BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

339 related articles for article (PubMed ID: 22939618)

  • 1. Single-stranded siRNAs activate RNAi in animals.
    Lima WF; Prakash TP; Murray HM; Kinberger GA; Li W; Chappell AE; Li CS; Murray SF; Gaus H; Seth PP; Swayze EE; Crooke ST
    Cell; 2012 Aug; 150(5):883-94. PubMed ID: 22939618
    [TBL] [Abstract][Full Text] [Related]  

  • 2. 5'-(E)-Vinylphosphonate: A Stable Phosphate Mimic Can Improve the RNAi Activity of siRNA-GalNAc Conjugates.
    Parmar R; Willoughby JL; Liu J; Foster DJ; Brigham B; Theile CS; Charisse K; Akinc A; Guidry E; Pei Y; Strapps W; Cancilla M; Stanton MG; Rajeev KG; Sepp-Lorenzino L; Manoharan M; Meyers R; Maier MA; Jadhav V
    Chembiochem; 2016 Jun; 17(11):985-9. PubMed ID: 27121751
    [TBL] [Abstract][Full Text] [Related]  

  • 3. 5΄-Vinylphosphonate improves tissue accumulation and efficacy of conjugated siRNAs in vivo.
    Haraszti RA; Roux L; Coles AH; Turanov AA; Alterman JF; Echeverria D; Godinho BMDC; Aronin N; Khvorova A
    Nucleic Acids Res; 2017 Jul; 45(13):7581-7592. PubMed ID: 28591791
    [TBL] [Abstract][Full Text] [Related]  

  • 4. Identification of metabolically stable 5'-phosphate analogs that support single-stranded siRNA activity.
    Prakash TP; Lima WF; Murray HM; Li W; Kinberger GA; Chappell AE; Gaus H; Seth PP; Bhat B; Crooke ST; Swayze EE
    Nucleic Acids Res; 2015 Mar; 43(6):2993-3011. PubMed ID: 25753666
    [TBL] [Abstract][Full Text] [Related]  

  • 5. Relative Quantification of siRNA Strand Loading into Ago2 for Design of Highly Active siRNAs.
    Angart PA; Adu-Berchie K; Carlson RJ; Vocelle DB; Chan C; Walton SP
    Methods Mol Biol; 2019; 1974():41-56. PubMed ID: 31098994
    [TBL] [Abstract][Full Text] [Related]  

  • 6. siRNA carrying an (E)-vinylphosphonate moiety at the 5΄ end of the guide strand augments gene silencing by enhanced binding to human Argonaute-2.
    Elkayam E; Parmar R; Brown CR; Willoughby JL; Theile CS; Manoharan M; Joshua-Tor L
    Nucleic Acids Res; 2017 Apr; 45(6):3528-3536. PubMed ID: 27903888
    [TBL] [Abstract][Full Text] [Related]  

  • 7. Induction of RNAi Responses by Short Left-Handed Hairpin RNAi Triggers.
    Hagopian JC; Hamil AS; van den Berg A; Meade BR; Eguchi A; Palm-Apergi C; Dowdy SF
    Nucleic Acid Ther; 2017 Oct; 27(5):260-271. PubMed ID: 28933656
    [TBL] [Abstract][Full Text] [Related]  

  • 8. Competition potency of siRNA is specified by the 5'-half sequence of the guide strand.
    Yoo JW; Kim S; Lee DK
    Biochem Biophys Res Commun; 2008 Feb; 367(1):78-83. PubMed ID: 18164261
    [TBL] [Abstract][Full Text] [Related]  

  • 9. Conversion of pre-RISC to holo-RISC by Ago2 during assembly of RNAi complexes.
    Kim K; Lee YS; Carthew RW
    RNA; 2007 Jan; 13(1):22-9. PubMed ID: 17123955
    [TBL] [Abstract][Full Text] [Related]  

  • 10. The 5' binding MID domain of human Argonaute2 tolerates chemically modified nucleotide analogues.
    Deleavey GF; Frank F; Hassler M; Wisnovsky S; Nagar B; Damha MJ
    Nucleic Acid Ther; 2013 Feb; 23(1):81-7. PubMed ID: 23289589
    [TBL] [Abstract][Full Text] [Related]  

  • 11. siRNA potency enhancement via chemical modifications of nucleotide bases at the 5'-end of the siRNA guide strand.
    Shinohara F; Oashi T; Harumoto T; Nishikawa T; Takayama Y; Miyagi H; Takahashi Y; Nakajima T; Sawada T; Koda Y; Makino A; Sato A; Hamaguchi K; Suzuki M; Yamamoto J; Tomari Y; Saito JI
    RNA; 2021 Feb; 27(2):163-173. PubMed ID: 33177188
    [TBL] [Abstract][Full Text] [Related]  

  • 12. Investigation of Strand-Selective Interaction of SNA-Modified siRNA with AGO2-MID.
    Kamiya Y; Takeyama Y; Mizuno T; Satoh F; Asanuma H
    Int J Mol Sci; 2020 Jul; 21(15):. PubMed ID: 32717920
    [TBL] [Abstract][Full Text] [Related]  

  • 13. High potency silencing by single-stranded boranophosphate siRNA.
    Hall AH; Wan J; Spesock A; Sergueeva Z; Shaw BR; Alexander KA
    Nucleic Acids Res; 2006; 34(9):2773-81. PubMed ID: 16717282
    [TBL] [Abstract][Full Text] [Related]  

  • 14. Terminal Duplex Stability and Nucleotide Identity Differentially Control siRNA Loading and Activity in RNA Interference.
    Angart PA; Carlson RJ; Adu-Berchie K; Walton SP
    Nucleic Acid Ther; 2016 Oct; 26(5):309-317. PubMed ID: 27399870
    [TBL] [Abstract][Full Text] [Related]  

  • 15. Effects of Chemical Modifications on siRNA Strand Selection in Mammalian Cells.
    Varley AJ; Hammill ML; Salim L; Desaulniers JP
    Nucleic Acid Ther; 2020 Aug; 30(4):229-236. PubMed ID: 32175808
    [TBL] [Abstract][Full Text] [Related]  

  • 16. Re-Engineering RNA Molecules into Therapeutic Agents.
    Egli M; Manoharan M
    Acc Chem Res; 2019 Apr; 52(4):1036-1047. PubMed ID: 30912917
    [TBL] [Abstract][Full Text] [Related]  

  • 17. Probing the Binding Interactions between Chemically Modified siRNAs and Human Argonaute 2 Using Microsecond Molecular Dynamics Simulations.
    Harikrishna S; Pradeepkumar PI
    J Chem Inf Model; 2017 Apr; 57(4):883-896. PubMed ID: 28287733
    [TBL] [Abstract][Full Text] [Related]  

  • 18. Differences in silencing of mismatched targets by sliced versus diced siRNAs.
    Sun G; Wang J; Huang Y; Yuan CW; Zhang K; Hu S; Chen L; Lin RJ; Yen Y; Riggs AD
    Nucleic Acids Res; 2018 Jul; 46(13):6806-6822. PubMed ID: 29718312
    [TBL] [Abstract][Full Text] [Related]  

  • 19. Structurally modulated codelivery of siRNA and Argonaute 2 for enhanced RNA interference.
    Li J; Wu C; Wang W; He Y; Elkayam E; Joshua-Tor L; Hammond PT
    Proc Natl Acad Sci U S A; 2018 Mar; 115(12):E2696-E2705. PubMed ID: 29432194
    [TBL] [Abstract][Full Text] [Related]  

  • 20. Loading of Argonaute Protein with Small Duplex RNA in Cellular Extracts.
    Gagnon KT
    Methods Mol Biol; 2016; 1421():53-67. PubMed ID: 26965257
    [TBL] [Abstract][Full Text] [Related]  

    [Next]    [New Search]
    of 17.