189 related articles for article (PubMed ID: 22925725)
1. Discovery of potent, novel Nrf2 inducers via quantum modeling, virtual screening, and in vitro experimental validation.
Williamson TP; Amirahmadi S; Joshi G; Kaludov NK; Martinov MN; Johnson DA; Johnson JA
Chem Biol Drug Des; 2012 Dec; 80(6):810-20. PubMed ID: 22925725
[TBL] [Abstract][Full Text] [Related]
2. Nuclear factor (erythroid-derived 2)-like 2 (NRF2) drug discovery: Biochemical toolbox to develop NRF2 activators by reversible binding of Kelch-like ECH-associated protein 1 (KEAP1).
Bresciani A; Missineo A; Gallo M; Cerretani M; Fezzardi P; Tomei L; Cicero DO; Altamura S; Santoprete A; Ingenito R; Bianchi E; Pacifici R; Dominguez C; Munoz-Sanjuan I; Harper S; Toledo-Sherman L; Park LC
Arch Biochem Biophys; 2017 Oct; 631():31-41. PubMed ID: 28801166
[TBL] [Abstract][Full Text] [Related]
3. Isoflavone biochanin A, a novel nuclear factor erythroid 2-related factor 2 (Nrf2)-antioxidant response element activator, protects against oxidative damage in HepG2 cells.
Liang F; Cao W; Huang Y; Fang Y; Cheng Y; Pan S; Xu X
Biofactors; 2019 Jul; 45(4):563-574. PubMed ID: 31131946
[TBL] [Abstract][Full Text] [Related]
4. Activation of the Nrf2-ARE pathway by siRNA knockdown of Keap1 reduces oxidative stress and provides partial protection from MPTP-mediated neurotoxicity.
Williamson TP; Johnson DA; Johnson JA
Neurotoxicology; 2012 Jun; 33(3):272-9. PubMed ID: 22342405
[TBL] [Abstract][Full Text] [Related]
5. Screening of natural compounds as activators of the keap1-nrf2 pathway.
Wu KC; McDonald PR; Liu J; Klaassen CD
Planta Med; 2014 Jan; 80(1):97-104. PubMed ID: 24310212
[TBL] [Abstract][Full Text] [Related]
6. Implementation of a high-throughput screen for identifying small molecules to activate the Keap1-Nrf2-ARE pathway.
Wu KC; McDonald PR; Liu JJ; Chaguturu R; Klaassen CD
PLoS One; 2012; 7(10):e44686. PubMed ID: 23056183
[TBL] [Abstract][Full Text] [Related]
7. Small molecule activators of the Nrf2-HO-1 antioxidant axis modulate heme metabolism and inflammation in BV2 microglia cells.
Foresti R; Bains SK; Pitchumony TS; de Castro Brás LE; Drago F; Dubois-Randé JL; Bucolo C; Motterlini R
Pharmacol Res; 2013 Oct; 76():132-48. PubMed ID: 23942037
[TBL] [Abstract][Full Text] [Related]
8. Antioxidant sulforaphane and sensitizer trinitrobenzene sulfonate induce carboxylesterase-1 through a novel element transactivated by nuclear factor-E2 related factor-2.
Chen YT; Shi D; Yang D; Yan B
Biochem Pharmacol; 2012 Sep; 84(6):864-71. PubMed ID: 22776248
[TBL] [Abstract][Full Text] [Related]
9. Nuclear factor E2-related factor 2-dependent antioxidant response element activation by tert-butylhydroquinone and sulforaphane occurring preferentially in astrocytes conditions neurons against oxidative insult.
Kraft AD; Johnson DA; Johnson JA
J Neurosci; 2004 Feb; 24(5):1101-12. PubMed ID: 14762128
[TBL] [Abstract][Full Text] [Related]
10. Characterization of novel small-molecule NRF2 activators: Structural and biochemical validation of stereospecific KEAP1 binding.
Huerta C; Jiang X; Trevino I; Bender CF; Ferguson DA; Probst B; Swinger KK; Stoll VS; Thomas PJ; Dulubova I; Visnick M; Wigley WC
Biochim Biophys Acta; 2016 Nov; 1860(11 Pt A):2537-2552. PubMed ID: 27474998
[TBL] [Abstract][Full Text] [Related]
11. Nrf2 activator via interference of Nrf2-Keap1 interaction has antioxidant and anti-inflammatory properties in Parkinson's disease animal model.
Kim S; Indu Viswanath AN; Park JH; Lee HE; Park AY; Choi JW; Kim HJ; Londhe AM; Jang BK; Lee J; Hwang H; Lim SM; Pae AN; Park KD
Neuropharmacology; 2020 May; 167():107989. PubMed ID: 32032607
[TBL] [Abstract][Full Text] [Related]
12. Bis-Michael Acceptors as Novel Probes to Study the Keap1/Nrf2/ARE Pathway.
Deny LJ; Traboulsi H; Cantin AM; Marsault É; Richter MV; Bélanger G
J Med Chem; 2016 Oct; 59(20):9431-9442. PubMed ID: 27682717
[TBL] [Abstract][Full Text] [Related]
13. NF-κB and Keap1 Interaction Represses Nrf2-Mediated Antioxidant Response in Rabbit Hemorrhagic Disease Virus Infection.
Hu B; Wei H; Song Y; Chen M; Fan Z; Qiu R; Zhu W; Xu W; Wang F
J Virol; 2020 May; 94(10):. PubMed ID: 32161178
[TBL] [Abstract][Full Text] [Related]
14. Discovery of Keap1-Nrf2 small-molecule inhibitors from phytochemicals based on molecular docking.
Li M; Huang W; Jie F; Wang M; Zhong Y; Chen Q; Lu B
Food Chem Toxicol; 2019 Nov; 133():110758. PubMed ID: 31412289
[TBL] [Abstract][Full Text] [Related]
15. Pharmacological stimulation of nuclear factor (erythroid-derived 2)-like 2 translation activates antioxidant responses.
Perez-Leal O; Barrero CA; Merali S
J Biol Chem; 2017 Aug; 292(34):14108-14121. PubMed ID: 28684421
[TBL] [Abstract][Full Text] [Related]
16. Identification of antioxidant peptides targeting Keap1-Nrf2-ARE pathway from in vitro digestion of pork sausage with partial substitution of NaCl by KCl.
Zou L; Yu X; Cai K; Xu B; Chen C; Xiao G
Food Res Int; 2023 Dec; 174(Pt 1):113585. PubMed ID: 37986452
[TBL] [Abstract][Full Text] [Related]
17. Discovery of the negative regulator of Nrf2, Keap1: a historical overview.
Itoh K; Mimura J; Yamamoto M
Antioxid Redox Signal; 2010 Dec; 13(11):1665-78. PubMed ID: 20446768
[TBL] [Abstract][Full Text] [Related]
18. Polysaccharide from Ostrea rivularis attenuates reproductive oxidative stress damage via activating Keap1-Nrf2/ARE pathway.
Li S; Song Z; Liu T; Liang J; Yuan J; Xu Z; Sun Z; Lai X; Xiong Q; Zhang D
Carbohydr Polym; 2018 Apr; 186():321-331. PubMed ID: 29455993
[TBL] [Abstract][Full Text] [Related]
19. An effective strategy for increasing the radiosensitivity of Human lung Cancer cells by blocking Nrf2-dependent antioxidant responses.
Lee S; Lim MJ; Kim MH; Yu CH; Yun YS; Ahn J; Song JY
Free Radic Biol Med; 2012 Aug; 53(4):807-16. PubMed ID: 22684019
[TBL] [Abstract][Full Text] [Related]
20. Neuroprotective effect of an Nrf2-ARE activator identified from a chemical library on dopaminergic neurons.
Izumi Y; Kataoka H; Inose Y; Akaike A; Koyama Y; Kume T
Eur J Pharmacol; 2018 Jan; 818():470-479. PubMed ID: 29154837
[TBL] [Abstract][Full Text] [Related]
[Next] [New Search]