308 related articles for article (PubMed ID: 22950863)
21. C-terminal maturation fragments of presenilin 1 and 2 control secretion of APP alpha and A beta by human cells and are degraded by proteasome.
da Costa CA; Ancolio K; Checler F
Mol Med; 1999 Mar; 5(3):160-8. PubMed ID: 10404513
[TBL] [Abstract][Full Text] [Related]
22. The large hydrophilic loop of presenilin 1 is important for regulating gamma-secretase complex assembly and dictating the amyloid beta peptide (Abeta) Profile without affecting Notch processing.
Wanngren J; Frånberg J; Svensson AI; Laudon H; Olsson F; Winblad B; Liu F; Näslund J; Lundkvist J; Karlström H
J Biol Chem; 2010 Mar; 285(12):8527-36. PubMed ID: 20106965
[TBL] [Abstract][Full Text] [Related]
23. Generation of Abeta38 and Abeta42 is independently and differentially affected by familial Alzheimer disease-associated presenilin mutations and gamma-secretase modulation.
Page RM; Baumann K; Tomioka M; Pérez-Revuelta BI; Fukumori A; Jacobsen H; Flohr A; Luebbers T; Ozmen L; Steiner H; Haass C
J Biol Chem; 2008 Jan; 283(2):677-83. PubMed ID: 17962197
[TBL] [Abstract][Full Text] [Related]
24. Presenilin 1 mutations activate gamma 42-secretase but reciprocally inhibit epsilon-secretase cleavage of amyloid precursor protein (APP) and S3-cleavage of notch.
Chen F; Gu Y; Hasegawa H; Ruan X; Arawaka S; Fraser P; Westaway D; Mount H; St George-Hyslop P
J Biol Chem; 2002 Sep; 277(39):36521-6. PubMed ID: 12119298
[TBL] [Abstract][Full Text] [Related]
25. Presenilin complexes with the C-terminal fragments of amyloid precursor protein at the sites of amyloid beta-protein generation.
Xia W; Ray WJ; Ostaszewski BL; Rahmati T; Kimberly WT; Wolfe MS; Zhang J; Goate AM; Selkoe DJ
Proc Natl Acad Sci U S A; 2000 Aug; 97(16):9299-304. PubMed ID: 10922078
[TBL] [Abstract][Full Text] [Related]
26. Dissociation between the processivity and total activity of γ-secretase: implications for the mechanism of Alzheimer's disease-causing presenilin mutations.
Quintero-Monzon O; Martin MM; Fernandez MA; Cappello CA; Krzysiak AJ; Osenkowski P; Wolfe MS
Biochemistry; 2011 Oct; 50(42):9023-35. PubMed ID: 21919498
[TBL] [Abstract][Full Text] [Related]
27. Genes and mechanisms involved in beta-amyloid generation and Alzheimer's disease.
Steiner H; Capell A; Leimer U; Haass C
Eur Arch Psychiatry Clin Neurosci; 1999; 249(6):266-70. PubMed ID: 10653281
[TBL] [Abstract][Full Text] [Related]
28. Analysis of Non-Amyloidogenic Mutations in APP Supports Loss of Function Hypothesis of Alzheimer's Disease.
Kim M; Bezprozvanny I
Int J Mol Sci; 2023 Jan; 24(3):. PubMed ID: 36768421
[TBL] [Abstract][Full Text] [Related]
29. Presenilin clinical mutations can affect gamma-secretase activity by different mechanisms.
Bentahir M; Nyabi O; Verhamme J; Tolia A; Horré K; Wiltfang J; Esselmann H; De Strooper B
J Neurochem; 2006 Feb; 96(3):732-42. PubMed ID: 16405513
[TBL] [Abstract][Full Text] [Related]
30. Presenilin 2 is the predominant γ-secretase in microglia and modulates cytokine release.
Jayadev S; Case A; Eastman AJ; Nguyen H; Pollak J; Wiley JC; Möller T; Morrison RS; Garden GA
PLoS One; 2010 Dec; 5(12):e15743. PubMed ID: 21206757
[TBL] [Abstract][Full Text] [Related]
31. [Study on expression of PS1 in APP-PS1 double gene stably transfected cell lines and its relation to gamma-secretase].
Liang P; Pan YX; Zhao XM; Du HZ; Zhang JM
Zhonghua Bing Li Xue Za Zhi; 2005 May; 34(5):297-301. PubMed ID: 16181553
[TBL] [Abstract][Full Text] [Related]
32. TRPC6 specifically interacts with APP to inhibit its cleavage by γ-secretase and reduce Aβ production.
Wang J; Lu R; Yang J; Li H; He Z; Jing N; Wang X; Wang Y
Nat Commun; 2015 Nov; 6():8876. PubMed ID: 26581893
[TBL] [Abstract][Full Text] [Related]
33. Identification of gamma-secretase inhibitor potency determinants on presenilin.
Zhao B; Yu M; Neitzel M; Marugg J; Jagodzinski J; Lee M; Hu K; Schenk D; Yednock T; Basi G
J Biol Chem; 2008 Feb; 283(5):2927-38. PubMed ID: 18032377
[TBL] [Abstract][Full Text] [Related]
34. Alzheimer's disease-linked mutations in presenilin-1 result in a drastic loss of activity in purified γ-secretase complexes.
Cacquevel M; Aeschbach L; Houacine J; Fraering PC
PLoS One; 2012; 7(4):e35133. PubMed ID: 22529981
[TBL] [Abstract][Full Text] [Related]
35. Hydrophilic loop 1 of Presenilin-1 and the APP GxxxG transmembrane motif regulate γ-secretase function in generating Alzheimer-causing Aβ peptides.
Liu L; Lauro BM; Wolfe MS; Selkoe DJ
J Biol Chem; 2021; 296():100393. PubMed ID: 33571524
[TBL] [Abstract][Full Text] [Related]
36. Alleles at the Nicastrin locus modify presenilin 1- deficiency phenotype.
Rozmahel R; Mount HT; Chen F; Nguyen V; Huang J; Erdebil S; Liauw J; Yu G; Hasegawa H; Gu Y; Song YQ; Schmidt SD; Nixon RA; Mathews PM; Bergeron C; Fraser P; Westaway D; St George-Hyslop P
Proc Natl Acad Sci U S A; 2002 Oct; 99(22):14452-7. PubMed ID: 12388777
[TBL] [Abstract][Full Text] [Related]
37. Acceleration of amyloidogenesis and memory impairment by estrogen deficiency through NF-κB dependent beta-secretase activation in presenilin 2 mutant mice.
Hwang CJ; Park MH; Choi MK; Choi JS; Oh KW; Hwang DY; Han SB; Hong JT
Brain Behav Immun; 2016 Mar; 53():113-122. PubMed ID: 26593275
[TBL] [Abstract][Full Text] [Related]
38. Photoactivated gamma-secretase inhibitors directed to the active site covalently label presenilin 1.
Li YM; Xu M; Lai MT; Huang Q; Castro JL; DiMuzio-Mower J; Harrison T; Lellis C; Nadin A; Neduvelil JG; Register RB; Sardana MK; Shearman MS; Smith AL; Shi XP; Yin KC; Shafer JA; Gardell SJ
Nature; 2000 Jun; 405(6787):689-94. PubMed ID: 10864326
[TBL] [Abstract][Full Text] [Related]
39. Presenilin transmembrane domain 8 conserved AXXXAXXXG motifs are required for the activity of the γ-secretase complex.
Marinangeli C; Tasiaux B; Opsomer R; Hage S; Sodero AO; Dewachter I; Octave JN; Smith SO; Constantinescu SN; Kienlen-Campard P
J Biol Chem; 2015 Mar; 290(11):7169-84. PubMed ID: 25614624
[TBL] [Abstract][Full Text] [Related]
40. Effects of Folic Acid on Secretases Involved in Aβ Deposition in APP/PS1 Mice.
Tian T; Bai D; Li W; Huang GW; Liu H
Nutrients; 2016 Sep; 8(9):. PubMed ID: 27618097
[TBL] [Abstract][Full Text] [Related]
[Previous] [Next] [New Search]
