220 related articles for article (PubMed ID: 22951255)
1. A sulfoximine-based inhibitor of human asparagine synthetase kills L-asparaginase-resistant leukemia cells.
Ikeuchi H; Ahn YM; Otokawa T; Watanabe B; Hegazy L; Hiratake J; Richards NG
Bioorg Med Chem; 2012 Oct; 20(19):5915-27. PubMed ID: 22951255
[TBL] [Abstract][Full Text] [Related]
2. An inhibitor of human asparagine synthetase suppresses proliferation of an L-asparaginase-resistant leukemia cell line.
Gutierrez JA; Pan YX; Koroniak L; Hiratake J; Kilberg MS; Richards NG
Chem Biol; 2006 Dec; 13(12):1339-47. PubMed ID: 17185229
[TBL] [Abstract][Full Text] [Related]
3. A critical electrostatic interaction mediates inhibitor recognition by human asparagine synthetase.
Ikeuchi H; Meyer ME; Ding Y; Hiratake J; Richards NG
Bioorg Med Chem; 2009 Sep; 17(18):6641-50. PubMed ID: 19683931
[TBL] [Abstract][Full Text] [Related]
4. Multiple adaptive mechanisms affect asparagine synthetase substrate availability in asparaginase-resistant MOLT-4 human leukaemia cells.
Aslanian AM; Kilberg MS
Biochem J; 2001 Aug; 358(Pt 1):59-67. PubMed ID: 11485552
[TBL] [Abstract][Full Text] [Related]
5. Glutaminase Activity of L-Asparaginase Contributes to Durable Preclinical Activity against Acute Lymphoblastic Leukemia.
Chan WK; Horvath TD; Tan L; Link T; Harutyunyan KG; Pontikos MA; Anishkin A; Du D; Martin LA; Yin E; Rempe SB; Sukharev S; Konopleva M; Weinstein JN; Lorenzi PL
Mol Cancer Ther; 2019 Sep; 18(9):1587-1592. PubMed ID: 31209181
[TBL] [Abstract][Full Text] [Related]
6. Asparagine synthetase expression alone is sufficient to induce l-asparaginase resistance in MOLT-4 human leukaemia cells.
Aslanian AM; Fletcher BS; Kilberg MS
Biochem J; 2001 Jul; 357(Pt 1):321-8. PubMed ID: 11415466
[TBL] [Abstract][Full Text] [Related]
7. Correlation between asparaginase sensitivity and asparagine synthetase protein content, but not mRNA, in acute lymphoblastic leukemia cell lines.
Su N; Pan YX; Zhou M; Harvey RC; Hunger SP; Kilberg MS
Pediatr Blood Cancer; 2008 Feb; 50(2):274-9. PubMed ID: 17514734
[TBL] [Abstract][Full Text] [Related]
8. L-Asparagine depletion levels and L-asparaginase activity in plasma of children with acute lymphoblastic leukemia under asparaginase treatment.
Tsurusawa M; Chin M; Iwai A; Nomura K; Maeba H; Taga T; Higa T; Kuno T; Hori T; Muto A; Yamagata M;
Cancer Chemother Pharmacol; 2004 Mar; 53(3):204-8. PubMed ID: 14634792
[TBL] [Abstract][Full Text] [Related]
9. Deamination of glutamine is a prerequisite for optimal asparagine deamination by asparaginases in vivo (CCG-1961).
Panosyan EH; Grigoryan RS; Avramis IA; Seibel NL; Gaynon PS; Siegel SE; Fingert HJ; Avramis VI
Anticancer Res; 2004; 24(2C):1121-5. PubMed ID: 15154634
[TBL] [Abstract][Full Text] [Related]
10. Low expression of asparagine synthetase in lymphoid blasts precludes its role in sensitivity to L-asparaginase.
Hermanova I; Zaliova M; Trka J; Starkova J
Exp Hematol; 2012 Aug; 40(8):657-65. PubMed ID: 22542578
[TBL] [Abstract][Full Text] [Related]
11. Amino acid control of asparagine synthetase: relation to asparaginase resistance in human leukemia cells.
Hutson RG; Kitoh T; Moraga Amador DA; Cosic S; Schuster SM; Kilberg MS
Am J Physiol; 1997 May; 272(5 Pt 1):C1691-9. PubMed ID: 9176161
[TBL] [Abstract][Full Text] [Related]
12. [Asparagine synthetase activity in pediatric acute lymphoblastic leukemia].
Jiang H; Gu LJ; Xue HL; Tang JY; Chen J; Pan C; Chen J
Zhongguo Dang Dai Er Ke Za Zhi; 2006 Aug; 8(4):272-4. PubMed ID: 16923354
[TBL] [Abstract][Full Text] [Related]
13. Role of asparaginase synthetase and asparagyl-transfer RNA synthetase in the cell-killing activity of asparaginase in Chinese hamster ovary cell mutants.
Waye MM; Stanners CP
Cancer Res; 1981 Aug; 41(8):3104-6. PubMed ID: 6113889
[TBL] [Abstract][Full Text] [Related]
14. Changes of amino acid serum levels in pediatric patients with higher-risk acute lymphoblastic leukemia (CCG-1961).
Grigoryan RS; Panosyan EH; Seibel NL; Gaynon PS; Avramis IA; Avramis VI
In Vivo; 2004; 18(2):107-12. PubMed ID: 15113036
[TBL] [Abstract][Full Text] [Related]
15. The inhibition of glutamine synthetase sensitizes human sarcoma cells to L-asparaginase.
Tardito S; Uggeri J; Bozzetti C; Bianchi MG; Rotoli BM; Franchi-Gazzola R; Gazzola GC; Gatti R; Bussolati O
Cancer Chemother Pharmacol; 2007 Oct; 60(5):751-8. PubMed ID: 17256128
[TBL] [Abstract][Full Text] [Related]
16. Mapping the aspartic acid binding site of Escherichia coli asparagine synthetase B using substrate analogs.
Parr IB; Boehlein SK; Dribben AB; Schuster SM; Richards NG
J Med Chem; 1996 Jun; 39(12):2367-78. PubMed ID: 8691431
[TBL] [Abstract][Full Text] [Related]
17. Asparagine synthetase chemotherapy.
Richards NG; Kilberg MS
Annu Rev Biochem; 2006; 75():629-54. PubMed ID: 16756505
[TBL] [Abstract][Full Text] [Related]
18. An isocratic fluorescence HPLC assay for the monitoring of l-asparaginase activity and l-asparagine depletion in children receiving E. colil-asparaginase for the treatment of acute lymphoblastic leukaemia.
Nath CE; Dallapozza L; Eslick AE; Misra A; Carr D; Earl JW
Biomed Chromatogr; 2009 Feb; 23(2):152-9. PubMed ID: 18823071
[TBL] [Abstract][Full Text] [Related]
19. Biochemical characterization of U937 cells resistant to L-asparaginase: the role of asparagine synthetase.
Kiriyama Y; Kubota M; Takimoto T; Kitoh T; Tanizawa A; Akiyama Y; Mikawa H
Leukemia; 1989 Apr; 3(4):294-7. PubMed ID: 2564453
[TBL] [Abstract][Full Text] [Related]
20. Pancreatic tumor sensitivity to plasma L-asparagine starvation.
Dufour E; Gay F; Aguera K; Scoazec JY; Horand F; Lorenzi PL; Godfrin Y
Pancreas; 2012 Aug; 41(6):940-8. PubMed ID: 22513289
[TBL] [Abstract][Full Text] [Related]
[Next] [New Search]
