225 related articles for article (PubMed ID: 22934984)
1. Discovery of novel scaffolds for Rho kinase 2 inhibitor through TRFRET-based high throughput screening assay.
Oh KS; Mun J; Cho JE; Lee S; Yi KY; Lim CJ; Lee JS; Park WJ; Lee BH
Comb Chem High Throughput Screen; 2013 Jan; 16(1):37-46. PubMed ID: 22934984
[TBL] [Abstract][Full Text] [Related]
2. Comparison of miniaturized time-resolved fluorescence resonance energy transfer and enzyme-coupled luciferase high-throughput screening assays to discover inhibitors of Rho-kinase II (ROCK-II).
Schröter T; Minond D; Weiser A; Dao C; Habel J; Spicer T; Chase P; Baillargeon P; Scampavia L; Schürer S; Chung C; Mader C; Southern M; Tsinoremas N; LoGrasso P; Hodder P
J Biomol Screen; 2008 Jan; 13(1):17-28. PubMed ID: 18227223
[TBL] [Abstract][Full Text] [Related]
3. Identification of novel scaffolds for IκB kinase beta inhibitor via a high-throughput screening TR-FRET assay.
Oh KS; Lee S; Choi JK; Lee BH
Comb Chem High Throughput Screen; 2010 Nov; 13(9):790-7. PubMed ID: 20615197
[TBL] [Abstract][Full Text] [Related]
4. A real-time, fluorescence-based assay for Rho-associated protein kinase activity.
Kelly MI; Bechtel TJ; Reddy DR; Hankore ED; Beck JR; Stains CI
Anal Chim Acta; 2015 Sep; 891():284-90. PubMed ID: 26388388
[TBL] [Abstract][Full Text] [Related]
5. Design of novel rho kinase inhibitors using energy based pharmacophore modeling, shape-based screening, in silico virtual screening, and biological evaluation.
Mishra RK; Alokam R; Singhal SM; Srivathsav G; Sriram D; Kaushik-Basu N; Manvar D; Yogeeswari P
J Chem Inf Model; 2014 Oct; 54(10):2876-86. PubMed ID: 25254429
[TBL] [Abstract][Full Text] [Related]
6. Integration of virtual screening with high-throughput screening for the identification of novel Rho-kinase I inhibitors.
Gong LL; Fang LH; Peng JH; Liu AL; Du GH
J Biotechnol; 2010 Feb; 145(3):295-303. PubMed ID: 19963024
[TBL] [Abstract][Full Text] [Related]
7. A Dual Readout Assay Based on Fluorescence Polarization and Time-Resolved Fluorescence Resonance Energy Transfer to Screen for RSK1 Inhibitors.
Jeong EM; Lee MY; Lee JH; Lee BH; Oh KS
Biol Pharm Bull; 2016; 39(4):547-55. PubMed ID: 27040627
[TBL] [Abstract][Full Text] [Related]
8. High-throughput screening against ~6.1 million structurally diverse, lead-like compounds to discover novel ROCK inhibitors for cerebral injury recovery.
Gong H; Yuan Z; Zhan L
Mol Divers; 2016 May; 20(2):537-49. PubMed ID: 26700101
[TBL] [Abstract][Full Text] [Related]
9. Development, validation and implementation of immobilized metal affinity for phosphochemicals (IMAP)-based high-throughput screening assays for low-molecular-weight compound libraries.
Sharlow ER; Leimgruber S; Yellow-Duke A; Barrett R; Wang QJ; Lazo JS
Nat Protoc; 2008; 3(8):1350-63. PubMed ID: 18714303
[TBL] [Abstract][Full Text] [Related]
10. Development of a High-Throughput Assay for Inhibitors of the Polo-Box Domain of Polo-Like Kinase 1 Based on Time-Resolved Fluorescence Energy Transfer.
Kim TG; Lee JH; Lee MY; Kim KU; Lee JH; Park CH; Lee BH; Oh KS
Biol Pharm Bull; 2017; 40(9):1454-1462. PubMed ID: 28867728
[TBL] [Abstract][Full Text] [Related]
11. Stepwise high-throughput virtual screening of Rho kinase inhibitors from natural product library and potential therapeutics for pulmonary hypertension.
Su H; Yan J; Xu J; Fan XZ; Sun XL; Chen KY
Pharm Biol; 2015 Aug; 53(8):1201-6. PubMed ID: 25853972
[TBL] [Abstract][Full Text] [Related]
12. Analysis of Iterative Screening with Stepwise Compound Selection Based on Novartis In-house HTS Data.
Paricharak S; IJzerman AP; Bender A; Nigsch F
ACS Chem Biol; 2016 May; 11(5):1255-64. PubMed ID: 26878899
[TBL] [Abstract][Full Text] [Related]
13. Multi-objective Optimization of Benzamide Derivatives as Rho Kinase Inhibitors.
Cardoso Gajo G; Rodrigues Silva D; Barigye SJ; da Cunha EFF
Mol Inform; 2018 Mar; 37(3):. PubMed ID: 28876533
[TBL] [Abstract][Full Text] [Related]
14. Hit to lead account of the discovery of bisbenzamide and related ureidobenzamide inhibitors of Rho kinase.
Morwick T; Büttner FH; Cywin CL; Dahmann G; Hickey E; Jakes S; Kaplita P; Kashem MA; Kerr S; Kugler S; Mao W; Marshall D; Paw Z; Shih CK; Wu F; Young E
J Med Chem; 2010 Jan; 53(2):759-77. PubMed ID: 20000469
[TBL] [Abstract][Full Text] [Related]
15. A high-throughput screen reveals new small-molecule activators and inhibitors of pantothenate kinases.
Sharma LK; Leonardi R; Lin W; Boyd VA; Goktug A; Shelat AA; Chen T; Jackowski S; Rock CO
J Med Chem; 2015 Feb; 58(3):1563-8. PubMed ID: 25569308
[TBL] [Abstract][Full Text] [Related]
16. High-content screening of feeder-free human embryonic stem cells to identify pro-survival small molecules.
Andrews PD; Becroft M; Aspegren A; Gilmour J; James MJ; McRae S; Kime R; Allcock RW; Abraham A; Jiang Z; Strehl R; Mountford JC; Milligan G; Houslay MD; Adams DR; Frearson JA
Biochem J; 2010 Nov; 432(1):21-33. PubMed ID: 20854259
[TBL] [Abstract][Full Text] [Related]
17. Discovery of a novel ROCK2 inhibitor with anti-migration effects via docking and high-content drug screening.
Chong CM; Kou MT; Pan P; Zhou H; Ai N; Li C; Zhong HJ; Leung CH; Hou T; Lee SM
Mol Biosyst; 2016 Aug; 12(9):2713-21. PubMed ID: 27354305
[TBL] [Abstract][Full Text] [Related]
18. Screening Library Design.
Ashenden SK
Methods Enzymol; 2018; 610():73-96. PubMed ID: 30390806
[TBL] [Abstract][Full Text] [Related]
19. Time-Resolved Fluorescence Resonance Energy Transfer Assay for Discovery of Small-Molecule Inhibitors of Methyl-CpG Binding Domain Protein 2.
Wyhs N; Walker D; Giovinazzo H; Yegnasubramanian S; Nelson WG
J Biomol Screen; 2014 Aug; 19(7):1060-9. PubMed ID: 24608100
[TBL] [Abstract][Full Text] [Related]
20. Fluorescence labels in kinases: a high-throughput kinase binding assay for the identification of DFG-out binding ligands.
Simard JR; Rauh D
Methods Mol Biol; 2012; 800():95-117. PubMed ID: 21964785
[TBL] [Abstract][Full Text] [Related]
[Next] [New Search]
