153 related articles for article (PubMed ID: 22823083)
1. The dynamics of drug-target interactions: drug-target residence time and its impact on efficacy and safety.
Copeland RA
Expert Opin Drug Discov; 2010 Apr; 5(4):305-10. PubMed ID: 22823083
[TBL] [Abstract][Full Text] [Related]
2. Conformational adaptation in drug-target interactions and residence time.
Copeland RA
Future Med Chem; 2011 Sep; 3(12):1491-501. PubMed ID: 21882942
[TBL] [Abstract][Full Text] [Related]
3. Drug-target residence time and its implications for lead optimization.
Copeland RA; Pompliano DL; Meek TD
Nat Rev Drug Discov; 2006 Sep; 5(9):730-9. PubMed ID: 16888652
[TBL] [Abstract][Full Text] [Related]
4. [Development of antituberculous drugs: current status and future prospects].
Tomioka H; Namba K
Kekkaku; 2006 Dec; 81(12):753-74. PubMed ID: 17240921
[TBL] [Abstract][Full Text] [Related]
5. Residence time of receptor-ligand complexes and its effect on biological function.
Tummino PJ; Copeland RA
Biochemistry; 2008 May; 47(20):5481-92. PubMed ID: 18412369
[TBL] [Abstract][Full Text] [Related]
6. The importance of drug-target residence time.
Zhang R; Monsma F
Curr Opin Drug Discov Devel; 2009 Jul; 12(4):488-96. PubMed ID: 19562645
[TBL] [Abstract][Full Text] [Related]
7. The importance of binding kinetics and drug-target residence time in pharmacology.
Knockenhauer KE; Copeland RA
Br J Pharmacol; 2023 May; ():. PubMed ID: 37160660
[TBL] [Abstract][Full Text] [Related]
8. Improving drug candidates by design: a focus on physicochemical properties as a means of improving compound disposition and safety.
Meanwell NA
Chem Res Toxicol; 2011 Sep; 24(9):1420-56. PubMed ID: 21790149
[TBL] [Abstract][Full Text] [Related]
9. The drug-target residence time model: a 10-year retrospective.
Copeland RA
Nat Rev Drug Discov; 2016 Feb; 15(2):87-95. PubMed ID: 26678621
[TBL] [Abstract][Full Text] [Related]
10. Structural alert/reactive metabolite concept as applied in medicinal chemistry to mitigate the risk of idiosyncratic drug toxicity: a perspective based on the critical examination of trends in the top 200 drugs marketed in the United States.
Stepan AF; Walker DP; Bauman J; Price DA; Baillie TA; Kalgutkar AS; Aleo MD
Chem Res Toxicol; 2011 Sep; 24(9):1345-410. PubMed ID: 21702456
[TBL] [Abstract][Full Text] [Related]
11. Complex disease-associated pharmacogenetics: drug efficacy, drug safety, and confirmation of a pathogenetic hypothesis (Alzheimer's disease).
Roses AD; Saunders AM; Huang Y; Strum J; Weisgraber KH; Mahley RW
Pharmacogenomics J; 2007 Feb; 7(1):10-28. PubMed ID: 16770341
[TBL] [Abstract][Full Text] [Related]
12. Application of drug efficiency index in drug discovery: a strategy towards low therapeutic dose.
Montanari D; Chiarparin E; Gleeson MP; Braggio S; Longhi R; Valko K; Rossi T
Expert Opin Drug Discov; 2011 Sep; 6(9):913-20. PubMed ID: 22646214
[TBL] [Abstract][Full Text] [Related]
13. Towards quantitative biology: integration of biological information to elucidate disease pathways and to guide drug discovery.
Fischer HP
Biotechnol Annu Rev; 2005; 11():1-68. PubMed ID: 16216773
[TBL] [Abstract][Full Text] [Related]
14. Evolution of the drug-target residence time model.
Copeland RA
Expert Opin Drug Discov; 2021 Dec; 16(12):1441-1451. PubMed ID: 34210223
[No Abstract] [Full Text] [Related]
15. Analytical method for simultaneously measuring ex vivo drug receptor occupancy and dissociation rate: application to (R)-dimethindene occupancy of central histamine H1 receptors.
Malany S; Hernandez LM; Smith WF; Crowe PD; Hoare SR
J Recept Signal Transduct Res; 2009; 29(2):84-93. PubMed ID: 19308787
[TBL] [Abstract][Full Text] [Related]
16. Rebinding: or why drugs may act longer in vivo than expected from their in vitro target residence time.
Vauquelin G
Expert Opin Drug Discov; 2010 Oct; 5(10):927-41. PubMed ID: 22823988
[TBL] [Abstract][Full Text] [Related]
17. Pharmacological promiscuity: dependence on compound properties and target specificity in a set of recent Roche compounds.
Peters JU; Schnider P; Mattei P; Kansy M
ChemMedChem; 2009 Apr; 4(4):680-6. PubMed ID: 19266525
[TBL] [Abstract][Full Text] [Related]
18. Revealing promiscuous drug-target interactions by chemical proteomics.
Bantscheff M; Scholten A; Heck AJ
Drug Discov Today; 2009 Nov; 14(21-22):1021-9. PubMed ID: 19596079
[TBL] [Abstract][Full Text] [Related]
19. Principles of pharmacodynamics and their applications in veterinary pharmacology.
Lees P; Cunningham FM; Elliott J
J Vet Pharmacol Ther; 2004 Dec; 27(6):397-414. PubMed ID: 15601436
[TBL] [Abstract][Full Text] [Related]
20. The translational value of ligand-receptor binding kinetics in drug discovery.
Liu H; Zhang H; IJzerman AP; Guo D
Br J Pharmacol; 2023 Sep; ():. PubMed ID: 37705429
[TBL] [Abstract][Full Text] [Related]
[Next] [New Search]