270 related articles for article (PubMed ID: 22985962)
1. Design, modification and 3D QSAR studies of novel 2,3-dihydrobenzo[b][1,4]dioxin-containing 4,5-dihydro-1H-pyrazole derivatives as inhibitors of B-Raf kinase.
Yang YS; Li QS; Sun S; Zhang YB; Wang XL; Zhang F; Tang JF; Zhu HL
Bioorg Med Chem; 2012 Oct; 20(20):6048-58. PubMed ID: 22985962
[TBL] [Abstract][Full Text] [Related]
2. Synthesis, biological evaluation and 3D-QSAR studies of novel 4,5-dihydro-1H-pyrazole niacinamide derivatives as BRAF inhibitors.
Li CY; Li QS; Yan L; Sun XG; Wei R; Gong HB; Zhu HL
Bioorg Med Chem; 2012 Jun; 20(12):3746-55. PubMed ID: 22583669
[TBL] [Abstract][Full Text] [Related]
3. Synthesis, biological evaluation of novel 4,5-dihydro-2H-pyrazole 2-hydroxyphenyl derivatives as BRAF inhibitors.
Liu JJ; Zhang H; Sun J; Wang ZC; Yang YS; Li DD; Zhang F; Gong HB; Zhu HL
Bioorg Med Chem; 2012 Oct; 20(20):6089-96. PubMed ID: 22985957
[TBL] [Abstract][Full Text] [Related]
4. Design, modification and 3D QSAR studies of novel naphthalin-containing pyrazoline derivatives with/without thiourea skeleton as anticancer agents.
Yang W; Hu Y; Yang YS; Zhang F; Zhang YB; Wang XL; Tang JF; Zhong WQ; Zhu HL
Bioorg Med Chem; 2013 Mar; 21(5):1050-63. PubMed ID: 23391364
[TBL] [Abstract][Full Text] [Related]
5. Design, synthesis and biological evaluation of novel 5-phenyl-1H-pyrazole derivatives as potential BRAF(V600E) inhibitors.
Wang SF; Zhu YL; Zhu PT; Makawana JA; Zhang YL; Zhao MY; Lv PC; Zhu HL
Bioorg Med Chem; 2014 Nov; 22(21):6201-8. PubMed ID: 25267006
[TBL] [Abstract][Full Text] [Related]
6. Novel pyrazoline derivatives as bi-inhibitor of COX-2 and B-Raf in treating cervical carcinoma.
Yu M; Yang H; Wu K; Ji Y; Ju L; Lu X
Bioorg Med Chem; 2014 Aug; 22(15):4109-18. PubMed ID: 24934992
[TBL] [Abstract][Full Text] [Related]
7. Design, biological evaluation and 3D QSAR studies of novel dioxin-containing triaryl pyrazoline derivatives as potential B-Raf inhibitors.
Yang YS; Yang B; Zou Y; Li G; Zhu HL
Bioorg Med Chem; 2016 Jul; 24(13):3052-3061. PubMed ID: 27238841
[TBL] [Abstract][Full Text] [Related]
8. Synthesis, biological evaluation and 3D-QSAR study of novel 4,5-dihydro-1H-pyrazole thiazole derivatives as BRAF(V⁶⁰⁰E) inhibitors.
Zhao MY; Yin Y; Yu XW; Sangani CB; Wang SF; Lu AM; Yang LF; Lv PC; Jiang MG; Zhu HL
Bioorg Med Chem; 2015 Jan; 23(1):46-54. PubMed ID: 25496804
[TBL] [Abstract][Full Text] [Related]
9. Modification, biological evaluation and 3D QSAR studies of novel 2-(1,3-diaryl- 4,5-dihydro-1H-pyrazol-5-yl)phenol derivatives as inhibitors of B-Raf kinase.
Yang YS; Zhang F; Tang DJ; Yang YH; Zhu HL
PLoS One; 2014; 9(5):e95702. PubMed ID: 24827980
[TBL] [Abstract][Full Text] [Related]
10. Design and biological evaluation of novel triaryl pyrazoline derivatives with dioxane moiety for selective BRAF
Li HL; Su MM; Xu YJ; Xu C; Yang YS; Zhu HL
Eur J Med Chem; 2018 Jul; 155():725-735. PubMed ID: 29940463
[TBL] [Abstract][Full Text] [Related]
11. Synthesis, molecular docking and evaluation of thiazolyl-pyrazoline derivatives containing benzodioxole as potential anticancer agents.
Wang HH; Qiu KM; Cui HE; Yang YS; Yin-Luo ; Xing M; Qiu XY; Bai LF; Zhu HL
Bioorg Med Chem; 2013 Jan; 21(2):448-55. PubMed ID: 23245802
[TBL] [Abstract][Full Text] [Related]
12. Synthesis, biological evaluation and molecular docking of novel 5-phenyl-1H-pyrazol derivatives as potential BRAF(V600E) inhibitors.
Dong JJ; Li QS; Wang SF; Li CY; Zhao X; Qiu HY; Zhao MY; Zhu HL
Org Biomol Chem; 2013 Oct; 11(37):6328-37. PubMed ID: 23942809
[TBL] [Abstract][Full Text] [Related]
13. Investigation of the differences in activity between hydroxycycloalkyl N1 substituted pyrazole derivatives as inhibitors of B-Raf kinase by using docking, molecular dynamics, QM/MM, and fragment-based de novo design: study of binding mode of diastereomer compounds.
Caballero J; Alzate-Morales JH; Vergara-Jaque A
J Chem Inf Model; 2011 Nov; 51(11):2920-31. PubMed ID: 22011048
[TBL] [Abstract][Full Text] [Related]
14. Identification of novel 3,5-diarylpyrazoline derivatives containing salicylamide moiety as potential anti-melanoma agents.
Li QS; Lv XH; Zhang YB; Dong JJ; Zhou WP; Yang Y; Zhu HL
Bioorg Med Chem Lett; 2012 Nov; 22(21):6596-601. PubMed ID: 23025996
[TBL] [Abstract][Full Text] [Related]
15. Structure based design and syntheses of amino-1H-pyrazole amide derivatives as selective Raf kinase inhibitors in melanoma cells.
Kim MH; Kim M; Yu H; Kim H; Yoo KH; Sim T; Hah JM
Bioorg Med Chem; 2011 Mar; 19(6):1915-23. PubMed ID: 21353571
[TBL] [Abstract][Full Text] [Related]
16. Computational study on the interaction of N1 substituted pyrazole derivatives with B-raf kinase: an unusual water wire hydrogen-bond network and novel interactions at the entrance of the active site.
Alzate-Morales JH; Vergara-Jaque A; Caballero J
J Chem Inf Model; 2010 Jun; 50(6):1101-12. PubMed ID: 20524689
[TBL] [Abstract][Full Text] [Related]
17. New diarylureas and diarylamides containing 1,3,4-triarylpyrazole scaffold: Synthesis, antiproliferative evaluation against melanoma cell lines, ERK kinase inhibition, and molecular docking studies.
Choi WK; El-Gamal MI; Choi HS; Baek D; Oh CH
Eur J Med Chem; 2011 Dec; 46(12):5754-62. PubMed ID: 22014559
[TBL] [Abstract][Full Text] [Related]
18. Design, biological evaluation and 3D QSAR studies of novel dioxin-containing pyrazoline derivatives with thiourea skeleton as selective HER-2 inhibitors.
Yang B; Yang YS; Yang N; Li G; Zhu HL
Sci Rep; 2016 Jun; 6():27571. PubMed ID: 27273260
[TBL] [Abstract][Full Text] [Related]
19. Discovery and optimization of pyrazoline compounds as B-Raf inhibitors.
Duffey MO; Adams R; Blackburn C; Chau RW; Chen S; Galvin KM; Garcia K; Gould AE; Greenspan PD; Harrison S; Huang SC; Kim MS; Kulkarni B; Langston S; Liu JX; Ma LT; Menon S; Nagayoshi M; Rowland RS; Vos TJ; Xu T; Yang JJ; Yu S; Zhang Q
Bioorg Med Chem Lett; 2010 Aug; 20(16):4800-4. PubMed ID: 20634068
[TBL] [Abstract][Full Text] [Related]
20. Design and synthesis of a new series of highly potent RAF kinase-inhibiting triarylpyrazole derivatives possessing antiproliferative activity against melanoma cells.
Khan MA; El-Gamal MI; Tarazi H; Choi HS; Oh CH
Future Med Chem; 2016 Dec; 8(18):2197-2211. PubMed ID: 27845592
[TBL] [Abstract][Full Text] [Related]
[Next] [New Search]
