These tools will no longer be maintained as of December 31, 2024. Archived website can be found here. PubMed4Hh GitHub repository can be found here. Contact NLM Customer Service if you have questions.


BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

109 related articles for article (PubMed ID: 22793665)

  • 1. Discovery of 3-(5-chloro-2-furoyl)-3,7-diazabicyclo[3.3.0]octane (TC-6683, AZD1446), a novel highly selective α4β2 nicotinic acetylcholine receptor agonist for the treatment of cognitive disorders.
    Mazurov AA; Miao L; Bhatti BS; Strachan JP; Akireddy S; Murthy S; Kombo D; Xiao YD; Hammond P; Zhang J; Hauser TA; Jordan KG; Miller CH; Speake JD; Gatto GJ; Yohannes D
    J Med Chem; 2012 Nov; 55(21):9181-94. PubMed ID: 22793665
    [TBL] [Abstract][Full Text] [Related]  

  • 2. Synthesis and structure-activity relationship studies of 3,6-diazabicyclo[3.2.0]heptanes as novel alpha4beta2 nicotinic acetylcholine receptor selective agonists.
    Ji J; Schrimpf MR; Sippy KB; Bunnelle WH; Li T; Anderson DJ; Faltynek C; Surowy CS; Dyhring T; Ahring PK; Meyer MD
    J Med Chem; 2007 Nov; 50(22):5493-508. PubMed ID: 17929796
    [TBL] [Abstract][Full Text] [Related]  

  • 3. Structure-activity studies of diazabicyclo[3.3.0]octane-substituted pyrazines and pyridines as potent α4β2 nicotinic acetylcholine receptor ligands.
    Scanio MJ; Shi L; Bunnelle WH; Anderson DJ; Helfrich RJ; Malysz J; Thorin-Hagene KK; Van Handel CE; Marsh KC; Lee CH; Gopalakrishnan M
    J Med Chem; 2011 Nov; 54(21):7678-92. PubMed ID: 21962147
    [TBL] [Abstract][Full Text] [Related]  

  • 4. Discovery of N-[(3R)-1-azabicyclo[2.2.2]oct-3-yl]furo[2,3-c]pyridine-5-carboxamide, an agonist of the alpha7 nicotinic acetylcholine receptor, for the potential treatment of cognitive deficits in schizophrenia: synthesis and structure--activity relationship.
    Wishka DG; Walker DP; Yates KM; Reitz SC; Jia S; Myers JK; Olson KL; Jacobsen EJ; Wolfe ML; Groppi VE; Hanchar AJ; Thornburgh BA; Cortes-Burgos LA; Wong EH; Staton BA; Raub TJ; Higdon NR; Wall TM; Hurst RS; Walters RR; Hoffmann WE; Hajos M; Franklin S; Carey G; Gold LH; Cook KK; Sands SB; Zhao SX; Soglia JR; Kalgutkar AS; Arneric SP; Rogers BN
    J Med Chem; 2006 Jul; 49(14):4425-36. PubMed ID: 16821801
    [TBL] [Abstract][Full Text] [Related]  

  • 5. Synthesis of 3,6-diazabicyclo[3.1.1]heptanes as novel ligands for neuronal nicotinic acetylcholine receptors.
    Murineddu G; Murruzzu C; Curzu MM; Chelucci G; Gotti C; Gaimarri A; Legnani L; Toma L; Pinna GA
    Bioorg Med Chem Lett; 2008 Dec; 18(23):6147-50. PubMed ID: 18938077
    [TBL] [Abstract][Full Text] [Related]  

  • 6. Synthesis and SAR studies of 1,4-diazabicyclo[3.2.2]nonane phenyl carbamates--subtype selective, high affinity alpha7 nicotinic acetylcholine receptor agonists.
    O'Donnell CJ; Peng L; O'Neill BT; Arnold EP; Mather RJ; Sands SB; Shrikhande A; Lebel LA; Spracklin DK; Nedza FM
    Bioorg Med Chem Lett; 2009 Aug; 19(16):4747-51. PubMed ID: 19576766
    [TBL] [Abstract][Full Text] [Related]  

  • 7. The novel alpha7 nicotinic acetylcholine receptor agonist N-[(3R)-1-azabicyclo[2.2.2]oct-3-yl]-7-[2-(methoxy)phenyl]-1-benzofuran-2-carboxamide improves working and recognition memory in rodents.
    Boess FG; De Vry J; Erb C; Flessner T; Hendrix M; Luithle J; Methfessel C; Riedl B; Schnizler K; van der Staay FJ; van Kampen M; Wiese WB; Koenig G
    J Pharmacol Exp Ther; 2007 May; 321(2):716-25. PubMed ID: 17308038
    [TBL] [Abstract][Full Text] [Related]  

  • 8. Synthesis and pharmacological characterization of exo-2-(2'-chloro-5-pyridinyl)-7-(endo and exo)-aminobicyclo[2.2.1]heptanes as novel epibatidine analogues.
    Carroll FI; Brieaddy LE; Navarro HA; Damaj MI; Martin BR
    J Med Chem; 2005 Nov; 48(23):7491-5. PubMed ID: 16279810
    [TBL] [Abstract][Full Text] [Related]  

  • 9. Epibatidine structure-activity relationships.
    Carroll FI
    Bioorg Med Chem Lett; 2004 Apr; 14(8):1889-96. PubMed ID: 15050621
    [TBL] [Abstract][Full Text] [Related]  

  • 10. 3D-QSAR and QSSR studies of 3,8-diazabicyclo[4.2.0]octane derivatives as neuronal nicotinic acetylcholine receptors by comparative molecular field analysis (CoMFA).
    Ye M; Dawson MI
    Bioorg Med Chem Lett; 2009 Jan; 19(1):127-31. PubMed ID: 19026537
    [TBL] [Abstract][Full Text] [Related]  

  • 11. Synthesis and nicotinic binding studies on enantiopure diazine analogues of the novel (2-chloro-5-pyridyl)-9-azabicyclo[4.2.1]non-2-ene UB-165.
    Gohlke H; Gündisch D; Schwarz S; Seitz G; Tilotta MC; Wegge T
    J Med Chem; 2002 Feb; 45(5):1064-72. PubMed ID: 11855986
    [TBL] [Abstract][Full Text] [Related]  

  • 12. Synthesis and nicotinic receptor activity of chemical space analogues of N-(3R)-1-azabicyclo[2.2.2]oct-3-yl-4-chlorobenzamide (PNU-282,987) and 1,4-diazabicyclo[3.2.2]nonane-4-carboxylic acid 4-bromophenyl ester (SSR180711).
    Bréthous L; Garcia-Delgado N; Schwartz J; Bertrand S; Bertrand D; Reymond JL
    J Med Chem; 2012 May; 55(10):4605-18. PubMed ID: 22591063
    [TBL] [Abstract][Full Text] [Related]  

  • 13. Discovery of 4-(5-methyloxazolo[4,5-b]pyridin-2-yl)-1,4-diazabicyclo[3.2.2]nonane (CP-810,123), a novel alpha 7 nicotinic acetylcholine receptor agonist for the treatment of cognitive disorders in schizophrenia: synthesis, SAR development, and in vivo efficacy in cognition models.
    O'Donnell CJ; Rogers BN; Bronk BS; Bryce DK; Coe JW; Cook KK; Duplantier AJ; Evrard E; Hajós M; Hoffmann WE; Hurst RS; Maklad N; Mather RJ; McLean S; Nedza FM; O'Neill BT; Peng L; Qian W; Rottas MM; Sands SB; Schmidt AW; Shrikhande AV; Spracklin DK; Wong DF; Zhang A; Zhang L
    J Med Chem; 2010 Feb; 53(3):1222-37. PubMed ID: 20043678
    [TBL] [Abstract][Full Text] [Related]  

  • 14. Epibatidine analogues as selective ligands for the alpha(x)beta2-containing subtypes of nicotinic acetylcholine receptors.
    Huang Y; Zhu Z; Xiao Y; Laruelle M
    Bioorg Med Chem Lett; 2005 Oct; 15(19):4385-8. PubMed ID: 16039849
    [TBL] [Abstract][Full Text] [Related]  

  • 15. The 3,7-diazabicyclo[3.3.1]nonane scaffold for subtype selective nicotinic acetylcholine receptor ligands. Part 2: carboxamide derivatives with different spacer motifs.
    Eibl C; Munoz L; Tomassoli I; Stokes C; Papke RL; Gündisch D
    Bioorg Med Chem; 2013 Dec; 21(23):7309-29. PubMed ID: 24145137
    [TBL] [Abstract][Full Text] [Related]  

  • 16. Synthesis and structure-activity relationships of 3,8-diazabicyclo[4.2.0]octane ligands, potent nicotinic acetylcholine receptor agonists.
    Frost JM; Bunnelle WH; Tietje KR; Anderson DJ; Rueter LE; Curzon P; Surowy CS; Ji J; Daanen JF; Kohlhaas KL; Buckley MJ; Henry RF; Dyhring T; Ahring PK; Meyer MD
    J Med Chem; 2006 Dec; 49(26):7843-53. PubMed ID: 17181167
    [TBL] [Abstract][Full Text] [Related]  

  • 17. Discovery of N-[(3R,5R)-1-azabicyclo[3.2.1]oct-3-yl]furo[2,3-c]pyridine-5-carboxamide as an agonist of the alpha7 nicotinic acetylcholine receptor: in vitro and in vivo activity.
    Acker BA; Jacobsen EJ; Rogers BN; Wishka DG; Reitz SC; Piotrowski DW; Myers JK; Wolfe ML; Groppi VE; Thornburgh BA; Tinholt PM; Walters RR; Olson BA; Fitzgerald L; Staton BA; Raub TJ; Krause M; Li KS; Hoffmann WE; Hajos M; Hurst RS; Walker DP
    Bioorg Med Chem Lett; 2008 Jun; 18(12):3611-5. PubMed ID: 18490160
    [TBL] [Abstract][Full Text] [Related]  

  • 18. Restoring long-term potentiation impaired by amyloid-beta oligomers: comparison of an acetylcholinesterase inhibitior and selective neuronal nicotinic receptor agonists.
    Kroker KS; Moreth J; Kussmaul L; Rast G; Rosenbrock H
    Brain Res Bull; 2013 Jul; 96():28-38. PubMed ID: 23639920
    [TBL] [Abstract][Full Text] [Related]  

  • 19. Novel nicotinic acetylcholine receptor agonists containing carbonyl moiety as a hydrogen bond acceptor.
    Mazurov AA; Kombo DC; Akireddy S; Murthy S; Hauser TA; Jordan KG; Gatto GJ; Yohannes D
    Bioorg Med Chem Lett; 2013 Jul; 23(13):3927-34. PubMed ID: 23692872
    [TBL] [Abstract][Full Text] [Related]  

  • 20. Synthesis, nicotinic acetylcholine receptor binding, and antinociceptive properties of 3'-substituted deschloroepibatidine analogues. Novel nicotinic antagonists.
    Carroll FI; Ma W; Yokota Y; Lee JR; Brieaddy LE; Navarro HA; Damaj MI; Martin BR
    J Med Chem; 2005 Feb; 48(4):1221-8. PubMed ID: 15715488
    [TBL] [Abstract][Full Text] [Related]  

    [Next]    [New Search]
    of 6.