These tools will no longer be maintained as of December 31, 2024. Archived website can be found here. PubMed4Hh GitHub repository can be found here. Contact NLM Customer Service if you have questions.


BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

140 related articles for article (PubMed ID: 22768308)

  • 1. Fluorophore labeled kinase detects ligands that bind within the MAPK insert of p38α kinase.
    Getlik M; Simard JR; Termathe M; Grütter C; Rabiller M; van Otterlo WA; Rauh D
    PLoS One; 2012; 7(7):e39713. PubMed ID: 22768308
    [TBL] [Abstract][Full Text] [Related]  

  • 2. A Comprehensive Structural Overview of p38α Mitogen-Activated Protein Kinase in Complex with ATP-Site and Non-ATP-Site Binders.
    Astolfi A; Manfroni G; Cecchetti V; Barreca ML
    ChemMedChem; 2018 Jan; 13(1):7-14. PubMed ID: 29210532
    [TBL] [Abstract][Full Text] [Related]  

  • 3. Human p38α mitogen-activated protein kinase in the Asp168-Phe169-Gly170-in (DFG-in) state can bind allosteric inhibitor Doramapimod.
    Suplatov D; Kopylov K; Sharapova Y; Švedas V
    J Biomol Struct Dyn; 2019 May; 37(8):2049-2060. PubMed ID: 29749295
    [TBL] [Abstract][Full Text] [Related]  

  • 4. Fluorescence polarization binding assay to develop inhibitors of inactive p38alpha mitogen-activated protein kinase.
    Munoz L; Selig R; Yeung YT; Peifer C; Hauser D; Laufer S
    Anal Biochem; 2010 Jun; 401(1):125-33. PubMed ID: 20175985
    [TBL] [Abstract][Full Text] [Related]  

  • 5. Covalent Lipid Pocket Ligands Targeting p38α MAPK Mutants.
    Bührmann M; Hardick J; Weisner J; Quambusch L; Rauh D
    Angew Chem Int Ed Engl; 2017 Oct; 56(43):13232-13236. PubMed ID: 28834017
    [TBL] [Abstract][Full Text] [Related]  

  • 6. p38alpha MAP kinase C-terminal domain binding pocket characterized by crystallographic and computational analyses.
    Perry JJ; Harris RM; Moiani D; Olson AJ; Tainer JA
    J Mol Biol; 2009 Aug; 391(1):1-11. PubMed ID: 19501598
    [TBL] [Abstract][Full Text] [Related]  

  • 7. Kinase in motion: insights into the dynamic nature of p38α by high-pressure NMR spectroscopic studies.
    Nielsen G; Jonker HR; Vajpai N; Grzesiek S; Schwalbe H
    Chembiochem; 2013 Sep; 14(14):1799-806. PubMed ID: 23843149
    [TBL] [Abstract][Full Text] [Related]  

  • 8. A distinct interaction mode revealed by the crystal structure of the kinase p38α with the MAPK binding domain of the phosphatase MKP5.
    Zhang YY; Wu JW; Wang ZX
    Sci Signal; 2011 Dec; 4(204):ra88. PubMed ID: 22375048
    [TBL] [Abstract][Full Text] [Related]  

  • 9. Fluorescence polarization-based assays for detecting compounds binding to inactive c-Jun N-terminal kinase 3 and p38α mitogen-activated protein kinase.
    Ansideri F; Lange A; El-Gokha A; Boeckler FM; Koch P
    Anal Biochem; 2016 Jun; 503():28-40. PubMed ID: 26954235
    [TBL] [Abstract][Full Text] [Related]  

  • 10. Direct monitoring of the conformational equilibria of the activation loop in the mitogen-activated protein kinase p38α.
    Roser P; Weisner J; Simard JR; Rauh D; Drescher M
    Chem Commun (Camb); 2018 Oct; 54(85):12057-12060. PubMed ID: 30295691
    [TBL] [Abstract][Full Text] [Related]  

  • 11. p38α MAPK and Type I Inhibitors: Binding Site Analysis and Use of Target Ensembles in Virtual Screening.
    Astolfi A; Iraci N; Sabatini S; Barreca ML; Cecchetti V
    Molecules; 2015 Aug; 20(9):15842-61. PubMed ID: 26334265
    [TBL] [Abstract][Full Text] [Related]  

  • 12. The design, synthesis and potential utility of fluorescence probes that target DFG-out conformation of p38alpha for high throughput screening binding assay.
    Tecle H; Feru F; Liu H; Kuhn C; Rennie G; Morris M; Shao J; Cheng AC; Gikunju D; Miret J; Coli R; Xi SH; Clugston SL; Low S; Kazmirski S; Ding YH; Cao Q; Johnson TL; Deshmukh GD; DiNitto JP; Wu JC; English JM
    Chem Biol Drug Des; 2009 Dec; 74(6):547-59. PubMed ID: 19843080
    [TBL] [Abstract][Full Text] [Related]  

  • 13. Fluorophore labeling of the glycine-rich loop as a method of identifying inhibitors that bind to active and inactive kinase conformations.
    Simard JR; Getlik M; Grütter C; Schneider R; Wulfert S; Rauh D
    J Am Chem Soc; 2010 Mar; 132(12):4152-60. PubMed ID: 20201574
    [TBL] [Abstract][Full Text] [Related]  

  • 14. High-throughput screening to identify inhibitors which stabilize inactive kinase conformations in p38alpha.
    Simard JR; Grütter C; Pawar V; Aust B; Wolf A; Rabiller M; Wulfert S; Robubi A; Klüter S; Ottmann C; Rauh D
    J Am Chem Soc; 2009 Dec; 131(51):18478-88. PubMed ID: 19950957
    [TBL] [Abstract][Full Text] [Related]  

  • 15. A Comprehensive Structural Overview of p38α MAPK in Complex with Type I Inhibitors.
    Astolfi A; Iraci N; Manfroni G; Barreca ML; Cecchetti V
    ChemMedChem; 2015 Jun; 10(6):957-69. PubMed ID: 26012502
    [TBL] [Abstract][Full Text] [Related]  

  • 16. Mutagenesis of p38alpha MAP kinase establishes key roles of Phe169 in function and structural dynamics and reveals a novel DFG-OUT state.
    Bukhtiyarova M; Karpusas M; Northrop K; Namboodiri HV; Springman EB
    Biochemistry; 2007 May; 46(19):5687-96. PubMed ID: 17441692
    [TBL] [Abstract][Full Text] [Related]  

  • 17. Lipid molecules induce p38α activation via a novel molecular switch.
    Tzarum N; Eisenberg-Domovich Y; Gills JJ; Dennis PA; Livnah O
    J Mol Biol; 2012 Dec; 424(5):339-53. PubMed ID: 23079240
    [TBL] [Abstract][Full Text] [Related]  

  • 18. Kinase crystal identification and ATP-competitive inhibitor screening using the fluorescent ligand SKF86002.
    Parker LJ; Taruya S; Tsuganezawa K; Ogawa N; Mikuni J; Honda K; Tomabechi Y; Handa N; Shirouzu M; Yokoyama S; Tanaka A
    Acta Crystallogr D Biol Crystallogr; 2014 Feb; 70(Pt 2):392-404. PubMed ID: 24531473
    [TBL] [Abstract][Full Text] [Related]  

  • 19. Rapid identification of ligand-binding sites by using an assignment-free NMR approach.
    Kodama Y; Takeuchi K; Shimba N; Ishikawa K; Suzuki E; Shimada I; Takahashi H
    J Med Chem; 2013 Nov; 56(22):9342-50. PubMed ID: 24171460
    [TBL] [Abstract][Full Text] [Related]  

  • 20. FLiK: a direct-binding assay for the identification and kinetic characterization of stabilizers of inactive kinase conformations.
    Simard JR; Rauh D
    Methods Enzymol; 2014; 548():147-71. PubMed ID: 25399645
    [TBL] [Abstract][Full Text] [Related]  

    [Next]    [New Search]
    of 7.