These tools will no longer be maintained as of December 31, 2024. Archived website can be found here. PubMed4Hh GitHub repository can be found here. Contact NLM Customer Service if you have questions.
221 related articles for article (PubMed ID: 22803810)
1. Development of o-chlorophenyl substituted pyrimidines as exceptionally potent aurora kinase inhibitors. Lawrence HR; Martin MP; Luo Y; Pireddu R; Yang H; Gevariya H; Ozcan S; Zhu JY; Kendig R; Rodriguez M; Elias R; Cheng JQ; Sebti SM; Schonbrunn E; Lawrence NJ J Med Chem; 2012 Sep; 55(17):7392-7416. PubMed ID: 22803810 [TBL] [Abstract][Full Text] [Related]
2. Identification, SAR studies, and X-ray co-crystallographic analysis of a novel furanopyrimidine aurora kinase A inhibitor. Coumar MS; Tsai MT; Chu CY; Uang BJ; Lin WH; Chang CY; Chang TY; Leou JS; Teng CH; Wu JS; Fang MY; Chen CH; Hsu JT; Wu SY; Chao YS; Hsieh HP ChemMedChem; 2010 Feb; 5(2):255-67. PubMed ID: 20039358 [TBL] [Abstract][Full Text] [Related]
3. SAR and inhibitor complex structure determination of a novel class of potent and specific Aurora kinase inhibitors. Heron NM; Anderson M; Blowers DP; Breed J; Eden JM; Green S; Hill GB; Johnson T; Jung FH; McMiken HH; Mortlock AA; Pannifer AD; Pauptit RA; Pink J; Roberts NJ; Rowsell S Bioorg Med Chem Lett; 2006 Mar; 16(5):1320-3. PubMed ID: 16337122 [TBL] [Abstract][Full Text] [Related]
4. Discovery of potent and selective thienopyrimidine inhibitors of Aurora kinases. McClellan WJ; Dai Y; Abad-Zapatero C; Albert DH; Bouska JJ; Glaser KB; Magoc TJ; Marcotte PA; Osterling DJ; Stewart KD; Davidsen SK; Michaelides MR Bioorg Med Chem Lett; 2011 Sep; 21(18):5620-4. PubMed ID: 21778056 [TBL] [Abstract][Full Text] [Related]
5. A class of 2,4-bisanilinopyrimidine Aurora A inhibitors with unusually high selectivity against Aurora B. Aliagas-Martin I; Burdick D; Corson L; Dotson J; Drummond J; Fields C; Huang OW; Hunsaker T; Kleinheinz T; Krueger E; Liang J; Moffat J; Phillips G; Pulk R; Rawson TE; Ultsch M; Walker L; Wiesmann C; Zhang B; Zhu BY; Cochran AG J Med Chem; 2009 May; 52(10):3300-7. PubMed ID: 19402633 [TBL] [Abstract][Full Text] [Related]
6. Selective aurora kinase inhibitors identified using a taxol-induced checkpoint sensitivity screen. Kwiatkowski N; Deng X; Wang J; Tan L; Villa F; Santaguida S; Huang HC; Mitchison T; Musacchio A; Gray N ACS Chem Biol; 2012 Jan; 7(1):185-96. PubMed ID: 21992004 [TBL] [Abstract][Full Text] [Related]
7. Discovery of N-phenyl-4-(thiazol-5-yl)pyrimidin-2-amine aurora kinase inhibitors. Wang S; Midgley CA; Scaërou F; Grabarek JB; Griffiths G; Jackson W; Kontopidis G; McClue SJ; McInnes C; Meades C; Mezna M; Plater A; Stuart I; Thomas MP; Wood G; Clarke RG; Blake DG; Zheleva DI; Lane DP; Jackson RC; Glover DM; Fischer PM J Med Chem; 2010 Jun; 53(11):4367-78. PubMed ID: 20462263 [TBL] [Abstract][Full Text] [Related]
8. Single step synthesis of new fused pyrimidine derivatives and their evaluation as potent Aurora-A kinase inhibitors. Shaaban MR; Saleh TS; Mayhoub AS; Farag AM Eur J Med Chem; 2011 Sep; 46(9):3690-5. PubMed ID: 21664013 [TBL] [Abstract][Full Text] [Related]
9. Fast-forwarding hit to lead: aurora and epidermal growth factor receptor kinase inhibitor lead identification. Coumar MS; Chu CY; Lin CW; Shiao HY; Ho YL; Reddy R; Lin WH; Chen CH; Peng YH; Leou JS; Lien TW; Huang CT; Fang MY; Wu SH; Wu JS; Chittimalla SK; Song JS; Hsu JT; Wu SY; Liao CC; Chao YS; Hsieh HP J Med Chem; 2010 Jul; 53(13):4980-8. PubMed ID: 20550212 [TBL] [Abstract][Full Text] [Related]
10. Structure-based drug design of novel Aurora kinase A inhibitors: structural basis for potency and specificity. Coumar MS; Leou JS; Shukla P; Wu JS; Dixit AK; Lin WH; Chang CY; Lien TW; Tan UK; Chen CH; Hsu JT; Chao YS; Wu SY; Hsieh HP J Med Chem; 2009 Feb; 52(4):1050-62. PubMed ID: 19140666 [TBL] [Abstract][Full Text] [Related]
17. Structure-based design of imidazo[1,2-a]pyrazine derivatives as selective inhibitors of Aurora-A kinase in cells. Bouloc N; Large JM; Kosmopoulou M; Sun C; Faisal A; Matteucci M; Reynisson J; Brown N; Atrash B; Blagg J; McDonald E; Linardopoulos S; Bayliss R; Bavetsias V Bioorg Med Chem Lett; 2010 Oct; 20(20):5988-93. PubMed ID: 20833547 [TBL] [Abstract][Full Text] [Related]
18. Substituted 4-(thiazol-5-yl)-2-(phenylamino)pyrimidines are highly active CDK9 inhibitors: synthesis, X-ray crystal structures, structure-activity relationship, and anticancer activities. Shao H; Shi S; Huang S; Hole AJ; Abbas AY; Baumli S; Liu X; Lam F; Foley DW; Fischer PM; Noble M; Endicott JA; Pepper C; Wang S J Med Chem; 2013 Feb; 56(3):640-59. PubMed ID: 23301767 [TBL] [Abstract][Full Text] [Related]
19. The discovery of the potent aurora inhibitor MK-0457 (VX-680). Bebbington D; Binch H; Charrier JD; Everitt S; Fraysse D; Golec J; Kay D; Knegtel R; Mak C; Mazzei F; Miller A; Mortimore M; O'Donnell M; Patel S; Pierard F; Pinder J; Pollard J; Ramaya S; Robinson D; Rutherford A; Studley J; Westcott J Bioorg Med Chem Lett; 2009 Jul; 19(13):3586-92. PubMed ID: 19447622 [TBL] [Abstract][Full Text] [Related]
20. Design, synthesis and bioevaluation of N-trisubstituted pyrimidine derivatives as potent aurora A kinase inhibitors. Luo Y; Deng YQ; Wang J; Long ZJ; Tu ZC; Peng W; Zhang JQ; Liu Q; Lu G Eur J Med Chem; 2014 May; 78():65-71. PubMed ID: 24681066 [TBL] [Abstract][Full Text] [Related] [Next] [New Search]