BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

119 related articles for article (PubMed ID: 22739084)

  • 21. Alpha1-adrenoceptor antagonists. 6. Structural optimization of pyridazinone-arylpiperazines. Study of the influence on affinity and selectivity of cyclic substituents at the pyridazinone ring and alkoxy groups at the arylpiperazine moiety.
    Betti L; Corelli F; Floridi M; Giannaccini G; Maccari L; Manetti F; Strappaghetti G; Botta M
    J Med Chem; 2003 Jul; 46(16):3555-8. PubMed ID: 12877594
    [TBL] [Abstract][Full Text] [Related]  

  • 22. Synthesis of 3-arylpiperazinylalkylpyrrolo[3,2-d]pyrimidine-2,4-dione derivatives as novel, potent, and selective alpha1-adrenoceptor ligands.
    Patanè E; Pittalà V; Guerrera F; Salerno L; Romeo G; Siracusa MA; Russo F; Manetti F; Botta M; Mereghetti I; Cagnotto A; Mennini T
    J Med Chem; 2005 Apr; 48(7):2420-31. PubMed ID: 15801833
    [TBL] [Abstract][Full Text] [Related]  

  • 23. 1,3-Dioxolane-based ligands incorporating a lactam or imide moiety: structure-affinity/activity relationship at alpha1-adrenoceptor subtypes and at 5-HT1A receptors.
    Franchini S; Prandi A; Baraldi A; Sorbi C; Tait A; Buccioni M; Marucci G; Cilia A; Pirona L; Fossa P; Cichero E; Brasili L
    Eur J Med Chem; 2010 Sep; 45(9):3740-51. PubMed ID: 20605276
    [TBL] [Abstract][Full Text] [Related]  

  • 24. Computer--based drug design, synthesis and biological evaluation of new pyrimidinone derivatives linked to arylpiperazine and 2'-carbethoxy-biphenylylmethyl moeities as alpha1-adrenoceptor antagonists and angiotensin II AT1 receptor antagonists.
    Ismail MA; Abou El Ella DA; Abouzid KA; Al-Ansary GH
    Pharmazie; 2010 Nov; 65(11):794-800. PubMed ID: 21155384
    [TBL] [Abstract][Full Text] [Related]  

  • 25. The hypotensive activity and alpha1-adrenoceptor antagonistic properties of some aroxyalkyl derivatives of 2-methoxyphenylpiperazine.
    Kubacka M; Mogilski S; Filipek B; Marona H
    Eur J Pharmacol; 2013 Jan; 698(1-3):335-44. PubMed ID: 23117089
    [TBL] [Abstract][Full Text] [Related]  

  • 26. Computer-aided insights into receptor-ligand interaction for novel 5-arylhydantoin derivatives as serotonin 5-HT
    Kucwaj-Brysz K; Kurczab R; Jastrzębska-Więsek M; Żesławska E; Satała G; Nitek W; Partyka A; Siwek A; Jankowska A; Wesołowska A; Kieć-Kononowicz K; Handzlik J
    Eur J Med Chem; 2018 Mar; 147():102-114. PubMed ID: 29425815
    [TBL] [Abstract][Full Text] [Related]  

  • 27. Synthesis and structure-activity relationships of a new model of arylpiperazines. 8. Computational simulation of ligand-receptor interaction of 5-HT(1A)R agonists with selectivity over alpha1-adrenoceptors.
    López-Rodríguez ML; Morcillo MJ; Fernández E; Benhamú B; Tejada I; Ayala D; Viso A; Campillo M; Pardo L; Delgado M; Manzanares J; Fuentes JA
    J Med Chem; 2005 Apr; 48(7):2548-58. PubMed ID: 15801844
    [TBL] [Abstract][Full Text] [Related]  

  • 28. Design, synthesis, crystal structure, biological evaluation and molecular docking studies of carbazole-arylpiperazine derivatives.
    Xu W; Huang J; Shao B; Xu X; Jiang R; Yuan M
    Bioorg Med Chem; 2016 Nov; 24(21):5565-5572. PubMed ID: 27663545
    [TBL] [Abstract][Full Text] [Related]  

  • 29. Probes for narcotic receptor-mediated phenomena. 25. Synthesis and evaluation of N-alkyl-substituted (alpha-piperazinylbenzyl)benzamides as novel, highly selective delta opioid receptor agonists.
    Katsura Y; Zhang X; Homma K; Rice KC; Calderon SN; Rothman RB; Yamamura HI; Davis P; Flippen-Anderson JL; Xu H; Becketts K; Foltz EJ; Porreca F
    J Med Chem; 1997 Aug; 40(18):2936-47. PubMed ID: 9288176
    [TBL] [Abstract][Full Text] [Related]  

  • 30. Alpha(1)-adrenoceptor antagonists. 4. Pharmacophore-based design, synthesis, and biological evaluation of new imidazo-, benzimidazo-, and indoloarylpiperazine derivatives.
    Betti L; Botta M; Corelli F; Floridi M; Giannaccini G; Maccari L; Manetti F; Strappaghetti G; Tafi A; Corsano S
    J Med Chem; 2002 Aug; 45(17):3603-11. PubMed ID: 12166933
    [TBL] [Abstract][Full Text] [Related]  

  • 31. Exploring the neuroleptic substituent in octoclothepin: potential ligands for positron emission tomography with subnanomolar affinity for α(1)-adrenoceptors.
    Kristensen JL; Püschl A; Jensen M; Risgaard R; Christoffersen CT; Bang-Andersen B; Balle T
    J Med Chem; 2010 Oct; 53(19):7021-34. PubMed ID: 20857909
    [TBL] [Abstract][Full Text] [Related]  

  • 32. 3-Arylpiperazinylethyl-1H-pyrrolo[2,3-d]pyrimidine-2,4(3H,7H)-dione derivatives as novel, high-affinity and selective alpha(1)-adrenoceptor ligands.
    Pittalà V; Romeo G; Salerno L; Siracusa MA; Modica M; Materia L; Mereghetti I; Cagnotto A; Mennini T; Marucci G; Angeli P; Russo F
    Bioorg Med Chem Lett; 2006 Jan; 16(1):150-3. PubMed ID: 16216506
    [TBL] [Abstract][Full Text] [Related]  

  • 33. Synthesis and molecular modeling of 1H-pyrrolopyrimidine-2,4-dione derivatives as ligands for the α1-adrenoceptors.
    Pittalà V; Siracusa MA; Modica MN; Salerno L; Pedretti A; Vistoli G; Cagnotto A; Mennini T; Romeo G
    Bioorg Med Chem; 2011 Sep; 19(17):5260-76. PubMed ID: 21802308
    [TBL] [Abstract][Full Text] [Related]  

  • 34. Design, synthesis, and alpha(1)-adrenoceptor binding properties of new arylpiperazine derivatives bearing a flavone nucleus as the terminal heterocyclic molecular portion.
    Betti L; Floridi M; Giannaccini G; Manetti F; Paparelli C; Strappaghetti G; Botta M
    Bioorg Med Chem; 2004 Mar; 12(6):1527-35. PubMed ID: 15018926
    [TBL] [Abstract][Full Text] [Related]  

  • 35. Search for new tools to combat Gram-negative resistant bacteria among amine derivatives of 5-arylidenehydantoin.
    Handzlik J; Szymańska E; Alibert S; Chevalier J; Otrębska E; Pękala E; Pagès JM; Kieć-Kononowicz K
    Bioorg Med Chem; 2013 Jan; 21(1):135-45. PubMed ID: 23218781
    [TBL] [Abstract][Full Text] [Related]  

  • 36. Molecular design and synthesis of 1,4-disubstituted piperazines as α(1)-adrenergic receptor blockers.
    Abou El-Ella DA; Hussein MM; Serya RA; Abdel Naby RM; Al-Abd AM; Saleh DO; El-Eraky WI; Abouzid KA
    Bioorg Chem; 2014 Jun; 54():21-30. PubMed ID: 24727279
    [TBL] [Abstract][Full Text] [Related]  

  • 37. Rational design, synthesis, biological evaluation, homology and docking studies of coumarin derivatives as α1 -adrenoceptor antagonists.
    Zhou X; Chen YD; Wang T; Wang XB; Kong LY
    Chem Biodivers; 2011 Jun; 8(6):1052-64. PubMed ID: 21674779
    [TBL] [Abstract][Full Text] [Related]  

  • 38. Ligand-based pharmacophore model of N-Aryl and N-Heteroaryl piperazine alpha 1A-adrenoceptors antagonists using GALAHAD.
    Zhao X; Yuan M; Huang B; Ji H; Zhu L
    J Mol Graph Model; 2010 Sep; 29(2):126-36. PubMed ID: 20538497
    [TBL] [Abstract][Full Text] [Related]  

  • 39. Synthesis and structure-activity relationships of a new model of arylpiperazines. 4. 1-[omega-(4-Arylpiperazin-1-yl)alkyl]-3-(diphenylmethylene) - 2, 5-pyrrolidinediones and -3-(9H-fluoren-9-ylidene)-2, 5-pyrrolidinediones: study of the steric requirements of the terminal amide fragment on 5-HT1A affinity/selectivity.
    López-Rodríguez ML; Morcillo MJ; Rovat TK; Fernández E; Vicente B; Sanz AM; Hernández M; Orensanz L
    J Med Chem; 1999 Jan; 42(1):36-49. PubMed ID: 9888831
    [TBL] [Abstract][Full Text] [Related]  

  • 40. [[(Arylpiperazinyl)alkyl]thio]thieno[2,3-d]pyrimidinone derivatives as high-affinity, selective 5-HT1A receptor ligands.
    Modica M; Santagati M; Russo F; Parotti L; De Gioia L; Selvaggini C; Salmona M; Mennini T
    J Med Chem; 1997 Feb; 40(4):574-85. PubMed ID: 9046348
    [TBL] [Abstract][Full Text] [Related]  

    [Previous]   [Next]    [New Search]
    of 6.