BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

103 related articles for article (PubMed ID: 22999871)

  • 1. Ariad Pharmaceutical's ninja cancer drug inhibits armies of mutants.
    Wolfson W
    Chem Biol; 2012 Sep; 19(9):1075-6. PubMed ID: 22999871
    [No Abstract]   [Full Text] [Related]  

  • 2. Efficacy of ponatinib against ABL tyrosine kinase inhibitor-resistant leukemia cells.
    Okabe S; Tauchi T; Tanaka Y; Ohyashiki K
    Biochem Biophys Res Commun; 2013 Jun; 435(3):506-11. PubMed ID: 23684619
    [TBL] [Abstract][Full Text] [Related]  

  • 3. Activity of omacetaxine mepesuccinate against ponatinib-resistant BCR-ABL-positive cells.
    Okabe S; Tauchi T; Tanaka Y; Katagiri S; Kitahara T; Ohyashiki K
    Blood; 2013 Oct; 122(17):3086-8. PubMed ID: 24159169
    [No Abstract]   [Full Text] [Related]  

  • 4. AP24534, a pan-BCR-ABL inhibitor for chronic myeloid leukemia, potently inhibits the T315I mutant and overcomes mutation-based resistance.
    O'Hare T; Shakespeare WC; Zhu X; Eide CA; Rivera VM; Wang F; Adrian LT; Zhou T; Huang WS; Xu Q; Metcalf CA; Tyner JW; Loriaux MM; Corbin AS; Wardwell S; Ning Y; Keats JA; Wang Y; Sundaramoorthi R; Thomas M; Zhou D; Snodgrass J; Commodore L; Sawyer TK; Dalgarno DC; Deininger MW; Druker BJ; Clackson T
    Cancer Cell; 2009 Nov; 16(5):401-12. PubMed ID: 19878872
    [TBL] [Abstract][Full Text] [Related]  

  • 5. Structural mechanism of the Pan-BCR-ABL inhibitor ponatinib (AP24534): lessons for overcoming kinase inhibitor resistance.
    Zhou T; Commodore L; Huang WS; Wang Y; Thomas M; Keats J; Xu Q; Rivera VM; Shakespeare WC; Clackson T; Dalgarno DC; Zhu X
    Chem Biol Drug Des; 2011 Jan; 77(1):1-11. PubMed ID: 21118377
    [TBL] [Abstract][Full Text] [Related]  

  • 6. Discovery of 3-[2-(imidazo[1,2-b]pyridazin-3-yl)ethynyl]-4-methyl-N-{4-[(4-methylpiperazin-1-yl)methyl]-3-(trifluoromethyl)phenyl}benzamide (AP24534), a potent, orally active pan-inhibitor of breakpoint cluster region-abelson (BCR-ABL) kinase including the T315I gatekeeper mutant.
    Huang WS; Metcalf CA; Sundaramoorthi R; Wang Y; Zou D; Thomas RM; Zhu X; Cai L; Wen D; Liu S; Romero J; Qi J; Chen I; Banda G; Lentini SP; Das S; Xu Q; Keats J; Wang F; Wardwell S; Ning Y; Snodgrass JT; Broudy MI; Russian K; Zhou T; Commodore L; Narasimhan NI; Mohemmad QK; Iuliucci J; Rivera VM; Dalgarno DC; Sawyer TK; Clackson T; Shakespeare WC
    J Med Chem; 2010 Jun; 53(12):4701-19. PubMed ID: 20513156
    [TBL] [Abstract][Full Text] [Related]  

  • 7. Ponatinib: targeting the T315I mutation in chronic myelogenous leukemia.
    Shah NP
    Clin Adv Hematol Oncol; 2011 Dec; 9(12):925-6. PubMed ID: 22252660
    [No Abstract]   [Full Text] [Related]  

  • 8. Structure, function, and resistance in chronic myeloid leukemia.
    Radich J
    Cancer Cell; 2014 Sep; 26(3):305-306. PubMed ID: 25203318
    [TBL] [Abstract][Full Text] [Related]  

  • 9. The clinical impact of ponatinib on the risk of bleeding in patients with chronic myeloid leukemia.
    Nazha A; Romo CG; Kantarjian H; Cortes J
    Haematologica; 2013 Oct; 98(10):e131. PubMed ID: 24091930
    [No Abstract]   [Full Text] [Related]  

  • 10. Platelet dysfunction associated with ponatinib, a new pan BCR-ABL inhibitor with efficacy for chronic myeloid leukemia resistant to multiple tyrosine kinase inhibitor therapy.
    Neelakantan P; Marin D; Laffan M; Goldman J; Apperley J; Milojkovic D
    Haematologica; 2012 Sep; 97(9):1444. PubMed ID: 22532521
    [No Abstract]   [Full Text] [Related]  

  • 11. Ponatinib (Iclusig) for CML and Ph+ ALL.
    Med Lett Drugs Ther; 2013 Sep; 55(1424):71-2. PubMed ID: 25970013
    [No Abstract]   [Full Text] [Related]  

  • 12. Ponatinib in the therapy of chronic myeloid leukemia.
    Poch Martell M; Sibai H; Deotare U; Lipton JH
    Expert Rev Hematol; 2016 Oct; 9(10):923-32. PubMed ID: 27590270
    [TBL] [Abstract][Full Text] [Related]  

  • 13. HS-438, a new inhibitor of imatinib-resistant BCR-ABL T315I mutation in chronic myeloid leukemia.
    Yun SM; Jung KH; Kim SJ; Fang Z; Son MK; Yan HH; Lee H; Kim J; Shin S; Hong S; Hong SS
    Cancer Lett; 2014 Jun; 348(1-2):50-60. PubMed ID: 24657654
    [TBL] [Abstract][Full Text] [Related]  

  • 14. Three novel patient-derived BCR/ABL mutants show different sensitivity to second and third generation tyrosine kinase inhibitors.
    Redaelli S; Mologni L; Rostagno R; Piazza R; Magistroni V; Ceccon M; Viltadi M; Flynn D; Gambacorti-Passerini C
    Am J Hematol; 2012 Nov; 87(11):E125-8. PubMed ID: 23044928
    [TBL] [Abstract][Full Text] [Related]  

  • 15. Unexpected Success of Watch and Wait Strategy in a Ponatinib-Intolerant Patient With Chronic Myeloid Leukemia.
    Engel NW; Constantin A; Fowlkes S; Assouline S
    J Oncol Pract; 2016 Jun; 12(6):592-4. PubMed ID: 27246687
    [No Abstract]   [Full Text] [Related]  

  • 16. Treatment of an adolescent with chronic myeloid leukemia and the T315I mutation with ponatinib.
    Nickel RS; Daves M; Keller F
    Pediatr Blood Cancer; 2015 Nov; 62(11):2050-1. PubMed ID: 25939962
    [No Abstract]   [Full Text] [Related]  

  • 17. Chronic myelogenous leukemia. Preface.
    DeAngelo DJ
    Hematol Oncol Clin North Am; 2011 Oct; 25(5):ix-x. PubMed ID: 22054737
    [No Abstract]   [Full Text] [Related]  

  • 18. Mutations of the BCR-ABL-kinase domain occur in a minority of patients with stable complete cytogenetic response to imatinib.
    Sherbenou DW; Wong MJ; Humayun A; McGreevey LS; Harrell P; Yang R; Mauro M; Heinrich MC; Press RD; Druker BJ; Deininger MW
    Leukemia; 2007 Mar; 21(3):489-93. PubMed ID: 17252009
    [TBL] [Abstract][Full Text] [Related]  

  • 19. Sustained clinical remission despite suboptimal molecular response to imatinib in e1a2 BCR-ABL chronic myeloid leukemia.
    Langabeer SE; Crampe M; Haslam K; Kelly J; Cahill MR
    Leuk Res; 2010 Jul; 34(7):e176-7. PubMed ID: 20153526
    [No Abstract]   [Full Text] [Related]  

  • 20. Chronic myeloid leukemia and BCR/ABL signal pathways are not associated with AKT1 pleckstrin homology domain (E17K) mutations.
    He Y; Zheng J; Hu Y; Xiao H; Liu J; Li X; Du W; Chen X; Hu Y; Huang S
    Eur J Haematol; 2010 Jan; 84(1):87-8. PubMed ID: 19744127
    [No Abstract]   [Full Text] [Related]  

    [Next]    [New Search]
    of 6.