217 related articles for article (PubMed ID: 22878509)
1. Identification of constitutional MLH1 epimutations and promoter variants in colorectal cancer patients from the Colon Cancer Family Registry.
Ward RL; Dobbins T; Lindor NM; Rapkins RW; Hitchins MP
Genet Med; 2013 Jan; 15(1):25-35. PubMed ID: 22878509
[TBL] [Abstract][Full Text] [Related]
2. De novo constitutional MLH1 epimutations confer early-onset colorectal cancer in two new sporadic Lynch syndrome cases, with derivation of the epimutation on the paternal allele in one.
Goel A; Nguyen TP; Leung HC; Nagasaka T; Rhees J; Hotchkiss E; Arnold M; Banerji P; Koi M; Kwok CT; Packham D; Lipton L; Boland CR; Ward RL; Hitchins MP
Int J Cancer; 2011 Feb; 128(4):869-78. PubMed ID: 20473912
[TBL] [Abstract][Full Text] [Related]
3. MLH1 methylation screening is effective in identifying epimutation carriers.
Pineda M; Mur P; Iniesta MD; Borràs E; Campos O; Vargas G; Iglesias S; Fernández A; Gruber SB; Lázaro C; Brunet J; Navarro M; Blanco I; Capellá G
Eur J Hum Genet; 2012 Dec; 20(12):1256-64. PubMed ID: 22763379
[TBL] [Abstract][Full Text] [Related]
4. The MLH1 c.-27C>A and c.85G>T variants are linked to dominantly inherited MLH1 epimutation and are borne on a European ancestral haplotype.
Kwok CT; Vogelaar IP; van Zelst-Stams WA; Mensenkamp AR; Ligtenberg MJ; Rapkins RW; Ward RL; Chun N; Ford JM; Ladabaum U; McKinnon WC; Greenblatt MS; Hitchins MP
Eur J Hum Genet; 2014 May; 22(5):617-24. PubMed ID: 24084575
[TBL] [Abstract][Full Text] [Related]
5. Evidence of constitutional MLH1 epimutation associated to transgenerational inheritance of cancer susceptibility.
Crépin M; Dieu MC; Lejeune S; Escande F; Boidin D; Porchet N; Morin G; Manouvrier S; Mathieu M; Buisine MP
Hum Mutat; 2012 Jan; 33(1):180-8. PubMed ID: 21953887
[TBL] [Abstract][Full Text] [Related]
6. Diversity of genetic events associated with MLH1 promoter methylation in Lynch syndrome families with heritable constitutional epimutation.
Leclerc J; Flament C; Lovecchio T; Delattre L; Ait Yahya E; Baert-Desurmont S; Burnichon N; Bronner M; Cabaret O; Lejeune S; Guimbaud R; Morin G; Mauillon J; Jonveaux P; Laurent-Puig P; Frébourg T; Porchet N; Buisine MP
Genet Med; 2018 Dec; 20(12):1589-1599. PubMed ID: 29790873
[TBL] [Abstract][Full Text] [Related]
7. Prevalence of MLH1 constitutional epimutations as a cause of Lynch syndrome in unselected versus selected consecutive series of patients with colorectal cancer.
Castillejo A; Hernández-Illán E; Rodriguez-Soler M; Pérez-Carbonell L; Egoavil C; Barberá VM; Castillejo MI; Guarinos C; Martínez-de-Dueñas E; Juan MJ; Sánchez-Heras AB; García-Casado Z; Ruiz-Ponte C; Brea-Fernández A; Juárez M; Bujanda L; Clofent J; Llor X; Andreu M; Castells A; Carracedo A; Alenda C; Payá A; Jover R; Soto JL
J Med Genet; 2015 Jul; 52(7):498-502. PubMed ID: 25908759
[TBL] [Abstract][Full Text] [Related]
8. Highly sensitive MLH1 methylation analysis in blood identifies a cancer patient with low-level mosaic MLH1 epimutation.
Dámaso E; Canet-Hermida J; Vargas-Parra G; Velasco À; Marín F; Darder E; Del Valle J; Fernández A; Izquierdo À; Mateu G; Oliveras G; Escribano C; Piñol V; Uchima HI; Soto JL; Hitchins M; Farrés R; Lázaro C; Queralt B; Brunet J; Capellá G; Pineda M
Clin Epigenetics; 2019 Nov; 11(1):171. PubMed ID: 31779681
[TBL] [Abstract][Full Text] [Related]
9. MLH1 germline epimutations as a factor in hereditary nonpolyposis colorectal cancer.
Hitchins M; Williams R; Cheong K; Halani N; Lin VA; Packham D; Ku S; Buckle A; Hawkins N; Burn J; Gallinger S; Goldblatt J; Kirk J; Tomlinson I; Scott R; Spigelman A; Suter C; Martin D; Suthers G; Ward R
Gastroenterology; 2005 Nov; 129(5):1392-9. PubMed ID: 16285940
[TBL] [Abstract][Full Text] [Related]
10. Identification of new cases of early-onset colorectal cancer with an MLH1 epimutation in an ethnically diverse South African cohort.
Hitchins MP; Owens SE; Kwok CT; Godsmark G; Algar UF; Ramesar RS
Clin Genet; 2011 Nov; 80(5):428-34. PubMed ID: 21375527
[TBL] [Abstract][Full Text] [Related]
11. Comprehensive analysis of the
Morak M; Ibisler A; Keller G; Jessen E; Laner A; Gonzales-Fassrainer D; Locher M; Massdorf T; Nissen AM; Benet-Pagès A; Holinski-Feder E
J Med Genet; 2018 Apr; 55(4):240-248. PubMed ID: 29472279
[TBL] [Abstract][Full Text] [Related]
12. Dominantly inherited constitutional epigenetic silencing of MLH1 in a cancer-affected family is linked to a single nucleotide variant within the 5'UTR.
Hitchins MP; Rapkins RW; Kwok CT; Srivastava S; Wong JJ; Khachigian LM; Polly P; Goldblatt J; Ward RL
Cancer Cell; 2011 Aug; 20(2):200-13. PubMed ID: 21840485
[TBL] [Abstract][Full Text] [Related]
13. MLH1-methylated endometrial cancer under 60 years of age as the "sentinel" cancer in female carriers of high-risk constitutional MLH1 epimutation.
Hitchins MP; Alvarez R; Zhou L; Aguirre F; Dámaso E; Pineda M; Capella G; Wong JJ; Yuan X; Ryan SR; Sathe DS; Baxter MD; Cannon T; Biswas R; DeMarco T; Grzelak D; Hampel H; Pearlman R
Gynecol Oncol; 2023 Apr; 171():129-140. PubMed ID: 36893489
[TBL] [Abstract][Full Text] [Related]
14. Concomitant mutation and epimutation of the MLH1 gene in a Lynch syndrome family.
Cini G; Carnevali I; Quaia M; Chiaravalli AM; Sala P; Giacomini E; Maestro R; Tibiletti MG; Viel A
Carcinogenesis; 2015 Apr; 36(4):452-8. PubMed ID: 25742745
[TBL] [Abstract][Full Text] [Related]
15. Finding the needle in a haystack: identification of cases of Lynch syndrome with MLH1 epimutation.
Hitchins MP
Fam Cancer; 2016 Jul; 15(3):413-22. PubMed ID: 26886015
[TBL] [Abstract][Full Text] [Related]
16. MLH1 constitutional and somatic methylation in patients with MLH1 negative tumors fulfilling the revised Bethesda criteria.
Crucianelli F; Tricarico R; Turchetti D; Gorelli G; Gensini F; Sestini R; Giunti L; Pedroni M; Ponz de Leon M; Civitelli S; Genuardi M
Epigenetics; 2014 Oct; 9(10):1431-8. PubMed ID: 25437057
[TBL] [Abstract][Full Text] [Related]
17. Primary constitutional MLH1 epimutations: a focal epigenetic event.
Dámaso E; Castillejo A; Arias MDM; Canet-Hermida J; Navarro M; Del Valle J; Campos O; Fernández A; Marín F; Turchetti D; García-Díaz JD; Lázaro C; Genuardi M; Rueda D; Alonso Á; Soto JL; Hitchins M; Pineda M; Capellá G
Br J Cancer; 2018 Oct; 119(8):978-987. PubMed ID: 30283143
[TBL] [Abstract][Full Text] [Related]
18. Mosaic Epigenetic Inheritance as a Cause of Early-Onset Colorectal Cancer.
Sloane MA; Nunez AC; Packham D; Kwok CT; Suthers G; Hesson LB; Ward RL
JAMA Oncol; 2015 Oct; 1(7):953-7. PubMed ID: 26181641
[TBL] [Abstract][Full Text] [Related]
19. Further evidence for heritability of an epimutation in one of 12 cases with MLH1 promoter methylation in blood cells clinically displaying HNPCC.
Morak M; Schackert HK; Rahner N; Betz B; Ebert M; Walldorf C; Royer-Pokora B; Schulmann K; von Knebel-Doeberitz M; Dietmaier W; Keller G; Kerker B; Leitner G; Holinski-Feder E
Eur J Hum Genet; 2008 Jul; 16(7):804-11. PubMed ID: 18301449
[TBL] [Abstract][Full Text] [Related]
20. Detection of allelic imbalance in MLH1 expression by pyrosequencing serves as a tool for the identification of germline defects in Lynch syndrome.
Kwok CT; Ward RL; Hawkins NJ; Hitchins MP
Fam Cancer; 2010 Sep; 9(3):345-56. PubMed ID: 20063070
[TBL] [Abstract][Full Text] [Related]
[Next] [New Search]
