135 related articles for article (PubMed ID: 22931458)
1. Femtomolar inhibitors bind to 5'-methylthioadenosine nucleosidases with favorable enthalpy and entropy.
Thomas K; Haapalainen AM; Burgos ES; Evans GB; Tyler PC; Gulab S; Guan R; Schramm VL
Biochemistry; 2012 Sep; 51(38):7541-50. PubMed ID: 22931458
[TBL] [Abstract][Full Text] [Related]
2. Active site and remote contributions to catalysis in methylthioadenosine nucleosidases.
Thomas K; Cameron SA; Almo SC; Burgos ES; Gulab SA; Schramm VL
Biochemistry; 2015 Apr; 54(15):2520-9. PubMed ID: 25806409
[TBL] [Abstract][Full Text] [Related]
3. Conformational freedom in tight binding enzymatic transition-state analogues.
Motley MW; Schramm VL; Schwartz SD
J Phys Chem B; 2013 Aug; 117(33):9591-7. PubMed ID: 23895500
[TBL] [Abstract][Full Text] [Related]
4. Mechanism of substrate specificity in 5'-methylthioadenosine/S-adenosylhomocysteine nucleosidases.
Siu KK; Asmus K; Zhang AN; Horvatin C; Li S; Liu T; Moffatt B; Woods VL; Howell PL
J Struct Biol; 2011 Jan; 173(1):86-98. PubMed ID: 20554051
[TBL] [Abstract][Full Text] [Related]
5. Femtomolar transition state analogue inhibitors of 5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase from Escherichia coli.
Singh V; Evans GB; Lenz DH; Mason JM; Clinch K; Mee S; Painter GF; Tyler PC; Furneaux RH; Lee JE; Howell PL; Schramm VL
J Biol Chem; 2005 May; 280(18):18265-73. PubMed ID: 15749708
[TBL] [Abstract][Full Text] [Related]
6. Structural comparison of MTA phosphorylase and MTA/AdoHcy nucleosidase explains substrate preferences and identifies regions exploitable for inhibitor design.
Lee JE; Settembre EC; Cornell KA; Riscoe MK; Sufrin JR; Ealick SE; Howell PL
Biochemistry; 2004 May; 43(18):5159-69. PubMed ID: 15122881
[TBL] [Abstract][Full Text] [Related]
7. Entropy-driven binding of picomolar transition state analogue inhibitors to human 5'-methylthioadenosine phosphorylase.
Guan R; Ho MC; Brenowitz M; Tyler PC; Evans GB; Almo SC; Schramm VL
Biochemistry; 2011 Nov; 50(47):10408-17. PubMed ID: 21985704
[TBL] [Abstract][Full Text] [Related]
8. Transition state structure of 5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase from Escherichia coli and its similarity to transition state analogues.
Singh V; Lee JE; Núñez S; Howell PL; Schramm VL
Biochemistry; 2005 Sep; 44(35):11647-59. PubMed ID: 16128565
[TBL] [Abstract][Full Text] [Related]
9. Structural snapshots of MTA/AdoHcy nucleosidase along the reaction coordinate provide insights into enzyme and nucleoside flexibility during catalysis.
Lee JE; Smith GD; Horvatin C; Huang DJ; Cornell KA; Riscoe MK; Howell PL
J Mol Biol; 2005 Sep; 352(3):559-74. PubMed ID: 16109423
[TBL] [Abstract][Full Text] [Related]
10. Thermodynamic characterization of allosteric glycogen phosphorylase inhibitors.
Anderka O; Loenze P; Klabunde T; Dreyer MK; Defossa E; Wendt KU; Schmoll D
Biochemistry; 2008 Apr; 47(16):4683-91. PubMed ID: 18373353
[TBL] [Abstract][Full Text] [Related]
11. Structure and inhibition of a quorum sensing target from Streptococcus pneumoniae.
Singh V; Shi W; Almo SC; Evans GB; Furneaux RH; Tyler PC; Painter GF; Lenz DH; Mee S; Zheng R; Schramm VL
Biochemistry; 2006 Oct; 45(43):12929-41. PubMed ID: 17059210
[TBL] [Abstract][Full Text] [Related]
12. Structural rationale for the affinity of pico- and femtomolar transition state analogues of Escherichia coli 5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase.
Lee JE; Singh V; Evans GB; Tyler PC; Furneaux RH; Cornell KA; Riscoe MK; Schramm VL; Howell PL
J Biol Chem; 2005 May; 280(18):18274-82. PubMed ID: 15746096
[TBL] [Abstract][Full Text] [Related]
13. Residence Times for Femtomolar and Picomolar Inhibitors of MTANs.
Brown M; Tyler PC; Schramm VL
Biochemistry; 2023 Jun; 62(11):1776-1785. PubMed ID: 37204861
[TBL] [Abstract][Full Text] [Related]
14. Transition-State Analogues of Campylobacter jejuni 5'-Methylthioadenosine Nucleosidase.
Ducati RG; Harijan RK; Cameron SA; Tyler PC; Evans GB; Schramm VL
ACS Chem Biol; 2018 Nov; 13(11):3173-3183. PubMed ID: 30339406
[TBL] [Abstract][Full Text] [Related]
15. Structure of Staphylococcus aureus 5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase.
Siu KK; Lee JE; Smith GD; Horvatin-Mrakovcic C; Howell PL
Acta Crystallogr Sect F Struct Biol Cryst Commun; 2008 May; 64(Pt 5):343-50. PubMed ID: 18453700
[TBL] [Abstract][Full Text] [Related]
16. Selective Inhibitors of Helicobacter pylori Methylthioadenosine Nucleosidase and Human Methylthioadenosine Phosphorylase.
Harijan RK; Hoff O; Ducati RG; Firestone RS; Hirsch BM; Evans GB; Schramm VL; Tyler PC
J Med Chem; 2019 Apr; 62(7):3286-3296. PubMed ID: 30860833
[TBL] [Abstract][Full Text] [Related]
17. Picomolar transition state analogue inhibitors of human 5'-methylthioadenosine phosphorylase and X-ray structure with MT-immucillin-A.
Singh V; Shi W; Evans GB; Tyler PC; Furneaux RH; Almo SC; Schramm VL
Biochemistry; 2004 Jan; 43(1):9-18. PubMed ID: 14705926
[TBL] [Abstract][Full Text] [Related]
18. Catalytic site cooperativity in dimeric methylthioadenosine nucleosidase.
Wang S; Thomas K; Schramm VL
Biochemistry; 2014 Mar; 53(9):1527-35. PubMed ID: 24502544
[TBL] [Abstract][Full Text] [Related]
19. Picomolar inhibitors as transition-state probes of 5'-methylthioadenosine nucleosidases.
Gutierrez JA; Luo M; Singh V; Li L; Brown RL; Norris GE; Evans GB; Furneaux RH; Tyler PC; Painter GF; Lenz DH; Schramm VL
ACS Chem Biol; 2007 Nov; 2(11):725-34. PubMed ID: 18030989
[TBL] [Abstract][Full Text] [Related]
20. Structure of E. coli 5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase reveals similarity to the purine nucleoside phosphorylases.
Lee JE; Cornell KA; Riscoe MK; Howell PL
Structure; 2001 Oct; 9(10):941-53. PubMed ID: 11591349
[TBL] [Abstract][Full Text] [Related]
[Next] [New Search]
