These tools will no longer be maintained as of December 31, 2024. Archived website can be found here. PubMed4Hh GitHub repository can be found here. Contact NLM Customer Service if you have questions.
922 related articles for article (PubMed ID: 22875023)
1. Hedgehog signaling is a novel therapeutic target in tamoxifen-resistant breast cancer aberrantly activated by PI3K/AKT pathway. Ramaswamy B; Lu Y; Teng KY; Nuovo G; Li X; Shapiro CL; Majumder S Cancer Res; 2012 Oct; 72(19):5048-59. PubMed ID: 22875023 [TBL] [Abstract][Full Text] [Related]
2. Targeting of the Hedgehog signal transduction pathway suppresses survival of malignant pleural mesothelioma cells in vitro. You M; Varona-Santos J; Singh S; Robbins DJ; Savaraj N; Nguyen DM J Thorac Cardiovasc Surg; 2014 Jan; 147(1):508-16. PubMed ID: 24094913 [TBL] [Abstract][Full Text] [Related]
3. In vitro and in vivo inhibition of breast cancer cell growth by targeting the Hedgehog/GLI pathway with SMO (GDC-0449) or GLI (GANT-61) inhibitors. Benvenuto M; Masuelli L; De Smaele E; Fantini M; Mattera R; Cucchi D; Bonanno E; Di Stefano E; Frajese GV; Orlandi A; Screpanti I; Gulino A; Modesti A; Bei R Oncotarget; 2016 Feb; 7(8):9250-70. PubMed ID: 26843616 [TBL] [Abstract][Full Text] [Related]
4. The Hedgehog signalling pathway mediates drug response of MCF-7 mammosphere cells in breast cancer patients. He M; Fu Y; Yan Y; Xiao Q; Wu H; Yao W; Zhao H; Zhao L; Jiang Q; Yu Z; Jin F; Mi X; Wang E; Cui Z; Fu L; Chen J; Wei M Clin Sci (Lond); 2015 Nov; 129(9):809-22. PubMed ID: 26201092 [TBL] [Abstract][Full Text] [Related]
5. Small molecule inhibition of GDC-0449 refractory smoothened mutants and downstream mechanisms of drug resistance. Dijkgraaf GJ; Alicke B; Weinmann L; Januario T; West K; Modrusan Z; Burdick D; Goldsmith R; Robarge K; Sutherlin D; Scales SJ; Gould SE; Yauch RL; de Sauvage FJ Cancer Res; 2011 Jan; 71(2):435-44. PubMed ID: 21123452 [TBL] [Abstract][Full Text] [Related]
6. SMO Gene Amplification and Activation of the Hedgehog Pathway as Novel Mechanisms of Resistance to Anti-Epidermal Growth Factor Receptor Drugs in Human Lung Cancer. Della Corte CM; Bellevicine C; Vicidomini G; Vitagliano D; Malapelle U; Accardo M; Fabozzi A; Fiorelli A; Fasano M; Papaccio F; Martinelli E; Troiani T; Troncone G; Santini M; Bianco R; Ciardiello F; Morgillo F Clin Cancer Res; 2015 Oct; 21(20):4686-97. PubMed ID: 26124204 [TBL] [Abstract][Full Text] [Related]
7. Endocrine resistance associated with activated ErbB system in breast cancer cells is reversed by inhibiting MAPK or PI3K/Akt signaling pathways. Ghayad SE; Vendrell JA; Ben Larbi S; Dumontet C; Bieche I; Cohen PA Int J Cancer; 2010 Jan; 126(2):545-62. PubMed ID: 19609946 [TBL] [Abstract][Full Text] [Related]
8. Cx43 deficiency confers EMT-mediated tamoxifen resistance to breast cancer via c-Src/PI3K/Akt pathway. Wu DP; Zhou Y; Hou LX; Zhu XX; Yi W; Yang SM; Lin TY; Huang JL; Zhang B; Yin XX Int J Biol Sci; 2021; 17(10):2380-2398. PubMed ID: 34326682 [TBL] [Abstract][Full Text] [Related]
9. Keratinocyte growth factor (KGF) regulates estrogen receptor-alpha (ER-alpha) expression and cell apoptosis via phosphatidylinositol 3-kinase (PI3K)/Akt pathway in human breast cancer cells. Chang HL; Sugimoto Y; Liu S; Wang LS; Huang YW; Ye W; Lin YC Anticancer Res; 2009 Aug; 29(8):3195-205. PubMed ID: 19661335 [TBL] [Abstract][Full Text] [Related]
10. Targeting the hedgehog signal transduction pathway at the level of GLI inhibits neuroblastoma cell growth in vitro and in vivo. Wickström M; Dyberg C; Shimokawa T; Milosevic J; Baryawno N; Fuskevåg OM; Larsson R; Kogner P; Zaphiropoulos PG; Johnsen JI Int J Cancer; 2013 Apr; 132(7):1516-24. PubMed ID: 22949014 [TBL] [Abstract][Full Text] [Related]
11. LKB1 inhibits breast cancer partially through repressing the Hedgehog signaling pathway. Zhuang Z; Wang K; Cheng X; Qu X; Jiang B; Li Z; Luo J; Shao Z; Duan T PLoS One; 2013; 8(7):e67431. PubMed ID: 23861764 [TBL] [Abstract][Full Text] [Related]
12. Overcoming endocrine resistance due to reduced PTEN levels in estrogen receptor-positive breast cancer by co-targeting mammalian target of rapamycin, protein kinase B, or mitogen-activated protein kinase kinase. Fu X; Creighton CJ; Biswal NC; Kumar V; Shea M; Herrera S; Contreras A; Gutierrez C; Wang T; Nanda S; Giuliano M; Morrison G; Nardone A; Karlin KL; Westbrook TF; Heiser LM; Anur P; Spellman P; Guichard SM; Smith PD; Davies BR; Klinowska T; Lee AV; Mills GB; Rimawi MF; Hilsenbeck SG; Gray JW; Joshi A; Osborne CK; Schiff R Breast Cancer Res; 2014 Sep; 16(5):430. PubMed ID: 25212826 [TBL] [Abstract][Full Text] [Related]
13. Inhibition of Hedgehog signalling by NVP-LDE225 (Erismodegib) interferes with growth and invasion of human renal cell carcinoma cells. D'Amato C; Rosa R; Marciano R; D'Amato V; Formisano L; Nappi L; Raimondo L; Di Mauro C; Servetto A; Fulciniti F; Cipolletta A; Bianco C; Ciardiello F; Veneziani BM; De Placido S; Bianco R Br J Cancer; 2014 Sep; 111(6):1168-79. PubMed ID: 25093491 [TBL] [Abstract][Full Text] [Related]
14. DYRK1B as therapeutic target in Hedgehog/GLI-dependent cancer cells with Smoothened inhibitor resistance. Gruber W; Hutzinger M; Elmer DP; Parigger T; Sternberg C; Cegielkowski L; Zaja M; Leban J; Michel S; Hamm S; Vitt D; Aberger F Oncotarget; 2016 Feb; 7(6):7134-48. PubMed ID: 26784250 [TBL] [Abstract][Full Text] [Related]
15. RETRACTED: CD44 expression denotes a subpopulation of gastric cancer cells in which Hedgehog signaling promotes chemotherapy resistance. Yoon C; Park DJ; Schmidt B; Thomas NJ; Lee HJ; Kim TS; Janjigian YY; Cohen DJ; Yoon SS Clin Cancer Res; 2014 Aug; 20(15):3974-88. PubMed ID: 24947926 [TBL] [Abstract][Full Text] [Related]
16. Defining causative factors contributing in the activation of hedgehog signaling in diffuse large B-cell lymphoma. Ramirez E; Singh RR; Kunkalla K; Liu Y; Qu C; Cain C; Multani AS; Lennon PA; Jackacky J; Ho M; Dawud S; Gu J; Yang S; Hu PC; Vega F Leuk Res; 2012 Oct; 36(10):1267-73. PubMed ID: 22809693 [TBL] [Abstract][Full Text] [Related]
17. AKT Antagonist AZD5363 Influences Estrogen Receptor Function in Endocrine-Resistant Breast Cancer and Synergizes with Fulvestrant (ICI182780) In Vivo. Ribas R; Pancholi S; Guest SK; Marangoni E; Gao Q; Thuleau A; Simigdala N; Polanska UM; Campbell H; Rani A; Liccardi G; Johnston S; Davies BR; Dowsett M; Martin LA Mol Cancer Ther; 2015 Sep; 14(9):2035-48. PubMed ID: 26116361 [TBL] [Abstract][Full Text] [Related]
18. Nonclassical activation of Hedgehog signaling enhances multidrug resistance and makes cancer cells refractory to Smoothened-targeting Hedgehog inhibition. Das S; Samant RS; Shevde LA J Biol Chem; 2013 Apr; 288(17):11824-33. PubMed ID: 23508962 [TBL] [Abstract][Full Text] [Related]
19. Hedgehog-signaling is upregulated in non-producing human adrenal adenomas and antagonism of hedgehog-signaling inhibits proliferation of NCI-H295R cells and an immortalized primary human adrenal cell line. Werminghaus P; Haase M; Hornsby PJ; Schinner S; Schott M; Malendowicz LK; Lammers BJ; Goretzki PE; Müller-Mattheis V; Markus Giessing ; Willenberg HS J Steroid Biochem Mol Biol; 2014 Jan; 139():7-15. PubMed ID: 24063979 [TBL] [Abstract][Full Text] [Related]
20. Adipocyte-conditioned medium induces tamoxifen resistance by activating PI3K/Akt/mTOR pathway in estrogen receptor-positive breast cancer cells. Nakatsuji M; Fujimori K Biochim Biophys Acta Mol Cell Res; 2024 Oct; 1871(7):119821. PubMed ID: 39159684 [TBL] [Abstract][Full Text] [Related] [Next] [New Search]