BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

140 related articles for article (PubMed ID: 22946514)

  • 1. Theoretical studies of chemical reactivity of metabolically activated forms of aromatic amines toward DNA.
    Shamovsky I; Ripa L; Blomberg N; Eriksson LA; Hansen P; Mee C; Tyrchan C; O'Donovan M; Sjö P
    Chem Res Toxicol; 2012 Oct; 25(10):2236-52. PubMed ID: 22946514
    [TBL] [Abstract][Full Text] [Related]  

  • 2. Explanation for main features of structure-genotoxicity relationships of aromatic amines by theoretical studies of their activation pathways in CYP1A2.
    Shamovsky I; Ripa L; Börjesson L; Mee C; Nordén B; Hansen P; Hasselgren C; O'Donovan M; Sjö P
    J Am Chem Soc; 2011 Oct; 133(40):16168-85. PubMed ID: 21894985
    [TBL] [Abstract][Full Text] [Related]  

  • 3. Mechanisms of cytochrome P450 1A2-mediated formation of N-hydroxy arylamines and heterocyclic amines and their reaction with guanyl residues.
    Guengerich FP; Humphreys WG; Yun CH; Hammons GJ; Kadlubar FF; Seto Y; Okazaki O; Martin MV
    Princess Takamatsu Symp; 1995; 23():78-84. PubMed ID: 8844798
    [TBL] [Abstract][Full Text] [Related]  

  • 4. Mechanism-Based Insights into Removing the Mutagenicity of Aromatic Amines by Small Structural Alterations.
    Shamovsky I; Ripa L; Narjes F; Bonn B; Schiesser S; Terstiege I; Tyrchan C
    J Med Chem; 2021 Jun; 64(12):8545-8563. PubMed ID: 34110134
    [TBL] [Abstract][Full Text] [Related]  

  • 5. Relative stabilities of nitrenium ions derived from polycyclic aromatic amines. Relationship to mutagenicity.
    Ford GP; Herman PS
    Chem Biol Interact; 1992 Jan; 81(1-2):1-18. PubMed ID: 1730143
    [TBL] [Abstract][Full Text] [Related]  

  • 6. Identification and characterization of novel stable deoxyguanosine and deoxyadenosine adducts of benzo[a]pyrene-7,8-quinone from reactions at physiological pH.
    Balu N; Padgett WT; Lambert GR; Swank AE; Richard AM; Nesnow S
    Chem Res Toxicol; 2004 Jun; 17(6):827-38. PubMed ID: 15206904
    [TBL] [Abstract][Full Text] [Related]  

  • 7. Direct time-resolved spectroscopic observation of arylnitrenium ion reactions with guanine-containing DNA oligomers.
    Xue J; Du L; Zhu R; Huang J; Phillips DL
    J Org Chem; 2014 Apr; 79(8):3610-4. PubMed ID: 24665944
    [TBL] [Abstract][Full Text] [Related]  

  • 8. Mutagenic properties of 3-(deoxyguanosin-N2-yl)-2-acetylaminofluorene, a persistent acetylaminofluorene-derived DNA adduct in mammalian cells.
    Yasui M; Dong H; Bonala RR; Suzuki N; Ohmori H; Hanaoka F; Johnson F; Grollman AP; Shibutani S
    Biochemistry; 2004 Nov; 43(47):15005-13. PubMed ID: 15554708
    [TBL] [Abstract][Full Text] [Related]  

  • 9. Synthesis and decomposition of an ester derivative of the procarcinogen and promutagen, PhIP, 2-amino-1-methyl-6-phenyl-1H-imidazo[4,5-b]pyridine: unusual nitrenium ion chemistry.
    Nguyen TM; Novak M
    J Org Chem; 2007 Jun; 72(13):4698-706. PubMed ID: 17542636
    [TBL] [Abstract][Full Text] [Related]  

  • 10. Mechanisms of formation of 8-oxoguanine due to reactions of one and two OH* radicals and the H2O2 molecule with guanine: A quantum computational study.
    Jena NR; Mishra PC
    J Phys Chem B; 2005 Jul; 109(29):14205-18. PubMed ID: 16852784
    [TBL] [Abstract][Full Text] [Related]  

  • 11. Ultimate carcinogenic metabolites from aromatic and heterocyclic aromatic amines: a computational study in relation to their mutagenic potency.
    Borosky GL
    Chem Res Toxicol; 2007 Feb; 20(2):171-80. PubMed ID: 17261035
    [TBL] [Abstract][Full Text] [Related]  

  • 12. Avoidance of the Ames test liability for aryl-amines via computation.
    McCarren P; Bebernitz GR; Gedeck P; Glowienke S; Grondine MS; Kirman LC; Klickstein J; Schuster HF; Whitehead L
    Bioorg Med Chem; 2011 May; 19(10):3173-82. PubMed ID: 21524589
    [TBL] [Abstract][Full Text] [Related]  

  • 13. Insight into mechanism of formation of c8 adducts in carcinogenic reactions of arylnitrenium ions with purine nucleosides.
    Yang ZZ; Qi SF; Zhao DX; Gong LD
    J Phys Chem B; 2009 Jan; 113(1):254-9. PubMed ID: 19072693
    [TBL] [Abstract][Full Text] [Related]  

  • 14. Effect of substitution site upon the oxidation potentials of alkylanilines, the mutagenicities of N-hydroxyalkylanilines, and the conformations of alkylaniline-DNA adducts.
    Marques MM; Mourato LL; Amorim MT; Santos MA; Melchior WB; Beland FA
    Chem Res Toxicol; 1997 Nov; 10(11):1266-74. PubMed ID: 9403181
    [TBL] [Abstract][Full Text] [Related]  

  • 15. Effect of ring size on conformations of aromatic amine-DNA adducts: the aniline-C8 guanine adduct resides in the B-DNA major groove.
    Shapiro R; Ellis S; Hingerty BE; Broyde S
    Chem Res Toxicol; 1998 Apr; 11(4):335-41. PubMed ID: 9548804
    [TBL] [Abstract][Full Text] [Related]  

  • 16. Mechanistic insights into the Michael addition of deoxyguanosine to catechol estrogen-3,4-quinones.
    Stack DE; Li G; Hill A; Hoffman N
    Chem Res Toxicol; 2008 Jul; 21(7):1415-25. PubMed ID: 18547067
    [TBL] [Abstract][Full Text] [Related]  

  • 17. Theoretical studies of the mechanism of N-hydroxylation of primary aromatic amines by cytochrome P450 1A2: radicaloid or anionic?
    Ripa L; Mee C; Sjö P; Shamovsky I
    Chem Res Toxicol; 2014 Feb; 27(2):265-78. PubMed ID: 24410629
    [TBL] [Abstract][Full Text] [Related]  

  • 18. Solution structure of an O6-[4-oxo-4-(3-pyridyl)butyl]guanine adduct in an 11 mer DNA duplex: evidence for formation of a base triplex.
    Peterson LA; Vu C; Hingerty BE; Broyde S; Cosman M
    Biochemistry; 2003 Nov; 42(45):13134-44. PubMed ID: 14609323
    [TBL] [Abstract][Full Text] [Related]  

  • 19. HPLC-ESI+-MS/MS analysis of N7-guanine-N7-guanine DNA cross-links in tissues of mice exposed to 1,3-butadiene.
    Goggin M; Loeber R; Park S; Walker V; Wickliffe J; Tretyakova N
    Chem Res Toxicol; 2007 May; 20(5):839-47. PubMed ID: 17455958
    [TBL] [Abstract][Full Text] [Related]  

  • 20. Lactoperoxidase-catalyzed activation of carcinogenic aromatic and heterocyclic amines.
    Gorlewska-Roberts KM; Teitel CH; Lay JO; Roberts DW; Kadlubar FF
    Chem Res Toxicol; 2004 Dec; 17(12):1659-66. PubMed ID: 15606142
    [TBL] [Abstract][Full Text] [Related]  

    [Next]    [New Search]
    of 7.