BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

127 related articles for article (PubMed ID: 22710403)

  • 1. The application of hepatic P450 reductase null gpt delta mice in studying the role of hepatic P450 in genotoxic carcinogen 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone-induced mutagenesis.
    Luan Y; Xing G; Qi X; Wu M; Li C; Yao J; Gong L; Nohmi T; Gu J; Zhou W; Zheng S; Ren J
    Arch Toxicol; 2012 Nov; 86(11):1753-61. PubMed ID: 22710403
    [TBL] [Abstract][Full Text] [Related]  

  • 2. Determination of the role of target tissue metabolism in lung carcinogenesis using conditional cytochrome P450 reductase-null mice.
    Weng Y; Fang C; Turesky RJ; Behr M; Kaminsky LS; Ding X
    Cancer Res; 2007 Aug; 67(16):7825-32. PubMed ID: 17699788
    [TBL] [Abstract][Full Text] [Related]  

  • 3. Mechanisms of chemopreventive effects of 8-methoxypsoralen against 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone-induced mouse lung adenomas.
    Miyazaki M; Yamazaki H; Takeuchi H; Saoo K; Yokohira M; Masumura K; Nohmi T; Funae Y; Imaida K; Kamataki T
    Carcinogenesis; 2005 Nov; 26(11):1947-55. PubMed ID: 15958517
    [TBL] [Abstract][Full Text] [Related]  

  • 4. Role of hepatic cytochrome P450 enzymes in the detoxication of aristolochic acid I; effects on DNA adduct, mutation, and tumor formation.
    Luan Y; Xing G; Ren J; Gu J
    Genes Environ; 2015; 37():11. PubMed ID: 27350808
    [TBL] [Abstract][Full Text] [Related]  

  • 5. Metabolic activation of benzo[a]pyrene in vitro by hepatic cytochrome P450 contrasts with detoxification in vivo: experiments with hepatic cytochrome P450 reductase null mice.
    Arlt VM; Stiborová M; Henderson CJ; Thiemann M; Frei E; Aimová D; Singh R; Gamboa da Costa G; Schmitz OJ; Farmer PB; Wolf CR; Phillips DH
    Carcinogenesis; 2008 Mar; 29(3):656-65. PubMed ID: 18204078
    [TBL] [Abstract][Full Text] [Related]  

  • 6. Mutagenesis induced by 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone-4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone and N-nitrosonornicotine in lacZ upper aerodigestive tissue and liver and inhibition by green tea.
    von Pressentin MM; Chen M; Guttenplan JB
    Carcinogenesis; 2001 Jan; 22(1):203-6. PubMed ID: 11159761
    [TBL] [Abstract][Full Text] [Related]  

  • 7. Role of cytochromes P450 1A1/2 in detoxication and activation of carcinogenic aristolochic acid I: studies with the hepatic NADPH:cytochrome P450 reductase null (HRN) mouse model.
    Levová K; Moserová M; Kotrbová V; Sulc M; Henderson CJ; Wolf CR; Phillips DH; Frei E; Schmeiser HH; Mares J; Arlt VM; Stiborová M
    Toxicol Sci; 2011 May; 121(1):43-56. PubMed ID: 21362632
    [TBL] [Abstract][Full Text] [Related]  

  • 8. Combined genotoxic effects of radiation and a tobacco-specific nitrosamine in the lung of gpt delta transgenic mice.
    Ikeda M; Masumura K; Sakamoto Y; Wang B; Nenoi M; Sakuma K; Hayata I; Nohmi T
    Mutat Res; 2007 Jan; 626(1-2):15-25. PubMed ID: 16962367
    [TBL] [Abstract][Full Text] [Related]  

  • 9. The pyridyloxobutyl DNA adduct, O6-[4-oxo-4-(3-pyridyl)butyl]guanine, is detected in tissues from 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone-treated A/J mice.
    Thomson NM; Kenney PM; Peterson LA
    Chem Res Toxicol; 2003 Jan; 16(1):1-6. PubMed ID: 12693024
    [TBL] [Abstract][Full Text] [Related]  

  • 10. Metabolic effects of CYP2A6 and CYP2A13 on 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK)-induced gene mutation--a mammalian cell-based mutagenesis approach.
    Chiang HC; Wang CY; Lee HL; Tsou TC
    Toxicol Appl Pharmacol; 2011 Jun; 253(2):145-52. PubMed ID: 21473878
    [TBL] [Abstract][Full Text] [Related]  

  • 11. Identification of cytochrome P450 enzymes critical for lung tumorigenesis by the tobacco-specific carcinogen 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK): insights from a novel Cyp2abfgs-null mouse.
    Li L; Megaraj V; Wei Y; Ding X
    Carcinogenesis; 2014 Nov; 35(11):2584-91. PubMed ID: 25173884
    [TBL] [Abstract][Full Text] [Related]  

  • 12. Role of hepatic cytochromes P450 in bioactivation of the anticancer drug ellipticine: studies with the hepatic NADPH:cytochrome P450 reductase null mouse.
    Stiborová M; Arlt VM; Henderson CJ; Wolf CR; Kotrbová V; Moserová M; Hudecek J; Phillips DH; Frei E
    Toxicol Appl Pharmacol; 2008 Feb; 226(3):318-27. PubMed ID: 17976674
    [TBL] [Abstract][Full Text] [Related]  

  • 13. Role of CYP2A13 in the bioactivation and lung tumorigenicity of the tobacco-specific lung procarcinogen 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone: in vivo studies using a CYP2A13-humanized mouse model.
    Megaraj V; Zhou X; Xie F; Liu Z; Yang W; Ding X
    Carcinogenesis; 2014 Jan; 35(1):131-7. PubMed ID: 23917075
    [TBL] [Abstract][Full Text] [Related]  

  • 14. Activation of 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK) in human lung microsomes by cytochromes P450, lipoxygenase, and hydroperoxides.
    Smith TJ; Stoner GD; Yang CS
    Cancer Res; 1995 Dec; 55(23):5566-73. PubMed ID: 7585636
    [TBL] [Abstract][Full Text] [Related]  

  • 15. Human CYP2A6 activation of 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK): mutational specificity in the gpt gene of AS52 cells.
    Tiano HF; Wang RL; Hosokawa M; Crespi C; Tindall KR; Langenbach R
    Carcinogenesis; 1994 Dec; 15(12):2859-66. PubMed ID: 8001247
    [TBL] [Abstract][Full Text] [Related]  

  • 16. Comparative metabolism of the tobacco-specific nitrosamines 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone and 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanol by rat cytochrome P450 2A3 and human cytochrome P450 2A13.
    Jalas JR; Ding X; Murphy SE
    Drug Metab Dispos; 2003 Oct; 31(10):1199-202. PubMed ID: 12975327
    [TBL] [Abstract][Full Text] [Related]  

  • 17. Mechanisms of inhibition of 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone bioactivation in mouse by dietary phenethyl isothiocyanate.
    Smith TJ; Guo Z; Li C; Ning SM; Thomas PE; Yang CS
    Cancer Res; 1993 Jul; 53(14):3276-82. PubMed ID: 8324738
    [TBL] [Abstract][Full Text] [Related]  

  • 18. Metabolism of 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone in human lung and liver microsomes and cytochromes P-450 expressed in hepatoma cells.
    Smith TJ; Guo Z; Gonzalez FJ; Guengerich FP; Stoner GD; Yang CS
    Cancer Res; 1992 Apr; 52(7):1757-63. PubMed ID: 1312898
    [TBL] [Abstract][Full Text] [Related]  

  • 19. Predicting the mutagenicity of tobacco-related N-nitrosamines in humans using 11 strains of Salmonella typhimurium YG7108, each coexpressing a form of human cytochrome P450 along with NADPH-cytochrome P450 reductase.
    Fujita K; Kamataki T
    Environ Mol Mutagen; 2001; 38(4):339-46. PubMed ID: 11774366
    [TBL] [Abstract][Full Text] [Related]  

  • 20. Kinetic analysis of the activation of 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone by heterologously expressed human P450 enzymes and the effect of P450-specific chemical inhibitors on this activation in human liver microsomes.
    Patten CJ; Smith TJ; Murphy SE; Wang MH; Lee J; Tynes RE; Koch P; Yang CS
    Arch Biochem Biophys; 1996 Sep; 333(1):127-38. PubMed ID: 8806763
    [TBL] [Abstract][Full Text] [Related]  

    [Next]    [New Search]
    of 7.