389 related articles for article (PubMed ID: 22916036)
1. Stromal liver kinase B1 [STK11] signaling loss induces oviductal adenomas and endometrial cancer by activating mammalian Target of Rapamycin Complex 1.
Tanwar PS; Kaneko-Tarui T; Zhang L; Tanaka Y; Crum CP; Teixeira JM
PLoS Genet; 2012; 8(8):e1002906. PubMed ID: 22916036
[TBL] [Abstract][Full Text] [Related]
2. Conditional deletion of Tsc1 in the female reproductive tract impedes normal oviductal and uterine function by enhancing mTORC1 signaling in mice.
Daikoku T; Yoshie M; Xie H; Sun X; Cha J; Ellenson LH; Dey SK
Mol Hum Reprod; 2013 Jul; 19(7):463-72. PubMed ID: 23475984
[TBL] [Abstract][Full Text] [Related]
3. Altered LKB1/AMPK/TSC1/TSC2/mTOR signaling causes disruption of Sertoli cell polarity and spermatogenesis.
Tanwar PS; Kaneko-Tarui T; Zhang L; Teixeira JM
Hum Mol Genet; 2012 Oct; 21(20):4394-405. PubMed ID: 22791749
[TBL] [Abstract][Full Text] [Related]
4. Loss of tuberous sclerosis complex-2 function and activation of mammalian target of rapamycin signaling in endometrial carcinoma.
Lu KH; Wu W; Dave B; Slomovitz BM; Burke TW; Munsell MF; Broaddus RR; Walker CL
Clin Cancer Res; 2008 May; 14(9):2543-50. PubMed ID: 18451215
[TBL] [Abstract][Full Text] [Related]
5. mTOR and HIF-1alpha-mediated tumor metabolism in an LKB1 mouse model of Peutz-Jeghers syndrome.
Shackelford DB; Vasquez DS; Corbeil J; Wu S; Leblanc M; Wu CL; Vera DR; Shaw RJ
Proc Natl Acad Sci U S A; 2009 Jul; 106(27):11137-42. PubMed ID: 19541609
[TBL] [Abstract][Full Text] [Related]
6. Dysregulation of mTOR activity through LKB1 inactivation.
Zhou W; Marcus AI; Vertino PM
Chin J Cancer; 2013 Aug; 32(8):427-33. PubMed ID: 23668926
[TBL] [Abstract][Full Text] [Related]
7. Important role of the LKB1-AMPK pathway in suppressing tumorigenesis in PTEN-deficient mice.
Huang X; Wullschleger S; Shpiro N; McGuire VA; Sakamoto K; Woods YL; McBurnie W; Fleming S; Alessi DR
Biochem J; 2008 Jun; 412(2):211-21. PubMed ID: 18387000
[TBL] [Abstract][Full Text] [Related]
8. Signaling events downstream of mammalian target of rapamycin complex 2 are attenuated in cells and tumors deficient for the tuberous sclerosis complex tumor suppressors.
Huang J; Wu S; Wu CL; Manning BD
Cancer Res; 2009 Aug; 69(15):6107-14. PubMed ID: 19602587
[TBL] [Abstract][Full Text] [Related]
9. Cell-type-dependent regulation of mTORC1 by REDD1 and the tumor suppressors TSC1/TSC2 and LKB1 in response to hypoxia.
Wolff NC; Vega-Rubin-de-Celis S; Xie XJ; Castrillon DH; Kabbani W; Brugarolas J
Mol Cell Biol; 2011 May; 31(9):1870-84. PubMed ID: 21383064
[TBL] [Abstract][Full Text] [Related]
10. Deletion of tuberous sclerosis 1 in somatic cells of the murine reproductive tract causes female infertility.
Tanaka Y; Park JH; Tanwar PS; Kaneko-Tarui T; Mittal S; Lee HJ; Teixeira JM
Endocrinology; 2012 Jan; 153(1):404-16. PubMed ID: 22128018
[TBL] [Abstract][Full Text] [Related]
11. Heterozygous inactivation of tsc2 enhances tumorigenesis in p53 mutant zebrafish.
Kim SH; Kowalski ML; Carson RP; Bridges LR; Ess KC
Dis Model Mech; 2013 Jul; 6(4):925-33. PubMed ID: 23580196
[TBL] [Abstract][Full Text] [Related]
12. TSC1 controls distribution of actin fibers through its effect on function of Rho family of small GTPases and regulates cell migration and polarity.
Ohsawa M; Kobayashi T; Okura H; Igarashi T; Mizuguchi M; Hino O
PLoS One; 2013; 8(1):e54503. PubMed ID: 23355874
[TBL] [Abstract][Full Text] [Related]
13. Lkb1 inactivation is sufficient to drive endometrial cancers that are aggressive yet highly responsive to mTOR inhibitor monotherapy.
Contreras CM; Akbay EA; Gallardo TD; Haynie JM; Sharma S; Tagao O; Bardeesy N; Takahashi M; Settleman J; Wong KK; Castrillon DH
Dis Model Mech; 2010; 3(3-4):181-93. PubMed ID: 20142330
[TBL] [Abstract][Full Text] [Related]
14. Mammalian target of rapamycin complex 1 (mTORC1) enhances bortezomib-induced death in tuberous sclerosis complex (TSC)-null cells by a c-MYC-dependent induction of the unfolded protein response.
Babcock JT; Nguyen HB; He Y; Hendricks JW; Wek RC; Quilliam LA
J Biol Chem; 2013 May; 288(22):15687-98. PubMed ID: 23612979
[TBL] [Abstract][Full Text] [Related]
15. Upregulation of 6-phosphofructo-2-kinase (PFKFB3) by hyperactivated mammalian target of rapamycin complex 1 is critical for tumor growth in tuberous sclerosis complex.
Wang Y; Tang S; Wu Y; Wan X; Zhou M; Li H; Zha X
IUBMB Life; 2020 May; 72(5):965-977. PubMed ID: 31958214
[TBL] [Abstract][Full Text] [Related]
16. Specific deletion of LKB1/
George JW; Patterson AL; Tanwar PS; Kajdacsy-Balla A; Prins GS; Teixeira JM
Proc Natl Acad Sci U S A; 2017 Mar; 114(13):3445-3450. PubMed ID: 28289208
[TBL] [Abstract][Full Text] [Related]
17. Smooth muscle protein-22-mediated deletion of Tsc1 results in cardiac hypertrophy that is mTORC1-mediated and reversed by rapamycin.
Malhowski AJ; Hira H; Bashiruddin S; Warburton R; Goto J; Robert B; Kwiatkowski DJ; Finlay GA
Hum Mol Genet; 2011 Apr; 20(7):1290-305. PubMed ID: 21212099
[TBL] [Abstract][Full Text] [Related]
18. Hyperplasia and fibrosis in mice with conditional loss of the TSC2 tumor suppressor in Müllerian duct mesenchyme-derived myometria.
Kaneko-Tarui T; Commandeur AE; Patterson AL; DeKuiper JL; Petillo D; Styer AK; Teixeira JM
Mol Hum Reprod; 2014 Nov; 20(11):1126-34. PubMed ID: 25189766
[TBL] [Abstract][Full Text] [Related]
19. A genetic mouse model of invasive endometrial cancer driven by concurrent loss of Pten and Lkb1 Is highly responsive to mTOR inhibition.
Cheng H; Liu P; Zhang F; Xu E; Symonds L; Ohlson CE; Bronson RT; Maira SM; Di Tomaso E; Li J; Myers AP; Cantley LC; Mills GB; Zhao JJ
Cancer Res; 2014 Jan; 74(1):15-23. PubMed ID: 24322983
[TBL] [Abstract][Full Text] [Related]
20. Mosaic Disorders of the PI3K/PTEN/AKT/TSC/mTORC1 Signaling Pathway.
Nathan N; Keppler-Noreuil KM; Biesecker LG; Moss J; Darling TN
Dermatol Clin; 2017 Jan; 35(1):51-60. PubMed ID: 27890237
[TBL] [Abstract][Full Text] [Related]
[Next] [New Search]
