BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

192 related articles for article (PubMed ID: 2296009)

  • 1. Hypoxia-selective antitumor agents. 3. Relationships between structure and cytotoxicity against cultured tumor cells for substituted N,N-bis(2-chloroethyl)anilines.
    Palmer BD; Wilson WR; Pullen SM; Denny WA
    J Med Chem; 1990 Jan; 33(1):112-21. PubMed ID: 2296009
    [TBL] [Abstract][Full Text] [Related]  

  • 2. Hypoxia-selective antitumor agents. 5. Synthesis of water-soluble nitroaniline mustards with selective cytotoxicity for hypoxic mammalian cells.
    Palmer BD; Wilson WR; Cliffe S; Denny WA
    J Med Chem; 1992 Aug; 35(17):3214-22. PubMed ID: 1507207
    [TBL] [Abstract][Full Text] [Related]  

  • 3. Reductive chemistry of the novel hypoxia-selective cytotoxin 5-[N,N-bis(2-chloroethyl)amino]-2,4-dinitrobenzamide.
    Palmer BD; van Zijl P; Denny WA; Wilson WR
    J Med Chem; 1995 Mar; 38(7):1229-41. PubMed ID: 7707325
    [TBL] [Abstract][Full Text] [Related]  

  • 4. Hypoxia-selective antitumor agents. 14. Synthesis and hypoxic cell cytotoxicity of regioisomers of the hypoxia-selective cytotoxin 5-[N,N-bis(2-chloroethyl)amino]-2,4-dinitrobenzamide.
    Palmer BD; Wilson WR; Anderson RF; Boyd M; Denny WA
    J Med Chem; 1996 Jun; 39(13):2518-28. PubMed ID: 8691449
    [TBL] [Abstract][Full Text] [Related]  

  • 5. Hypoxia-selective antitumor agents. 9. Structure-activity relationships for hypoxia-selective cytotoxicity among analogues of 5-[N,N-bis(2-chloroethyl)amino]-2,4-dinitrobenzamide.
    Palmer BD; Wilson WR; Atwell GJ; Schultz D; Xu XZ; Denny WA
    J Med Chem; 1994 Jul; 37(14):2175-84. PubMed ID: 8035424
    [TBL] [Abstract][Full Text] [Related]  

  • 6. Hypoxia-selective antitumor agents. 12. Nitrobenzyl quaternary salts as bioreductive prodrugs of the alkylating agent mechlorethamine.
    Tercel M; Wilson WR; Anderson RF; Denny WA
    J Med Chem; 1996 Mar; 39(5):1084-94. PubMed ID: 8676343
    [TBL] [Abstract][Full Text] [Related]  

  • 7. Hypoxia-selective antitumor agents. 7. Metal complexes of aliphatic mustards as a new class of hypoxia-selective cytotoxins. Synthesis and evaluation of cobalt(III) complexes of bidentate mustards.
    Ware DC; Palmer BD; Wilson WR; Denny WA
    J Med Chem; 1993 Jun; 36(13):1839-46. PubMed ID: 8515422
    [TBL] [Abstract][Full Text] [Related]  

  • 8. DNA-directed alkylating agents. 1. Structure-activity relationships for acridine-linked aniline mustards: consequences of varying the reactivity of the mustard.
    Gourdie TA; Valu KK; Gravatt GL; Boritzki TJ; Baguley BC; Wakelin LP; Wilson WR; Woodgate PD; Denny WA
    J Med Chem; 1990 Apr; 33(4):1177-86. PubMed ID: 2319563
    [TBL] [Abstract][Full Text] [Related]  

  • 9. DNA-directed alkylating agents. 3. Structure-activity relationships for acridine-linked aniline mustards: consequences of varying the length of the linker chain.
    Valu KK; Gourdie TA; Boritzki TJ; Gravatt GL; Baguley BC; Wilson WR; Wakelin LP; Woodgate PD; Denny WA
    J Med Chem; 1990 Nov; 33(11):3014-9. PubMed ID: 2231599
    [TBL] [Abstract][Full Text] [Related]  

  • 10. Structure-activity relationships of 1,2,4-benzotriazine 1,4-dioxides as hypoxia-selective analogues of tirapazamine.
    Hay MP; Gamage SA; Kovacs MS; Pruijn FB; Anderson RF; Patterson AV; Wilson WR; Brown JM; Denny WA
    J Med Chem; 2003 Jan; 46(1):169-82. PubMed ID: 12502371
    [TBL] [Abstract][Full Text] [Related]  

  • 11. Effect of nitroreduction on the alkylating reactivity and cytotoxicity of the 2,4-dinitrobenzamide-5-aziridine CB 1954 and the corresponding nitrogen mustard SN 23862: distinct mechanisms of bioreductive activation.
    Helsby NA; Wheeler SJ; Pruijn FB; Palmer BD; Yang S; Denny WA; Wilson WR
    Chem Res Toxicol; 2003 Apr; 16(4):469-78. PubMed ID: 12703963
    [TBL] [Abstract][Full Text] [Related]  

  • 12. Bis(dialkyl)dithiocarbamato cobalt(III) complexes of bidentate nitrogen mustards: synthesis, reduction chemistry and biological evaluation as hypoxia-selective cytotoxins.
    Ware DC; Palmer HR; Pruijn FB; Anderson RF; Brothers PJ; Denny WA; Wilson WR
    Anticancer Drug Des; 1998 Mar; 13(2):81-103. PubMed ID: 9524553
    [TBL] [Abstract][Full Text] [Related]  

  • 13. Sequence selectivity, cross-linking efficiency and cytotoxicity of DNA-targeted 4-anilinoquinoline aniline mustards.
    McClean S; Costelloe C; Denny WA; Searcey M; Wakelin LP
    Anticancer Drug Des; 1999 Jun; 14(3):187-204. PubMed ID: 10500495
    [TBL] [Abstract][Full Text] [Related]  

  • 14. Significant differences in biological parameters between prodrugs cleavable by carboxypeptidase G2 that generate 3,5-difluoro-phenol and -aniline nitrogen mustards in gene-directed enzyme prodrug therapy systems.
    Niculescu-Duvaz I; Scanlon I; Niculescu-Duvaz D; Friedlos F; Martin J; Marais R; Springer CJ
    J Med Chem; 2004 May; 47(10):2651-8. PubMed ID: 15115406
    [TBL] [Abstract][Full Text] [Related]  

  • 15. Pharmacokinetics and metabolism of the nitrogen mustard bioreductive drug 5.
    Kestell P; Pruijn FB; Siim BG; Palmer BD; Wilson WR
    Cancer Chemother Pharmacol; 2000; 46(5):365-74. PubMed ID: 11127940
    [TBL] [Abstract][Full Text] [Related]  

  • 16. Relationships between structure, toxicity and genetic effects in Salmonella typhimurium and Saccharomyces cerevisiae for substituted aniline mustards.
    Ferguson LR; Palmer BD; Denny WA
    Mutat Res; 1989 Sep; 224(1):95-104. PubMed ID: 2671716
    [TBL] [Abstract][Full Text] [Related]  

  • 17. The effect of functional groups on reduction and activation of quinone bioreductive agents by DT-diaphorase.
    Fourie J; Oleschuk CJ; Guziec F; Guziec L; Fiterman DJ; Monterrosa C; Begleiter A
    Cancer Chemother Pharmacol; 2002 Feb; 49(2):101-10. PubMed ID: 11862423
    [TBL] [Abstract][Full Text] [Related]  

  • 18. Hypoxia-selective antitumor agents. 8. Bis(nitroimidazolyl)alkanecarboxamides: a new class of hypoxia-selective cytotoxins and hypoxic cell radiosensitisers.
    Hay MP; Wilson WR; Moselen JW; Palmer BD; Denny WA
    J Med Chem; 1994 Feb; 37(3):381-91. PubMed ID: 8308864
    [TBL] [Abstract][Full Text] [Related]  

  • 19. Nitracrine N-oxides: effects of variations in the nature of the side chain N-oxide on hypoxia-selective cytotoxicity.
    Lee HH; Wilson WR; Denny WA
    Anticancer Drug Des; 1999 Dec; 14(6):487-97. PubMed ID: 10834270
    [TBL] [Abstract][Full Text] [Related]  

  • 20. Hypoxia-selective antitumor agents. 10. bis(nitroimidazoles) and related Bis(nitroheterocycles): development of derivatives with higher rates of metabolic activation under hypoxia and improved aqueous solubility.
    Hay MP; Lee HH; Wilson WR; Roberts PB; Denny WA
    J Med Chem; 1995 May; 38(11):1928-41. PubMed ID: 7783125
    [TBL] [Abstract][Full Text] [Related]  

    [Next]    [New Search]
    of 10.