458 related articles for article (PubMed ID: 22820095)
1. Low-density lipoprotein receptor-related protein 1: a physiological Aβ homeostatic mechanism with multiple therapeutic opportunities.
Sagare AP; Deane R; Zlokovic BV
Pharmacol Ther; 2012 Oct; 136(1):94-105. PubMed ID: 22820095
[TBL] [Abstract][Full Text] [Related]
2. Clearance of amyloid-beta peptide across the blood-brain barrier: implication for therapies in Alzheimer's disease.
Deane R; Bell RD; Sagare A; Zlokovic BV
CNS Neurol Disord Drug Targets; 2009 Mar; 8(1):16-30. PubMed ID: 19275634
[TBL] [Abstract][Full Text] [Related]
3. Low-density lipoprotein receptor-related protein-1: a serial clearance homeostatic mechanism controlling Alzheimer's amyloid β-peptide elimination from the brain.
Zlokovic BV; Deane R; Sagare AP; Bell RD; Winkler EA
J Neurochem; 2010 Dec; 115(5):1077-89. PubMed ID: 20854368
[TBL] [Abstract][Full Text] [Related]
4. Inhibition of ADAM10 promotes the clearance of Aβ across the BBB by reducing LRP1 ectodomain shedding.
Shackleton B; Crawford F; Bachmeier C
Fluids Barriers CNS; 2016 Aug; 13(1):14. PubMed ID: 27503326
[TBL] [Abstract][Full Text] [Related]
5. A lipoprotein receptor cluster IV mutant preferentially binds amyloid-β and regulates its clearance from the mouse brain.
Sagare AP; Bell RD; Srivastava A; Sengillo JD; Singh I; Nishida Y; Chow N; Zlokovic BV
J Biol Chem; 2013 May; 288(21):15154-66. PubMed ID: 23580652
[TBL] [Abstract][Full Text] [Related]
6. The role of the cell surface LRP and soluble LRP in blood-brain barrier Abeta clearance in Alzheimer's disease.
Deane R; Sagare A; Zlokovic BV
Curr Pharm Des; 2008; 14(16):1601-5. PubMed ID: 18673201
[TBL] [Abstract][Full Text] [Related]
7. Blood-brain barrier-associated pericytes internalize and clear aggregated amyloid-β42 by LRP1-dependent apolipoprotein E isoform-specific mechanism.
Ma Q; Zhao Z; Sagare AP; Wu Y; Wang M; Owens NC; Verghese PB; Herz J; Holtzman DM; Zlokovic BV
Mol Neurodegener; 2018 Oct; 13(1):57. PubMed ID: 30340601
[TBL] [Abstract][Full Text] [Related]
8. 1,25-Dihydroxyvitamin D3 regulates expression of LRP1 and RAGE in vitro and in vivo, enhancing Aβ1-40 brain-to-blood efflux and peripheral uptake transport.
Guo YX; He LY; Zhang M; Wang F; Liu F; Peng WX
Neuroscience; 2016 May; 322():28-38. PubMed ID: 26820600
[TBL] [Abstract][Full Text] [Related]
9. Effect of High Cholesterol Regulation of LRP1 and RAGE on Aβ Transport Across the Blood-Brain Barrier in Alzheimer's Disease.
Zhou R; Chen LL; Yang H; Li L; Liu J; Chen L; Hong WJ; Wang CG; Ma JJ; Huang J; Zhou XF; Liu D; Zhou HD
Curr Alzheimer Res; 2021; 18(5):428-442. PubMed ID: 34488598
[TBL] [Abstract][Full Text] [Related]
10. The concerted amyloid-beta clearance of LRP1 and ABCB1/P-gp across the blood-brain barrier is linked by PICALM.
Storck SE; Hartz AMS; Bernard J; Wolf A; Kachlmeier A; Mahringer A; Weggen S; Pahnke J; Pietrzik CU
Brain Behav Immun; 2018 Oct; 73():21-33. PubMed ID: 30041013
[TBL] [Abstract][Full Text] [Related]
11. LRP1 in brain vascular smooth muscle cells mediates local clearance of Alzheimer's amyloid-β.
Kanekiyo T; Liu CC; Shinohara M; Li J; Bu G
J Neurosci; 2012 Nov; 32(46):16458-65. PubMed ID: 23152628
[TBL] [Abstract][Full Text] [Related]
12. Amylin Enhances Amyloid-β Peptide Brain to Blood Efflux Across the Blood-Brain Barrier.
Mohamed LA; Zhu H; Mousa YM; Wang E; Qiu WQ; Kaddoumi A
J Alzheimers Dis; 2017; 56(3):1087-1099. PubMed ID: 28059785
[TBL] [Abstract][Full Text] [Related]
13. Astrocytic LRP1 Mediates Brain Aβ Clearance and Impacts Amyloid Deposition.
Liu CC; Hu J; Zhao N; Wang J; Wang N; Cirrito JR; Kanekiyo T; Holtzman DM; Bu G
J Neurosci; 2017 Apr; 37(15):4023-4031. PubMed ID: 28275161
[TBL] [Abstract][Full Text] [Related]
14. The role of LRP1 in Aβ efflux transport across the blood-brain barrier and cognitive dysfunction in diabetes mellitus.
P X; Zz L; Gg J; Lp W; Cm B; Yl W; Chen MF; W L
Neurochem Int; 2022 Nov; 160():105417. PubMed ID: 36067928
[TBL] [Abstract][Full Text] [Related]
15. Role of the blood-brain barrier in the pathogenesis of Alzheimer's disease.
Deane R; Zlokovic BV
Curr Alzheimer Res; 2007 Apr; 4(2):191-7. PubMed ID: 17430246
[TBL] [Abstract][Full Text] [Related]
16. LRP1 Has a Predominant Role in Production over Clearance of Aβ in a Mouse Model of Alzheimer's Disease.
Van Gool B; Storck SE; Reekmans SM; Lechat B; Gordts PLSM; Pradier L; Pietrzik CU; Roebroek AJM
Mol Neurobiol; 2019 Oct; 56(10):7234-7245. PubMed ID: 31004319
[TBL] [Abstract][Full Text] [Related]
17. Endothelial LRP1 transports amyloid-β(1-42) across the blood-brain barrier.
Storck SE; Meister S; Nahrath J; Meißner JN; Schubert N; Di Spiezio A; Baches S; Vandenbroucke RE; Bouter Y; Prikulis I; Korth C; Weggen S; Heimann A; Schwaninger M; Bayer TA; Pietrzik CU
J Clin Invest; 2016 Jan; 126(1):123-36. PubMed ID: 26619118
[TBL] [Abstract][Full Text] [Related]
18. Endothelial LRP1 - A Potential Target for the Treatment of Alzheimer's Disease : Theme: Drug Discovery, Development and Delivery in Alzheimer's Disease Guest Editor: Davide Brambilla.
Storck SE; Pietrzik CU
Pharm Res; 2017 Dec; 34(12):2637-2651. PubMed ID: 28948494
[TBL] [Abstract][Full Text] [Related]
19. Identification of a beta-amyloid-binding plasma protein, LRP1: implications for biomarker research and therapy in Alzheimer's disease.
Zetterberg H
Biomark Med; 2007 Oct; 1(3):347-8. PubMed ID: 20477378
[TBL] [Abstract][Full Text] [Related]
20. Apolipoprotein E increases cell association of amyloid-β 40 through heparan sulfate and LRP1 dependent pathways.
O'Callaghan P; Noborn F; Sehlin D; Li JP; Lannfelt L; Lindahl U; Zhang X
Amyloid; 2014 Jun; 21(2):76-87. PubMed ID: 24491019
[TBL] [Abstract][Full Text] [Related]
[Next] [New Search]
