BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

183 related articles for article (PubMed ID: 22915839)

  • 1. 17AAG Treatment Accelerates Doxorubicin Induced Cellular Senescence: Hsp90 Interferes with Enforced Senescence of Tumor Cells.
    Sarangi U; Paithankar KR; Kumar JU; Subramaniam V; Sreedhar AS
    Drug Target Insights; 2012; 6():19-39. PubMed ID: 22915839
    [TBL] [Abstract][Full Text] [Related]  

  • 2. Compromising the constitutive p16
    Kanugovi AV; Joseph C; Siripini S; Paithankar K; Amere SS
    J Cell Biochem; 2020 Apr; 121(4):2770-2781. PubMed ID: 31692039
    [TBL] [Abstract][Full Text] [Related]  

  • 3. The conformation-specific Hsp90 inhibition interferes with the oncogenic RAF kinase adaptation and triggers premature cellular senescence, hence, acts as a tumor suppressor mechanism.
    Kanugovi Vijayavittal A; Amere Subbarao S
    Biochim Biophys Acta Mol Cell Res; 2021 Mar; 1868(3):118943. PubMed ID: 33359710
    [TBL] [Abstract][Full Text] [Related]  

  • 4. Interaction between mTOR pathway inhibition and autophagy induction attenuates adriamycin-induced vascular smooth muscle cell senescence through decreased expressions of p53/p21/p16.
    Sung JY; Lee KY; Kim JR; Choi HC
    Exp Gerontol; 2018 Aug; 109():51-58. PubMed ID: 28797827
    [TBL] [Abstract][Full Text] [Related]  

  • 5. Cellular Senescence in Diabetes Mellitus: Distinct Senotherapeutic Strategies for Adipose Tissue and Pancreatic β Cells.
    Murakami T; Inagaki N; Kondoh H
    Front Endocrinol (Lausanne); 2022; 13():869414. PubMed ID: 35432205
    [TBL] [Abstract][Full Text] [Related]  

  • 6. Repercussion of Mitochondria Deformity Induced by Anti-Hsp90 Drug 17AAG in Human Tumor Cells.
    Vishal C; Kumar JU; Veera Brahmendra Swamy C; Nandini R; Srinivas G; Kumaresan R; Shashi S; Sreedhar AS
    Drug Target Insights; 2011; 5():11-32. PubMed ID: 22087060
    [TBL] [Abstract][Full Text] [Related]  

  • 7. Techniques to Induce and Quantify Cellular Senescence.
    Noren Hooten N; Evans MK
    J Vis Exp; 2017 May; (123):. PubMed ID: 28518126
    [TBL] [Abstract][Full Text] [Related]  

  • 8. Senescence-associated heterochromatin foci are dispensable for cellular senescence, occur in a cell type- and insult-dependent manner and follow expression of p16(ink4a).
    Kosar M; Bartkova J; Hubackova S; Hodny Z; Lukas J; Bartek J
    Cell Cycle; 2011 Feb; 10(3):457-68. PubMed ID: 21248468
    [TBL] [Abstract][Full Text] [Related]  

  • 9. Depletion of ERK2 but not ERK1 abrogates oncogenic Ras-induced senescence.
    Shin J; Yang J; Lee JC; Baek KH
    Cell Signal; 2013 Dec; 25(12):2540-7. PubMed ID: 23993963
    [TBL] [Abstract][Full Text] [Related]  

  • 10. Hypoxia suppresses conversion from proliferative arrest to cellular senescence.
    Leontieva OV; Natarajan V; Demidenko ZN; Burdelya LG; Gudkov AV; Blagosklonny MV
    Proc Natl Acad Sci U S A; 2012 Aug; 109(33):13314-8. PubMed ID: 22847439
    [TBL] [Abstract][Full Text] [Related]  

  • 11. 90-kDa heat shock protein inhibition abrogates the topoisomerase I poison-induced G2/M checkpoint in p53-null tumor cells by depleting Chk1 and Wee1.
    Tse AN; Sheikh TN; Alan H; Chou TC; Schwartz GK
    Mol Pharmacol; 2009 Jan; 75(1):124-33. PubMed ID: 18820127
    [TBL] [Abstract][Full Text] [Related]  

  • 12. Hsp90 inhibition sensitizes DLBCL cells to cisplatin.
    Schmidt L; Issa II; Haraldsdóttir H; Hald JL; Schmitz A; Due H; Dybkær K
    Cancer Chemother Pharmacol; 2022 Apr; 89(4):431-440. PubMed ID: 35190872
    [TBL] [Abstract][Full Text] [Related]  

  • 13. Cancer cell survival following DNA damage-mediated premature senescence is regulated by mammalian target of rapamycin (mTOR)-dependent Inhibition of sirtuin 1.
    Back JH; Rezvani HR; Zhu Y; Guyonnet-Duperat V; Athar M; Ratner D; Kim AL
    J Biol Chem; 2011 May; 286(21):19100-8. PubMed ID: 21471201
    [TBL] [Abstract][Full Text] [Related]  

  • 14. p38 MAPK and JNK antagonistically control senescence and cytoplasmic p16INK4A expression in doxorubicin-treated endothelial progenitor cells.
    Spallarossa P; Altieri P; Barisione C; Passalacqua M; Aloi C; Fugazza G; Frassoni F; Podestà M; Canepa M; Ghigliotti G; Brunelli C
    PLoS One; 2010 Dec; 5(12):e15583. PubMed ID: 21187925
    [TBL] [Abstract][Full Text] [Related]  

  • 15. Comparison of 17-dimethylaminoethylamino-17-demethoxy-geldanamycin (17DMAG) and 17-allylamino-17-demethoxygeldanamycin (17AAG) in vitro: effects on Hsp90 and client proteins in melanoma models.
    Smith V; Sausville EA; Camalier RF; Fiebig HH; Burger AM
    Cancer Chemother Pharmacol; 2005 Aug; 56(2):126-37. PubMed ID: 15841378
    [TBL] [Abstract][Full Text] [Related]  

  • 16. Mitogen-activated protein kinase p38 and retinoblastoma protein signalling is required for DNA damage-mediated formation of senescence-associated heterochromatic foci in tumour cells.
    Zhang Y; Gao Y; Zhao L; Han L; Lu Y; Hou P; Shi X; Liu X; Tian B; Wang X; Huang B; Lu J
    FEBS J; 2013 Sep; 280(18):4625-39. PubMed ID: 23859194
    [TBL] [Abstract][Full Text] [Related]  

  • 17. Senescence mechanisms of nucleus pulposus chondrocytes in human intervertebral discs.
    Kim KW; Chung HN; Ha KY; Lee JS; Kim YY
    Spine J; 2009 Aug; 9(8):658-66. PubMed ID: 19540815
    [TBL] [Abstract][Full Text] [Related]  

  • 18. Tumor suppressor and aging biomarker p16(INK4a) induces cellular senescence without the associated inflammatory secretory phenotype.
    Coppé JP; Rodier F; Patil CK; Freund A; Desprez PY; Campisi J
    J Biol Chem; 2011 Oct; 286(42):36396-403. PubMed ID: 21880712
    [TBL] [Abstract][Full Text] [Related]  

  • 19. Tumor Suppression Efficacy of Heat Shock Protein 90 Inhibitor 17AAG in a Liposarcoma Mouse Model.
    Nam S; Kim H; Hong D; Park JB; Kim SJ
    Anticancer Res; 2017 Nov; 37(11):6291-6302. PubMed ID: 29061812
    [TBL] [Abstract][Full Text] [Related]  

  • 20. Epigallocatechin gallate suppresses premature senescence of preadipocytes by inhibition of PI3K/Akt/mTOR pathway and induces senescent cell death by regulation of Bax/Bcl-2 pathway.
    Kumar R; Sharma A; Kumari A; Gulati A; Padwad Y; Sharma R
    Biogerontology; 2019 Apr; 20(2):171-189. PubMed ID: 30456590
    [TBL] [Abstract][Full Text] [Related]  

    [Next]    [New Search]
    of 10.