BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

214 related articles for article (PubMed ID: 22835548)

  • 1. Indole-3-carbinol disrupts estrogen receptor-alpha dependent expression of insulin-like growth factor-1 receptor and insulin receptor substrate-1 and proliferation of human breast cancer cells.
    Marconett CN; Singhal AK; Sundar SN; Firestone GL
    Mol Cell Endocrinol; 2012 Nov; 363(1-2):74-84. PubMed ID: 22835548
    [TBL] [Abstract][Full Text] [Related]  

  • 2. Indole-3-carbinol downregulation of telomerase gene expression requires the inhibition of estrogen receptor-alpha and Sp1 transcription factor interactions within the hTERT promoter and mediates the G1 cell cycle arrest of human breast cancer cells.
    Marconett CN; Sundar SN; Tseng M; Tin AS; Tran KQ; Mahuron KM; Bjeldanes LF; Firestone GL
    Carcinogenesis; 2011 Sep; 32(9):1315-23. PubMed ID: 21693539
    [TBL] [Abstract][Full Text] [Related]  

  • 3. Indole-3-carbinol selectively uncouples expression and activity of estrogen receptor subtypes in human breast cancer cells.
    Sundar SN; Kerekatte V; Equinozio CN; Doan VB; Bjeldanes LF; Firestone GL
    Mol Endocrinol; 2006 Dec; 20(12):3070-82. PubMed ID: 16901971
    [TBL] [Abstract][Full Text] [Related]  

  • 4. Indole-3-carbinol and its N-alkoxy derivatives preferentially target ERα-positive breast cancer cells.
    Caruso JA; Campana R; Wei C; Su CH; Hanks AM; Bornmann WG; Keyomarsi K
    Cell Cycle; 2014; 13(16):2587-99. PubMed ID: 25486199
    [TBL] [Abstract][Full Text] [Related]  

  • 5. Upregulation of IRS1 Enhances IGF1 Response in Y537S and D538G ESR1 Mutant Breast Cancer Cells.
    Li Z; Levine KM; Bahreini A; Wang P; Chu D; Park BH; Oesterreich S; Lee AV
    Endocrinology; 2018 Jan; 159(1):285-296. PubMed ID: 29029116
    [TBL] [Abstract][Full Text] [Related]  

  • 6. Resveratrol regulates the cell viability promoted by 17β-estradiol or bisphenol A via down-regulation of the cross-talk between estrogen receptor α and insulin growth factor-1 receptor in BG-1 ovarian cancer cells.
    Kang NH; Hwang KA; Lee HR; Choi DW; Choi KC
    Food Chem Toxicol; 2013 Sep; 59():373-9. PubMed ID: 23810794
    [TBL] [Abstract][Full Text] [Related]  

  • 7. Indole-3-carbinol triggers aryl hydrocarbon receptor-dependent estrogen receptor (ER)alpha protein degradation in breast cancer cells disrupting an ERalpha-GATA3 transcriptional cross-regulatory loop.
    Marconett CN; Sundar SN; Poindexter KM; Stueve TR; Bjeldanes LF; Firestone GL
    Mol Biol Cell; 2010 Apr; 21(7):1166-77. PubMed ID: 20130088
    [TBL] [Abstract][Full Text] [Related]  

  • 8. 1-Benzyl-indole-3-carbinol is a novel indole-3-carbinol derivative with significantly enhanced potency of anti-proliferative and anti-estrogenic properties in human breast cancer cells.
    Nguyen HH; Lavrenov SN; Sundar SN; Nguyen DH; Tseng M; Marconett CN; Kung J; Staub RE; Preobrazhenskaya MN; Bjeldanes LF; Firestone GL
    Chem Biol Interact; 2010 Aug; 186(3):255-66. PubMed ID: 20570586
    [TBL] [Abstract][Full Text] [Related]  

  • 9. Indole-3-carbinol inhibits CDK6 expression in human MCF-7 breast cancer cells by disrupting Sp1 transcription factor interactions with a composite element in the CDK6 gene promoter.
    Cram EJ; Liu BD; Bjeldanes LF; Firestone GL
    J Biol Chem; 2001 Jun; 276(25):22332-40. PubMed ID: 11297539
    [TBL] [Abstract][Full Text] [Related]  

  • 10. Indole-3-carbinol inhibits the expression of cyclin-dependent kinase-6 and induces a G1 cell cycle arrest of human breast cancer cells independent of estrogen receptor signaling.
    Cover CM; Hsieh SJ; Tran SH; Hallden G; Kim GS; Bjeldanes LF; Firestone GL
    J Biol Chem; 1998 Feb; 273(7):3838-47. PubMed ID: 9461564
    [TBL] [Abstract][Full Text] [Related]  

  • 11. Inhibition of oncogenic BRAF activity by indole-3-carbinol disrupts microphthalmia-associated transcription factor expression and arrests melanoma cell proliferation.
    Kundu A; Quirit JG; Khouri MG; Firestone GL
    Mol Carcinog; 2017 Jan; 56(1):49-61. PubMed ID: 26878440
    [TBL] [Abstract][Full Text] [Related]  

  • 12. BRCA1 and BRCA2 as molecular targets for phytochemicals indole-3-carbinol and genistein in breast and prostate cancer cells.
    Fan S; Meng Q; Auborn K; Carter T; Rosen EM
    Br J Cancer; 2006 Feb; 94(3):407-26. PubMed ID: 16434996
    [TBL] [Abstract][Full Text] [Related]  

  • 13. Indole-3-carbinol and 3-3'-diindolylmethane antiproliferative signaling pathways control cell-cycle gene transcription in human breast cancer cells by regulating promoter-Sp1 transcription factor interactions.
    Firestone GL; Bjeldanes LF
    J Nutr; 2003 Jul; 133(7 Suppl):2448S-2455S. PubMed ID: 12840223
    [TBL] [Abstract][Full Text] [Related]  

  • 14. Low levels of 3,3'-diindolylmethane activate estrogen receptor α and induce proliferation of breast cancer cells in the absence of estradiol.
    Marques M; Laflamme L; Benassou I; Cissokho C; Guillemette B; Gaudreau L
    BMC Cancer; 2014 Jul; 14():524. PubMed ID: 25048790
    [TBL] [Abstract][Full Text] [Related]  

  • 15. A new indole-3-carbinol tetrameric derivative inhibits cyclin-dependent kinase 6 expression, and induces G1 cell cycle arrest in both estrogen-dependent and estrogen-independent breast cancer cell lines.
    Brandi G; Paiardini M; Cervasi B; Fiorucci C; Filippone P; De Marco C; Zaffaroni N; Magnani M
    Cancer Res; 2003 Jul; 63(14):4028-36. PubMed ID: 12874002
    [TBL] [Abstract][Full Text] [Related]  

  • 16. Indole-3-carbinol is a negative regulator of estrogen receptor-alpha signaling in human tumor cells.
    Meng Q; Yuan F; Goldberg ID; Rosen EM; Auborn K; Fan S
    J Nutr; 2000 Dec; 130(12):2927-31. PubMed ID: 11110848
    [TBL] [Abstract][Full Text] [Related]  

  • 17. Cooperative antiproliferative signaling by aspirin and indole-3-carbinol targets microphthalmia-associated transcription factor gene expression and promoter activity in human melanoma cells.
    Poindexter KM; Matthew S; Aronchik I; Firestone GL
    Cell Biol Toxicol; 2016 Apr; 32(2):103-19. PubMed ID: 27055402
    [TBL] [Abstract][Full Text] [Related]  

  • 18. Anacardic acid inhibits estrogen receptor alpha-DNA binding and reduces target gene transcription and breast cancer cell proliferation.
    Schultz DJ; Wickramasinghe NS; Ivanova MM; Isaacs SM; Dougherty SM; Imbert-Fernandez Y; Cunningham AR; Chen C; Klinge CM
    Mol Cancer Ther; 2010 Mar; 9(3):594-605. PubMed ID: 20197399
    [TBL] [Abstract][Full Text] [Related]  

  • 19. Re-expression of estrogen receptor alpha in estrogen receptor alpha-negative MCF-7 cells restores both estrogen and insulin-like growth factor-mediated signaling and growth.
    Oesterreich S; Zhang P; Guler RL; Sun X; Curran EM; Welshons WV; Osborne CK; Lee AV
    Cancer Res; 2001 Aug; 61(15):5771-7. PubMed ID: 11479214
    [TBL] [Abstract][Full Text] [Related]  

  • 20. Genetic analysis of type-1 insulin-like growth factor receptor signaling through insulin receptor substrate-1 and -2 in pancreatic beta cells.
    Xuan S; Szabolcs M; Cinti F; Perincheri S; Accili D; Efstratiadis A
    J Biol Chem; 2010 Dec; 285(52):41044-50. PubMed ID: 20947509
    [TBL] [Abstract][Full Text] [Related]  

    [Next]    [New Search]
    of 11.