BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

199 related articles for article (PubMed ID: 22830422)

  • 1. Inhibition of phosphodiesterase-4 (PDE4) activity triggers luminal apoptosis and AKT dephosphorylation in a 3-D colonic-crypt model.
    Tsunoda T; Ota T; Fujimoto T; Doi K; Tanaka Y; Yoshida Y; Ogawa M; Matsuzaki H; Hamabashiri M; Tyson DR; Kuroki M; Miyamoto S; Shirasawa S
    Mol Cancer; 2012 Jul; 11():46. PubMed ID: 22830422
    [TBL] [Abstract][Full Text] [Related]  

  • 2. Phosphodiesterase 4B is an effective therapeutic target in colorectal cancer.
    Kim DU; Kwak B; Kim SW
    Biochem Biophys Res Commun; 2019 Jan; 508(3):825-831. PubMed ID: 30528730
    [TBL] [Abstract][Full Text] [Related]  

  • 3. Apremilast Induces Apoptosis of Human Colorectal Cancer Cells with Mutant
    Nishi K; Luo H; Ishikura S; Doi K; Iwaihara Y; Wills L; Baillie GS; Sakata T; Shirasawa S; Tsunoda T
    Anticancer Res; 2017 Jul; 37(7):3833-3839. PubMed ID: 28668883
    [TBL] [Abstract][Full Text] [Related]  

  • 4. ALPK2 is crucial for luminal apoptosis and DNA repair-related gene expression in a three-dimensional colonic-crypt model.
    Yoshida Y; Tsunoda T; Doi K; Fujimoto T; Tanaka Y; Ota T; Ogawa M; Matsuzaki H; Kuroki M; Iwasaki A; Shirasawa S
    Anticancer Res; 2012 Jun; 32(6):2301-8. PubMed ID: 22641666
    [TBL] [Abstract][Full Text] [Related]  

  • 5. Inhibition of PDE4/PDE4B improves renal function and ameliorates inflammation in cisplatin-induced acute kidney injury.
    Xu M; Yu X; Meng X; Huang S; Zhang Y; Zhang A; Jia Z
    Am J Physiol Renal Physiol; 2020 Mar; 318(3):F576-F588. PubMed ID: 31961716
    [TBL] [Abstract][Full Text] [Related]  

  • 6. Phosphodiesterase-4 inhibition confers a neuroprotective efficacy against early brain injury following experimental subarachnoid hemorrhage in rats by attenuating neuronal apoptosis through the SIRT1/Akt pathway.
    Li Q; Peng Y; Fan L; Xu H; He P; Cao S; Li J; Chen T; Ruan W; Chen G
    Biomed Pharmacother; 2018 Mar; 99():947-955. PubMed ID: 29710495
    [TBL] [Abstract][Full Text] [Related]  

  • 7. The unrecognized effects of phosphodiesterase 4 on epithelial cells in pulmonary inflammation.
    Konrad FM; Bury A; Schick MA; Ngamsri KC; Reutershan J
    PLoS One; 2015; 10(4):e0121725. PubMed ID: 25909327
    [TBL] [Abstract][Full Text] [Related]  

  • 8. Phosphodiesterase 4B negatively regulates endotoxin-activated interleukin-1 receptor antagonist responses in macrophages.
    Yang JX; Hsieh KC; Chen YL; Lee CK; Conti M; Chuang TH; Wu CP; Jin SC
    Sci Rep; 2017 Apr; 7():46165. PubMed ID: 28383060
    [TBL] [Abstract][Full Text] [Related]  

  • 9. Resveratrol induces luminal apoptosis of human colorectal cancer HCT116 cells in three-dimensional culture.
    Tsunoda T; Ishikura S; Doi K; Matsuzaki H; Iwaihara Y; Shirasawa S
    Anticancer Res; 2014 Aug; 34(8):4551-5. PubMed ID: 25075098
    [TBL] [Abstract][Full Text] [Related]  

  • 10. Phosphodiesterase 4b expression plays a major role in alcohol-induced neuro-inflammation.
    Avila DV; Myers SA; Zhang J; Kharebava G; McClain CJ; Kim HY; Whittemore SR; Gobejishvili L; Barve S
    Neuropharmacology; 2017 Oct; 125():376-385. PubMed ID: 28807677
    [TBL] [Abstract][Full Text] [Related]  

  • 11. Three-dimensionally specific inhibition of DNA repair-related genes by activated KRAS in colon crypt model.
    Tsunoda T; Takashima Y; Fujimoto T; Koyanagi M; Yoshida Y; Doi K; Tanaka Y; Kuroki M; Sasazuki T; Shirasawa S
    Neoplasia; 2010 May; 12(5):397-404. PubMed ID: 20454511
    [TBL] [Abstract][Full Text] [Related]  

  • 12. Oncogenic KRAS regulates miR-200c and miR-221/222 in a 3D-specific manner in colorectal cancer cells.
    Tsunoda T; Takashima Y; Yoshida Y; Doi K; Tanaka Y; Fujimoto T; Machida T; Ota T; Koyanagi M; Kuroki M; Sasazuki T; Shirasawa S
    Anticancer Res; 2011 Jul; 31(7):2453-9. PubMed ID: 21873159
    [TBL] [Abstract][Full Text] [Related]  

  • 13. PDEδ inhibition impedes the proliferation and survival of human colorectal cancer cell lines harboring oncogenic KRas.
    Klein CH; Truxius DC; Vogel HA; Harizanova J; Murarka S; Martín-Gago P; Bastiaens PIH
    Int J Cancer; 2019 Feb; 144(4):767-776. PubMed ID: 30194764
    [TBL] [Abstract][Full Text] [Related]  

  • 14. Dysregulation of hepatic cAMP levels via altered Pde4b expression plays a critical role in alcohol-induced steatosis.
    Avila DV; Barker DF; Zhang J; McClain CJ; Barve S; Gobejishvili L
    J Pathol; 2016 Sep; 240(1):96-107. PubMed ID: 27287961
    [TBL] [Abstract][Full Text] [Related]  

  • 15. A phosphodiesterase 4B-dependent interplay between tumor cells and the microenvironment regulates angiogenesis in B-cell lymphoma.
    Suhasini AN; Wang L; Holder KN; Lin AP; Bhatnagar H; Kim SW; Moritz AW; Aguiar RCT
    Leukemia; 2016 Mar; 30(3):617-626. PubMed ID: 26503641
    [TBL] [Abstract][Full Text] [Related]  

  • 16. Gene set enrichment analysis unveils the mechanism for the phosphodiesterase 4B control of glucocorticoid response in B-cell lymphoma.
    Kim SW; Rai D; Aguiar RC
    Clin Cancer Res; 2011 Nov; 17(21):6723-32. PubMed ID: 21742807
    [TBL] [Abstract][Full Text] [Related]  

  • 17. The phosphodiesterase PDE4B limits cAMP-associated PI3K/AKT-dependent apoptosis in diffuse large B-cell lymphoma.
    Smith PG; Wang F; Wilkinson KN; Savage KJ; Klein U; Neuberg DS; Bollag G; Shipp MA; Aguiar RC
    Blood; 2005 Jan; 105(1):308-16. PubMed ID: 15331441
    [TBL] [Abstract][Full Text] [Related]  

  • 18. 4-Acetyl-Antroquinonol B Improves the Sensitization of Cetuximab on Both Kras Mutant and Wild Type Colorectal Cancer by Modulating the Expression of Ras/Raf/miR-193a-3p Signaling Axis.
    Chu YC; Tsai TY; Yadav VK; Deng L; Huang CC; Tzeng YM; Yeh CT; Chen MY
    Int J Mol Sci; 2021 Jul; 22(14):. PubMed ID: 34299137
    [TBL] [Abstract][Full Text] [Related]  

  • 19. Long noncoding RNA SNHG14 accelerates cell proliferation, migration, invasion and suppresses apoptosis in colorectal cancer cells by targeting miR-944/KRAS axis through PI3K/AKT pathway.
    Pei Q; Liu GS; Li HP; Zhang Y; Xu XC; Gao H; Zhang W; Li T
    Eur Rev Med Pharmacol Sci; 2019 Nov; 23(22):9871-9881. PubMed ID: 31799655
    [TBL] [Abstract][Full Text] [Related]  

  • 20. miR-450b-5p induced by oncogenic KRAS is required for colorectal cancer progression.
    Ye YP; Wu P; Gu CC; Deng DL; Jiao HL; Li TT; Wang SY; Wang YX; Xiao ZY; Wei WT; Chen YR; Qiu JF; Yang RW; Lin J; Liang L; Liao WT; Ding YQ
    Oncotarget; 2016 Sep; 7(38):61312-61324. PubMed ID: 27494869
    [TBL] [Abstract][Full Text] [Related]  

    [Next]    [New Search]
    of 10.