengoa-Vergniory N; Williamson M; Kirkiz E; Roberts R; Corda G; Sloan M; Saqlain S; Cherubini M; Poppinga J; Bogtofte H; Cioroch M; Hester S; Wade-Martins R
J Neurosci; 2021 Apr; 41(16):3731-3746. PubMed ID: 33563726
[TBL] [Abstract][Full Text] [Related]
7. Alpha-synuclein-induced mitochondrial dysfunction is mediated via a sirtuin 3-dependent pathway.
Park JH; Burgess JD; Faroqi AH; DeMeo NN; Fiesel FC; Springer W; Delenclos M; McLean PJ
Mol Neurodegener; 2020 Jan; 15(1):5. PubMed ID: 31931835
[TBL] [Abstract][Full Text] [Related]
8. Truncated peroxisome proliferator-activated receptor-γ coactivator 1α splice variant is severely altered in Huntington's disease.
Johri A; Starkov AA; Chandra A; Hennessey T; Sharma A; Orobello S; Squitieri F; Yang L; Beal MF
Neurodegener Dis; 2011; 8(6):496-503. PubMed ID: 21757867
[TBL] [Abstract][Full Text] [Related]
9. PGC-1α activity in nigral dopamine neurons determines vulnerability to α-synuclein.
Ciron C; Zheng L; Bobela W; Knott GW; Leone TC; Kelly DP; Schneider BL
Acta Neuropathol Commun; 2015 Apr; 3():16. PubMed ID: 25853296
[TBL] [Abstract][Full Text] [Related]
10. Detrimental effects of oxidative losses in parkin activity in a model of sporadic Parkinson's disease are attenuated by restoration of PGC1alpha.
Siddiqui A; Rane A; Rajagopalan S; Chinta SJ; Andersen JK
Neurobiol Dis; 2016 Sep; 93():115-20. PubMed ID: 27185595
[TBL] [Abstract][Full Text] [Related]
11. The mitochondrial chaperone protein TRAP1 mitigates α-Synuclein toxicity.
Butler EK; Voigt A; Lutz AK; Toegel JP; Gerhardt E; Karsten P; Falkenburger B; Reinartz A; Winklhofer KF; Schulz JB
PLoS Genet; 2012 Feb; 8(2):e1002488. PubMed ID: 22319455
[TBL] [Abstract][Full Text] [Related]
12. Insulin Resistance Promotes Parkinson's Disease through Aberrant Expression of α-Synuclein, Mitochondrial Dysfunction, and Deregulation of the Polo-Like Kinase 2 Signaling.
Hong CT; Chen KY; Wang W; Chiu JY; Wu D; Chao TY; Hu CJ; Chau KD; Bamodu OA
Cells; 2020 Mar; 9(3):. PubMed ID: 32192190
[No Abstract] [Full Text] [Related]
13. Reprint of: revisiting oxidative stress and mitochondrial dysfunction in the pathogenesis of Parkinson disease-resemblance to the effect of amphetamine drugs of abuse.
Perfeito R; Cunha-Oliveira T; Rego AC
Free Radic Biol Med; 2013 Sep; 62():186-201. PubMed ID: 23743292
[TBL] [Abstract][Full Text] [Related]
14. TOM40 mediates mitochondrial dysfunction induced by α-synuclein accumulation in Parkinson's disease.
Bender A; Desplats P; Spencer B; Rockenstein E; Adame A; Elstner M; Laub C; Mueller S; Koob AO; Mante M; Pham E; Klopstock T; Masliah E
PLoS One; 2013; 8(4):e62277. PubMed ID: 23626796
[TBL] [Abstract][Full Text] [Related]
15. Aggregated α-synuclein and complex I deficiency: exploration of their relationship in differentiated neurons.
Reeve AK; Ludtmann MH; Angelova PR; Simcox EM; Horrocks MH; Klenerman D; Gandhi S; Turnbull DM; Abramov AY
Cell Death Dis; 2015 Jul; 6(7):e1820. PubMed ID: 26181201
[TBL] [Abstract][Full Text] [Related]
16. α-Synuclein binds to TOM20 and inhibits mitochondrial protein import in Parkinson's disease.
Di Maio R; Barrett PJ; Hoffman EK; Barrett CW; Zharikov A; Borah A; Hu X; McCoy J; Chu CT; Burton EA; Hastings TG; Greenamyre JT
Sci Transl Med; 2016 Jun; 8(342):342ra78. PubMed ID: 27280685
[TBL] [Abstract][Full Text] [Related]
17. Reduced expression of peroxisome-proliferator activated receptor gamma coactivator-1alpha enhances alpha-synuclein oligomerization and down regulates AKT/GSK3beta signaling pathway in human neuronal cells that inducibly express alpha-synuclein.
Ebrahim AS; Ko LW; Yen SH
Neurosci Lett; 2010 Apr; 473(2):120-5. PubMed ID: 20178833
[TBL] [Abstract][Full Text] [Related]
18. Impaired mitochondrial dynamics and function in the pathogenesis of Parkinson's disease.
Büeler H
Exp Neurol; 2009 Aug; 218(2):235-46. PubMed ID: 19303005
[TBL] [Abstract][Full Text] [Related]
19. Heat shock protein 22 modulates NRF1/TFAM-dependent mitochondrial biogenesis and DRP1-sparked mitochondrial apoptosis through AMPK-PGC1α signaling pathway to alleviate the early brain injury of subarachnoid hemorrhage in rats.
Fan H; Ding R; Liu W; Zhang X; Li R; Wei B; Su S; Jin F; Wei C; He X; Li X; Duan C
Redox Biol; 2021 Apr; 40():101856. PubMed ID: 33472123
[TBL] [Abstract][Full Text] [Related]
20. Mitochondrial translocation of alpha-synuclein is promoted by intracellular acidification.
Cole NB; Dieuliis D; Leo P; Mitchell DC; Nussbaum RL
Exp Cell Res; 2008 Jun; 314(10):2076-89. PubMed ID: 18440504
[TBL] [Abstract][Full Text] [Related]
[Next] [New Search]