BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

393 related articles for article (PubMed ID: 22855816)

  • 1. Cross-linking of cell surface amyloid precursor protein leads to increased β-amyloid peptide production in hippocampal neurons: implications for Alzheimer's disease.
    Lefort R; Pozueta J; Shelanski M
    J Neurosci; 2012 Aug; 32(31):10674-85. PubMed ID: 22855816
    [TBL] [Abstract][Full Text] [Related]  

  • 2. Beta-amyloid accumulation in APP mutant neurons reduces PSD-95 and GluR1 in synapses.
    Almeida CG; Tampellini D; Takahashi RH; Greengard P; Lin MT; Snyder EM; Gouras GK
    Neurobiol Dis; 2005 Nov; 20(2):187-98. PubMed ID: 16242627
    [TBL] [Abstract][Full Text] [Related]  

  • 3. Decrease in brain soluble amyloid precursor protein β (sAPPβ) in Alzheimer's disease cortex.
    Wu G; Sankaranarayanan S; Hsieh SH; Simon AJ; Savage MJ
    J Neurosci Res; 2011 Jun; 89(6):822-32. PubMed ID: 21433051
    [TBL] [Abstract][Full Text] [Related]  

  • 4. Glucocorticoids facilitate astrocytic amyloid-β peptide deposition by increasing the expression of APP and BACE1 and decreasing the expression of amyloid-β-degrading proteases.
    Wang Y; Li M; Tang J; Song M; Xu X; Xiong J; Li J; Bai Y
    Endocrinology; 2011 Jul; 152(7):2704-15. PubMed ID: 21558319
    [TBL] [Abstract][Full Text] [Related]  

  • 5. PAR-4 is involved in regulation of beta-secretase cleavage of the Alzheimer amyloid precursor protein.
    Xie J; Guo Q
    J Biol Chem; 2005 Apr; 280(14):13824-32. PubMed ID: 15671026
    [TBL] [Abstract][Full Text] [Related]  

  • 6. GEPT extract reduces Abeta deposition by regulating the balance between production and degradation of Abeta in APPV717I transgenic mice.
    Tian J; Shi J; Zhang L; Yin J; Hu Q; Xu Y; Sheng S; Wang P; Ren Y; Wang R; Wang Y
    Curr Alzheimer Res; 2009 Apr; 6(2):118-31. PubMed ID: 19355846
    [TBL] [Abstract][Full Text] [Related]  

  • 7. Mild oxidative stress induces redistribution of BACE1 in non-apoptotic conditions and promotes the amyloidogenic processing of Alzheimer's disease amyloid precursor protein.
    Tan JL; Li QX; Ciccotosto GD; Crouch PJ; Culvenor JG; White AR; Evin G
    PLoS One; 2013; 8(4):e61246. PubMed ID: 23613819
    [TBL] [Abstract][Full Text] [Related]  

  • 8. BRI2 inhibits amyloid beta-peptide precursor protein processing by interfering with the docking of secretases to the substrate.
    Matsuda S; Giliberto L; Matsuda Y; McGowan EM; D'Adamio L
    J Neurosci; 2008 Aug; 28(35):8668-76. PubMed ID: 18753367
    [TBL] [Abstract][Full Text] [Related]  

  • 9. Failure of the interaction between presenilin 1 and the substrate of gamma-secretase to produce Abeta in insect cells.
    Pitsi D; Kienlen-Campard P; Octave JN
    J Neurochem; 2002 Oct; 83(2):390-9. PubMed ID: 12423249
    [TBL] [Abstract][Full Text] [Related]  

  • 10. Phosphorylation of the translation initiation factor eIF2alpha increases BACE1 levels and promotes amyloidogenesis.
    O'Connor T; Sadleir KR; Maus E; Velliquette RA; Zhao J; Cole SL; Eimer WA; Hitt B; Bembinster LA; Lammich S; Lichtenthaler SF; Hébert SS; De Strooper B; Haass C; Bennett DA; Vassar R
    Neuron; 2008 Dec; 60(6):988-1009. PubMed ID: 19109907
    [TBL] [Abstract][Full Text] [Related]  

  • 11. The metalloprotease inhibitor TIMP-3 regulates amyloid precursor protein and apolipoprotein E receptor proteolysis.
    Hoe HS; Cooper MJ; Burns MP; Lewis PA; van der Brug M; Chakraborty G; Cartagena CM; Pak DT; Cookson MR; Rebeck GW
    J Neurosci; 2007 Oct; 27(40):10895-905. PubMed ID: 17913923
    [TBL] [Abstract][Full Text] [Related]  

  • 12. Retention in endoplasmic reticulum 1 (RER1) modulates amyloid-β (Aβ) production by altering trafficking of γ-secretase and amyloid precursor protein (APP).
    Park HJ; Shabashvili D; Nekorchuk MD; Shyqyriu E; Jung JI; Ladd TB; Moore BD; Felsenstein KM; Golde TE; Kim SH
    J Biol Chem; 2012 Nov; 287(48):40629-40. PubMed ID: 23043097
    [TBL] [Abstract][Full Text] [Related]  

  • 13. Effects of gamma-secretase cleavage-region mutations on APP processing and Abeta formation: interpretation with sequential cleavage and alpha-helical model.
    Tan J; Mao G; Cui MZ; Kang SC; Lamb B; Wong BS; Sy MS; Xu X
    J Neurochem; 2008 Nov; 107(3):722-33. PubMed ID: 18752644
    [TBL] [Abstract][Full Text] [Related]  

  • 14. Novel mutations introduced at the beta-site of amyloid beta protein precursor enhance the production of amyloid beta peptide by BACE1 in vitro and in cells.
    Shi XP; Tugusheva K; Bruce JE; Lucka A; Chen-Dodson E; Hu B; Wu GX; Price E; Register RB; Lineberger J; Miller R; Tang MJ; Espeseth A; Kahana J; Wolfe A; Crouthamel MC; Sankaranarayanan S; Simon A; Chen L; Lai MT; Pietrak B; DiMuzio J; Li Y; Xu M; Huang Q; Garsky V; Sardana MK; Hazuda DJ
    J Alzheimers Dis; 2005 Apr; 7(2):139-48; discussion 173-80. PubMed ID: 15851852
    [TBL] [Abstract][Full Text] [Related]  

  • 15. BACE1: the beta-secretase enzyme in Alzheimer's disease.
    Vassar R
    J Mol Neurosci; 2004; 23(1-2):105-14. PubMed ID: 15126696
    [TBL] [Abstract][Full Text] [Related]  

  • 16. Involvement of caspases in proteolytic cleavage of Alzheimer's amyloid-beta precursor protein and amyloidogenic A beta peptide formation.
    Gervais FG; Xu D; Robertson GS; Vaillancourt JP; Zhu Y; Huang J; LeBlanc A; Smith D; Rigby M; Shearman MS; Clarke EE; Zheng H; Van Der Ploeg LH; Ruffolo SC; Thornberry NA; Xanthoudakis S; Zamboni RJ; Roy S; Nicholson DW
    Cell; 1999 Apr; 97(3):395-406. PubMed ID: 10319819
    [TBL] [Abstract][Full Text] [Related]  

  • 17. Loss of cleavage at β'-site contributes to apparent increase in β-amyloid peptide (Aβ) secretion by β-secretase (BACE1)-glycosylphosphatidylinositol (GPI) processing of amyloid precursor protein.
    Vetrivel KS; Barman A; Chen Y; Nguyen PD; Wagner SL; Prabhakar R; Thinakaran G
    J Biol Chem; 2011 Jul; 286(29):26166-77. PubMed ID: 21642424
    [TBL] [Abstract][Full Text] [Related]  

  • 18. Sphingolipid storage affects autophagic metabolism of the amyloid precursor protein and promotes Abeta generation.
    Tamboli IY; Hampel H; Tien NT; Tolksdorf K; Breiden B; Mathews PM; Saftig P; Sandhoff K; Walter J
    J Neurosci; 2011 Feb; 31(5):1837-49. PubMed ID: 21289194
    [TBL] [Abstract][Full Text] [Related]  

  • 19. Enhanced cleavage of APP by co-expressed Bace1 alters the distribution of APP and its fragments in neuronal and non-neuronal cells.
    Aow J; Huang TR; Thinakaran G; Koo EH
    Mol Neurobiol; 2022 May; 59(5):3073-3090. PubMed ID: 35266114
    [TBL] [Abstract][Full Text] [Related]  

  • 20. Cerebrolysin decreases amyloid-beta production by regulating amyloid protein precursor maturation in a transgenic model of Alzheimer's disease.
    Rockenstein E; Torrance M; Mante M; Adame A; Paulino A; Rose JB; Crews L; Moessler H; Masliah E
    J Neurosci Res; 2006 May; 83(7):1252-61. PubMed ID: 16511867
    [TBL] [Abstract][Full Text] [Related]  

    [Next]    [New Search]
    of 20.