BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

232 related articles for article (PubMed ID: 23003922)

  • 1. RNA interference-mediated phosphodiesterase 4D splice variants knock-down in the prefrontal cortex produces antidepressant-like and cognition-enhancing effects.
    Wang ZZ; Zhang Y; Liu YQ; Zhao N; Zhang YZ; Yuan L; An L; Li J; Wang XY; Qin JJ; Wilson SP; O'Donnell JM; Zhang HT; Li YF
    Br J Pharmacol; 2013 Feb; 168(4):1001-14. PubMed ID: 23003922
    [TBL] [Abstract][Full Text] [Related]  

  • 2. Phosphodiesterase-4D Knock-down in the Prefrontal Cortex Alleviates Chronic Unpredictable Stress-Induced Depressive-Like Behaviors and Memory Deficits in Mice.
    Wang ZZ; Yang WX; Zhang Y; Zhao N; Zhang YZ; Liu YQ; Xu Y; Wilson SP; O'Donnell JM; Zhang HT; Li YF
    Sci Rep; 2015 Jul; 5():11332. PubMed ID: 26161529
    [TBL] [Abstract][Full Text] [Related]  

  • 3. Phosphodiesterase-4D knock-out and RNA interference-mediated knock-down enhance memory and increase hippocampal neurogenesis via increased cAMP signaling.
    Li YF; Cheng YF; Huang Y; Conti M; Wilson SP; O'Donnell JM; Zhang HT
    J Neurosci; 2011 Jan; 31(1):172-83. PubMed ID: 21209202
    [TBL] [Abstract][Full Text] [Related]  

  • 4. Antidepressant-like profile and reduced sensitivity to rolipram in mice deficient in the PDE4D phosphodiesterase enzyme.
    Zhang HT; Huang Y; Jin SL; Frith SA; Suvarna N; Conti M; O'Donnell JM
    Neuropsychopharmacology; 2002 Oct; 27(4):587-95. PubMed ID: 12377395
    [TBL] [Abstract][Full Text] [Related]  

  • 5. Chlorbipram: a novel PDE4 inhibitor with improved safety as a potential antidepressant and cognitive enhancer.
    Zhang MZ; Zhou ZZ; Yuan X; Cheng YF; Bi BT; Gong MF; Chen YP; Xu JP
    Eur J Pharmacol; 2013 Dec; 721(1-3):56-63. PubMed ID: 24113523
    [TBL] [Abstract][Full Text] [Related]  

  • 6. RNA interference-mediated knockdown of long-form phosphodiesterase-4D (PDE4D) enzyme reverses amyloid-β42-induced memory deficits in mice.
    Zhang C; Cheng Y; Wang H; Wang C; Wilson SP; Xu J; Zhang HT
    J Alzheimers Dis; 2014; 38(2):269-80. PubMed ID: 23948935
    [TBL] [Abstract][Full Text] [Related]  

  • 7. Discovery of N-Alkyl Catecholamides as Selective Phosphodiesterase-4 Inhibitors with Anti-neuroinflammation Potential Exhibiting Antidepressant-like Effects at Non-emetic Doses.
    Zhou ZZ; Cheng YF; Zou ZQ; Ge BC; Yu H; Huang C; Wang HT; Yang XM; Xu JP
    ACS Chem Neurosci; 2017 Jan; 8(1):135-146. PubMed ID: 27690383
    [TBL] [Abstract][Full Text] [Related]  

  • 8. Improvement of spatial memory function in APPswe/PS1dE9 mice after chronic inhibition of phosphodiesterase type 4D.
    Sierksma AS; van den Hove DL; Pfau F; Philippens M; Bruno O; Fedele E; Ricciarelli R; Steinbusch HW; Vanmierlo T; Prickaerts J
    Neuropharmacology; 2014 Feb; 77():120-30. PubMed ID: 24067928
    [TBL] [Abstract][Full Text] [Related]  

  • 9. Cyclic AMP-specific phosphodiesterase-4 as a target for the development of antidepressant drugs.
    Zhang HT
    Curr Pharm Des; 2009; 15(14):1688-98. PubMed ID: 19442182
    [TBL] [Abstract][Full Text] [Related]  

  • 10. Etazolate abrogates the lipopolysaccharide (LPS)-induced downregulation of the cAMP/pCREB/BDNF signaling, neuroinflammatory response and depressive-like behavior in mice.
    Guo J; Lin P; Zhao X; Zhang J; Wei X; Wang Q; Wang C
    Neuroscience; 2014 Mar; 263():1-14. PubMed ID: 24434771
    [TBL] [Abstract][Full Text] [Related]  

  • 11. A new model of Pde4d deficiency: genetic knock-down of PDE4D enzyme in rats produces an antidepressant phenotype without spatial cognitive effects.
    Schaefer TL; Braun AA; Amos-Kroohs RM; Williams MT; Ostertag E; Vorhees CV
    Genes Brain Behav; 2012 Jul; 11(5):614-22. PubMed ID: 22487514
    [TBL] [Abstract][Full Text] [Related]  

  • 12. The PDE4 inhibitor roflumilast improves memory in rodents at non-emetic doses.
    Vanmierlo T; Creemers P; Akkerman S; van Duinen M; Sambeth A; De Vry J; Uz T; Blokland A; Prickaerts J
    Behav Brain Res; 2016 Apr; 303():26-33. PubMed ID: 26794595
    [TBL] [Abstract][Full Text] [Related]  

  • 13. Interaction between the antidepressant-like behavioral effects of beta adrenergic agonists and the cyclic AMP PDE inhibitor rolipram in rats.
    Zhang HT; Huang Y; Mishler K; Roerig SC; O'Donnell JM
    Psychopharmacology (Berl); 2005 Oct; 182(1):104-15. PubMed ID: 16010541
    [TBL] [Abstract][Full Text] [Related]  

  • 14. Antidepressant-like effect of etazolate, a cyclic nucleotide phosphodiesterase 4 inhibitor--an approach using rodent behavioral antidepressant tests battery.
    Jindal A; Mahesh R; Gautam B; Bhatt S; Pandey D
    Eur J Pharmacol; 2012 Aug; 689(1-3):125-31. PubMed ID: 22698578
    [TBL] [Abstract][Full Text] [Related]  

  • 15. Attenuation of ethanol abstinence-induced anxiety- and depressive-like behavior by the phosphodiesterase-4 inhibitor rolipram in rodents.
    Gong MF; Wen RT; Xu Y; Pan JC; Fei N; Zhou YM; Xu JP; Liang JH; Zhang HT
    Psychopharmacology (Berl); 2017 Oct; 234(20):3143-3151. PubMed ID: 28748375
    [TBL] [Abstract][Full Text] [Related]  

  • 16. The PDE4 cAMP-Specific Phosphodiesterases: Targets for Drugs with Antidepressant and Memory-Enhancing Action.
    Bolger GB
    Adv Neurobiol; 2017; 17():63-102. PubMed ID: 28956330
    [TBL] [Abstract][Full Text] [Related]  

  • 17. PAN-selective inhibition of cAMP-phosphodiesterase 4 (PDE4) induces gastroparesis in mice.
    McDonough W; Aragon IV; Rich J; Murphy JM; Abou Saleh L; Boyd A; Koloteva A; Richter W
    FASEB J; 2020 Sep; 34(9):12533-12548. PubMed ID: 32738081
    [TBL] [Abstract][Full Text] [Related]  

  • 18. GEBR-7b, a novel PDE4D selective inhibitor that improves memory in rodents at non-emetic doses.
    Bruno O; Fedele E; Prickaerts J; Parker LA; Canepa E; Brullo C; Cavallero A; Gardella E; Balbi A; Domenicotti C; Bollen E; Gijselaers HJ; Vanmierlo T; Erb K; Limebeer CL; Argellati F; Marinari UM; Pronzato MA; Ricciarelli R
    Br J Pharmacol; 2011 Dec; 164(8):2054-63. PubMed ID: 21649644
    [TBL] [Abstract][Full Text] [Related]  

  • 19. Short-term or long-term treatments with a phosphodiesterase-4 (PDE4) inhibitor result in opposing agonist-induced Ca(2+) responses in endothelial cells.
    Campos-Toimil M; Keravis T; Orallo F; Takeda K; Lugnier C
    Br J Pharmacol; 2008 May; 154(1):82-92. PubMed ID: 18311187
    [TBL] [Abstract][Full Text] [Related]  

  • 20. Mice deficient in phosphodiesterase-4A display anxiogenic-like behavior.
    Hansen RT; Conti M; Zhang HT
    Psychopharmacology (Berl); 2014 Aug; 231(15):2941-54. PubMed ID: 24563185
    [TBL] [Abstract][Full Text] [Related]  

    [Next]    [New Search]
    of 12.