These tools will no longer be maintained as of December 31, 2024. Archived website can be found here. PubMed4Hh GitHub repository can be found here. Contact NLM Customer Service if you have questions.


BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

186 related articles for article (PubMed ID: 22994453)

  • 1. Inherent sex-dependent regulation of human hepatic CYP3A5.
    Thangavel C; Boopathi E; Shapiro BH
    Br J Pharmacol; 2013 Feb; 168(4):988-1000. PubMed ID: 22994453
    [TBL] [Abstract][Full Text] [Related]  

  • 2. Intrinsic sexually dimorphic expression of the principal human CYP3A4 correlated with suboptimal activation of GH/glucocorticoid-dependent transcriptional pathways in men.
    Thangavel C; Boopathi E; Shapiro BH
    Endocrinology; 2011 Dec; 152(12):4813-24. PubMed ID: 21952236
    [TBL] [Abstract][Full Text] [Related]  

  • 3. Arsenic decreases RXRα-dependent transcription of CYP3A and suppresses immune regulators in hepatocytes.
    Noreault-Conti TL; Fellows A; Jacobs JM; Trask HW; Strom SC; Evans RM; Wrighton SA; Sinclair PR; Sinclair JF; Nichols RC
    Int Immunopharmacol; 2012 Apr; 12(4):651-6. PubMed ID: 22310326
    [TBL] [Abstract][Full Text] [Related]  

  • 4. Lower expression of HNF4α and PGC1α might impair rifampicin-mediated CYP3A4 induction under conditions where PXR is overexpressed in human fetal liver cells.
    Takezawa T; Matsunaga T; Aikawa K; Nakamura K; Ohmori S
    Drug Metab Pharmacokinet; 2012; 27(4):430-8. PubMed ID: 22333269
    [TBL] [Abstract][Full Text] [Related]  

  • 5. The induction of cytochrome P450 3A5 (CYP3A5) in the human liver and intestine is mediated by the xenobiotic sensors pregnane X receptor (PXR) and constitutively activated receptor (CAR).
    Burk O; Koch I; Raucy J; Hustert E; Eichelbaum M; Brockmöller J; Zanger UM; Wojnowski L
    J Biol Chem; 2004 Sep; 279(37):38379-85. PubMed ID: 15252010
    [TBL] [Abstract][Full Text] [Related]  

  • 6. U0126, a mitogen-activated protein kinase kinase 1 and 2 (MEK1 and 2) inhibitor, selectively up-regulates main isoforms of CYP3A subfamily via a pregnane X receptor (PXR) in HepG2 cells.
    Smutny T; Bitman M; Urban M; Dubecka M; Vrzal R; Dvorak Z; Pavek P
    Arch Toxicol; 2014 Dec; 88(12):2243-59. PubMed ID: 24819614
    [TBL] [Abstract][Full Text] [Related]  

  • 7. Dexamethasone induces pregnane X receptor and retinoid X receptor-alpha expression in human hepatocytes: synergistic increase of CYP3A4 induction by pregnane X receptor activators.
    Pascussi JM; Drocourt L; Fabre JM; Maurel P; Vilarem MJ
    Mol Pharmacol; 2000 Aug; 58(2):361-72. PubMed ID: 10908304
    [TBL] [Abstract][Full Text] [Related]  

  • 8. Positive and negative regulation of human hepatic hydroxysteroid sulfotransferase (SULT2A1) gene transcription by rifampicin: roles of hepatocyte nuclear factor 4alpha and pregnane X receptor.
    Fang HL; Strom SC; Ellis E; Duanmu Z; Fu J; Duniec-Dmuchowski Z; Falany CN; Falany JL; Kocarek TA; Runge-Morris M
    J Pharmacol Exp Ther; 2007 Nov; 323(2):586-98. PubMed ID: 17687072
    [TBL] [Abstract][Full Text] [Related]  

  • 9. Valproic acid induces CYP3A4 and MDR1 gene expression by activation of constitutive androstane receptor and pregnane X receptor pathways.
    Cerveny L; Svecova L; Anzenbacherova E; Vrzal R; Staud F; Dvorak Z; Ulrichova J; Anzenbacher P; Pavek P
    Drug Metab Dispos; 2007 Jul; 35(7):1032-41. PubMed ID: 17392393
    [TBL] [Abstract][Full Text] [Related]  

  • 10. Rifampicin induction of CYP3A4 requires pregnane X receptor cross talk with hepatocyte nuclear factor 4alpha and coactivators, and suppression of small heterodimer partner gene expression.
    Li T; Chiang JY
    Drug Metab Dispos; 2006 May; 34(5):756-64. PubMed ID: 16455805
    [TBL] [Abstract][Full Text] [Related]  

  • 11. Sex-dependent regulation of hepatic CYP3A by growth hormone: Roles of HNF6, C/EBPα, and RXRα.
    Li J; Wan Y; Na S; Liu X; Dong G; Yang Z; Yang J; Yue J
    Biochem Pharmacol; 2015 Jan; 93(1):92-103. PubMed ID: 25451687
    [TBL] [Abstract][Full Text] [Related]  

  • 12. Dual effect of dexamethasone on CYP3A4 gene expression in human hepatocytes. Sequential role of glucocorticoid receptor and pregnane X receptor.
    Pascussi JM; Drocourt L; Gerbal-Chaloin S; Fabre JM; Maurel P; Vilarem MJ
    Eur J Biochem; 2001 Dec; 268(24):6346-58. PubMed ID: 11737189
    [TBL] [Abstract][Full Text] [Related]  

  • 13. Inhibition of CYP3A4 expression by ketoconazole is mediated by the disruption of pregnane X receptor, steroid receptor coactivator-1, and hepatocyte nuclear factor 4alpha interaction.
    Lim YP; Kuo SC; Lai ML; Huang JD
    Pharmacogenet Genomics; 2009 Jan; 19(1):11-24. PubMed ID: 19077665
    [TBL] [Abstract][Full Text] [Related]  

  • 14. Stable overexpression of pregnane X receptor in HepG2 cells increases its potential for bioartificial liver application.
    Nibourg GA; Huisman MT; van der Hoeven TV; van Gulik TM; Chamuleau RA; Hoekstra R
    Liver Transpl; 2010 Sep; 16(9):1075-85. PubMed ID: 20818746
    [TBL] [Abstract][Full Text] [Related]  

  • 15. Comparison of the induction profile for drug disposition proteins by typical nuclear receptor activators in human hepatic and intestinal cells.
    Martin P; Riley R; Back DJ; Owen A
    Br J Pharmacol; 2008 Feb; 153(4):805-19. PubMed ID: 18037906
    [TBL] [Abstract][Full Text] [Related]  

  • 16. Suppression of the pregnane X receptor during endoplasmic reticulum stress is achieved by down-regulating hepatocyte nuclear factor-4α and up-regulating liver-enriched inhibitory protein.
    Vachirayonsti T; Ho KW; Yang D; Yan B
    Toxicol Sci; 2015 Apr; 144(2):382-92. PubMed ID: 25616597
    [TBL] [Abstract][Full Text] [Related]  

  • 17. Two-stage glucocorticoid induction of CYP3A23 through both the glucocorticoid and pregnane X receptors.
    Huss JM; Kasper CB
    Mol Pharmacol; 2000 Jul; 58(1):48-57. PubMed ID: 10860926
    [TBL] [Abstract][Full Text] [Related]  

  • 18. Sexually dimorphic regulation of hepatic isoforms of human cytochrome p450 by growth hormone.
    Dhir RN; Dworakowski W; Thangavel C; Shapiro BH
    J Pharmacol Exp Ther; 2006 Jan; 316(1):87-94. PubMed ID: 16160083
    [TBL] [Abstract][Full Text] [Related]  

  • 19. Benzodiazepines medazepam and midazolam are activators of pregnane X receptor and weak inducers of CYP3A4: investigation in primary cultures of human hepatocytes and hepatocarcinoma cell lines.
    Vrzal R; Kubesova K; Pavek P; Dvorak Z
    Toxicol Lett; 2010 Mar; 193(2):183-8. PubMed ID: 20080160
    [TBL] [Abstract][Full Text] [Related]  

  • 20. Effects of atorvastatin metabolites on induction of drug-metabolizing enzymes and membrane transporters through human pregnane X receptor.
    Hoffart E; Ghebreghiorghis L; Nussler AK; Thasler WE; Weiss TS; Schwab M; Burk O
    Br J Pharmacol; 2012 Mar; 165(5):1595-608. PubMed ID: 21913896
    [TBL] [Abstract][Full Text] [Related]  

    [Next]    [New Search]
    of 10.