These tools will no longer be maintained as of December 31, 2024. Archived website can be found here. PubMed4Hh GitHub repository can be found here. Contact NLM Customer Service if you have questions.


BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

105 related articles for article (PubMed ID: 22858099)

  • 1. Discovery of potent and selective rhodanine type IKKβ inhibitors by hit-to-lead strategy.
    Song H; Lee YS; Roh EJ; Seo JH; Oh KS; Lee BH; Han H; Shin KJ
    Bioorg Med Chem Lett; 2012 Sep; 22(17):5668-74. PubMed ID: 22858099
    [TBL] [Abstract][Full Text] [Related]  

  • 2. A selective small molecule IkappaB Kinase beta inhibitor blocks nuclear factor kappaB-mediated inflammatory responses in human fibroblast-like synoviocytes, chondrocytes, and mast cells.
    Wen D; Nong Y; Morgan JG; Gangurde P; Bielecki A; Dasilva J; Keaveney M; Cheng H; Fraser C; Schopf L; Hepperle M; Harriman G; Jaffee BD; Ocain TD; Xu Y
    J Pharmacol Exp Ther; 2006 Jun; 317(3):989-1001. PubMed ID: 16525037
    [TBL] [Abstract][Full Text] [Related]  

  • 3. Targeting IKKβ for the treatment of rheumatoid arthritis.
    Bamborough P; Morse MA; Ray KP
    Drug News Perspect; 2010 Oct; 23(8):483-90. PubMed ID: 21031164
    [TBL] [Abstract][Full Text] [Related]  

  • 4. Discovery of imidazo[1,2-b]pyridazine derivatives as IKKbeta inhibitors. Part 1: Hit-to-lead study and structure-activity relationship.
    Shimizu H; Tanaka S; Toki T; Yasumatsu I; Akimoto T; Morishita K; Yamasaki T; Yasukochi T; Iimura S
    Bioorg Med Chem Lett; 2010 Sep; 20(17):5113-8. PubMed ID: 20675134
    [TBL] [Abstract][Full Text] [Related]  

  • 5. Discovery of piperidinyl aminopyrimidine derivatives as IKK-2 inhibitors.
    Kim S; Jung JK; Lee HS; Kim Y; Kim J; Choi K; Baek DJ; Moon B; Oh KS; Lee BH; Shin KJ; Pae AN; Nam G; Roh EJ; Cho YS; Choo H
    Bioorg Med Chem Lett; 2011 May; 21(10):3002-6. PubMed ID: 21489792
    [TBL] [Abstract][Full Text] [Related]  

  • 6. Identification and characterization of potent, selective and metabolically stable IKKβ inhibitor.
    Kim D; Kim YG; Seo JH; Shin KJ
    Bioorg Med Chem Lett; 2016 Feb; 26(4):1120-3. PubMed ID: 26826731
    [TBL] [Abstract][Full Text] [Related]  

  • 7. A homogeneous time-resolved fluorescence-based high-throughput screening system for discovery of inhibitors of IKKbeta-NEMO interaction.
    Gotoh Y; Nagata H; Kase H; Shimonishi M; Ido M
    Anal Biochem; 2010 Oct; 405(1):19-27. PubMed ID: 20522330
    [TBL] [Abstract][Full Text] [Related]  

  • 8. Regulation and function of IKK and IKK-related kinases.
    Häcker H; Karin M
    Sci STKE; 2006 Oct; 2006(357):re13. PubMed ID: 17047224
    [TBL] [Abstract][Full Text] [Related]  

  • 9. IKKbeta inhibition protects against bone and cartilage destruction in a rat model of rheumatoid arthritis.
    Schopf L; Savinainen A; Anderson K; Kujawa J; DuPont M; Silva M; Siebert E; Chandra S; Morgan J; Gangurde P; Wen D; Lane J; Xu Y; Hepperle M; Harriman G; Ocain T; Jaffee B
    Arthritis Rheum; 2006 Oct; 54(10):3163-73. PubMed ID: 17009244
    [TBL] [Abstract][Full Text] [Related]  

  • 10. Periodic, partial inhibition of IkappaB Kinase beta-mediated signaling yields therapeutic benefit in preclinical models of rheumatoid arthritis.
    Gillooly KM; Pattoli MA; Taylor TL; Chen L; Cheng L; Gregor KR; Whitney GS; Susulic V; Watterson SH; Kempson J; Pitts WJ; Booth-Lute H; Yang G; Davies P; Kukral DW; Strnad J; McIntyre KW; Darienzo CJ; Salter-Cid L; Yang Z; Wang-Iverson DB; Burke JR
    J Pharmacol Exp Ther; 2009 Nov; 331(2):349-60. PubMed ID: 19652024
    [TBL] [Abstract][Full Text] [Related]  

  • 11. The discovery of thienopyridine analogues as potent IkappaB kinase beta inhibitors. Part II.
    Wu JP; Fleck R; Brickwood J; Capolino A; Catron K; Chen Z; Cywin C; Emeigh J; Foerst M; Ginn J; Hrapchak M; Hickey E; Hao MH; Kashem M; Li J; Liu W; Morwick T; Nelson R; Marshall D; Martin L; Nemoto P; Potocki I; Liuzzi M; Peet GW; Scouten E; Stefany D; Turner M; Weldon S; Zimmitti C; Spero D; Kelly TA
    Bioorg Med Chem Lett; 2009 Oct; 19(19):5547-51. PubMed ID: 19716697
    [TBL] [Abstract][Full Text] [Related]  

  • 12. Identification of angular naphthopyrones from the Philippine echinoderm Comanthus species as inhibitors of the NF-κB signaling pathway.
    Chovolou Y; Ebada SS; Wätjen W; Proksch P
    Eur J Pharmacol; 2011 Apr; 657(1-3):26-34. PubMed ID: 21296074
    [TBL] [Abstract][Full Text] [Related]  

  • 13. Hit identification of IKKβ natural product inhibitor.
    Leung CH; Chan DS; Li YW; Fong WF; Ma DL
    BMC Pharmacol Toxicol; 2013 Jan; 14():3. PubMed ID: 23294515
    [TBL] [Abstract][Full Text] [Related]  

  • 14. Evolution of the thienopyridine class of inhibitors of IkappaB kinase-beta: part I: hit-to-lead strategies.
    Morwick T; Berry A; Brickwood J; Cardozo M; Catron K; DeTuri M; Emeigh J; Homon C; Hrapchak M; Jacober S; Jakes S; Kaplita P; Kelly TA; Ksiazek J; Liuzzi M; Magolda R; Mao C; Marshall D; McNeil D; Prokopowicz A; Sarko C; Scouten E; Sledziona C; Sun S; Watrous J; Wu JP; Cywin CL
    J Med Chem; 2006 May; 49(10):2898-908. PubMed ID: 16686533
    [TBL] [Abstract][Full Text] [Related]  

  • 15. IKKbeta inhibitors identification part I: homology model assisted structure based virtual screening.
    Nagarajan S; Doddareddy Mr; Choo H; Cho YS; Oh KS; Lee BH; Pae AN
    Bioorg Med Chem; 2009 Apr; 17(7):2759-66. PubMed ID: 19285872
    [TBL] [Abstract][Full Text] [Related]  

  • 16. Doxorubicin-induced activation of NF-κB in melanoma cells is abrogated by inhibition of IKKβ, but not by a novel IKKα inhibitor.
    Pletz N; Schön M; Ziegelbauer K; Emmert S; Liu N; Dobbelstein M; Schön MP
    Exp Dermatol; 2012 Apr; 21(4):301-4. PubMed ID: 22320445
    [TBL] [Abstract][Full Text] [Related]  

  • 17. Honokiol inhibits TNF-alpha-stimulated NF-kappaB activation and NF-kappaB-regulated gene expression through suppression of IKK activation.
    Tse AK; Wan CK; Shen XL; Yang M; Fong WF
    Biochem Pharmacol; 2005 Nov; 70(10):1443-57. PubMed ID: 16181613
    [TBL] [Abstract][Full Text] [Related]  

  • 18. Inhibition of inflammatory cytokine production from rheumatoid synovial fibroblasts by a novel IkappaB kinase inhibitor.
    Tsuchiya A; Imai K; Asamitsu K; Waguri-Nagaya Y; Otsuka T; Okamoto T
    J Pharmacol Exp Ther; 2010 Apr; 333(1):236-43. PubMed ID: 20053934
    [TBL] [Abstract][Full Text] [Related]  

  • 19. Discovery of imidazo[1,2-b]pyridazines as IKKβ inhibitors. Part 3: exploration of effective compounds in arthritis models.
    Shimizu H; Yamasaki T; Yoneda Y; Muro F; Hamada T; Yasukochi T; Tanaka S; Toki T; Yokoyama M; Morishita K; Iimura S
    Bioorg Med Chem Lett; 2011 Aug; 21(15):4550-5. PubMed ID: 21705219
    [TBL] [Abstract][Full Text] [Related]  

  • 20. Phosphorylation-dependent association of the G4-1/G5PR regulatory subunit with IKKβ negatively modulates NF-κB activation through recruitment of protein phosphatase 5.
    Chiang CW; Liu WK; Chiang CW; Chou CK
    Biochem J; 2011 Jan; 433(1):187-96. PubMed ID: 20925653
    [TBL] [Abstract][Full Text] [Related]  

    [Next]    [New Search]
    of 6.