BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

174 related articles for article (PubMed ID: 22732182)

  • 1. Subtleties in GPCR drug discovery: a medicinal chemistry perspective.
    Fujioka M; Omori N
    Drug Discov Today; 2012 Oct; 17(19-20):1133-8. PubMed ID: 22732182
    [TBL] [Abstract][Full Text] [Related]  

  • 2. Inverse agonism or neutral antagonism at G-protein coupled receptors: a medicinal chemistry challenge worth pursuing?
    Greasley PJ; Clapham JC
    Eur J Pharmacol; 2006 Dec; 553(1-3):1-9. PubMed ID: 17081515
    [TBL] [Abstract][Full Text] [Related]  

  • 3. Biased agonism at G protein-coupled receptors: the promise and the challenges--a medicinal chemistry perspective.
    Shonberg J; Lopez L; Scammells PJ; Christopoulos A; Capuano B; Lane JR
    Med Res Rev; 2014 Nov; 34(6):1286-330. PubMed ID: 24796277
    [TBL] [Abstract][Full Text] [Related]  

  • 4. Structure-based drug design for G protein-coupled receptors.
    Congreve M; Dias JM; Marshall FH
    Prog Med Chem; 2014; 53():1-63. PubMed ID: 24418607
    [TBL] [Abstract][Full Text] [Related]  

  • 5. The 7 TM G-protein-coupled receptor target family.
    Jacoby E; Bouhelal R; Gerspacher M; Seuwen K
    ChemMedChem; 2006 Aug; 1(8):761-82. PubMed ID: 16902930
    [TBL] [Abstract][Full Text] [Related]  

  • 6. Using ligand-induced conformational change to screen for compounds targeting G-protein-coupled receptors.
    O'Dowd BF; Alijaniaram M; Ji X; Nguyen T; Eglen RM; George SR
    J Biomol Screen; 2007 Mar; 12(2):175-85. PubMed ID: 17289935
    [TBL] [Abstract][Full Text] [Related]  

  • 7. Evaluation of cellular dielectric spectroscopy, a whole-cell, label-free technology for drug discovery on Gi-coupled GPCRs.
    Peters MF; Knappenberger KS; Wilkins D; Sygowski LA; Lazor LA; Liu J; Scott CW
    J Biomol Screen; 2007 Apr; 12(3):312-9. PubMed ID: 17307886
    [TBL] [Abstract][Full Text] [Related]  

  • 8. Development of a cyclic adenosine monophosphate assay for Gi-coupled G protein-coupled receptors by utilizing the endogenous calcitonin activity in Chinese hamster ovary cells.
    Wang Y; Kong Y; Shei GJ; Kang L; Cvijic ME
    Assay Drug Dev Technol; 2011 Oct; 9(5):522-31. PubMed ID: 21561374
    [TBL] [Abstract][Full Text] [Related]  

  • 9. GLIDA: GPCR-ligand database for chemical genomic drug discovery.
    Okuno Y; Yang J; Taneishi K; Yabuuchi H; Tsujimoto G
    Nucleic Acids Res; 2006 Jan; 34(Database issue):D673-7. PubMed ID: 16381956
    [TBL] [Abstract][Full Text] [Related]  

  • 10. G-protein-coupled receptor-focused drug discovery using a target class platform approach.
    Heilker R; Wolff M; Tautermann CS; Bieler M
    Drug Discov Today; 2009 Mar; 14(5-6):231-40. PubMed ID: 19121411
    [TBL] [Abstract][Full Text] [Related]  

  • 11. Ligand and decoy sets for docking to G protein-coupled receptors.
    Gatica EA; Cavasotto CN
    J Chem Inf Model; 2012 Jan; 52(1):1-6. PubMed ID: 22168315
    [TBL] [Abstract][Full Text] [Related]  

  • 12. Recent developments in constitutive receptor activity and inverse agonism, and their potential for GPCR drug discovery.
    Bond RA; Ijzerman AP
    Trends Pharmacol Sci; 2006 Feb; 27(2):92-6. PubMed ID: 16406086
    [TBL] [Abstract][Full Text] [Related]  

  • 13. G protein-coupled receptor modulation with pepducins: moving closer to the clinic.
    Dimond P; Carlson K; Bouvier M; Gerard C; Xu L; Covic L; Agarwal A; Ernst OP; Janz JM; Schwartz TW; Gardella TJ; Milligan G; Kuliopulos A; Sakmar TP; Hunt SW
    Ann N Y Acad Sci; 2011 May; 1226():34-49. PubMed ID: 21615752
    [TBL] [Abstract][Full Text] [Related]  

  • 14. From purified GPCRs to drug discovery: the promise of protein-based methodologies.
    Alkhalfioui F; Magnin T; Wagner R
    Curr Opin Pharmacol; 2009 Oct; 9(5):629-35. PubMed ID: 19443270
    [TBL] [Abstract][Full Text] [Related]  

  • 15. G-protein coupled receptors virtual screening using genetic algorithm focused chemical space.
    Sage C; Wang R; Jones G
    J Chem Inf Model; 2011 Aug; 51(8):1754-61. PubMed ID: 21761904
    [TBL] [Abstract][Full Text] [Related]  

  • 16. G protein-coupled receptor internalization assays in the high-content screening format.
    Haasen D; Schnapp A; Valler MJ; Heilker R
    Methods Enzymol; 2006; 414():121-39. PubMed ID: 17110190
    [TBL] [Abstract][Full Text] [Related]  

  • 17. GPCR assay automation for leveraging lead optimization.
    Cvijic ME; Chen J; Kubala S; Nolfo J; Kolodin G; Zhang L
    J Lab Autom; 2012 Aug; 17(4):266-74. PubMed ID: 22505604
    [TBL] [Abstract][Full Text] [Related]  

  • 18. New insights from structural biology into the druggability of G protein-coupled receptors.
    Mason JS; Bortolato A; Congreve M; Marshall FH
    Trends Pharmacol Sci; 2012 May; 33(5):249-60. PubMed ID: 22465153
    [TBL] [Abstract][Full Text] [Related]  

  • 19. Allosteric modulation of G protein-coupled receptors: a pharmacological perspective.
    Keov P; Sexton PM; Christopoulos A
    Neuropharmacology; 2011 Jan; 60(1):24-35. PubMed ID: 20637785
    [TBL] [Abstract][Full Text] [Related]  

  • 20. Strategies for the identification of allosteric modulators of G-protein-coupled receptors.
    Burford NT; Watson J; Bertekap R; Alt A
    Biochem Pharmacol; 2011 Mar; 81(6):691-702. PubMed ID: 21184747
    [TBL] [Abstract][Full Text] [Related]  

    [Next]    [New Search]
    of 9.