These tools will no longer be maintained as of December 31, 2024. Archived website can be found here. PubMed4Hh GitHub repository can be found here. Contact NLM Customer Service if you have questions.


BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

69 related articles for article (PubMed ID: 22828407)

  • 1. Selective small molecule inhibitors of p110α and δ isoforms of phosphoinosityl-3-kinase are cytotoxic to human acute myeloid leukemia progenitors.
    Xing Y; Gerhard B; Hogge DE
    Exp Hematol; 2012 Nov; 40(11):922-33. PubMed ID: 22828407
    [TBL] [Abstract][Full Text] [Related]  

  • 2. Combined inhibition of the phosphoinosityl-3-kinase (PI3Kinase) P110δ subunit and mitogen-extracellular activated protein kinase (MEKinase) shows synergistic cytotoxicity against human acute myeloid leukemia progenitors.
    Xing Y; Hogge DE
    Leuk Res; 2013 Jun; 37(6):697-704. PubMed ID: 23522913
    [TBL] [Abstract][Full Text] [Related]  

  • 3. Combined inhibition of integrin linked kinase and FMS-like tyrosine kinase 3 is cytotoxic to acute myeloid leukemia progenitor cells.
    Muranyi AL; Dedhar S; Hogge DE
    Exp Hematol; 2009 Apr; 37(4):450-60. PubMed ID: 19302919
    [TBL] [Abstract][Full Text] [Related]  

  • 4. A diphtheria toxin-interleukin 3 fusion protein is cytotoxic to primitive acute myeloid leukemia progenitors but spares normal progenitors.
    Feuring-Buske M; Frankel AE; Alexander RL; Gerhard B; Hogge DE
    Cancer Res; 2002 Mar; 62(6):1730-6. PubMed ID: 11912147
    [TBL] [Abstract][Full Text] [Related]  

  • 5. Targeting integrin linked kinase and FMS-like tyrosine kinase-3 is cytotoxic to acute myeloid leukemia stem cells but spares normal progenitors.
    Muranyi AL; Dedhar S; Hogge DE
    Leuk Res; 2010 Oct; 34(10):1358-65. PubMed ID: 20193963
    [TBL] [Abstract][Full Text] [Related]  

  • 6. A selective inhibitor of the p110delta isoform of PI 3-kinase inhibits AML cell proliferation and survival and increases the cytotoxic effects of VP16.
    Billottet C; Grandage VL; Gale RE; Quattropani A; Rommel C; Vanhaesebroeck B; Khwaja A
    Oncogene; 2006 Oct; 25(50):6648-59. PubMed ID: 16702948
    [TBL] [Abstract][Full Text] [Related]  

  • 7. Liposomal encapsulation of a synergistic molar ratio of cytarabine and daunorubicin enhances selective toxicity for acute myeloid leukemia progenitors as compared to analogous normal hematopoietic cells.
    Kim HP; Gerhard B; Harasym TO; Mayer LD; Hogge DE
    Exp Hematol; 2011 Jul; 39(7):741-50. PubMed ID: 21530609
    [TBL] [Abstract][Full Text] [Related]  

  • 8. Both p110alpha and p110beta isoforms of phosphatidylinositol 3-OH-kinase are required for insulin signalling in the hypothalamus.
    Tups A; Anderson GM; Rizwan M; Augustine RA; Chaussade C; Shepherd PR; Grattan DR
    J Neuroendocrinol; 2010 Jun; 22(6):534-42. PubMed ID: 20236230
    [TBL] [Abstract][Full Text] [Related]  

  • 9. Targeting the PI3K/AKT/mTOR signaling network in acute myelogenous leukemia.
    Martelli AM; Evangelisti C; Chiarini F; Grimaldi C; Manzoli L; McCubrey JA
    Expert Opin Investig Drugs; 2009 Sep; 18(9):1333-49. PubMed ID: 19678801
    [TBL] [Abstract][Full Text] [Related]  

  • 10. Role of PI3K and AKT specific isoforms in ovarian cancer cell migration, invasion and proliferation through the p70S6K1 pathway.
    Meng Q; Xia C; Fang J; Rojanasakul Y; Jiang BH
    Cell Signal; 2006 Dec; 18(12):2262-71. PubMed ID: 16839745
    [TBL] [Abstract][Full Text] [Related]  

  • 11. Variant diphtheria toxin-interleukin-3 fusion proteins with increased receptor affinity have enhanced cytotoxicity against acute myeloid leukemia progenitors.
    Hogge DE; Yalcintepe L; Wong SH; Gerhard B; Frankel AE
    Clin Cancer Res; 2006 Feb; 12(4):1284-91. PubMed ID: 16489085
    [TBL] [Abstract][Full Text] [Related]  

  • 12. Protein kinase CK2alpha as an unfavorable prognostic marker and novel therapeutic target in acute myeloid leukemia.
    Kim JS; Eom JI; Cheong JW; Choi AJ; Lee JK; Yang WI; Min YH
    Clin Cancer Res; 2007 Feb; 13(3):1019-28. PubMed ID: 17289898
    [TBL] [Abstract][Full Text] [Related]  

  • 13. PI3-kinase p110α mediates β1 integrin-induced Akt activation and membrane protrusion during cell attachment and initial spreading.
    Zeller KS; Idevall-Hagren O; Stefansson A; Velling T; Jackson SP; Downward J; Tengholm A; Johansson S
    Cell Signal; 2010 Dec; 22(12):1838-48. PubMed ID: 20667469
    [TBL] [Abstract][Full Text] [Related]  

  • 14. Selective and potent small-molecule inhibitors of PI3Ks.
    Jeong Y; Kwon D; Hong S
    Future Med Chem; 2014 May; 6(7):737-56. PubMed ID: 24941870
    [TBL] [Abstract][Full Text] [Related]  

  • 15. Long-term marrow culture of cells from patients with acute myelogenous leukemia. Selection in favor of normal phenotypes in some but not all cases.
    Coulombel L; Eaves C; Kalousek D; Gupta C; Eaves A
    J Clin Invest; 1985 Mar; 75(3):961-9. PubMed ID: 3856572
    [TBL] [Abstract][Full Text] [Related]  

  • 16. Mucin1 expression is enriched in the human stem cell fraction of cord blood and is upregulated in majority of the AML cases.
    Fatrai S; Schepers H; Tadema H; Vellenga E; Daenen SM; Schuringa JJ
    Exp Hematol; 2008 Oct; 36(10):1254-65. PubMed ID: 18640764
    [TBL] [Abstract][Full Text] [Related]  

  • 17. Arsenic disulfide synergizes with the phosphoinositide 3-kinase inhibitor PI-103 to eradicate acute myeloid leukemia stem cells by inducing differentiation.
    Hong Z; Xiao M; Yang Y; Han Z; Cao Y; Li C; Wu Y; Gong Q; Zhou X; Xu D; Meng L; Ma D; Zhou J
    Carcinogenesis; 2011 Oct; 32(10):1550-8. PubMed ID: 21803735
    [TBL] [Abstract][Full Text] [Related]  

  • 18. Hematopoiesis and RAS-driven myeloid leukemia differentially require PI3K isoform p110α.
    Gritsman K; Yuzugullu H; Von T; Yan H; Clayton L; Fritsch C; Maira SM; Hollingworth G; Choi C; Khandan T; Paktinat M; Okabe RO; Roberts TM; Zhao JJ
    J Clin Invest; 2014 Apr; 124(4):1794-809. PubMed ID: 24569456
    [TBL] [Abstract][Full Text] [Related]  

  • 19. The effect of granulocyte-macrophage colony-stimulating factor on undifferentiated and mature acute myelogenous leukemia blast progenitors.
    Estrov Z; Park CH; Reading CL; Estey EH; Talpaz M; Kurzrock R; Deisseroth AB; Gutterman JU
    Exp Hematol; 1992 Aug; 20(7):886-90. PubMed ID: 1628706
    [TBL] [Abstract][Full Text] [Related]  

  • 20. Essential role for the p110delta isoform in phosphoinositide 3-kinase activation and cell proliferation in acute myeloid leukemia.
    Sujobert P; Bardet V; Cornillet-Lefebvre P; Hayflick JS; Prie N; Verdier F; Vanhaesebroeck B; Muller O; Pesce F; Ifrah N; Hunault-Berger M; Berthou C; Villemagne B; Jourdan E; Audhuy B; Solary E; Witz B; Harousseau JL; Himberlin C; Lamy T; Lioure B; Cahn JY; Dreyfus F; Mayeux P; Lacombe C; Bouscary D
    Blood; 2005 Aug; 106(3):1063-6. PubMed ID: 15840695
    [TBL] [Abstract][Full Text] [Related]  

    [Next]    [New Search]
    of 4.