71 related articles for article (PubMed ID: 22950516)
1. Interconversion of active and inactive conformations of urokinase-type plasminogen activator.
Liu Z; Kromann-Hansen T; Lund IK; Hosseini M; Jensen KJ; Høyer-Hansen G; Andreasen PA; Sørensen HP
Biochemistry; 2012 Oct; 51(39):7804-11. PubMed ID: 22950516
[TBL] [Abstract][Full Text] [Related]
2. Allosteric inactivation of a trypsin-like serine protease by an antibody binding to the 37- and 70-loops.
Kromann-Hansen T; Lund IK; Liu Z; Andreasen PA; Høyer-Hansen G; Sørensen HP
Biochemistry; 2013 Oct; 52(40):7114-26. PubMed ID: 24079451
[TBL] [Abstract][Full Text] [Related]
3. A cyclic peptidylic inhibitor of murine urokinase-type plasminogen activator: changing species specificity by substitution of a single residue.
Andersen LM; Wind T; Hansen HD; Andreasen PA
Biochem J; 2008 Jun; 412(3):447-57. PubMed ID: 18318660
[TBL] [Abstract][Full Text] [Related]
4. Elucidation of the contribution of active site and exosite interactions to affinity and specificity of peptidylic serine protease inhibitors using non-natural arginine analogs.
Hosseini M; Jiang L; Sørensen HP; Jensen JK; Christensen A; Fogh S; Yuan C; Andersen LM; Huang M; Andreasen PA; Jensen KJ
Mol Pharmacol; 2011 Oct; 80(4):585-97. PubMed ID: 21719463
[TBL] [Abstract][Full Text] [Related]
5. Ligand binding modulates the structural dynamics and activity of urokinase-type plasminogen activator: A possible mechanism of plasminogen activation.
Kromann-Hansen T; Lange EL; Lund IK; Høyer-Hansen G; Andreasen PA; Komives EA
PLoS One; 2018; 13(2):e0192661. PubMed ID: 29420634
[TBL] [Abstract][Full Text] [Related]
6. Nonproteolytic induction of catalytic activity into the single-chain form of urokinase-type plasminogen activator by dipeptides.
Bøtkjaer KA; Byszuk AA; Andersen LM; Christensen A; Andreasen PA; Blouse GE
Biochemistry; 2009 Oct; 48(40):9606-17. PubMed ID: 19705874
[TBL] [Abstract][Full Text] [Related]
7. Discovery of a novel conformational equilibrium in urokinase-type plasminogen activator.
Kromann-Hansen T; Louise Lange E; Peter Sørensen H; Hassanzadeh-Ghassabeh G; Huang M; Jensen JK; Muyldermans S; Declerck PJ; Komives EA; Andreasen PA
Sci Rep; 2017 Jun; 7(1):3385. PubMed ID: 28611361
[TBL] [Abstract][Full Text] [Related]
8. Activation of the zymogen to urokinase-type plasminogen activator is associated with increased interdomain flexibility.
Behrens MA; Botkjaer KA; Goswami S; Oliveira CL; Jensen JK; Schar CR; Declerck PJ; Peterson CB; Andreasen PA; Pedersen JS
J Mol Biol; 2011 Aug; 411(2):417-29. PubMed ID: 21669207
[TBL] [Abstract][Full Text] [Related]
9. Distinctive binding modes and inhibitory mechanisms of two peptidic inhibitors of urokinase-type plasminogen activator with isomeric P1 residues.
Jiang L; Zhao B; Xu P; Sørensen HP; Jensen JK; Christensen A; Hosseini M; Nielsen NC; Jensen KJ; Andreasen PA; Huang M
Int J Biochem Cell Biol; 2015 May; 62():88-92. PubMed ID: 25744057
[TBL] [Abstract][Full Text] [Related]
10. A novel serine protease inhibition motif involving a multi-centered short hydrogen bonding network at the active site.
Katz BA; Elrod K; Luong C; Rice MJ; Mackman RL; Sprengeler PA; Spencer J; Hataye J; Janc J; Link J; Litvak J; Rai R; Rice K; Sideris S; Verner E; Young W
J Mol Biol; 2001 Apr; 307(5):1451-86. PubMed ID: 11292354
[TBL] [Abstract][Full Text] [Related]
11. Structural basis of specificity of a peptidyl urokinase inhibitor, upain-1.
Zhao G; Yuan C; Wind T; Huang Z; Andreasen PA; Huang M
J Struct Biol; 2007 Oct; 160(1):1-10. PubMed ID: 17692534
[TBL] [Abstract][Full Text] [Related]
12. Selection of High-Affinity Peptidic Serine Protease Inhibitors with Increased Binding Entropy from a Back-Flip Library of Peptide-Protease Fusions.
Sørensen HP; Xu P; Jiang L; Kromann-Hansen T; Jensen KJ; Huang M; Andreasen PA
J Mol Biol; 2015 Sep; 427(19):3110-22. PubMed ID: 26281711
[TBL] [Abstract][Full Text] [Related]
13. Structure of human pro-chymase: a model for the activating transition of granule-associated proteases.
Reiling KK; Krucinski J; Miercke LJ; Raymond WW; Caughey GH; Stroud RM
Biochemistry; 2003 Mar; 42(9):2616-24. PubMed ID: 12614156
[TBL] [Abstract][Full Text] [Related]
14. The 2.3 A crystal structure of the catalytic domain of recombinant two-chain human tissue-type plasminogen activator.
Lamba D; Bauer M; Huber R; Fischer S; Rudolph R; Kohnert U; Bode W
J Mol Biol; 1996 Apr; 258(1):117-35. PubMed ID: 8613982
[TBL] [Abstract][Full Text] [Related]
15. Cleavage of peptidic inhibitors by target protease is caused by peptide conformational transition.
Jiang L; Oldenburg E; Kromann-Hansen T; Xu P; Jensen JK; Andreasen PA; Huang M
Biochim Biophys Acta Gen Subj; 2018 Sep; 1862(9):2017-2023. PubMed ID: 29959058
[TBL] [Abstract][Full Text] [Related]
16. Binding areas of urokinase-type plasminogen activator-plasminogen activator inhibitor-1 complex for endocytosis receptors of the low-density lipoprotein receptor family, determined by site-directed mutagenesis.
Skeldal S; Larsen JV; Pedersen KE; Petersen HH; Egelund R; Christensen A; Jensen JK; Gliemann J; Andreasen PA
FEBS J; 2006 Nov; 273(22):5143-59. PubMed ID: 17042782
[TBL] [Abstract][Full Text] [Related]
17. The Light Chain Allosterically Enhances the Protease Activity of Murine Urokinase-Type Plasminogen Activator.
Torres-Paris C; Song HJ; Engelberger F; Ramírez-Sarmiento CA; Komives EA
Biochemistry; 2024 Jun; 63(11):1434-1444. PubMed ID: 38780522
[TBL] [Abstract][Full Text] [Related]
18. Structural Principles in the Development of Cyclic Peptidic Enzyme Inhibitors.
Xu P; Andreasen PA; Huang M
Int J Biol Sci; 2017; 13(10):1222-1233. PubMed ID: 29104489
[TBL] [Abstract][Full Text] [Related]
19. The crystal structure of the catalytic domain of human urokinase-type plasminogen activator.
Spraggon G; Phillips C; Nowak UK; Ponting CP; Saunders D; Dobson CM; Stuart DI; Jones EY
Structure; 1995 Jul; 3(7):681-91. PubMed ID: 8591045
[TBL] [Abstract][Full Text] [Related]
20. A site-directed mutagenesis of pro-urokinase which substantially reduces its intrinsic activity.
Liu JN; Tang W; Sun ZY; Kung W; Pannell R; Sarmientos P; Gurewich V
Biochemistry; 1996 Nov; 35(45):14070-6. PubMed ID: 8916892
[TBL] [Abstract][Full Text] [Related]
[Next] [New Search]
