BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

247 related articles for article (PubMed ID: 22735814)

  • 1. Activation of PI3K/Akt signaling by n-terminal SH2 domain mutants of the p85α regulatory subunit of PI3K is enhanced by deletion of its c-terminal SH2 domain.
    Hofmann BT; Jücker M
    Cell Signal; 2012 Oct; 24(10):1950-4. PubMed ID: 22735814
    [TBL] [Abstract][Full Text] [Related]  

  • 2. Expression of a mutated form of the p85alpha regulatory subunit of phosphatidylinositol 3-kinase in a Hodgkin's lymphoma-derived cell line (CO).
    Jücker M; Südel K; Horn S; Sickel M; Wegner W; Fiedler W; Feldman RA
    Leukemia; 2002 May; 16(5):894-901. PubMed ID: 11986952
    [TBL] [Abstract][Full Text] [Related]  

  • 3. Mutations in the catalytic subunit of class IA PI3K confer leukemogenic potential to hematopoietic cells.
    Horn S; Bergholz U; Jücker M; McCubrey JA; Trümper L; Stocking C; Bäsecke J
    Oncogene; 2008 Jul; 27(29):4096-106. PubMed ID: 18317450
    [TBL] [Abstract][Full Text] [Related]  

  • 4. The tyrosine phosphatase SHP-2 is required for mediating phosphatidylinositol 3-kinase/Akt activation by growth factors.
    Wu CJ; O'Rourke DM; Feng GS; Johnson GR; Wang Q; Greene MI
    Oncogene; 2001 Sep; 20(42):6018-25. PubMed ID: 11593409
    [TBL] [Abstract][Full Text] [Related]  

  • 5. Infectious bursal disease virus activates the phosphatidylinositol 3-kinase (PI3K)/Akt signaling pathway by interaction of VP5 protein with the p85α subunit of PI3K.
    Wei L; Hou L; Zhu S; Wang J; Zhou J; Liu J
    Virology; 2011 Aug; 417(1):211-20. PubMed ID: 21723579
    [TBL] [Abstract][Full Text] [Related]  

  • 6. Domain analysis reveals striking functional differences between the regulatory subunits of phosphatidylinositol 3-kinase (PI3K), p85α and p85β.
    Ito Y; Vogt PK; Hart JR
    Oncotarget; 2017 Aug; 8(34):55863-55876. PubMed ID: 28915558
    [TBL] [Abstract][Full Text] [Related]  

  • 7. The SH3 and BH domains of the p85alpha adapter subunit play a critical role in regulating class Ia phosphoinositide 3-kinase function.
    Beeton CA; Das P; Waterfield MD; Shepherd PR
    Mol Cell Biol Res Commun; 1999 May; 1(2):153-7. PubMed ID: 10356365
    [TBL] [Abstract][Full Text] [Related]  

  • 8. Cancer-derived mutations in the regulatory subunit p85alpha of phosphoinositide 3-kinase function through the catalytic subunit p110alpha.
    Sun M; Hillmann P; Hofmann BT; Hart JR; Vogt PK
    Proc Natl Acad Sci U S A; 2010 Aug; 107(35):15547-52. PubMed ID: 20713702
    [TBL] [Abstract][Full Text] [Related]  

  • 9. Cancer-associated mutations in the p85α N-terminal SH2 domain activate a spectrum of receptor tyrosine kinases.
    Li X; Lau AYT; Ng ASN; Aldehaiman A; Zhou Y; Ng PKS; Arold ST; Cheung LWT
    Proc Natl Acad Sci U S A; 2021 Sep; 118(37):. PubMed ID: 34507989
    [TBL] [Abstract][Full Text] [Related]  

  • 10. SHP-2 regulates the phosphatidylinositide 3'-kinase/Akt pathway and suppresses caspase 3-mediated apoptosis.
    Ivins Zito C; Kontaridis MI; Fornaro M; Feng GS; Bennett AM
    J Cell Physiol; 2004 May; 199(2):227-36. PubMed ID: 15040005
    [TBL] [Abstract][Full Text] [Related]  

  • 11. Regulation of lipid binding underlies the activation mechanism of class IA PI3-kinases.
    Hon WC; Berndt A; Williams RL
    Oncogene; 2012 Aug; 31(32):3655-66. PubMed ID: 22120714
    [TBL] [Abstract][Full Text] [Related]  

  • 12. Functional interactions between isolated SH2 domains and insulin/Ras signaling pathways of Xenopus oocytes: opposite effects of the carboxy- and amino-terminal SH2 domains of p85 PI 3-kinase.
    Aroca P; Mahadevan D; Santos E
    Oncogene; 1996 Nov; 13(9):1839-46. PubMed ID: 8934529
    [TBL] [Abstract][Full Text] [Related]  

  • 13. Solution structure of the C-terminal SH2 domain of the p85 alpha regulatory subunit of phosphoinositide 3-kinase.
    Siegal G; Davis B; Kristensen SM; Sankar A; Linacre J; Stein RC; Panayotou G; Waterfield MD; Driscoll PC
    J Mol Biol; 1998 Feb; 276(2):461-78. PubMed ID: 9512716
    [TBL] [Abstract][Full Text] [Related]  

  • 14. Defining How Oncogenic and Developmental Mutations of PIK3R1 Alter the Regulation of Class IA Phosphoinositide 3-Kinases.
    Dornan GL; Stariha JTB; Rathinaswamy MK; Powell CJ; Boulanger MJ; Burke JE
    Structure; 2020 Feb; 28(2):145-156.e5. PubMed ID: 31831213
    [TBL] [Abstract][Full Text] [Related]  

  • 15. TGF-β promotes PI3K-AKT signaling and prostate cancer cell migration through the TRAF6-mediated ubiquitylation of p85α.
    Hamidi A; Song J; Thakur N; Itoh S; Marcusson A; Bergh A; Heldin CH; Landström M
    Sci Signal; 2017 Jul; 10(486):. PubMed ID: 28676490
    [TBL] [Abstract][Full Text] [Related]  

  • 16. Inhibition of PI3K binding to activators by serine phosphorylation of PI3K regulatory subunit p85alpha Src homology-2 domains.
    Lee JY; Chiu YH; Asara J; Cantley LC
    Proc Natl Acad Sci U S A; 2011 Aug; 108(34):14157-62. PubMed ID: 21825134
    [TBL] [Abstract][Full Text] [Related]  

  • 17. Progressive changes in the leukemogenic signaling in BCR/ABL-transformed cells.
    Nieborowska-Skorska M; Slupianek A; Skorski T
    Oncogene; 2000 Aug; 19(36):4117-24. PubMed ID: 10962572
    [TBL] [Abstract][Full Text] [Related]  

  • 18. Activation of the focal adhesion kinase signaling pathway by structural alterations in the carboxyl-terminal region of c-Crk II.
    Zvara A; Fajardo JE; Escalante M; Cotton G; Muir T; Kirsch KH; Birge RB
    Oncogene; 2001 Feb; 20(8):951-61. PubMed ID: 11314030
    [TBL] [Abstract][Full Text] [Related]  

  • 19. Multiple roles for the p85α isoform in the regulation and function of PI3K signalling and receptor trafficking.
    Mellor P; Furber LA; Nyarko JN; Anderson DH
    Biochem J; 2012 Jan; 441(1):23-37. PubMed ID: 22168437
    [TBL] [Abstract][Full Text] [Related]  

  • 20. Thyroid-hormone-dependent activation of the phosphoinositide 3-kinase/Akt cascade requires Src and enhances neuronal survival.
    Cao X; Kambe F; Yamauchi M; Seo H
    Biochem J; 2009 Nov; 424(2):201-9. PubMed ID: 19747164
    [TBL] [Abstract][Full Text] [Related]  

    [Next]    [New Search]
    of 13.