These tools will no longer be maintained as of December 31, 2024. Archived website can be found here. PubMed4Hh GitHub repository can be found here. Contact NLM Customer Service if you have questions.


BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

273 related articles for article (PubMed ID: 2271601)

  • 1. Properties of bacteriophage T4 thymidylate synthase following mutagenic changes in the active site and folate binding region.
    LaPat-Polasko L; Maley GF; Maley F
    Biochemistry; 1990 Oct; 29(41):9561-72. PubMed ID: 2271601
    [TBL] [Abstract][Full Text] [Related]  

  • 2. Catalytic cysteine of thymidylate synthase is activated upon substrate binding.
    Phan J; Mahdavian E; Nivens MC; Minor W; Berger S; Spencer HT; Dunlap RB; Lebioda L
    Biochemistry; 2000 Jun; 39(23):6969-78. PubMed ID: 10841779
    [TBL] [Abstract][Full Text] [Related]  

  • 3. An anomaly in the active site region of thymidylate synthase.
    Maley GF; Maley F
    Adv Enzyme Regul; 1989; 29():181-7. PubMed ID: 2699152
    [TBL] [Abstract][Full Text] [Related]  

  • 4. Kinetic scheme for thymidylate synthase from Escherichia coli: determination from measurements of ligand binding, primary and secondary isotope effects, and pre-steady-state catalysis.
    Spencer HT; Villafranca JE; Appleman JR
    Biochemistry; 1997 Apr; 36(14):4212-22. PubMed ID: 9100016
    [TBL] [Abstract][Full Text] [Related]  

  • 5. Kinetic studies on drug-resistant variants of Escherichia coli thymidylate synthase: functional effects of amino acid substitutions at residue 4.
    Mahdavian E; Spencer HT; Dunlap RB
    Arch Biochem Biophys; 1999 Aug; 368(2):257-64. PubMed ID: 10441376
    [TBL] [Abstract][Full Text] [Related]  

  • 6. Substitution of glutamine for glutamic acid-58 in Escherichia coli thymidylate synthase results in pronounced decreases in catalytic activity and ligand binding.
    Zapf JW; Weir MS; Emerick V; Villafranca JE; Dunlap RB
    Biochemistry; 1993 Sep; 32(36):9274-81. PubMed ID: 8103678
    [TBL] [Abstract][Full Text] [Related]  

  • 7. Crystal structures of thymidylate synthase mutant R166Q: structural basis for the nearly complete loss of catalytic activity.
    Sotelo-Mundo RR; Changchien L; Maley F; Montfort WR
    J Biochem Mol Toxicol; 2006; 20(2):88-92. PubMed ID: 16615077
    [TBL] [Abstract][Full Text] [Related]  

  • 8. Mode of action of site-directed irreversible folate analogue inhibitors of thymidylate synthase.
    Lobo AP; Nair MG; Changchien L; Weichsel A; Montfort WR; Maley F
    Biochemistry; 1998 Mar; 37(13):4535-42. PubMed ID: 9521774
    [TBL] [Abstract][Full Text] [Related]  

  • 9. Properties of a defined mutant of Escherichia coli thymidylate synthase.
    Maley GF; Maley F
    J Biol Chem; 1988 Jun; 263(16):7620-7. PubMed ID: 3286637
    [TBL] [Abstract][Full Text] [Related]  

  • 10. An essential role for water in an enzyme reaction mechanism: the crystal structure of the thymidylate synthase mutant E58Q.
    Sage CR; Rutenber EE; Stout TJ; Stroud RM
    Biochemistry; 1996 Dec; 35(50):16270-81. PubMed ID: 8973201
    [TBL] [Abstract][Full Text] [Related]  

  • 11. Electrostatic guidance of catalysis by a conserved glutamic acid in Escherichia coli dTMP synthase and bacteriophage T4 dCMP hydroxymethylase.
    Hardy LW; Graves KL; Nalivaika E
    Biochemistry; 1995 Jul; 34(26):8422-32. PubMed ID: 7599133
    [TBL] [Abstract][Full Text] [Related]  

  • 12. Functional effects of a naturally occurring amino acid substitution in human thymidylate synthase.
    Hughey CT; Barbour KW; Berger FG; Berger SH
    Mol Pharmacol; 1993 Aug; 44(2):316-23. PubMed ID: 8355668
    [TBL] [Abstract][Full Text] [Related]  

  • 13. Structural and functional analysis of surface domains unique to bacteriophage T4 thymidylate synthase.
    Hazebrouck S; Maley F; Machtelinckx V; Sonigo P; Kupiec JJ
    Biochemistry; 1999 Feb; 38(7):2094-101. PubMed ID: 10026292
    [TBL] [Abstract][Full Text] [Related]  

  • 14. Drug-resistant variants of Escherichia coli thymidylate synthase: effects of substitutions at Pro-254.
    Fantz C; Shaw D; Jennings W; Forsthoefel A; Kitchens M; Phan J; Minor W; Lebioda L; Berger FG; Spencer HT
    Mol Pharmacol; 2000 Feb; 57(2):359-66. PubMed ID: 10648646
    [TBL] [Abstract][Full Text] [Related]  

  • 15. Role of an invariant lysine residue in folate binding on Escherichia coli thymidylate synthase: calorimetric and crystallographic analysis of the K48Q mutant.
    Arvizu-Flores AA; Sugich-Miranda R; Arreola R; Garcia-Orozco KD; Velazquez-Contreras EF; Montfort WR; Maley F; Sotelo-Mundo RR
    Int J Biochem Cell Biol; 2008; 40(10):2206-17. PubMed ID: 18403248
    [TBL] [Abstract][Full Text] [Related]  

  • 16. Substitution at residue 214 of human thymidylate synthase alters nucleotide binding and isomerization of ligand-protein complexes.
    Steadman DJ; Spencer HT; Dunlap RB; Berger SH
    Biochemistry; 1999 Apr; 38(17):5582-7. PubMed ID: 10220346
    [TBL] [Abstract][Full Text] [Related]  

  • 17. Conservation and Role of Electrostatics in Thymidylate Synthase.
    Garg D; Skouloubris S; Briffotaux J; Myllykallio H; Wade RC
    Sci Rep; 2015 Nov; 5():17356. PubMed ID: 26612036
    [TBL] [Abstract][Full Text] [Related]  

  • 18. Site-directed mutagenesis of arginine 179 of thymidylate synthase. A nonessential substrate-binding residue.
    Santi DV; Pinter K; Kealey J; Davisson VJ
    J Biol Chem; 1990 Apr; 265(12):6770-5. PubMed ID: 2182628
    [TBL] [Abstract][Full Text] [Related]  

  • 19. Modifications of the active center of T4 thioredoxin by site-directed mutagenesis.
    Joelson T; Sjöberg BM; Eklund H
    J Biol Chem; 1990 Feb; 265(6):3183-8. PubMed ID: 2406248
    [TBL] [Abstract][Full Text] [Related]  

  • 20. Catalytic mechanism of Chlamydia trachomatis flavin-dependent thymidylate synthase.
    Griffin J; Roshick C; Iliffe-Lee E; McClarty G
    J Biol Chem; 2005 Feb; 280(7):5456-67. PubMed ID: 15591067
    [TBL] [Abstract][Full Text] [Related]  

    [Next]    [New Search]
    of 14.