BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

98 related articles for article (PubMed ID: 22800535)

  • 1. Carbonylhydrazide-based molecular tongs inhibit wild-type and mutated HIV-1 protease dimerization.
    Dufau L; Marques Ressurreição AS; Fanelli R; Kihal N; Vidu A; Milcent T; Soulier JL; Rodrigo J; Desvergne A; Leblanc K; Bernadat G; Crousse B; Reboud-Ravaux M; Ongeri S
    J Med Chem; 2012 Aug; 55(15):6762-75. PubMed ID: 22800535
    [TBL] [Abstract][Full Text] [Related]  

  • 2. Molecular tongs containing amino acid mimetic fragments: new inhibitors of wild-type and mutated HIV-1 protease dimerization.
    Bannwarth L; Kessler A; Pèthe S; Collinet B; Merabet N; Boggetto N; Sicsic S; Reboud-Ravaux M; Ongeri S
    J Med Chem; 2006 Jul; 49(15):4657-64. PubMed ID: 16854071
    [TBL] [Abstract][Full Text] [Related]  

  • 3. Toward the first nonpeptidic molecular tong inhibitor of wild-type and mutated HIV-1 protease dimerization.
    Vidu A; Dufau L; Bannwarth L; Soulier JL; Sicsic S; Piarulli U; Reboud-Ravaux M; Ongeri S
    ChemMedChem; 2010 Nov; 5(11):1899-906. PubMed ID: 20936621
    [TBL] [Abstract][Full Text] [Related]  

  • 4. Design, synthesis, and evaluation of conformationally constrained tongs, new inhibitors of HIV-1 protease dimerization.
    Bouras A; Boggetto N; Benatalah Z; de Rosny E; Sicsic S; Reboud-Ravaux M
    J Med Chem; 1999 Mar; 42(6):957-62. PubMed ID: 10090778
    [TBL] [Abstract][Full Text] [Related]  

  • 5. New constrained "molecular tongs" designed to dissociate HIV-1 protease dimer.
    Merabet N; Dumond J; Collinet B; Van Baelinghem L; Boggetto N; Ongeri S; Ressad F; Reboud-Ravaux M; Sicsic S
    J Med Chem; 2004 Dec; 47(25):6392-400. PubMed ID: 15566308
    [TBL] [Abstract][Full Text] [Related]  

  • 6. Disruption of the HIV-1 protease dimer with interface peptides: structural studies using NMR spectroscopy combined with [2-(13)C]-Trp selective labeling.
    Frutos S; Rodriguez-Mias RA; Madurga S; Collinet B; Reboud-Ravaux M; Ludevid D; Giralt E
    Biopolymers; 2007; 88(2):164-73. PubMed ID: 17236209
    [TBL] [Abstract][Full Text] [Related]  

  • 7. Dimer disruption and monomer sequestration by alkyl tripeptides are successful strategies for inhibiting wild-type and multidrug-resistant mutated HIV-1 proteases.
    Bannwarth L; Rose T; Dufau L; Vanderesse R; Dumond J; Jamart-Grégoire B; Pannecouque C; De Clercq E; Reboud-Ravaux M
    Biochemistry; 2009 Jan; 48(2):379-87. PubMed ID: 19105629
    [TBL] [Abstract][Full Text] [Related]  

  • 8. Design and synthesis of new inhibitors of HIV-1 protease dimerization with conformationally constrained templates.
    Song M; Rajesh S; Hayashi Y; Kiso Y
    Bioorg Med Chem Lett; 2001 Sep; 11(18):2465-8. PubMed ID: 11549448
    [TBL] [Abstract][Full Text] [Related]  

  • 9. Development of low molecular weight HIV-1 protease dimerization inhibitors.
    Hwang YS; Chmielewski J
    J Med Chem; 2005 Mar; 48(6):2239-42. PubMed ID: 15771466
    [TBL] [Abstract][Full Text] [Related]  

  • 10. An alternative strategy for inhibiting multidrug-resistant mutants of the dimeric HIV-1 protease by targeting the subunit interface.
    Bannwarth L; Reboud-Ravaux M
    Biochem Soc Trans; 2007 Jun; 35(Pt 3):551-4. PubMed ID: 17511649
    [TBL] [Abstract][Full Text] [Related]  

  • 11. Dual inhibitors for aspartic proteases HIV-1 PR and renin: advancements in AIDS-hypertension-diabetes linkage via molecular dynamics, inhibition assays, and binding free energy calculations.
    Tzoupis H; Leonis G; Megariotis G; Supuran CT; Mavromoustakos T; Papadopoulos MG
    J Med Chem; 2012 Jun; 55(12):5784-96. PubMed ID: 22621689
    [TBL] [Abstract][Full Text] [Related]  

  • 12. Potent HIV protease inhibitors containing a novel (hydroxyethyl)amide isostere.
    Beaulieu PL; Wernic D; Abraham A; Anderson PC; Bogri T; Bousquet Y; Croteau G; Guse I; Lamarre D; Liard F; Paris W; Thibeault D; Pav S; Tong L
    J Med Chem; 1997 Jul; 40(14):2164-76. PubMed ID: 9216835
    [TBL] [Abstract][Full Text] [Related]  

  • 13. Lysine derivatives as potent HIV protease inhibitors. Discovery, synthesis and structure-activity relationship studies.
    Bouzide A; Sauvé G; Yelle J
    Bioorg Med Chem Lett; 2005 Mar; 15(5):1509-13. PubMed ID: 15713418
    [TBL] [Abstract][Full Text] [Related]  

  • 14. Novel strategies for targeting the dimerization interface of HIV protease with cross-linked interfacial peptides.
    Bowman MJ; Chmielewski J
    Biopolymers; 2002; 66(2):126-33. PubMed ID: 12325162
    [TBL] [Abstract][Full Text] [Related]  

  • 15. Small-molecule dimerization inhibitors of wild-type and mutant HIV protease: a focused library approach.
    Shultz MD; Ham YW; Lee SG; Davis DA; Brown C; Chmielewski J
    J Am Chem Soc; 2004 Aug; 126(32):9886-7. PubMed ID: 15303839
    [TBL] [Abstract][Full Text] [Related]  

  • 16. An ethylenamine inhibitor binds tightly to both wild type and mutant HIV-1 proteases. Structure and energy study.
    Skálová T; Hasek J; Dohnálek J; Petroková H; Buchtelová E; Dusková J; Soucek M; Majer P; Uhlíková T; Konvalinka J
    J Med Chem; 2003 Apr; 46(9):1636-44. PubMed ID: 12699382
    [TBL] [Abstract][Full Text] [Related]  

  • 17. A phenylnorstatine inhibitor binding to HIV-1 protease: geometry, protonation, and subsite-pocket interactions analyzed at atomic resolution.
    Brynda J; Rezacova P; Fabry M; Horejsi M; Stouracova R; Sedlacek J; Soucek M; Hradilek M; Lepsik M; Konvalinka J
    J Med Chem; 2004 Apr; 47(8):2030-6. PubMed ID: 15056001
    [TBL] [Abstract][Full Text] [Related]  

  • 18. Molecular analysis of the HIV-1 resistance development: enzymatic activities, crystal structures, and thermodynamics of nelfinavir-resistant HIV protease mutants.
    Kozísek M; Bray J; Rezácová P; Sasková K; Brynda J; Pokorná J; Mammano F; Rulísek L; Konvalinka J
    J Mol Biol; 2007 Dec; 374(4):1005-16. PubMed ID: 17977555
    [TBL] [Abstract][Full Text] [Related]  

  • 19. Design, synthesis, evaluation, and crystallographic-based structural studies of HIV-1 protease inhibitors with reduced response to the V82A mutation.
    Clemente JC; Robbins A; Graña P; Paleo MR; Correa JF; Villaverde MC; Sardina FJ; Govindasamy L; Agbandje-McKenna M; McKenna R; Dunn BM; Sussman F
    J Med Chem; 2008 Feb; 51(4):852-60. PubMed ID: 18215016
    [TBL] [Abstract][Full Text] [Related]  

  • 20. Dimerization inhibitors of HIV-1 protease based on a bicyclic guanidinium subunit.
    Breccia P; Boggetto N; Pérez-Fernández R; Van Gool M; Takahashi M; René L; Prados P; Badet B; Reboud-Ravaux M; de Mendoza J
    J Med Chem; 2003 Nov; 46(24):5196-207. PubMed ID: 14613322
    [TBL] [Abstract][Full Text] [Related]  

    [Next]    [New Search]
    of 5.