BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

173 related articles for article (PubMed ID: 22831455)

  • 1. A designer bleomycin with significantly improved DNA cleavage activity.
    Huang SX; Feng Z; Wang L; Galm U; Wendt-Pienkowski E; Yang D; Tao M; Coughlin JM; Duan Y; Shen B
    J Am Chem Soc; 2012 Aug; 134(32):13501-9. PubMed ID: 22831455
    [TBL] [Abstract][Full Text] [Related]  

  • 2. Engineered production and evaluation of 6'-deoxy-tallysomycin H-1 revealing new insights into the structure-activity relationship of the anticancer drug bleomycin.
    Yang D; Hindra ; Dong LB; Crnovcic I; Shen B
    J Antibiot (Tokyo); 2017 Aug; ():. PubMed ID: 28831149
    [TBL] [Abstract][Full Text] [Related]  

  • 3. BlmB and TlmB provide resistance to the bleomycin family of antitumor antibiotics by N-acetylating metal-free bleomycin, tallysomycin, phleomycin, and zorbamycin.
    Coughlin JM; Rudolf JD; Wendt-Pienkowski E; Wang L; Unsin C; Galm U; Yang D; Tao M; Shen B
    Biochemistry; 2014 Nov; 53(44):6901-9. PubMed ID: 25299801
    [TBL] [Abstract][Full Text] [Related]  

  • 4. Zorbamycin has a different DNA sequence selectivity compared with bleomycin and analogues.
    Chen JK; Yang D; Shen B; Neilan BA; Murray V
    Bioorg Med Chem; 2016 Nov; 24(22):6094-6101. PubMed ID: 27745992
    [TBL] [Abstract][Full Text] [Related]  

  • 5. Bleomycin analogues preferentially cleave at the transcription start sites of actively transcribed genes in human cells.
    Chen JK; Yang D; Shen B; Murray V
    Int J Biochem Cell Biol; 2017 Apr; 85():56-65. PubMed ID: 28167289
    [TBL] [Abstract][Full Text] [Related]  

  • 6. Crystal Structure of the Zorbamycin-Binding Protein ZbmA, the Primary Self-Resistance Element in Streptomyces flavoviridis ATCC21892.
    Rudolf JD; Bigelow L; Chang C; Cuff ME; Lohman JR; Chang CY; Ma M; Yang D; Clancy S; Babnigg G; Joachimiak A; Phillips GN; Shen B
    Biochemistry; 2015 Nov; 54(45):6842-51. PubMed ID: 26512730
    [TBL] [Abstract][Full Text] [Related]  

  • 7. Comparative analysis of the biosynthetic gene clusters and pathways for three structurally related antitumor antibiotics: bleomycin, tallysomycin, and zorbamycin.
    Galm U; Wendt-Pienkowski E; Wang L; Huang SX; Unsin C; Tao M; Coughlin JM; Shen B
    J Nat Prod; 2011 Mar; 74(3):526-36. PubMed ID: 21210656
    [TBL] [Abstract][Full Text] [Related]  

  • 8. The genome-wide sequence specificity of DNA cleavage by bleomycin analogues in human cells.
    Murray V; Chen JK; Yang D; Shen B
    Bioorg Med Chem; 2018 Aug; 26(14):4168-4178. PubMed ID: 30006142
    [TBL] [Abstract][Full Text] [Related]  

  • 9. Activities of recombinant human bleomycin hydrolase on bleomycins and engineered analogues revealing new opportunities to overcome bleomycin-induced pulmonary toxicity.
    Crnovcic I; Gan F; Yang D; Dong LB; Schultz PG; Shen B
    Bioorg Med Chem Lett; 2018 Sep; 28(16):2670-2674. PubMed ID: 29730026
    [TBL] [Abstract][Full Text] [Related]  

  • 10. The biosynthetic gene cluster of zorbamycin, a member of the bleomycin family of antitumor antibiotics, from Streptomyces flavoviridis ATCC 21892.
    Galm U; Wendt-Pienkowski E; Wang L; George NP; Oh TJ; Yi F; Tao M; Coughlin JM; Shen B
    Mol Biosyst; 2009 Jan; 5(1):77-90. PubMed ID: 19081934
    [TBL] [Abstract][Full Text] [Related]  

  • 11. Genome Mining of Streptomyces mobaraensis DSM40847 as a Bleomycin Producer Providing a Biotechnology Platform To Engineer Designer Bleomycin Analogues.
    Hindra ; Yang D; Teng Q; Dong LB; Crnovčić I; Huang T; Ge H; Shen B
    Org Lett; 2017 Mar; 19(6):1386-1389. PubMed ID: 28256838
    [TBL] [Abstract][Full Text] [Related]  

  • 12. The tallysomycin biosynthetic gene cluster from Streptoalloteichus hindustanus E465-94 ATCC 31158 unveiling new insights into the biosynthesis of the bleomycin family of antitumor antibiotics.
    Tao M; Wang L; Wendt-Pienkowski E; George NP; Galm U; Zhang G; Coughlin JM; Shen B
    Mol Biosyst; 2007 Jan; 3(1):60-74. PubMed ID: 17216057
    [TBL] [Abstract][Full Text] [Related]  

  • 13. Deoxidized gulose moiety attenuates the pulmonary toxicity of 6'-deoxy-bleomycin Z without effect on its antitumor activity.
    Kong J; Xiong Y; Duan Y; Zhu X
    Biomed Pharmacother; 2021 Apr; 136():111222. PubMed ID: 33450497
    [TBL] [Abstract][Full Text] [Related]  

  • 14. Strain improvement by combined UV mutagenesis and ribosome engineering and subsequent fermentation optimization for enhanced 6'-deoxy-bleomycin Z production.
    Zhu X; Kong J; Yang H; Huang R; Huang Y; Yang D; Shen B; Duan Y
    Appl Microbiol Biotechnol; 2018 Feb; 102(4):1651-1661. PubMed ID: 29279956
    [TBL] [Abstract][Full Text] [Related]  

  • 15. The biosynthetic gene cluster for the antitumor drug bleomycin from Streptomyces verticillus ATCC15003 supporting functional interactions between nonribosomal peptide synthetases and a polyketide synthase.
    Du L; Sánchez C; Chen M; Edwards DJ; Shen B
    Chem Biol; 2000 Aug; 7(8):623-42. PubMed ID: 11048953
    [TBL] [Abstract][Full Text] [Related]  

  • 16. The disaccharide moiety of bleomycin facilitates uptake by cancer cells.
    Schroeder BR; Ghare MI; Bhattacharya C; Paul R; Yu Z; Zaleski PA; Bozeman TC; Rishel MJ; Hecht SM
    J Am Chem Soc; 2014 Oct; 136(39):13641-56. PubMed ID: 25184545
    [TBL] [Abstract][Full Text] [Related]  

  • 17. The discovery and development of microbial bleomycin analogues.
    Kong J; Yi L; Xiong Y; Huang Y; Yang D; Yan X; Shen B; Duan Y; Zhu X
    Appl Microbiol Biotechnol; 2018 Aug; 102(16):6791-6798. PubMed ID: 29876605
    [TBL] [Abstract][Full Text] [Related]  

  • 18. A short DNA sequence confers strong bleomycin binding to hairpin DNAs.
    Tang C; Paul A; Alam MP; Roy B; Wilson WD; Hecht SM
    J Am Chem Soc; 2014 Oct; 136(39):13715-26. PubMed ID: 25188011
    [TBL] [Abstract][Full Text] [Related]  

  • 19. Efficient nuclear DNA cleavage in human cancer cells by synthetic bleomycin mimics.
    Li Q; van der Wijst MG; Kazemier HG; Rots MG; Roelfes G
    ACS Chem Biol; 2014 Apr; 9(4):1044-51. PubMed ID: 24527883
    [TBL] [Abstract][Full Text] [Related]  

  • 20. Functional characterization of tlmH in Streptoalloteichus hindustanus E465-94 ATCC 31158 unveiling new insight into tallysomycin biosynthesis and affording a novel bleomycin analog.
    Tao M; Wang L; Wendt-Pienkowski E; Zhang N; Yang D; Galm U; Coughlin JM; Xu Z; Shen B
    Mol Biosyst; 2010 Feb; 6(2):349-56. PubMed ID: 20094654
    [TBL] [Abstract][Full Text] [Related]  

    [Next]    [New Search]
    of 9.