96 related articles for article (PubMed ID: 22765651)
21. Evaluation of WO2013116562A, an orally active PI3Kδ inhibitor for the treatment of asthma.
Norman P
Expert Opin Ther Pat; 2014 May; 24(5):603-7. PubMed ID: 24387136
[TBL] [Abstract][Full Text] [Related]
22. Discovery of novel class 1 phosphatidylinositide 3-kinases (PI3K) fragment inhibitors through structure-based virtual screening.
Giordanetto F; Kull B; Dellsén A
Bioorg Med Chem Lett; 2011 Jan; 21(2):829-35. PubMed ID: 21169017
[TBL] [Abstract][Full Text] [Related]
23. Fascaplysin-inspired diindolyls as selective inhibitors of CDK4/cyclin D1.
Aubry C; Wilson AJ; Emmerson D; Murphy E; Chan YY; Dickens MP; García MD; Jenkins PR; Mahale S; Chaudhuri B
Bioorg Med Chem; 2009 Aug; 17(16):6073-84. PubMed ID: 19632122
[TBL] [Abstract][Full Text] [Related]
24. Design and synthesis of 3-(4,5,6,7-tetrahydro-3H-imidazo[4,5-c]pyridin-2-yl)-1H-quinolin-2-ones as VEGFR-2 kinase inhibitors.
Han SY; Choi JW; Yang J; Chae CH; Lee J; Jung H; Lee K; Ha JD; Kim HR; Cho SY
Bioorg Med Chem Lett; 2012 Apr; 22(8):2837-42. PubMed ID: 22450128
[TBL] [Abstract][Full Text] [Related]
25. Synthesis and antiplatelet activity of ethyl 4-(1-benzyl-1H-indazol-3-yl)benzoate (YD-3) derivatives.
Chen HS; Kuo SC; Teng CM; Lee FY; Wang JP; Lee YC; Kuo CW; Huang CC; Wu CC; Huang LJ
Bioorg Med Chem; 2008 Feb; 16(3):1262-78. PubMed ID: 17988878
[TBL] [Abstract][Full Text] [Related]
26. Potent enantioselective inhibition of DNA-dependent protein kinase (DNA-PK) by atropisomeric chromenone derivatives.
Clapham KM; Rennison T; Jones G; Craven F; Bardos J; Golding BT; Griffin RJ; Haggerty K; Hardcastle IR; Thommes P; Ting A; Cano C
Org Biomol Chem; 2012 Sep; 10(33):6747-57. PubMed ID: 22814419
[TBL] [Abstract][Full Text] [Related]
27. Discovery of potent and selective inhibitors of the mammalian target of rapamycin (mTOR) kinase.
Nowak P; Cole DC; Brooijmans N; Bursavich MG; Curran KJ; Ellingboe JW; Gibbons JJ; Hollander I; Hu Y; Kaplan J; Malwitz DJ; Toral-Barza L; Verheijen JC; Zask A; Zhang WG; Yu K
J Med Chem; 2009 Nov; 52(22):7081-9. PubMed ID: 19848404
[TBL] [Abstract][Full Text] [Related]
28. Evaluation of WO2012037132 - a novel scaffold for selective JAK1 inhibition.
Norman P
Expert Opin Ther Pat; 2012 Sep; 22(9):1105-9. PubMed ID: 22812580
[TBL] [Abstract][Full Text] [Related]
29. Synthesis and biological evaluation of 5-[(aryl)(1H-imidazol-1-yl)methyl]-1H-indoles: potent and selective aromatase inhibitors.
Lézé MP; Le Borgne M; Pinson P; Palusczak A; Duflos M; Le Baut G; Hartmann RW
Bioorg Med Chem Lett; 2006 Mar; 16(5):1134-7. PubMed ID: 16380254
[TBL] [Abstract][Full Text] [Related]
30. Discovery of 5-[[4-[(2,3-dimethyl-2H-indazol-6-yl)methylamino]-2-pyrimidinyl]amino]-2-methyl-benzenesulfonamide (Pazopanib), a novel and potent vascular endothelial growth factor receptor inhibitor.
Harris PA; Boloor A; Cheung M; Kumar R; Crosby RM; Davis-Ward RG; Epperly AH; Hinkle KW; Hunter RN; Johnson JH; Knick VB; Laudeman CP; Luttrell DK; Mook RA; Nolte RT; Rudolph SK; Szewczyk JR; Truesdale AT; Veal JM; Wang L; Stafford JA
J Med Chem; 2008 Aug; 51(15):4632-40. PubMed ID: 18620382
[TBL] [Abstract][Full Text] [Related]
31. The discovery of N-cyclopropyl-4-methyl-3-[6-(4-methylpiperazin-1-yl)-4-oxoquinazolin-3(4H)-yl]benzamide (AZD6703), a clinical p38α MAP kinase inhibitor for the treatment of inflammatory diseases.
Brown DS; Cumming JG; Bethel P; Finlayson J; Gerhardt S; Nash I; Pauptit RA; Pike KG; Reid A; Snelson W; Swallow S; Thompson C
Bioorg Med Chem Lett; 2012 Jun; 22(12):3879-83. PubMed ID: 22608965
[TBL] [Abstract][Full Text] [Related]
32. Crystalline form of a neutrophil elastase inhibitor, 6-methyl-5-(1-methyl-1H-pyrazol-5-yl)-N-{[5-(methylsulfonyl)pyridin-2-yl]methyl}-2-oxo-1-[3-(trifluoromethyl)phenyl]-1,2-dihydropyridine-3-carboxamide p-toluene sulfonate - is it AZD-9668?: WO-2010094964.
Norman P
Expert Opin Ther Pat; 2011 Feb; 21(2):277-80. PubMed ID: 21222548
[TBL] [Abstract][Full Text] [Related]
33. Synthesis and biological evaluation of imidazo[1,2-a]pyridine derivatives as novel PI3 kinase p110alpha inhibitors.
Hayakawa M; Kaizawa H; Kawaguchi K; Ishikawa N; Koizumi T; Ohishi T; Yamano M; Okada M; Ohta M; Tsukamoto S; Raynaud FI; Waterfield MD; Parker P; Workman P
Bioorg Med Chem; 2007 Jan; 15(1):403-12. PubMed ID: 17049248
[TBL] [Abstract][Full Text] [Related]
34. PI3K: a potential therapeutic target for cancer.
Chen Y; Wang BC; Xiao Y
J Cell Physiol; 2012 Jul; 227(7):2818-21. PubMed ID: 21938729
[TBL] [Abstract][Full Text] [Related]
35. Discovery of 3-(2-aminoethyl)-5-(3-phenyl-propylidene)-thiazolidine-2,4-dione as a dual inhibitor of the Raf/MEK/ERK and the PI3K/Akt signaling pathways.
Li Q; Wu J; Zheng H; Liu K; Guo TL; Liu Y; Eblen ST; Grant S; Zhang S
Bioorg Med Chem Lett; 2010 Aug; 20(15):4526-30. PubMed ID: 20580230
[TBL] [Abstract][Full Text] [Related]
36. Design, synthesis, and evaluation of novel 4-thiazolylimidazoles as inhibitors of transforming growth factor-β type I receptor kinase.
Amada H; Sekiguchi Y; Ono N; Matsunaga Y; Koami T; Asanuma H; Shiozawa F; Endo M; Ikeda A; Aoki M; Fujimoto N; Wada R; Sato M
Bioorg Med Chem Lett; 2012 Mar; 22(5):2024-9. PubMed ID: 22325945
[TBL] [Abstract][Full Text] [Related]
37. Synthesis, molecular docking and evaluation of thiazolyl-pyrazoline derivatives as EGFR TK inhibitors and potential anticancer agents.
Lv PC; Li DD; Li QS; Lu X; Xiao ZP; Zhu HL
Bioorg Med Chem Lett; 2011 Sep; 21(18):5374-7. PubMed ID: 21802290
[TBL] [Abstract][Full Text] [Related]
38. Discovery of novel imidazo[1,2-a]pyridines as inhibitors of the insulin-like growth factor-1 receptor tyrosine kinase.
Ducray R; Simpson I; Jung FH; Nissink JW; Kenny PW; Fitzek M; Walker GE; Ward LT; Hudson K
Bioorg Med Chem Lett; 2011 Aug; 21(16):4698-701. PubMed ID: 21775140
[TBL] [Abstract][Full Text] [Related]
39. 2-(6-Phenyl-1H-indazol-3-yl)-1H-benzo[d]imidazoles: design and synthesis of a potent and isoform selective PKC-zeta inhibitor.
Trujillo JI; Kiefer JR; Huang W; Thorarensen A; Xing L; Caspers NL; Day JE; Mathis KJ; Kretzmer KK; Reitz BA; Weinberg RA; Stegeman RA; Wrightstone A; Christine L; Compton R; Li X
Bioorg Med Chem Lett; 2009 Feb; 19(3):908-11. PubMed ID: 19097791
[TBL] [Abstract][Full Text] [Related]
40. Evaluation of WO-2012085582 and WO-2012085583 two identified MABAs: backups to AZD-2115?
Norman P
Expert Opin Ther Pat; 2012 Nov; 22(11):1377-83. PubMed ID: 22917191
[TBL] [Abstract][Full Text] [Related]
[Previous] [Next] [New Search]
