106 related articles for article (PubMed ID: 22910224)
1. Discovery of pyrrolo[3,2-c]quinoline-4-one derivatives as novel hedgehog signaling inhibitors.
Ohashi T; Oguro Y; Tanaka T; Shiokawa Z; Shibata S; Sato Y; Yamakawa H; Hattori H; Yamamoto Y; Kondo S; Miyamoto M; Tojo H; Baba A; Sasaki S
Bioorg Med Chem; 2012 Sep; 20(18):5496-506. PubMed ID: 22910224
[TBL] [Abstract][Full Text] [Related]
2. Discovery of the investigational drug TAK-441, a pyrrolo[3,2-c]pyridine derivative, as a highly potent and orally active hedgehog signaling inhibitor: modification of the core skeleton for improved solubility.
Ohashi T; Oguro Y; Tanaka T; Shiokawa Z; Tanaka Y; Shibata S; Sato Y; Yamakawa H; Hattori H; Yamamoto Y; Kondo S; Miyamoto M; Nishihara M; Ishimura Y; Tojo H; Baba A; Sasaki S
Bioorg Med Chem; 2012 Sep; 20(18):5507-17. PubMed ID: 22898254
[TBL] [Abstract][Full Text] [Related]
3. Design, synthesis, and biological evaluation of optimized phthalazine derivatives as hedgehog signaling pathway inhibitors.
Lu X; Peng Y; Wang C; Yang J; Bao X; Dong Q; Zhao W; Tan W; Dong X
Eur J Med Chem; 2017 Sep; 138():384-395. PubMed ID: 28688278
[TBL] [Abstract][Full Text] [Related]
4. A small-molecule antagonist of the hedgehog signaling pathway.
Lee J; Wu X; Pasca di Magliano M; Peters EC; Wang Y; Hong J; Hebrok M; Ding S; Cho CY; Schultz PG
Chembiochem; 2007 Nov; 8(16):1916-9. PubMed ID: 17886323
[No Abstract] [Full Text] [Related]
5. Discovery of Novel Macrocyclic Hedgehog Pathway Inhibitors Acting by Suppressing the Gli-Mediated Transcription.
Liu G; Huang W; Wang J; Liu X; Yang J; Zhang Y; Geng Y; Tan W; Zhang A
J Med Chem; 2017 Oct; 60(19):8218-8245. PubMed ID: 28873303
[TBL] [Abstract][Full Text] [Related]
6. Design, synthesis, and evaluation of hybrid vitamin D3 side chain analogues as hedgehog pathway inhibitors.
Banerjee U; DeBerardinis AM; Hadden MK
Bioorg Med Chem; 2015 Feb; 23(3):548-55. PubMed ID: 25549899
[TBL] [Abstract][Full Text] [Related]
7. Synthesis and evaluation of novel dimethylpyridazine derivatives as hedgehog signaling pathway inhibitors.
Wang C; Zhu M; Lu X; Wang H; Zhao W; Zhang X; Dong X
Bioorg Med Chem; 2018 Jul; 26(12):3308-3320. PubMed ID: 29739714
[TBL] [Abstract][Full Text] [Related]
8. Pharmacokinetic-pharmacodynamic analysis of vismodegib in preclinical models of mutational and ligand-dependent Hedgehog pathway activation.
Wong H; Alicke B; West KA; Pacheco P; La H; Januario T; Yauch RL; de Sauvage FJ; Gould SE
Clin Cancer Res; 2011 Jul; 17(14):4682-92. PubMed ID: 21610148
[TBL] [Abstract][Full Text] [Related]
9. Synthesis and biological evaluation of SANT-2 and analogues as inhibitors of the hedgehog signaling pathway.
Büttner A; Seifert K; Cottin T; Sarli V; Tzagkaroulaki L; Scholz S; Giannis A
Bioorg Med Chem; 2009 Jul; 17(14):4943-54. PubMed ID: 19541490
[TBL] [Abstract][Full Text] [Related]
10. Discovery of a potent and orally active hedgehog pathway antagonist (IPI-926).
Tremblay MR; Lescarbeau A; Grogan MJ; Tan E; Lin G; Austad BC; Yu LC; Behnke ML; Nair SJ; Hagel M; White K; Conley J; Manna JD; Alvarez-Diez TM; Hoyt J; Woodward CN; Sydor JR; Pink M; MacDougall J; Campbell MJ; Cushing J; Ferguson J; Curtis MS; McGovern K; Read MA; Palombella VJ; Adams J; Castro AC
J Med Chem; 2009 Jul; 52(14):4400-18. PubMed ID: 19522463
[TBL] [Abstract][Full Text] [Related]
11. AT-101 inhibits hedgehog pathway activity and cancer growth.
Wang J; Peng Y; Liu Y; Yang J; Huang M; Tan W
Cancer Chemother Pharmacol; 2015 Sep; 76(3):461-9. PubMed ID: 26113054
[TBL] [Abstract][Full Text] [Related]
12. Pharmacokinetic and pharmacodynamic modeling of hedgehog inhibitor TAK-441 for the inhibition of Gli1 messenger RNA expression and antitumor efficacy in xenografted tumor model mice.
Kogame A; Tagawa Y; Shibata S; Tojo H; Miyamoto M; Tohyama K; Kondo T; Prakash S; Shyu WC; Asahi S
Drug Metab Dispos; 2013 Apr; 41(4):727-34. PubMed ID: 23298863
[TBL] [Abstract][Full Text] [Related]
13. Salinomycin exerts anticancer effects on human breast carcinoma MCF-7 cancer stem cells via modulation of Hedgehog signaling.
Lu Y; Ma W; Mao J; Yu X; Hou Z; Fan S; Song B; Wang H; Li J; Kang L; Liu P; Liu Q; Li L
Chem Biol Interact; 2015 Feb; 228():100-7. PubMed ID: 25499043
[TBL] [Abstract][Full Text] [Related]
14. Arsenic antagonizes the Hedgehog pathway by preventing ciliary accumulation and reducing stability of the Gli2 transcriptional effector.
Kim J; Lee JJ; Kim J; Gardner D; Beachy PA
Proc Natl Acad Sci U S A; 2010 Jul; 107(30):13432-7. PubMed ID: 20624968
[TBL] [Abstract][Full Text] [Related]
15. MK-4101, a Potent Inhibitor of the Hedgehog Pathway, Is Highly Active against Medulloblastoma and Basal Cell Carcinoma.
Filocamo G; Brunetti M; Colaceci F; Sasso R; Tanori M; Pasquali E; Alfonsi R; Mancuso M; Saran A; Lahm A; Di Marcotullio L; Steinkühler C; Pazzaglia S
Mol Cancer Ther; 2016 Jun; 15(6):1177-89. PubMed ID: 26960983
[TBL] [Abstract][Full Text] [Related]
16. Cynanbungeigenin C and D, a pair of novel epimers from Cynanchum bungei, suppress hedgehog pathway-dependent medulloblastoma by blocking signaling at the level of Gli.
Li XY; Zhou LF; Gao LJ; Wei Y; Xu SF; Chen FY; Huang WJ; Tan WF; Ye YP
Cancer Lett; 2018 Apr; 420():195-207. PubMed ID: 29425683
[TBL] [Abstract][Full Text] [Related]
17. Hedgehog signaling stimulates the conversion of cholesterol to steroids.
Tang C; Pan Y; Luo H; Xiong W; Zhu H; Ruan H; Wang J; Zou C; Tang L; Iguchi T; Long F; Wu X
Cell Signal; 2015 Mar; 27(3):487-97. PubMed ID: 25582983
[TBL] [Abstract][Full Text] [Related]
18. Histone acetyltransferase PCAF is required for Hedgehog-Gli-dependent transcription and cancer cell proliferation.
Malatesta M; Steinhauer C; Mohammad F; Pandey DP; Squatrito M; Helin K
Cancer Res; 2013 Oct; 73(20):6323-33. PubMed ID: 23943798
[TBL] [Abstract][Full Text] [Related]
19. Synthesis and evaluation of novel benzylphthalazine derivatives as hedgehog signaling pathway inhibitors.
Bao X; Peng Y; Lu X; Yang J; Zhao W; Tan W; Dong X
Bioorg Med Chem Lett; 2016 Jul; 26(13):3048-3051. PubMed ID: 27180012
[TBL] [Abstract][Full Text] [Related]
20. 1-amino-4-benzylphthalazines as orally bioavailable smoothened antagonists with antitumor activity.
Miller-Moslin K; Peukert S; Jain RK; McEwan MA; Karki R; Llamas L; Yusuff N; He F; Li Y; Sun Y; Dai M; Perez L; Michael W; Sheng T; Lei H; Zhang R; Williams J; Bourret A; Ramamurthy A; Yuan J; Guo R; Matsumoto M; Vattay A; Maniara W; Amaral A; Dorsch M; Kelleher JF
J Med Chem; 2009 Jul; 52(13):3954-68. PubMed ID: 19469545
[TBL] [Abstract][Full Text] [Related]
[Next] [New Search]