BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

211 related articles for article (PubMed ID: 22795085)

  • 1. Crystal structure of 12-lipoxygenase catalytic-domain-inhibitor complex identifies a substrate-binding channel for catalysis.
    Xu S; Mueser TC; Marnett LJ; Funk MO
    Structure; 2012 Sep; 20(9):1490-7. PubMed ID: 22795085
    [TBL] [Abstract][Full Text] [Related]  

  • 2. Mechanism of inhibition of porcine leukocyte 12-lipoxygenase by the isoform-specific inhibitor 4-(2-oxapentadeca-4-yne)phenylpropanoic acid.
    Richards KM; Moody JS; Marnett LJ
    Biochemistry; 1999 Dec; 38(50):16529-38. PubMed ID: 10600114
    [TBL] [Abstract][Full Text] [Related]  

  • 3. Kinetics of inhibition of leukocyte 12-lipoxygenase by the isoform-specific inhibitor 4-(2-oxapentadeca-4-yne)phenylpropanoic acid.
    Moody JS; Marnett LJ
    Biochemistry; 2002 Aug; 41(32):10297-303. PubMed ID: 12162745
    [TBL] [Abstract][Full Text] [Related]  

  • 4. Crystal structure of a lipoxygenase in complex with substrate: the arachidonic acid-binding site of 8R-lipoxygenase.
    Neau DB; Bender G; Boeglin WE; Bartlett SG; Brash AR; Newcomer ME
    J Biol Chem; 2014 Nov; 289(46):31905-31913. PubMed ID: 25231982
    [TBL] [Abstract][Full Text] [Related]  

  • 5. Molecular dioxygen enters the active site of 12/15-lipoxygenase via dynamic oxygen access channels.
    Saam J; Ivanov I; Walther M; Holzhütter HG; Kuhn H
    Proc Natl Acad Sci U S A; 2007 Aug; 104(33):13319-24. PubMed ID: 17675410
    [TBL] [Abstract][Full Text] [Related]  

  • 6. Interaction between non-heme iron of lipoxygenases and cumene hydroperoxide: basis for enzyme activation, inactivation, and inhibition.
    Vahedi-Faridi A; Brault PA; Shah P; Kim YW; Dunham WR; Funk MO
    J Am Chem Soc; 2004 Feb; 126(7):2006-15. PubMed ID: 14971933
    [TBL] [Abstract][Full Text] [Related]  

  • 7. Exploration of binding site pattern in arachidonic acid metabolizing enzymes, Cyclooxygenases and Lipoxygenases.
    Reddy KK; Vidya Rajan VK; Gupta A; Aparoy P; Reddanna P
    BMC Res Notes; 2015 Apr; 8():152. PubMed ID: 25886468
    [TBL] [Abstract][Full Text] [Related]  

  • 8. In vitro study of isoflavones and isoflavans as potent inhibitors of human 12- and 15-lipoxygenases.
    Mascayano C; Espinosa V; Sepúlveda-Boza S; Hoobler EK; Perry S
    Chem Biol Drug Des; 2013 Sep; 82(3):317-25. PubMed ID: 23663316
    [TBL] [Abstract][Full Text] [Related]  

  • 9. The N-terminal β-barrel domain of mammalian lipoxygenases including mouse 5-lipoxygenase is not essential for catalytic activity and membrane binding but exhibits regulatory functions.
    Walther M; Hofheinz K; Vogel R; Roffeis J; Kühn H
    Arch Biochem Biophys; 2011 Dec; 516(1):1-9. PubMed ID: 21951814
    [TBL] [Abstract][Full Text] [Related]  

  • 10. Arachidonate 12-lipoxygenases with reference to their selective inhibitors.
    Yamamoto S; Katsukawa M; Nakano A; Hiraki E; Nishimura K; Jisaka M; Yokota K; Ueda N
    Biochem Biophys Res Commun; 2005 Dec; 338(1):122-7. PubMed ID: 16171776
    [TBL] [Abstract][Full Text] [Related]  

  • 11. Tight association of N-terminal and catalytic subunits of rabbit 12/15-lipoxygenase is important for protein stability and catalytic activity.
    Ivanov I; Di Venere A; Horn T; Scheerer P; Nicolai E; Stehling S; Richter C; Skrzypczak-Jankun E; Mei G; Maccarrone M; Kühn H
    Biochim Biophys Acta; 2011 Dec; 1811(12):1001-10. PubMed ID: 21875687
    [TBL] [Abstract][Full Text] [Related]  

  • 12. Suicide inactivation of porcine leukocyte 12-lipoxygenase associated with its incorporation of 15-hydroperoxy-5,8,11,13-eicosatetraenoic acid derivative.
    Kishimoto K; Nakamura M; Suzuki H; Yoshimoto T; Yamamoto S; Takao T; Shimonishi Y; Tanabe T
    Biochim Biophys Acta; 1996 Mar; 1300(1):56-62. PubMed ID: 8608163
    [TBL] [Abstract][Full Text] [Related]  

  • 13. LOX1 inhibition with small molecules.
    Gousiadou C; Kouskoumvekaki I
    J Mol Graph Model; 2016 Jan; 63():99-109. PubMed ID: 26722761
    [TBL] [Abstract][Full Text] [Related]  

  • 14. Structural and mechanistic insights into 5-lipoxygenase inhibition by natural products.
    Gilbert NC; Gerstmeier J; Schexnaydre EE; Börner F; Garscha U; Neau DB; Werz O; Newcomer ME
    Nat Chem Biol; 2020 Jul; 16(7):783-790. PubMed ID: 32393899
    [TBL] [Abstract][Full Text] [Related]  

  • 15. The 1.85 A structure of an 8R-lipoxygenase suggests a general model for lipoxygenase product specificity.
    Neau DB; Gilbert NC; Bartlett SG; Boeglin W; Brash AR; Newcomer ME
    Biochemistry; 2009 Aug; 48(33):7906-15. PubMed ID: 19594169
    [TBL] [Abstract][Full Text] [Related]  

  • 16. The three-dimensional structure of an arachidonic acid 15-lipoxygenase.
    Boyington JC; Gaffney BJ; Amzel LM
    Science; 1993 Jun; 260(5113):1482-6. PubMed ID: 8502991
    [TBL] [Abstract][Full Text] [Related]  

  • 17. Lipoxygenase inhibitory activity of alkyl protocatechuates.
    Ha TJ; Shimizu K; Kubo I
    Food Chem; 2014 Sep; 159():471-6. PubMed ID: 24767084
    [TBL] [Abstract][Full Text] [Related]  

  • 18. Defining the arachidonic acid binding site of human 15-lipoxygenase. Molecular modeling and mutagenesis.
    Gan QF; Browner MF; Sloane DL; Sigal E
    J Biol Chem; 1996 Oct; 271(41):25412-8. PubMed ID: 8810309
    [TBL] [Abstract][Full Text] [Related]  

  • 19. Novel benzofuran and benzothiophene biphenyls as inhibitors of protein tyrosine phosphatase 1B with antihyperglycemic properties.
    Malamas MS; Sredy J; Moxham C; Katz A; Xu W; McDevitt R; Adebayo FO; Sawicki DR; Seestaller L; Sullivan D; Taylor JR
    J Med Chem; 2000 Apr; 43(7):1293-310. PubMed ID: 10753467
    [TBL] [Abstract][Full Text] [Related]  

  • 20. Site-directed mutagenesis studies on the iron-binding domain and the determinant for the substrate oxygenation site of porcine leukocyte arachidonate 12-lipoxygenase.
    Suzuki H; Kishimoto K; Yoshimoto T; Yamamoto S; Kanai F; Ebina Y; Miyatake A; Tanabe T
    Biochim Biophys Acta; 1994 Jan; 1210(3):308-16. PubMed ID: 8305485
    [TBL] [Abstract][Full Text] [Related]  

    [Next]    [New Search]
    of 11.