BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

167 related articles for article (PubMed ID: 22926225)

  • 1. The multiobjective based design, synthesis and evaluation of the arylsulfonamide/amide derivatives of aryloxyethyl- and arylthioethyl- piperidines and pyrrolidines as a novel class of potent 5-HT₇ receptor antagonists.
    Zajdel P; Kurczab R; Grychowska K; Satała G; Pawłowski M; Bojarski AJ
    Eur J Med Chem; 2012 Oct; 56():348-60. PubMed ID: 22926225
    [TBL] [Abstract][Full Text] [Related]  

  • 2. Towards new 5-HT7 antagonists among arylsulfonamide derivatives of (aryloxy)ethyl-alkyl amines: Multiobjective based design, synthesis, and antidepressant and anxiolytic properties.
    Canale V; Kurczab R; Partyka A; Satała G; Lenda T; Jastrzębska-Więsek M; Wesołowska A; Bojarski AJ; Zajdel P
    Eur J Med Chem; 2016 Jan; 108():334-346. PubMed ID: 26698537
    [TBL] [Abstract][Full Text] [Related]  

  • 3. Synthesis and biological evaluation of benzoisothiazole derivatives possessing N,N-dimethylformimidamide group as 5-HT₆ receptor antagonists.
    Yoo E; Hayat F; Rhim H; Park Choo HY
    Bioorg Med Chem; 2012 Apr; 20(8):2707-12. PubMed ID: 22405919
    [TBL] [Abstract][Full Text] [Related]  

  • 4. Synthesis and structure-affinity relationships of novel N-(1-ethyl-4-methylhexahydro-1,4-diazepin-6-yl)pyridine-3-carboxamides with potent serotonin 5-HT3 and dopamine D2 receptor antagonistic activity.
    Hirokawa Y; Fujiwara I; Suzuki K; Harada H; Yoshikawa T; Yoshida N; Kato S
    J Med Chem; 2003 Feb; 46(5):702-15. PubMed ID: 12593651
    [TBL] [Abstract][Full Text] [Related]  

  • 5. Synthesis of new serotonin 5-HT7 receptor ligands. Determinants of 5-HT7/5-HT1A receptor selectivity.
    Medina RA; Sallander J; Benhamú B; Porras E; Campillo M; Pardo L; López-Rodríguez ML
    J Med Chem; 2009 Apr; 52(8):2384-92. PubMed ID: 19326916
    [TBL] [Abstract][Full Text] [Related]  

  • 6. 2,3-Dihydro-2-oxo-1H-benzimidazole-1-carboxamides with selective affinity for the 5-HT(4) receptor: synthesis and structure-affinity and structure-activity relationships of a new series of partial agonist and antagonist derivatives.
    Tapia I; Alonso-Cires L; López-Tudanca PL; Mosquera R; Labeaga L; Innerárity A; Orjales A
    J Med Chem; 1999 Jul; 42(15):2870-80. PubMed ID: 10425096
    [TBL] [Abstract][Full Text] [Related]  

  • 7. Arylsulfonamide derivatives of (aryloxy)ethyl pyrrolidines and piperidines as α
    Rak A; Canale V; Marciniec K; Żmudzki P; Kotańska M; Knutelska J; Siwek A; Stachowicz G; Bednarski M; Nowiński L; Zygmunt M; Zajdel P; Sapa J
    Bioorg Med Chem; 2016 Nov; 24(21):5582-5591. PubMed ID: 27658792
    [TBL] [Abstract][Full Text] [Related]  

  • 8. Structure-affinity relationship study on N-(1,2,3,4-tetrahydronaphthalen-1-yl)-4-aryl-1-piperazinealkylamides, a new class of 5-hydroxytryptamine7 receptor agents.
    Leopoldo M; Berardi F; Colabufo NA; Contino M; Lacivita E; Niso M; Perrone R; Tortorella V
    J Med Chem; 2004 Dec; 47(26):6616-24. PubMed ID: 15588097
    [TBL] [Abstract][Full Text] [Related]  

  • 9. 7-Arylpiperazinylalkyl and 7-tetrahydroisoquinolinylalkyl derivatives of 8-alkoxy-purine-2,6-dione and some of their purine-2,6,8-trione analogs as 5-HT(1A), 5-HT(2A), and 5-HT(7) serotonin receptor ligands.
    Chłoń-Rzepa G; Zmudzki P; Zajdel P; Bojarski AJ; Duszyńska B; Nikiforuk A; Tatarczyńska E; Pawłowski M
    Bioorg Med Chem; 2007 Aug; 15(15):5239-50. PubMed ID: 17517514
    [TBL] [Abstract][Full Text] [Related]  

  • 10. Investigations on the 1-(2-biphenyl)piperazine motif: identification of new potent and selective ligands for the serotonin(7) (5-HT(7)) receptor with agonist or antagonist action in vitro or ex vivo.
    Lacivita E; Patarnello D; Stroth N; Caroli A; Niso M; Contino M; De Giorgio P; Di Pilato P; Colabufo NA; Berardi F; Perrone R; Svenningsson P; Hedlund PB; Leopoldo M
    J Med Chem; 2012 Jul; 55(14):6375-80. PubMed ID: 22738316
    [TBL] [Abstract][Full Text] [Related]  

  • 11. New arylpiperazine 5-HT(1A) receptor ligands containing the pyrimido[2,1-f]purine fragment: synthesis, in vitro, and in vivo pharmacological evaluation.
    Jurczyk S; Kołaczkowski M; Maryniak E; Zajdel P; Pawłowski M; Tatarczyńska E; Kłodzińska A; Chojnacka-Wójcik E; Bojarski AJ; Charakchieva-Minol S; Duszyńska B; Nowak G; Maciag D
    J Med Chem; 2004 May; 47(10):2659-66. PubMed ID: 15115407
    [TBL] [Abstract][Full Text] [Related]  

  • 12. N-Alkylated arylsulfonamides of (aryloxy)ethyl piperidines: 5-HT(7) receptor selectivity versus multireceptor profile.
    Canale V; Kurczab R; Partyka A; Satała G; Słoczyńska K; Kos T; Jastrzębska-Więsek M; Siwek A; Pękala E; Bojarski AJ; Wesołowska A; Popik P; Zajdel P
    Bioorg Med Chem; 2016 Jan; 24(2):130-9. PubMed ID: 26706111
    [TBL] [Abstract][Full Text] [Related]  

  • 13. Cyclopropyl-tryptamine analogues: synthesis and biological evaluation as 5-HT(6) receptor ligands.
    Szalata C; Szymoniak J; Fabis F; Butt-Gueulle S; Rault S; Bertus P; Gérard S; Sapi J
    ChemMedChem; 2013 Jan; 8(1):70-3. PubMed ID: 23129513
    [TBL] [Abstract][Full Text] [Related]  

  • 14. Synthesis and structure-activity relationship (SAR) of (5,7-disubstituted 3-phenylsulfonyl-pyrazolo[1,5-a]pyrimidin-2-yl)-methylamines as potent serotonin 5-HT(6) receptor (5-HT(6)R) antagonists.
    Ivachtchenko AV; Golovina ES; Kadieva MG; Kysil VM; Mitkin OD; Tkachenko SE; Okun IM
    J Med Chem; 2011 Dec; 54(23):8161-73. PubMed ID: 22029285
    [TBL] [Abstract][Full Text] [Related]  

  • 15. Synthesis and structure-activity relationships of new carbonyl guanidine derivatives as novel dual 5-HT2B and 5-HT7 receptor antagonists.
    Moritomo A; Yamada H; Watanabe T; Itahana H; Akuzawa S; Okada M; Ohta M
    Bioorg Med Chem; 2013 Dec; 21(24):7841-52. PubMed ID: 24189186
    [TBL] [Abstract][Full Text] [Related]  

  • 16. Novel arylsulfonamide derivatives with 5-HT₆/5-HT₇ receptor antagonism targeting behavioral and psychological symptoms of dementia.
    Kołaczkowski M; Marcinkowska M; Bucki A; Pawłowski M; Mitka K; Jaśkowska J; Kowalski P; Kazek G; Siwek A; Wasik A; Wesołowska A; Mierzejewski P; Bienkowski P
    J Med Chem; 2014 Jun; 57(11):4543-57. PubMed ID: 24805037
    [TBL] [Abstract][Full Text] [Related]  

  • 17. Benzimidazole derivatives. Part 5: design and synthesis of new benzimidazole-arylpiperazine derivatives acting as mixed 5-HT1A/5-HT3 ligands.
    López-Rodríguez ML; Benhamú B; Morcillo MJ; Tejada I; Avila D; Marco I; Schiapparelli L; Frechilla D; Del Río J
    Bioorg Med Chem; 2004 Oct; 12(19):5181-91. PubMed ID: 15351401
    [TBL] [Abstract][Full Text] [Related]  

  • 18. Solid-supported synthesis, molecular modeling, and biological activity of long-chain arylpiperazine derivatives with cyclic amino acid amide fragments as 5-HT(7) and 5-HT(1A) receptor ligands.
    Canale V; Guzik P; Kurczab R; Verdie P; Satała G; Kubica B; Pawłowski M; Martinez J; Subra G; Bojarski AJ; Zajdel P
    Eur J Med Chem; 2014 May; 78():10-22. PubMed ID: 24675176
    [TBL] [Abstract][Full Text] [Related]  

  • 19. Synthesis by microwave irradiation and binding properties of novel 5-HT(1A) receptor ligands.
    Caliendo G; Fiorino F; Perissutti E; Severino B; Gessi S; Cattabriga E; Borea PA; Santagada V
    Eur J Med Chem; 2001; 36(11-12):873-86. PubMed ID: 11755230
    [TBL] [Abstract][Full Text] [Related]  

  • 20. New 1-arylindoles based serotonin 5-HT7 antagonists. Synthesis and binding evaluation studies.
    Sagnes C; Fournet G; Satala G; Bojarski AJ; Joseph B
    Eur J Med Chem; 2014 Mar; 75():159-68. PubMed ID: 24531229
    [TBL] [Abstract][Full Text] [Related]  

    [Next]    [New Search]
    of 9.