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5. Concurrent Inhibition of Pim and FLT3 Kinases Enhances Apoptosis of FLT3-ITD Acute Myeloid Leukemia Cells through Increased Mcl-1 Proteasomal Degradation. Kapoor S; Natarajan K; Baldwin PR; Doshi KA; Lapidus RG; Mathias TJ; Scarpa M; Trotta R; Davila E; Kraus M; Huszar D; Tron AE; Perrotti D; Baer MR Clin Cancer Res; 2018 Jan; 24(1):234-247. PubMed ID: 29074603 [No Abstract] [Full Text] [Related]
6. Reversal of acquired drug resistance in FLT3-mutated acute myeloid leukemia cells via distinct drug combination strategies. Zhang W; Gao C; Konopleva M; Chen Y; Jacamo RO; Borthakur G; Cortes JE; Ravandi F; Ramachandran A; Andreeff M Clin Cancer Res; 2014 May; 20(9):2363-74. PubMed ID: 24619500 [TBL] [Abstract][Full Text] [Related]
7. H2O2 production downstream of FLT3 is mediated by p22phox in the endoplasmic reticulum and is required for STAT5 signalling. Woolley JF; Naughton R; Stanicka J; Gough DR; Bhatt L; Dickinson BC; Chang CJ; Cotter TG PLoS One; 2012; 7(7):e34050. PubMed ID: 22807997 [TBL] [Abstract][Full Text] [Related]
8. CCL5 mediates target-kinase independent resistance to FLT3 inhibitors in FLT3-ITD-positive AML. Waldeck S; Rassner M; Keye P; Follo M; Herchenbach D; Endres C; Charlet A; Andrieux G; Salzer U; Boerries M; Duyster J; von Bubnoff N Mol Oncol; 2020 Apr; 14(4):779-794. PubMed ID: 31955503 [TBL] [Abstract][Full Text] [Related]
9. Activity of ponatinib against clinically-relevant AC220-resistant kinase domain mutants of FLT3-ITD. Smith CC; Lasater EA; Zhu X; Lin KC; Stewart WK; Damon LE; Salerno S; Shah NP Blood; 2013 Apr; 121(16):3165-71. PubMed ID: 23430109 [TBL] [Abstract][Full Text] [Related]
10. All-trans retinoic acid synergizes with FLT3 inhibition to eliminate FLT3/ITD+ leukemia stem cells in vitro and in vivo. Ma HS; Greenblatt SM; Shirley CM; Duffield AS; Bruner JK; Li L; Nguyen B; Jung E; Aplan PD; Ghiaur G; Jones RJ; Small D Blood; 2016 Jun; 127(23):2867-78. PubMed ID: 27103744 [TBL] [Abstract][Full Text] [Related]
11. Over-expression of FoxM1 is associated with adverse prognosis and FLT3-ITD in acute myeloid leukemia. Liu LL; Zhang DH; Mao X; Zhang XH; Zhang B Biochem Biophys Res Commun; 2014 Mar; 446(1):280-5. PubMed ID: 24582753 [TBL] [Abstract][Full Text] [Related]
12. Quizartinib (AC220): a promising option for acute myeloid leukemia. Zhou F; Ge Z; Chen B Drug Des Devel Ther; 2019; 13():1117-1125. PubMed ID: 31114157 [TBL] [Abstract][Full Text] [Related]
13. Cabozantinib is selectively cytotoxic in acute myeloid leukemia cells with FLT3-internal tandem duplication (FLT3-ITD). Lu JW; Wang AN; Liao HA; Chen CY; Hou HA; Hu CY; Tien HF; Ou DL; Lin LI Cancer Lett; 2016 Jul; 376(2):218-25. PubMed ID: 27060207 [TBL] [Abstract][Full Text] [Related]
14. Combination of the histone deacetylase inhibitor LBH589 and the hsp90 inhibitor 17-AAG is highly active against human CML-BC cells and AML cells with activating mutation of FLT-3. George P; Bali P; Annavarapu S; Scuto A; Fiskus W; Guo F; Sigua C; Sondarva G; Moscinski L; Atadja P; Bhalla K Blood; 2005 Feb; 105(4):1768-76. PubMed ID: 15514006 [TBL] [Abstract][Full Text] [Related]
15. Dasatinib overcomes stroma-based resistance to the FLT3 inhibitor quizartinib using multiple mechanisms. Patel AB; Pomicter AD; Yan D; Eiring AM; Antelope O; Schumacher JA; Kelley TW; Tantravahi SK; Kovacsovics TJ; Shami PJ; O'Hare T; Deininger MW Leukemia; 2020 Nov; 34(11):2981-2991. PubMed ID: 32409689 [TBL] [Abstract][Full Text] [Related]
16. DNA repair contributes to the drug-resistant phenotype of primary acute myeloid leukaemia cells with FLT3 internal tandem duplications and is reversed by the FLT3 inhibitor PKC412. Seedhouse CH; Hunter HM; Lloyd-Lewis B; Massip AM; Pallis M; Carter GI; Grundy M; Shang S; Russell NH Leukemia; 2006 Dec; 20(12):2130-6. PubMed ID: 17066094 [TBL] [Abstract][Full Text] [Related]
17. FLT3 activating mutations display differential sensitivity to multiple tyrosine kinase inhibitors. Nguyen B; Williams AB; Young DJ; Ma H; Li L; Levis M; Brown P; Small D Oncotarget; 2017 Feb; 8(7):10931-10944. PubMed ID: 28077790 [TBL] [Abstract][Full Text] [Related]
18. FLT3 inhibition upregulates HDAC8 via FOXO to inactivate p53 and promote maintenance of FLT3-ITD+ acute myeloid leukemia. Long J; Jia MY; Fang WY; Chen XJ; Mu LL; Wang ZY; Shen Y; Xiang RF; Wang LN; Wang L; Jiang CH; Jiang JL; Zhang WJ; Sun YD; Chang L; Gao WH; Wang Y; Li JM; Hong DL; Liang AB; Hu J Blood; 2020 Apr; 135(17):1472-1483. PubMed ID: 32315388 [TBL] [Abstract][Full Text] [Related]
19. Bis(1H-indol-2-yl)methanones are effective inhibitors of FLT3-ITD tyrosine kinase and partially overcome resistance to PKC412A in vitro. Heidel F; Lipka DB; Mirea FK; Mahboobi S; Grundler R; Kancha RK; Duyster J; Naumann M; Huber C; Böhmer FD; Fischer T Br J Haematol; 2009 Mar; 144(6):865-74. PubMed ID: 19183186 [TBL] [Abstract][Full Text] [Related]
20. Inhibitors of class I HDACs and of FLT3 combine synergistically against leukemia cells with mutant FLT3. Wachholz V; Mustafa AM; Zeyn Y; Henninger SJ; Beyer M; Dzulko M; Piée-Staffa A; Brachetti C; Haehnel PS; Sellmer A; Mahboobi S; Kindler T; Brenner W; Nikolova T; Krämer OH Arch Toxicol; 2022 Jan; 96(1):177-193. PubMed ID: 34665271 [TBL] [Abstract][Full Text] [Related] [Next] [New Search]