These tools will no longer be maintained as of December 31, 2024. Archived website can be found here. PubMed4Hh GitHub repository can be found here. Contact NLM Customer Service if you have questions.


BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

362 related articles for article (PubMed ID: 22843411)

  • 1. Calpastatin-mediated inhibition of calpains in the mouse brain prevents mutant ataxin 3 proteolysis, nuclear localization and aggregation, relieving Machado-Joseph disease.
    Simões AT; Gonçalves N; Koeppen A; Déglon N; Kügler S; Duarte CB; Pereira de Almeida L
    Brain; 2012 Aug; 135(Pt 8):2428-39. PubMed ID: 22843411
    [TBL] [Abstract][Full Text] [Related]  

  • 2. Calpain-mediated ataxin-3 cleavage in the molecular pathogenesis of spinocerebellar ataxia type 3 (SCA3).
    Hübener J; Weber JJ; Richter C; Honold L; Weiss A; Murad F; Breuer P; Wüllner U; Bellstedt P; Paquet-Durand F; Takano J; Saido TC; Riess O; Nguyen HP
    Hum Mol Genet; 2013 Feb; 22(3):508-18. PubMed ID: 23100324
    [TBL] [Abstract][Full Text] [Related]  

  • 3. Identification of the calpain-generated toxic fragment of ataxin-3 protein provides new avenues for therapy of Machado-Joseph disease| Spinocerebellar ataxia type 3.
    Simões AT; Carmona V; Duarte-Neves J; Cunha-Santos J; Pereira de Almeida L
    Neuropathol Appl Neurobiol; 2022 Feb; 48(1):e12748. PubMed ID: 34273111
    [TBL] [Abstract][Full Text] [Related]  

  • 4. Calpain inhibition reduces ataxin-3 cleavage alleviating neuropathology and motor impairments in mouse models of Machado-Joseph disease.
    Simões AT; Gonçalves N; Nobre RJ; Duarte CB; Pereira de Almeida L
    Hum Mol Genet; 2014 Sep; 23(18):4932-44. PubMed ID: 24817574
    [TBL] [Abstract][Full Text] [Related]  

  • 5. A combinatorial approach to identify calpain cleavage sites in the Machado-Joseph disease protein ataxin-3.
    Weber JJ; Golla M; Guaitoli G; Wanichawan P; Hayer SN; Hauser S; Krahl AC; Nagel M; Samer S; Aronica E; Carlson CR; Schöls L; Riess O; Gloeckner CJ; Nguyen HP; Hübener-Schmid J
    Brain; 2017 May; 140(5):1280-1299. PubMed ID: 28334907
    [TBL] [Abstract][Full Text] [Related]  

  • 6. Calpain inhibition is sufficient to suppress aggregation of polyglutamine-expanded ataxin-3.
    Haacke A; Hartl FU; Breuer P
    J Biol Chem; 2007 Jun; 282(26):18851-6. PubMed ID: 17488727
    [TBL] [Abstract][Full Text] [Related]  

  • 7. Calpain Inhibition Is Protective in Machado-Joseph Disease Zebrafish Due to Induction of Autophagy.
    Watchon M; Yuan KC; Mackovski N; Svahn AJ; Cole NJ; Goldsbury C; Rinkwitz S; Becker TS; Nicholson GA; Laird AS
    J Neurosci; 2017 Aug; 37(32):7782-7794. PubMed ID: 28687604
    [TBL] [Abstract][Full Text] [Related]  

  • 8. Overexpression of the autophagic beclin-1 protein clears mutant ataxin-3 and alleviates Machado-Joseph disease.
    Nascimento-Ferreira I; Santos-Ferreira T; Sousa-Ferreira L; Auregan G; Onofre I; Alves S; Dufour N; Colomer Gould VF; Koeppen A; Déglon N; Pereira de Almeida L
    Brain; 2011 May; 134(Pt 5):1400-15. PubMed ID: 21478185
    [TBL] [Abstract][Full Text] [Related]  

  • 9. Re-establishing ataxin-2 downregulates translation of mutant ataxin-3 and alleviates Machado-Joseph disease.
    Nóbrega C; Carmo-Silva S; Albuquerque D; Vasconcelos-Ferreira A; Vijayakumar UG; Mendonça L; Hirai H; de Almeida LP
    Brain; 2015 Dec; 138(Pt 12):3537-54. PubMed ID: 26490332
    [TBL] [Abstract][Full Text] [Related]  

  • 10. Beclin 1 mitigates motor and neuropathological deficits in genetic mouse models of Machado-Joseph disease.
    Nascimento-Ferreira I; Nóbrega C; Vasconcelos-Ferreira A; Onofre I; Albuquerque D; Aveleira C; Hirai H; Déglon N; Pereira de Almeida L
    Brain; 2013 Jul; 136(Pt 7):2173-88. PubMed ID: 23801739
    [TBL] [Abstract][Full Text] [Related]  

  • 11. Caspase-mediated proteolysis of the polyglutamine disease protein ataxin-3.
    Berke SJ; Schmied FA; Brunt ER; Ellerby LM; Paulson HL
    J Neurochem; 2004 May; 89(4):908-18. PubMed ID: 15140190
    [TBL] [Abstract][Full Text] [Related]  

  • 12. A mutant ataxin-3 putative-cleavage fragment in brains of Machado-Joseph disease patients and transgenic mice is cytotoxic above a critical concentration.
    Goti D; Katzen SM; Mez J; Kurtis N; Kiluk J; Ben-Haïem L; Jenkins NA; Copeland NG; Kakizuka A; Sharp AH; Ross CA; Mouton PR; Colomer V
    J Neurosci; 2004 Nov; 24(45):10266-79. PubMed ID: 15537899
    [TBL] [Abstract][Full Text] [Related]  

  • 13. n-Butylidenephthalide exhibits protection against neurotoxicity through regulation of tryptophan 2, 3 dioxygenase in spinocerebellar ataxia type 3.
    Rajamani K; Liu JW; Wu CH; Chiang IT; You DH; Lin SY; Hsieh DK; Lin SZ; Harn HJ; Chiou TW
    Neuropharmacology; 2017 May; 117():434-446. PubMed ID: 28223212
    [TBL] [Abstract][Full Text] [Related]  

  • 14. Silencing mutant ataxin-3 rescues motor deficits and neuropathology in Machado-Joseph disease transgenic mice.
    Nóbrega C; Nascimento-Ferreira I; Onofre I; Albuquerque D; Hirai H; Déglon N; de Almeida LP
    PLoS One; 2013; 8(1):e52396. PubMed ID: 23349684
    [TBL] [Abstract][Full Text] [Related]  

  • 15. A mutant ataxin-3 fragment results from processing at a site N-terminal to amino acid 190 in brain of Machado-Joseph disease-like transgenic mice.
    Colomer Gould VF; Goti D; Pearce D; Gonzalez GA; Gao H; Bermudez de Leon M; Jenkins NA; Copeland NG; Ross CA; Brown DR
    Neurobiol Dis; 2007 Sep; 27(3):362-9. PubMed ID: 17632007
    [TBL] [Abstract][Full Text] [Related]  

  • 16. Caffeine and adenosine A(2A) receptor inactivation decrease striatal neuropathology in a lentiviral-based model of Machado-Joseph disease.
    Gonçalves N; Simões AT; Cunha RA; de Almeida LP
    Ann Neurol; 2013 May; 73(5):655-66. PubMed ID: 23625556
    [TBL] [Abstract][Full Text] [Related]  

  • 17. Polyglutamine-induced neurodegeneration in SCA3 is not mitigated by non-expanded ataxin-3: conclusions from double-transgenic mouse models.
    Hübener J; Riess O
    Neurobiol Dis; 2010 Apr; 38(1):116-24. PubMed ID: 20079840
    [TBL] [Abstract][Full Text] [Related]  

  • 18. Striatal and nigral pathology in a lentiviral rat model of Machado-Joseph disease.
    Alves S; Régulier E; Nascimento-Ferreira I; Hassig R; Dufour N; Koeppen A; Carvalho AL; Simões S; de Lima MC; Brouillet E; Gould VC; Déglon N; de Almeida LP
    Hum Mol Genet; 2008 Jul; 17(14):2071-83. PubMed ID: 18385100
    [TBL] [Abstract][Full Text] [Related]  

  • 19. Excitation-induced ataxin-3 aggregation in neurons from patients with Machado-Joseph disease.
    Koch P; Breuer P; Peitz M; Jungverdorben J; Kesavan J; Poppe D; Doerr J; Ladewig J; Mertens J; Tüting T; Hoffmann P; Klockgether T; Evert BO; Wüllner U; Brüstle O
    Nature; 2011 Nov; 480(7378):543-6. PubMed ID: 22113611
    [TBL] [Abstract][Full Text] [Related]  

  • 20. Ibuprofen enhances synaptic function and neural progenitors proliferation markers and improves neuropathology and motor coordination in Machado-Joseph disease models.
    Mendonça LS; Nóbrega C; Tavino S; Brinkhaus M; Matos C; Tomé S; Moreira R; Henriques D; Kaspar BK; Pereira de Almeida L
    Hum Mol Genet; 2019 Nov; 28(22):3691-3703. PubMed ID: 31127937
    [TBL] [Abstract][Full Text] [Related]  

    [Next]    [New Search]
    of 19.