386 related articles for article (PubMed ID: 22815884)
1. R-Spondin potentiates Wnt/β-catenin signaling through orphan receptors LGR4 and LGR5.
Ruffner H; Sprunger J; Charlat O; Leighton-Davies J; Grosshans B; Salathe A; Zietzling S; Beck V; Therier M; Isken A; Xie Y; Zhang Y; Hao H; Shi X; Liu D; Song Q; Clay I; Hintzen G; Tchorz J; Bouchez LC; Michaud G; Finan P; Myer VE; Bouwmeester T; Porter J; Hild M; Bassilana F; Parker CN; Cong F
PLoS One; 2012; 7(7):e40976. PubMed ID: 22815884
[TBL] [Abstract][Full Text] [Related]
2. Non-equivalence of Wnt and R-spondin ligands during Lgr5
Yan KS; Janda CY; Chang J; Zheng GXY; Larkin KA; Luca VC; Chia LA; Mah AT; Han A; Terry JM; Ootani A; Roelf K; Lee M; Yuan J; Li X; Bolen CR; Wilhelmy J; Davies PS; Ueno H; von Furstenberg RJ; Belgrader P; Ziraldo SB; Ordonez H; Henning SJ; Wong MH; Snyder MP; Weissman IL; Hsueh AJ; Mikkelsen TS; Garcia KC; Kuo CJ
Nature; 2017 May; 545(7653):238-242. PubMed ID: 28467820
[TBL] [Abstract][Full Text] [Related]
3. R-spondins function as ligands of the orphan receptors LGR4 and LGR5 to regulate Wnt/beta-catenin signaling.
Carmon KS; Gong X; Lin Q; Thomas A; Liu Q
Proc Natl Acad Sci U S A; 2011 Jul; 108(28):11452-7. PubMed ID: 21693646
[TBL] [Abstract][Full Text] [Related]
4. Unlike LGR4, LGR5 potentiates Wnt-β-catenin signaling without sequestering E3 ligases.
Park S; Wu L; Tu J; Yu W; Toh Y; Carmon KS; Liu QJ
Sci Signal; 2020 Dec; 13(660):. PubMed ID: 33262293
[No Abstract] [Full Text] [Related]
5. RSPO-LGR4 functions via IQGAP1 to potentiate Wnt signaling.
Carmon KS; Gong X; Yi J; Thomas A; Liu Q
Proc Natl Acad Sci U S A; 2014 Apr; 111(13):E1221-9. PubMed ID: 24639526
[TBL] [Abstract][Full Text] [Related]
6. Differential activities and mechanisms of the four R-spondins in potentiating Wnt/β-catenin signaling.
Park S; Cui J; Yu W; Wu L; Carmon KS; Liu QJ
J Biol Chem; 2018 Jun; 293(25):9759-9769. PubMed ID: 29752411
[TBL] [Abstract][Full Text] [Related]
7. Regulation of the follistatin gene by RSPO-LGR4 signaling via activation of the WNT/β-catenin pathway in skeletal myogenesis.
Han XH; Jin YR; Tan L; Kosciuk T; Lee JS; Yoon JK
Mol Cell Biol; 2014 Feb; 34(4):752-64. PubMed ID: 24344199
[TBL] [Abstract][Full Text] [Related]
8. LGR4 and LGR5 form distinct homodimers that only LGR4 complexes with RNF43/ZNRF3 to provide high affinity binding of R-spondin ligands.
Toh Y; Wu L; Park S; Wang A; Tu J; Yu W; Zuo M; Carmon KS; Liu QJ
Sci Rep; 2023 Jul; 13(1):10796. PubMed ID: 37402772
[TBL] [Abstract][Full Text] [Related]
9. LGR6 is a high affinity receptor of R-spondins and potentially functions as a tumor suppressor.
Gong X; Carmon KS; Lin Q; Thomas A; Yi J; Liu Q
PLoS One; 2012; 7(5):e37137. PubMed ID: 22615920
[TBL] [Abstract][Full Text] [Related]
10. Lgr5 homologues associate with Wnt receptors and mediate R-spondin signalling.
de Lau W; Barker N; Low TY; Koo BK; Li VS; Teunissen H; Kujala P; Haegebarth A; Peters PJ; van de Wetering M; Stange DE; van Es JE; Guardavaccaro D; Schasfoort RB; Mohri Y; Nishimori K; Mohammed S; Heck AJ; Clevers H
Nature; 2011 Jul; 476(7360):293-7. PubMed ID: 21727895
[TBL] [Abstract][Full Text] [Related]
11. LGR4 and LGR5 are R-spondin receptors mediating Wnt/β-catenin and Wnt/PCP signalling.
Glinka A; Dolde C; Kirsch N; Huang YL; Kazanskaya O; Ingelfinger D; Boutros M; Cruciat CM; Niehrs C
EMBO Rep; 2011 Sep; 12(10):1055-61. PubMed ID: 21909076
[TBL] [Abstract][Full Text] [Related]
12. The RSPO-LGR4/5-ZNRF3/RNF43 module in liver homeostasis, regeneration, and disease.
Annunziato S; Sun T; Tchorz JS
Hepatology; 2022 Sep; 76(3):888-899. PubMed ID: 35006616
[TBL] [Abstract][Full Text] [Related]
13. The RSPO-LGR4/5-ZNRF3/RNF43 module controls liver zonation and size.
Planas-Paz L; Orsini V; Boulter L; Calabrese D; Pikiolek M; Nigsch F; Xie Y; Roma G; Donovan A; Marti P; Beckmann N; Dill MT; Carbone W; Bergling S; Isken A; Mueller M; Kinzel B; Yang Y; Mao X; Nicholson TB; Zamponi R; Capodieci P; Valdez R; Rivera D; Loew A; Ukomadu C; Terracciano LM; Bouwmeester T; Cong F; Heim MH; Forbes SJ; Ruffner H; Tchorz JS
Nat Cell Biol; 2016 May; 18(5):467-79. PubMed ID: 27088858
[TBL] [Abstract][Full Text] [Related]
14. Therapeutic Targeting of Tumor-Derived R-Spondin Attenuates β-Catenin Signaling and Tumorigenesis in Multiple Cancer Types.
Chartier C; Raval J; Axelrod F; Bond C; Cain J; Dee-Hoskins C; Ma S; Fischer MM; Shah J; Wei J; Ji M; Lam A; Stroud M; Yen WC; Yeung P; Cancilla B; O'Young G; Wang M; Kapoun AM; Lewicki J; Hoey T; Gurney A
Cancer Res; 2016 Feb; 76(3):713-23. PubMed ID: 26719531
[TBL] [Abstract][Full Text] [Related]
15. Structural basis for R-spondin recognition by LGR4/5/6 receptors.
Wang D; Huang B; Zhang S; Yu X; Wu W; Wang X
Genes Dev; 2013 Jun; 27(12):1339-44. PubMed ID: 23756652
[TBL] [Abstract][Full Text] [Related]
16. Structure and function of LGR5: an enigmatic G-protein coupled receptor marking stem cells.
Kumar KK; Burgess AW; Gulbis JM
Protein Sci; 2014 May; 23(5):551-65. PubMed ID: 24677446
[TBL] [Abstract][Full Text] [Related]
17. Mouse cristin/R-spondin family proteins are novel ligands for the Frizzled 8 and LRP6 receptors and activate beta-catenin-dependent gene expression.
Nam JS; Turcotte TJ; Smith PF; Choi S; Yoon JK
J Biol Chem; 2006 May; 281(19):13247-13257. PubMed ID: 16543246
[TBL] [Abstract][Full Text] [Related]
18. Reconstitution of R-spondin:LGR4:ZNRF3 adult stem cell growth factor signaling complexes with recombinant proteins produced in Escherichia coli.
Moad HE; Pioszak AA
Biochemistry; 2013 Oct; 52(41):7295-304. PubMed ID: 24050775
[TBL] [Abstract][Full Text] [Related]
19. LGR5 receptor promotes cell-cell adhesion in stem cells and colon cancer cells via the IQGAP1-Rac1 pathway.
Carmon KS; Gong X; Yi J; Wu L; Thomas A; Moore CM; Masuho I; Timson DJ; Martemyanov KA; Liu QJ
J Biol Chem; 2017 Sep; 292(36):14989-15001. PubMed ID: 28739799
[TBL] [Abstract][Full Text] [Related]
20. Aberrantly expressed LGR4 empowers Wnt signaling in multiple myeloma by hijacking osteoblast-derived R-spondins.
van Andel H; Ren Z; Koopmans I; Joosten SP; Kocemba KA; de Lau W; Kersten MJ; de Bruin AM; Guikema JE; Clevers H; Spaargaren M; Pals ST
Proc Natl Acad Sci U S A; 2017 Jan; 114(2):376-381. PubMed ID: 28028233
[TBL] [Abstract][Full Text] [Related]
[Next] [New Search]