These tools will no longer be maintained as of December 31, 2024. Archived website can be found here. PubMed4Hh GitHub repository can be found here. Contact NLM Customer Service if you have questions.
2. Virtual screening identification of nonfolate compounds, including a CNS drug, as antiparasitic agents inhibiting pteridine reductase. Ferrari S; Morandi F; Motiejunas D; Nerini E; Henrich S; Luciani R; Venturelli A; Lazzari S; Calò S; Gupta S; Hannaert V; Michels PA; Wade RC; Costi MP J Med Chem; 2011 Jan; 54(1):211-21. PubMed ID: 21126022 [TBL] [Abstract][Full Text] [Related]
3. Biochemical effects of riluzole on Leishmania parasites. Guerrieri D; Ferrari S; Costi MP; Michels PA Exp Parasitol; 2013 Mar; 133(3):250-4. PubMed ID: 23206955 [TBL] [Abstract][Full Text] [Related]
4. Discovery of potent pteridine reductase inhibitors to guide antiparasite drug development. Cavazzuti A; Paglietti G; Hunter WN; Gamarro F; Piras S; Loriga M; Allecca S; Corona P; McLuskey K; Tulloch L; Gibellini F; Ferrari S; Costi MP Proc Natl Acad Sci U S A; 2008 Feb; 105(5):1448-53. PubMed ID: 18245389 [TBL] [Abstract][Full Text] [Related]
5. Biochemical and genetic tests for inhibitors of Leishmania pteridine pathways. Hardy LW; Matthews W; Nare B; Beverley SM Exp Parasitol; 1997 Nov; 87(3):157-69. PubMed ID: 9371081 [TBL] [Abstract][Full Text] [Related]
6. New approaches to Leishmania chemotherapy: pteridine reductase 1 (PTR1) as a target and modulator of antifolate sensitivity. Nare B; Luba J; Hardy LW; Beverley S Parasitology; 1997; 114 Suppl():S101-10. PubMed ID: 9309772 [TBL] [Abstract][Full Text] [Related]
7. An integrated approach towards the discovery of novel non-nucleoside Leishmania major pteridine reductase 1 inhibitors. Leite FHA; Froes TQ; da Silva SG; de Souza EIM; Vital-Fujii DG; Trossini GHG; Pita SSDR; Castilho MS Eur J Med Chem; 2017 May; 132():322-332. PubMed ID: 28407565 [TBL] [Abstract][Full Text] [Related]
8. Structures of Leishmania major pteridine reductase complexes reveal the active site features important for ligand binding and to guide inhibitor design. Schüttelkopf AW; Hardy LW; Beverley SM; Hunter WN J Mol Biol; 2005 Sep; 352(1):105-16. PubMed ID: 16055151 [TBL] [Abstract][Full Text] [Related]
9. Structural Insights into the Development of Cycloguanil Derivatives as Landi G; Linciano P; Borsari C; Bertolacini CP; Moraes CB; Cordeiro-da-Silva A; Gul S; Witt G; Kuzikov M; Costi MP; Pozzi C; Mangani S ACS Infect Dis; 2019 Jul; 5(7):1105-1114. PubMed ID: 31012301 [TBL] [Abstract][Full Text] [Related]
10. The roles of pteridine reductase 1 and dihydrofolate reductase-thymidylate synthase in pteridine metabolism in the protozoan parasite Leishmania major. Nare B; Hardy LW; Beverley SM J Biol Chem; 1997 May; 272(21):13883-91. PubMed ID: 9153248 [TBL] [Abstract][Full Text] [Related]
12. Inhibition of Leishmania major pteridine reductase by 2,4,6-triaminoquinazoline: structure of the NADPH ternary complex. McLuskey K; Gibellini F; Carvalho P; Avery MA; Hunter WN Acta Crystallogr D Biol Crystallogr; 2004 Oct; 60(Pt 10):1780-5. PubMed ID: 15388924 [TBL] [Abstract][Full Text] [Related]
13. In Silico Identification and In Vitro Evaluation of Natural Inhibitors of Leishmania major Pteridine Reductase I. Herrmann FC; Sivakumar N; Jose J; Costi MP; Pozzi C; Schmidt TJ Molecules; 2017 Dec; 22(12):. PubMed ID: 29211037 [TBL] [Abstract][Full Text] [Related]
14. Biochemical and Genetic Tests for Inhibitors of Leishmania Pteridine Pathways. Hardy LW; Matthews W; Nare B; Beverley SM Exp Parasitol; 1997 Nov; 87(3):158-70. PubMed ID: 9398595 [TBL] [Abstract][Full Text] [Related]
15. Chroman-4-One Derivatives Targeting Pteridine Reductase 1 and Showing Anti-Parasitic Activity. Di Pisa F; Landi G; Dello Iacono L; Pozzi C; Borsari C; Ferrari S; Santucci M; Santarem N; Cordeiro-da-Silva A; Moraes CB; Alcantara LM; Fontana V; Freitas-Junior LH; Gul S; Kuzikov M; Behrens B; Pöhner I; Wade RC; Costi MP; Mangani S Molecules; 2017 Mar; 22(3):. PubMed ID: 28282886 [TBL] [Abstract][Full Text] [Related]
16. Leishmania major pteridine reductase 1 belongs to the short chain dehydrogenase family: stereochemical and kinetic evidence. Luba J; Nare B; Liang PH; Anderson KS; Beverley SM; Hardy LW Biochemistry; 1998 Mar; 37(12):4093-104. PubMed ID: 9521731 [TBL] [Abstract][Full Text] [Related]
17. Pteridine salvage throughout the Leishmania infectious cycle: implications for antifolate chemotherapy. Cunningham ML; Beverley SM Mol Biochem Parasitol; 2001 Apr; 113(2):199-213. PubMed ID: 11295174 [TBL] [Abstract][Full Text] [Related]
18. Structure-based design of pteridine reductase inhibitors targeting African sleeping sickness and the leishmaniases. Tulloch LB; Martini VP; Iulek J; Huggan JK; Lee JH; Gibson CL; Smith TK; Suckling CJ; Hunter WN J Med Chem; 2010 Jan; 53(1):221-9. PubMed ID: 19916554 [TBL] [Abstract][Full Text] [Related]