BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

254 related articles for article (PubMed ID: 22821149)

  • 1. BAY 1000394, a novel cyclin-dependent kinase inhibitor, with potent antitumor activity in mono- and in combination treatment upon oral application.
    Siemeister G; Lücking U; Wengner AM; Lienau P; Steinke W; Schatz C; Mumberg D; Ziegelbauer K
    Mol Cancer Ther; 2012 Oct; 11(10):2265-73. PubMed ID: 22821149
    [TBL] [Abstract][Full Text] [Related]  

  • 2. In vitro and in vivo activity of R547: a potent and selective cyclin-dependent kinase inhibitor currently in phase I clinical trials.
    DePinto W; Chu XJ; Yin X; Smith M; Packman K; Goelzer P; Lovey A; Chen Y; Qian H; Hamid R; Xiang Q; Tovar C; Blain R; Nevins T; Higgins B; Luistro L; Kolinsky K; Felix B; Hussain S; Heimbrook D
    Mol Cancer Ther; 2006 Nov; 5(11):2644-58. PubMed ID: 17121911
    [TBL] [Abstract][Full Text] [Related]  

  • 3. The development of a selective cyclin-dependent kinase inhibitor that shows antitumor activity.
    Ali S; Heathcote DA; Kroll SH; Jogalekar AS; Scheiper B; Patel H; Brackow J; Siwicka A; Fuchter MJ; Periyasamy M; Tolhurst RS; Kanneganti SK; Snyder JP; Liotta DC; Aboagye EO; Barrett AG; Coombes RC
    Cancer Res; 2009 Aug; 69(15):6208-15. PubMed ID: 19638587
    [TBL] [Abstract][Full Text] [Related]  

  • 4. A novel pyrazolo[1,5-a]pyrimidine is a potent inhibitor of cyclin-dependent protein kinases 1, 2, and 9, which demonstrates antitumor effects in human tumor xenografts following oral administration.
    Heathcote DA; Patel H; Kroll SH; Hazel P; Periyasamy M; Alikian M; Kanneganti SK; Jogalekar AS; Scheiper B; Barbazanges M; Blum A; Brackow J; Siwicka A; Pace RD; Fuchter MJ; Snyder JP; Liotta DC; Freemont PS; Aboagye EO; Coombes RC; Barrett AG; Ali S
    J Med Chem; 2010 Dec; 53(24):8508-22. PubMed ID: 21080703
    [TBL] [Abstract][Full Text] [Related]  

  • 5. ICEC0942, an Orally Bioavailable Selective Inhibitor of CDK7 for Cancer Treatment.
    Patel H; Periyasamy M; Sava GP; Bondke A; Slafer BW; Kroll SHB; Barbazanges M; Starkey R; Ottaviani S; Harrod A; Aboagye EO; Buluwela L; Fuchter MJ; Barrett AGM; Coombes RC; Ali S
    Mol Cancer Ther; 2018 Jun; 17(6):1156-1166. PubMed ID: 29545334
    [TBL] [Abstract][Full Text] [Related]  

  • 6. In vitro antitumor properties of a novel cyclin-dependent kinase inhibitor, P276-00.
    Joshi KS; Rathos MJ; Joshi RD; Sivakumar M; Mascarenhas M; Kamble S; Lal B; Sharma S
    Mol Cancer Ther; 2007 Mar; 6(3):918-25. PubMed ID: 17363486
    [TBL] [Abstract][Full Text] [Related]  

  • 7. Dual targeting of CDK and tropomyosin receptor kinase families by the oral inhibitor PHA-848125, an agent with broad-spectrum antitumor efficacy.
    Albanese C; Alzani R; Amboldi N; Avanzi N; Ballinari D; Brasca MG; Festuccia C; Fiorentini F; Locatelli G; Pastori W; Patton V; Roletto F; Colotta F; Galvani A; Isacchi A; Moll J; Pesenti E; Mercurio C; Ciomei M
    Mol Cancer Ther; 2010 Aug; 9(8):2243-54. PubMed ID: 20682657
    [TBL] [Abstract][Full Text] [Related]  

  • 8. Conformational Adaption May Explain the Slow Dissociation Kinetics of Roniciclib (BAY 1000394), a Type I CDK Inhibitor with Kinetic Selectivity for CDK2 and CDK9.
    Ayaz P; Andres D; Kwiatkowski DA; Kolbe CC; Lienau P; Siemeister G; Lücking U; Stegmann CM
    ACS Chem Biol; 2016 Jun; 11(6):1710-9. PubMed ID: 27090615
    [TBL] [Abstract][Full Text] [Related]  

  • 9. AZD5438, a potent oral inhibitor of cyclin-dependent kinases 1, 2, and 9, leads to pharmacodynamic changes and potent antitumor effects in human tumor xenografts.
    Byth KF; Thomas A; Hughes G; Forder C; McGregor A; Geh C; Oakes S; Green C; Walker M; Newcombe N; Green S; Growcott J; Barker A; Wilkinson RW
    Mol Cancer Ther; 2009 Jul; 8(7):1856-66. PubMed ID: 19509270
    [TBL] [Abstract][Full Text] [Related]  

  • 10. Development of a cyclin-dependent kinase inhibitor devoid of ABC transporter-dependent drug resistance.
    Kaliszczak M; Patel H; Kroll SH; Carroll L; Smith G; Delaney S; Heathcote DA; Bondke A; Fuchter MJ; Coombes RC; Barrett AG; Ali S; Aboagye EO
    Br J Cancer; 2013 Oct; 109(9):2356-67. PubMed ID: 24071597
    [TBL] [Abstract][Full Text] [Related]  

  • 11. Pharmacologic properties of AG-012986, a pan-cyclin-dependent kinase inhibitor with antitumor efficacy.
    Zhang C; Lundgren K; Yan Z; Arango ME; Price S; Huber A; Higgins J; Troche G; Skaptason J; Koudriakova T; Nonomiya J; Yang M; O'Connor P; Bender S; Los G; Lewis C; Jessen B
    Mol Cancer Ther; 2008 Apr; 7(4):818-28. PubMed ID: 18413795
    [TBL] [Abstract][Full Text] [Related]  

  • 12. Meriolins, a new class of cell death inducing kinase inhibitors with enhanced selectivity for cyclin-dependent kinases.
    Bettayeb K; Tirado OM; Marionneau-Lambot S; Ferandin Y; Lozach O; Morris JC; Mateo-Lozano S; Drueckes P; Schächtele C; Kubbutat MH; Liger F; Marquet B; Joseph B; Echalier A; Endicott JA; Notario V; Meijer L
    Cancer Res; 2007 Sep; 67(17):8325-34. PubMed ID: 17804748
    [TBL] [Abstract][Full Text] [Related]  

  • 13. The lab oddity prevails: discovery of pan-CDK inhibitor (R)-S-cyclopropyl-S-(4-{[4-{[(1R,2R)-2-hydroxy-1-methylpropyl]oxy}-5-(trifluoromethyl)pyrimidin-2-yl]amino}phenyl)sulfoximide (BAY 1000394) for the treatment of cancer.
    Lücking U; Jautelat R; Krüger M; Brumby T; Lienau P; Schäfer M; Briem H; Schulze J; Hillisch A; Reichel A; Wengner AM; Siemeister G
    ChemMedChem; 2013 Jul; 8(7):1067-85. PubMed ID: 23671017
    [TBL] [Abstract][Full Text] [Related]  

  • 14. 5-Substituted 3-isopropyl-7-[4-(2-pyridyl)benzyl]amino-1(2)H-pyrazolo[4,3-d]pyrimidines with anti-proliferative activity as potent and selective inhibitors of cyclin-dependent kinases.
    Vymětalová L; Havlíček L; Šturc A; Skrášková Z; Jorda R; Pospíšil T; Strnad M; Kryštof V
    Eur J Med Chem; 2016 Mar; 110():291-301. PubMed ID: 26851505
    [TBL] [Abstract][Full Text] [Related]  

  • 15. The Cyclin-dependent kinase inhibitor CYC202 (R-roscovitine) inhibits retinoblastoma protein phosphorylation, causes loss of Cyclin D1, and activates the mitogen-activated protein kinase pathway.
    Whittaker SR; Walton MI; Garrett MD; Workman P
    Cancer Res; 2004 Jan; 64(1):262-72. PubMed ID: 14729633
    [TBL] [Abstract][Full Text] [Related]  

  • 16. Design, synthesis and biological evaluation of 6-pyridylmethylaminopurines as CDK inhibitors.
    Wilson SC; Atrash B; Barlow C; Eccles S; Fischer PM; Hayes A; Kelland L; Jackson W; Jarman M; Mirza A; Moreno J; Nutley BP; Raynaud FI; Sheldrake P; Walton M; Westwood R; Whittaker S; Workman P; McDonald E
    Bioorg Med Chem; 2011 Nov; 19(22):6949-65. PubMed ID: 21982796
    [TBL] [Abstract][Full Text] [Related]  

  • 17. Discovery of [4-Amino-2-(1-methanesulfonylpiperidin-4-ylamino)pyrimidin-5-yl](2,3-difluoro-6- methoxyphenyl)methanone (R547), a potent and selective cyclin-dependent kinase inhibitor with significant in vivo antitumor activity.
    Chu XJ; DePinto W; Bartkovitz D; So SS; Vu BT; Packman K; Lukacs C; Ding Q; Jiang N; Wang K; Goelzer P; Yin X; Smith MA; Higgins BX; Chen Y; Xiang Q; Moliterni J; Kaplan G; Graves B; Lovey A; Fotouhi N
    J Med Chem; 2006 Nov; 49(22):6549-60. PubMed ID: 17064073
    [TBL] [Abstract][Full Text] [Related]  

  • 18. Cyclin-dependent kinase inhibitor Dinaciclib (SCH727965) inhibits pancreatic cancer growth and progression in murine xenograft models.
    Feldmann G; Mishra A; Bisht S; Karikari C; Garrido-Laguna I; Rasheed Z; Ottenhof NA; Dadon T; Alvarez H; Fendrich V; Rajeshkumar NV; Matsui W; Brossart P; Hidalgo M; Bannerji R; Maitra A; Nelkin BD
    Cancer Biol Ther; 2011 Oct; 12(7):598-609. PubMed ID: 21768779
    [TBL] [Abstract][Full Text] [Related]  

  • 19. Preclinical development of G1T38: A novel, potent and selective inhibitor of cyclin dependent kinases 4/6 for use as an oral antineoplastic in patients with CDK4/6 sensitive tumors.
    Bisi JE; Sorrentino JA; Jordan JL; Darr DD; Roberts PJ; Tavares FX; Strum JC
    Oncotarget; 2017 Jun; 8(26):42343-42358. PubMed ID: 28418845
    [TBL] [Abstract][Full Text] [Related]  

  • 20. Novel CDKs inhibitors for the treatment of solid tumour by simultaneously regulating the cell cycle and transcription control.
    Wang X; Deng K; Wang C; Li Y; Wang T; Huang Z; Ma Y; Sun P; Shi Y; Yang S; Fan Y; Xiang R
    J Enzyme Inhib Med Chem; 2020 Dec; 35(1):414-423. PubMed ID: 31899991
    [TBL] [Abstract][Full Text] [Related]  

    [Next]    [New Search]
    of 13.