BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

311 related articles for article (PubMed ID: 22950863)

  • 1. Evidence that enzyme processivity mediates differential Aβ production by PS1 and PS2.
    Pintchovski SA; Schenk DB; Basi GS
    Curr Alzheimer Res; 2013 Jan; 10(1):4-10. PubMed ID: 22950863
    [TBL] [Abstract][Full Text] [Related]  

  • 2. Different transmembrane domains determine the specificity and efficiency of the cleavage activity of the γ-secretase subunit presenilin.
    Schmidt FC; Fitz K; Feilen LP; Okochi M; Steiner H; Langosch D
    J Biol Chem; 2023 May; 299(5):104626. PubMed ID: 36944398
    [TBL] [Abstract][Full Text] [Related]  

  • 3. Specific combinations of presenilins and Aph1s affect the substrate specificity and activity of γ-secretase.
    Yonemura Y; Futai E; Yagishita S; Kaether C; Ishiura S
    Biochem Biophys Res Commun; 2016 Sep; 478(4):1751-7. PubMed ID: 27608597
    [TBL] [Abstract][Full Text] [Related]  

  • 4. Specificity of presenilin-1- and presenilin-2-dependent γ-secretases towards substrate processing.
    Stanga S; Vrancx C; Tasiaux B; Marinangeli C; Karlström H; Kienlen-Campard P
    J Cell Mol Med; 2018 Feb; 22(2):823-833. PubMed ID: 28994238
    [TBL] [Abstract][Full Text] [Related]  

  • 5. Comparison of presenilin 1 and presenilin 2 γ-secretase activities using a yeast reconstitution system.
    Yonemura Y; Futai E; Yagishita S; Suo S; Tomita T; Iwatsubo T; Ishiura S
    J Biol Chem; 2011 Dec; 286(52):44569-75. PubMed ID: 22074918
    [TBL] [Abstract][Full Text] [Related]  

  • 6. Minor contribution of presenilin 2 for γ-secretase activity in mouse embryonic fibroblasts and adult mouse brain.
    Frånberg J; Svensson AI; Winblad B; Karlström H; Frykman S
    Biochem Biophys Res Commun; 2011 Jan; 404(1):564-8. PubMed ID: 21146496
    [TBL] [Abstract][Full Text] [Related]  

  • 7. Quantitative comparison of presenilin protein expression reveals greater activity of PS2-γ-secretase.
    Eccles MK; Main N; Carlessi R; Armstrong AM; Sabale M; Roberts-Mok B; Tirnitz-Parker JEE; Agostino M; Groth D; Fraser PE; Verdile G
    FASEB J; 2024 Jan; 38(1):e23396. PubMed ID: 38156414
    [TBL] [Abstract][Full Text] [Related]  

  • 8. γ-Secretase complexes containing caspase-cleaved presenilin-1 increase intracellular Aβ(42) /Aβ(40) ratio.
    Hedskog L; Petersen CA; Svensson AI; Welander H; Tjernberg LO; Karlström H; Ankarcrona M
    J Cell Mol Med; 2011 Oct; 15(10):2150-63. PubMed ID: 21054783
    [TBL] [Abstract][Full Text] [Related]  

  • 9. Identification of presenilin 1-selective γ-secretase inhibitors with reconstituted γ-secretase complexes.
    Lee J; Song L; Terracina G; Bara T; Josien H; Asberom T; Sasikumar TK; Burnett DA; Clader J; Parker EM; Zhang L
    Biochemistry; 2011 Jun; 50(22):4973-80. PubMed ID: 21528914
    [TBL] [Abstract][Full Text] [Related]  

  • 10. Major carboxyl terminal fragments generated by γ-secretase processing of the Alzheimer amyloid precursor are 50 and 51 amino acids long.
    Pinnix I; Ghiso JA; Pappolla MA; Sambamurti K
    Am J Geriatr Psychiatry; 2013 May; 21(5):474-83. PubMed ID: 23570890
    [TBL] [Abstract][Full Text] [Related]  

  • 11. Conformational Models of APP Processing by Gamma Secretase Based on Analysis of Pathogenic Mutations.
    Kim M; Bezprozvanny I
    Int J Mol Sci; 2021 Dec; 22(24):. PubMed ID: 34948396
    [TBL] [Abstract][Full Text] [Related]  

  • 12. The transmembrane aspartates in presenilin 1 and 2 are obligatory for gamma-secretase activity and amyloid beta-protein generation.
    Kimberly WT; Xia W; Rahmati T; Wolfe MS; Selkoe DJ
    J Biol Chem; 2000 Feb; 275(5):3173-8. PubMed ID: 10652302
    [TBL] [Abstract][Full Text] [Related]  

  • 13. Dissociated phenotypes in presenilin transgenic mice define functionally distinct gamma-secretases.
    Mastrangelo P; Mathews PM; Chishti MA; Schmidt SD; Gu Y; Yang J; Mazzella MJ; Coomaraswamy J; Horne P; Strome B; Pelly H; Levesque G; Ebeling C; Jiang Y; Nixon RA; Rozmahel R; Fraser PE; St George-Hyslop P; Carlson GA; Westaway D
    Proc Natl Acad Sci U S A; 2005 Jun; 102(25):8972-7. PubMed ID: 15951428
    [TBL] [Abstract][Full Text] [Related]  

  • 14. Three-amino acid spacing of presenilin endoproteolysis suggests a general stepwise cleavage of gamma-secretase-mediated intramembrane proteolysis.
    Fukumori A; Fluhrer R; Steiner H; Haass C
    J Neurosci; 2010 Jun; 30(23):7853-62. PubMed ID: 20534834
    [TBL] [Abstract][Full Text] [Related]  

  • 15. Regulation of amyloid precursor protein processing by presenilin 1 (PS1) and PS2 in PS1 knockout cells.
    Palacino JJ; Berechid BE; Alexander P; Eckman C; Younkin S; Nye JS; Wolozin B
    J Biol Chem; 2000 Jan; 275(1):215-22. PubMed ID: 10617607
    [TBL] [Abstract][Full Text] [Related]  

  • 16. A presenilin-1 mutation identified in familial Alzheimer disease with cotton wool plaques causes a nearly complete loss of gamma-secretase activity.
    Heilig EA; Xia W; Shen J; Kelleher RJ
    J Biol Chem; 2010 Jul; 285(29):22350-9. PubMed ID: 20460383
    [TBL] [Abstract][Full Text] [Related]  

  • 17. Presenilin-1 mutations of leucine 166 equally affect the generation of the Notch and APP intracellular domains independent of their effect on Abeta 42 production.
    Moehlmann T; Winkler E; Xia X; Edbauer D; Murrell J; Capell A; Kaether C; Zheng H; Ghetti B; Haass C; Steiner H
    Proc Natl Acad Sci U S A; 2002 Jun; 99(12):8025-30. PubMed ID: 12048239
    [TBL] [Abstract][Full Text] [Related]  

  • 18. Flexible and Accurate Substrate Processing with Distinct Presenilin/γ-Secretases in Human Cortical Neurons.
    Watanabe H; Imaizumi K; Cai T; Zhou Z; Tomita T; Okano H
    eNeuro; 2021; 8(2):. PubMed ID: 33608391
    [TBL] [Abstract][Full Text] [Related]  

  • 19. γ-Secretase modulators exhibit selectivity for modulation of APP cleavage but inverse γ-secretase modulators do not.
    Lessard CB; Rodriguez E; Ladd TB; Minter LM; Osborne BA; Miele L; Golde TE; Ran Y
    Alzheimers Res Ther; 2020 May; 12(1):61. PubMed ID: 32430033
    [TBL] [Abstract][Full Text] [Related]  

  • 20. Cell-free generation of the notch1 intracellular domain (NICD) and APP-CTfgamma: evidence for distinct intramembranous "gamma-secretase" activities.
    Ikeuchi T; Sisodia SS
    Neuromolecular Med; 2002; 1(1):43-54. PubMed ID: 12025815
    [TBL] [Abstract][Full Text] [Related]  

    [Next]    [New Search]
    of 16.