BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

379 related articles for article (PubMed ID: 22826432)

  • 1. Sp1 facilitates DNA double-strand break repair through a nontranscriptional mechanism.
    Beishline K; Kelly CM; Olofsson BA; Koduri S; Emrich J; Greenberg RA; Azizkhan-Clifford J
    Mol Cell Biol; 2012 Sep; 32(18):3790-9. PubMed ID: 22826432
    [TBL] [Abstract][Full Text] [Related]  

  • 2. Mre11-Rad50-Nbs1 is a keystone complex connecting DNA repair machinery, double-strand break signaling, and the chromatin template.
    Williams RS; Williams JS; Tainer JA
    Biochem Cell Biol; 2007 Aug; 85(4):509-20. PubMed ID: 17713585
    [TBL] [Abstract][Full Text] [Related]  

  • 3. 53BP1-dependent robust localized KAP-1 phosphorylation is essential for heterochromatic DNA double-strand break repair.
    Noon AT; Shibata A; Rief N; Löbrich M; Stewart GS; Jeggo PA; Goodarzi AA
    Nat Cell Biol; 2010 Feb; 12(2):177-84. PubMed ID: 20081839
    [TBL] [Abstract][Full Text] [Related]  

  • 4. Ataxia telangiectasia-mutated (ATM) kinase activity is regulated by ATP-driven conformational changes in the Mre11/Rad50/Nbs1 (MRN) complex.
    Lee JH; Mand MR; Deshpande RA; Kinoshita E; Yang SH; Wyman C; Paull TT
    J Biol Chem; 2013 May; 288(18):12840-51. PubMed ID: 23525106
    [TBL] [Abstract][Full Text] [Related]  

  • 5. Loss of the tumor suppressor BIN1 enables ATM Ser/Thr kinase activation by the nuclear protein E2F1 and renders cancer cells resistant to cisplatin.
    Folk WP; Kumari A; Iwasaki T; Pyndiah S; Johnson JC; Cassimere EK; Abdulovic-Cui AL; Sakamuro D
    J Biol Chem; 2019 Apr; 294(14):5700-5719. PubMed ID: 30733337
    [TBL] [Abstract][Full Text] [Related]  

  • 6. Autophosphorylation and ATM activation: additional sites add to the complexity.
    Kozlov SV; Graham ME; Jakob B; Tobias F; Kijas AW; Tanuji M; Chen P; Robinson PJ; Taucher-Scholz G; Suzuki K; So S; Chen D; Lavin MF
    J Biol Chem; 2011 Mar; 286(11):9107-19. PubMed ID: 21149446
    [TBL] [Abstract][Full Text] [Related]  

  • 7. Mre11-Rad50-Nbs1-dependent processing of DNA breaks generates oligonucleotides that stimulate ATM activity.
    Jazayeri A; Balestrini A; Garner E; Haber JE; Costanzo V
    EMBO J; 2008 Jul; 27(14):1953-62. PubMed ID: 18596698
    [TBL] [Abstract][Full Text] [Related]  

  • 8. The Mre11/Rad50/Nbs1 complex and its role as a DNA double-strand break sensor for ATM.
    Paull TT; Lee JH
    Cell Cycle; 2005 Jun; 4(6):737-40. PubMed ID: 15908798
    [TBL] [Abstract][Full Text] [Related]  

  • 9. Rad50 zinc hook is important for the Mre11 complex to bind chromosomal DNA double-stranded breaks and initiate various DNA damage responses.
    He J; Shi LZ; Truong LN; Lu CS; Razavian N; Li Y; Negrete A; Shiloach J; Berns MW; Wu X
    J Biol Chem; 2012 Sep; 287(38):31747-56. PubMed ID: 22833675
    [TBL] [Abstract][Full Text] [Related]  

  • 10. MRN complex function in the repair of chromosomal Rag-mediated DNA double-strand breaks.
    Helmink BA; Bredemeyer AL; Lee BS; Huang CY; Sharma GG; Walker LM; Bednarski JJ; Lee WL; Pandita TK; Bassing CH; Sleckman BP
    J Exp Med; 2009 Mar; 206(3):669-79. PubMed ID: 19221393
    [TBL] [Abstract][Full Text] [Related]  

  • 11. Localization of Double-Strand Break Repair Proteins to Viral Replication Compartments following Lytic Reactivation of Kaposi's Sarcoma-Associated Herpesvirus.
    Hollingworth R; Horniblow RD; Forrest C; Stewart GS; Grand RJ
    J Virol; 2017 Nov; 91(22):. PubMed ID: 28855246
    [TBL] [Abstract][Full Text] [Related]  

  • 12. NBN phosphorylation regulates the accumulation of MRN and ATM at sites of DNA double-strand breaks.
    Wen J; Cerosaletti K; Schultz KJ; Wright JA; Concannon P
    Oncogene; 2013 Sep; 32(37):4448-56. PubMed ID: 23146902
    [TBL] [Abstract][Full Text] [Related]  

  • 13. ATM activation by DNA double-strand breaks through the Mre11-Rad50-Nbs1 complex.
    Lee JH; Paull TT
    Science; 2005 Apr; 308(5721):551-4. PubMed ID: 15790808
    [TBL] [Abstract][Full Text] [Related]  

  • 14. Smad7 enhances ATM activity by facilitating the interaction between ATM and Mre11-Rad50-Nbs1 complex in DNA double-strand break repair.
    Park S; Kang JM; Kim SJ; Kim H; Hong S; Lee YJ; Kim SJ
    Cell Mol Life Sci; 2015 Feb; 72(3):583-596. PubMed ID: 25063542
    [TBL] [Abstract][Full Text] [Related]  

  • 15. Activation of ataxia telangiectasia mutated by DNA strand break-inducing agents correlates closely with the number of DNA double strand breaks.
    Ismail IH; Nyström S; Nygren J; Hammarsten O
    J Biol Chem; 2005 Feb; 280(6):4649-55. PubMed ID: 15546858
    [TBL] [Abstract][Full Text] [Related]  

  • 16. Rad17 recruits the MRE11-RAD50-NBS1 complex to regulate the cellular response to DNA double-strand breaks.
    Wang Q; Goldstein M; Alexander P; Wakeman TP; Sun T; Feng J; Lou Z; Kastan MB; Wang XF
    EMBO J; 2014 Apr; 33(8):862-77. PubMed ID: 24534091
    [TBL] [Abstract][Full Text] [Related]  

  • 17. ATP puts the brake on DNA double-strand break repair: a new study shows that ATP switches the Mre11-Rad50-Nbs1 repair factor between signaling and processing of DNA ends.
    Hopfner KP
    Bioessays; 2014 Dec; 36(12):1170-8. PubMed ID: 25213441
    [TBL] [Abstract][Full Text] [Related]  

  • 18. DNA-PK and ATM phosphorylation sites in XLF/Cernunnos are not required for repair of DNA double strand breaks.
    Yu Y; Mahaney BL; Yano K; Ye R; Fang S; Douglas P; Chen DJ; Lees-Miller SP
    DNA Repair (Amst); 2008 Oct; 7(10):1680-92. PubMed ID: 18644470
    [TBL] [Abstract][Full Text] [Related]  

  • 19. Independent roles for nibrin and Mre11-Rad50 in the activation and function of Atm.
    Cerosaletti K; Concannon P
    J Biol Chem; 2004 Sep; 279(37):38813-9. PubMed ID: 15234984
    [TBL] [Abstract][Full Text] [Related]  

  • 20. The impact of heterochromatin on DSB repair.
    Goodarzi AA; Noon AT; Jeggo PA
    Biochem Soc Trans; 2009 Jun; 37(Pt 3):569-76. PubMed ID: 19442252
    [TBL] [Abstract][Full Text] [Related]  

    [Next]    [New Search]
    of 19.