BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

235 related articles for article (PubMed ID: 22963240)

  • 1. De novo engineering of a human cystathionine-γ-lyase for systemic (L)-Methionine depletion cancer therapy.
    Stone E; Paley O; Hu J; Ekerdt B; Cheung NK; Georgiou G
    ACS Chem Biol; 2012 Nov; 7(11):1822-9. PubMed ID: 22963240
    [TBL] [Abstract][Full Text] [Related]  

  • 2. Structural Snapshots of an Engineered Cystathionine-γ-lyase Reveal the Critical Role of Electrostatic Interactions in the Active Site.
    Yan W; Stone E; Zhang YJ
    Biochemistry; 2017 Feb; 56(6):876-885. PubMed ID: 28106980
    [TBL] [Abstract][Full Text] [Related]  

  • 3. Methionine tumor starvation by erythrocyte-encapsulated methionine gamma-lyase activity controlled with per os vitamin B6.
    Gay F; Aguera K; Sénéchal K; Tainturier A; Berlier W; Maucort-Boulch D; Honnorat J; Horand F; Godfrin Y; Bourgeaux V
    Cancer Med; 2017 Jun; 6(6):1437-1452. PubMed ID: 28544589
    [TBL] [Abstract][Full Text] [Related]  

  • 4. The role of cysteine 116 in the active site of the antitumor enzyme L-methionine gamma-lyase from Pseudomonas putida.
    Kudou D; Misaki S; Yamashita M; Tamura T; Esaki N; Inagaki K
    Biosci Biotechnol Biochem; 2008 Jul; 72(7):1722-30. PubMed ID: 18603802
    [TBL] [Abstract][Full Text] [Related]  

  • 5. Crystal structure of the pyridoxal 5'-phosphate dependent L-methionine gamma-lyase from Pseudomonas putida.
    Motoshima H; Inagaki K; Kumasaka T; Furuichi M; Inoue H; Tamura T; Esaki N; Soda K; Tanaka N; Yamamoto M; Tanaka H
    J Biochem; 2000 Sep; 128(3):349-54. PubMed ID: 10965031
    [TBL] [Abstract][Full Text] [Related]  

  • 6. Enzyme-mediated depletion of serum l-Met abrogates prostate cancer growth via multiple mechanisms without evidence of systemic toxicity.
    Lu WC; Saha A; Yan W; Garrison K; Lamb C; Pandey R; Irani S; Lodi A; Lu X; Tiziani S; Zhang YJ; Georgiou G; DiGiovanni J; Stone E
    Proc Natl Acad Sci U S A; 2020 Jun; 117(23):13000-13011. PubMed ID: 32434918
    [TBL] [Abstract][Full Text] [Related]  

  • 7. Development of Recombinant Methioninase for Cancer Treatment.
    Hoffman RM; Tan Y; Li S; Han Q; Yagi S; Takakura T; Takimoto A; Inagaki K; Kudou D
    Methods Mol Biol; 2019; 1866():107-131. PubMed ID: 30725412
    [TBL] [Abstract][Full Text] [Related]  

  • 8. Structural analysis of the L-methionine gamma-lyase gene from Pseudomonas putida.
    Inoue H; Inagaki K; Sugimoto M; Esaki N; Soda K; Tanaka H
    J Biochem; 1995 May; 117(5):1120-5. PubMed ID: 8586629
    [TBL] [Abstract][Full Text] [Related]  

  • 9. Gene cloning and characterization of Pseudomonas putida L-methionine-alpha-deamino-gamma-mercaptomethane-lyase.
    Hori H; Takabayashi K; Orvis L; Carson DA; Nobori T
    Cancer Res; 1996 May; 56(9):2116-22. PubMed ID: 8616859
    [TBL] [Abstract][Full Text] [Related]  

  • 10. Novel method for l-methionine determination using l-methionine decarboxylase and application of the enzyme for l-homocysteine determination.
    Okawa A; Hayashi M; Inagaki J; Okajima T; Tamura T; Inagaki K
    Biosci Biotechnol Biochem; 2020 May; 84(5):927-935. PubMed ID: 31959065
    [TBL] [Abstract][Full Text] [Related]  

  • 11. Structure of the antitumour enzyme L-methionine gamma-lyase from Pseudomonas putida at 1.8 A resolution.
    Kudou D; Misaki S; Yamashita M; Tamura T; Takakura T; Yoshioka T; Yagi S; Hoffman RM; Takimoto A; Esaki N; Inagaki K
    J Biochem; 2007 Apr; 141(4):535-44. PubMed ID: 17289792
    [TBL] [Abstract][Full Text] [Related]  

  • 12. The role of amino acid residues in the active site of L-methionine γ-lyase from Pseudomonas putida.
    Fukumoto M; Kudou D; Murano S; Shiba T; Sato D; Tamura T; Harada S; Inagaki K
    Biosci Biotechnol Biochem; 2012; 76(7):1275-84. PubMed ID: 22785484
    [TBL] [Abstract][Full Text] [Related]  

  • 13. Overexpression and large-scale production of recombinant L-methionine-alpha-deamino-gamma-mercaptomethane-lyase for novel anticancer therapy.
    Tan Y; Xu M; Tan X; Tan X; Wang X; Saikawa Y; Nagahama T; Sun X; Lenz M; Hoffman RM
    Protein Expr Purif; 1997 Mar; 9(2):233-45. PubMed ID: 9056489
    [TBL] [Abstract][Full Text] [Related]  

  • 14. Molecular and Spectroscopic Characterization of Aspergillus flavipes and Pseudomonas putida L-Methionine γ-Lyase in Vitro.
    El-Sayed AS; Ruff LE; Ghany SE; Ali GS; Esener S
    Appl Biochem Biotechnol; 2017 Apr; 181(4):1513-1532. PubMed ID: 27796875
    [TBL] [Abstract][Full Text] [Related]  

  • 15. Suicide inactivation of bacterial cystathionine gamma-synthase and methionine gamma-lyase during processing of L-propargylglycine.
    Johnston M; Jankowski D; Marcotte P; Tanaka H; Esaki N; Soda K; Walsh C
    Biochemistry; 1979 Oct; 18(21):4690-701. PubMed ID: 387077
    [TBL] [Abstract][Full Text] [Related]  

  • 16. A role for glutamate-333 of Saccharomyces cerevisiae cystathionine γ-lyase as a determinant of specificity.
    Hopwood EM; Ahmed D; Aitken SM
    Biochim Biophys Acta; 2014 Feb; 1844(2):465-72. PubMed ID: 24291053
    [TBL] [Abstract][Full Text] [Related]  

  • 17. The primitive protozoon Trichomonas vaginalis contains two methionine gamma-lyase genes that encode members of the gamma-family of pyridoxal 5'-phosphate-dependent enzymes.
    McKie AE; Edlind T; Walker J; Mottram JC; Coombs GH
    J Biol Chem; 1998 Mar; 273(10):5549-56. PubMed ID: 9488680
    [TBL] [Abstract][Full Text] [Related]  

  • 18. Engineering methionine γ-lyase from Citrobacter freundii for anticancer activity.
    Raboni S; Revtovich S; Demitri N; Giabbai B; Storici P; Cocconcelli C; Faggiano S; Rosini E; Pollegioni L; Galati S; Buschini A; Morozova E; Kulikova V; Nikulin A; Gabellieri E; Cioni P; Demidkina T; Mozzarelli A
    Biochim Biophys Acta Proteins Proteom; 2018 Dec; 1866(12):1260-1270. PubMed ID: 30268810
    [TBL] [Abstract][Full Text] [Related]  

  • 19. Role of tyrosine 114 of L-methionine gamma-lyase from Pseudomonas putida.
    Inoue H; Inagaki K; Adachi N; Tamura T; Esaki N; Soda K; Tanaka H
    Biosci Biotechnol Biochem; 2000 Nov; 64(11):2336-43. PubMed ID: 11193400
    [TBL] [Abstract][Full Text] [Related]  

  • 20. The PatB protein of Bacillus subtilis is a C-S-lyase.
    Auger S; Gomez MP; Danchin A; Martin-Verstraete I
    Biochimie; 2005 Feb; 87(2):231-8. PubMed ID: 15760717
    [TBL] [Abstract][Full Text] [Related]  

    [Next]    [New Search]
    of 12.