These tools will no longer be maintained as of December 31, 2024. Archived website can be found here. PubMed4Hh GitHub repository can be found here. Contact NLM Customer Service if you have questions.
238 related articles for article (PubMed ID: 23010456)
1. Synthesis and structure-activity relationship of fused-pyrimidine derivatives as a series of novel GPR119 agonists. Negoro K; Yonetoku Y; Moritomo A; Hayakawa M; Iikubo K; Yoshida S; Takeuchi M; Ohta M Bioorg Med Chem; 2012 Nov; 20(21):6442-51. PubMed ID: 23010456 [TBL] [Abstract][Full Text] [Related]
2. Discovery and biological evaluation of novel 4-amino-2-phenylpyrimidine derivatives as potent and orally active GPR119 agonists. Negoro K; Yonetoku Y; Misawa-Mukai H; Hamaguchi W; Maruyama T; Yoshida S; Takeuchi M; Ohta M Bioorg Med Chem; 2012 Sep; 20(17):5235-46. PubMed ID: 22836190 [TBL] [Abstract][Full Text] [Related]
3. Synthesis and structure-activity relationship of 4-amino-2-phenylpyrimidine derivatives as a series of novel GPR119 agonists. Negoro K; Yonetoku Y; Maruyama T; Yoshida S; Takeuchi M; Ohta M Bioorg Med Chem; 2012 Apr; 20(7):2369-75. PubMed ID: 22365911 [TBL] [Abstract][Full Text] [Related]
4. Discovery of pyrazolo[3,4-d]pyrimidine derivatives as GPR119 agonists. Gillespie P; Goodnow RA; Saha G; Bose G; Moulik K; Zwingelstein C; Myers M; Conde-Knape K; Pietranico-Cole S; So SS Bioorg Med Chem Lett; 2014 Feb; 24(3):949-53. PubMed ID: 24412066 [TBL] [Abstract][Full Text] [Related]
5. Synthesis and evaluation of novel fused pyrimidine derivatives as GPR119 agonists. Fang Y; Xiong L; Hu J; Zhang S; Xie S; Tu L; Wan Y; Jin Y; Li X; Hu S; Yang Z Bioorg Chem; 2019 May; 86():103-111. PubMed ID: 30685641 [TBL] [Abstract][Full Text] [Related]
6. Design and synthesis of novel pyrimido[5,4-d]pyrimidine derivatives as GPR119 agonist for treatment of type 2 diabetes. Fang Y; Xu J; Li Z; Yang Z; Xiong L; Jin Y; Wang Q; Xie S; Zhu W; Chang S Bioorg Med Chem; 2018 Aug; 26(14):4080-4087. PubMed ID: 30100020 [TBL] [Abstract][Full Text] [Related]
7. Discovery of 6,7-dihydro-5H-pyrrolo[2,3-a]pyrimidines as orally available G protein-coupled receptor 119 agonists. Katamreddy SR; Carpenter AJ; Ammala CE; Boros EE; Brashear RL; Briscoe CP; Bullard SR; Caldwell RD; Conlee CR; Croom DK; Hart SM; Heyer DO; Johnson PR; Kashatus JA; Minick DJ; Peckham GE; Ross SA; Roller SG; Samano VA; Sauls HR; Tadepalli SM; Thompson JB; Xu Y; Way JM J Med Chem; 2012 Dec; 55(24):10972-94. PubMed ID: 23214471 [TBL] [Abstract][Full Text] [Related]
8. Optimization of a novel series of potent and orally bioavailable GPR119 agonists. Koshizawa T; Morimoto T; Watanabe G; Watanabe T; Yamasaki N; Sawada Y; Fukuda T; Okuda A; Shibuya K; Ohgiya T Bioorg Med Chem Lett; 2017 Aug; 27(15):3249-3253. PubMed ID: 28648463 [TBL] [Abstract][Full Text] [Related]
9. Discovery of 5-methyl-2-(4-((4-(methylsulfonyl)benzyl)oxy)phenyl)-4-(piperazin-1-yl)pyrimidine derivatives as novel GRP119 agonists for the treatment of diabetes and obesity. Chen J; Sang Z; Li L; He L; Ma L Mol Divers; 2017 Aug; 21(3):637-654. PubMed ID: 28656523 [TBL] [Abstract][Full Text] [Related]
10. Synthesis and biological evaluation of thienopyrimidine derivatives as GPR119 agonists. Jeon MK; Lee KM; Kim IH; Jang YK; Kang SK; Lee JM; Jung KY; Kumar JA; Rhee SD; Jung WH; Song JS; Bae MA; Kim KR; Ahn JH Bioorg Med Chem Lett; 2014 Sep; 24(17):4281-5. PubMed ID: 25082125 [TBL] [Abstract][Full Text] [Related]
11. Discovery of structurally novel, potent and orally efficacious GPR119 agonists. Alper P; Azimioara M; Cow C; Mutnick D; Nikulin V; Michellys PY; Wang Z; Reding E; Paliotti M; Li J; Bao D; Zoll J; Kim Y; Zimmerman M; Groessel T; Tuntland T; Joseph SB; McNamara P; Seidel HM; Epple R Bioorg Med Chem Lett; 2014 May; 24(10):2383-7. PubMed ID: 24751443 [TBL] [Abstract][Full Text] [Related]
12. Discovery of the first potent and orally efficacious agonist of the orphan G-protein coupled receptor 119. Semple G; Fioravanti B; Pereira G; Calderon I; Uy J; Choi K; Xiong Y; Ren A; Morgan M; Dave V; Thomsen W; Unett DJ; Xing C; Bossie S; Carroll C; Chu ZL; Grottick AJ; Hauser EK; Leonard J; Jones RM J Med Chem; 2008 Sep; 51(17):5172-5. PubMed ID: 18698756 [TBL] [Abstract][Full Text] [Related]
13. Discovery of orally active sulfonylphenyl thieno[3,2-d]pyrimidine derivatives as GPR119 agonists. Kim H; Kim M; Oh K; Lee S; Lim S; Lee S; Kim YH; Suh KH; Min KH Eur J Med Chem; 2023 Oct; 258():115584. PubMed ID: 37356344 [TBL] [Abstract][Full Text] [Related]
14. Synthesis and SAR studies of bicyclic amine series GPR119 agonists. Sakairi M; Kogami M; Torii M; Kataoka H; Fujieda H; Makino M; Kataoka D; Okamoto R; Miyazawa T; Okabe M; Inoue M; Takahashi N; Harada S; Watanabe N Bioorg Med Chem Lett; 2012 Aug; 22(15):5123-8. PubMed ID: 22765901 [TBL] [Abstract][Full Text] [Related]
15. Discovery of novel pyrimidine and malonamide derivatives as TGR5 agonists. Park EJ; Ahn YG; Jung SH; Bang HJ; Kim M; Hong DJ; Kim J; Suh KH; Kim YJ; Kim D; Kim EY; Lee K; Min KH Bioorg Med Chem Lett; 2014 Sep; 24(17):4271-5. PubMed ID: 25082126 [TBL] [Abstract][Full Text] [Related]
16. Synthesis and biological evaluation of 5-nitropyrimidine analogs with azabicyclic substituents as GPR119 agonists. Yang Z; Fang Y; Pham TA; Lee J; Park H Bioorg Med Chem Lett; 2013 Mar; 23(5):1519-21. PubMed ID: 23374864 [TBL] [Abstract][Full Text] [Related]
17. Discovery of a nortropanol derivative as a potent and orally active GPR119 agonist for type 2 diabetes. Xia Y; Chackalamannil S; Greenlee WJ; Jayne C; Neustadt B; Stamford A; Vaccaro H; Xu XL; Baker H; O'Neill K; Woods M; Hawes B; Kowalski T Bioorg Med Chem Lett; 2011 Jun; 21(11):3290-6. PubMed ID: 21536438 [TBL] [Abstract][Full Text] [Related]
18. Optimisation of novel 4, 8-disubstituted dihydropyrimido[5,4- Fang Y; Zhang S; Li M; Xiong L; Tu L; Xie S; Jin Y; Liu Y; Yang Z; Liu R J Enzyme Inhib Med Chem; 2020 Dec; 35(1):50-58. PubMed ID: 31656107 [TBL] [Abstract][Full Text] [Related]
19. Discovery of a novel series of indolinylpyrimidine-based GPR119 agonists: Elimination of ether-a-go-go-related gene liability using a hydrogen bond acceptor-focused approach. Kamaura M; Kubo O; Sugimoto H; Noguchi N; Miyashita H; Abe S; Matsuda K; Tsujihata Y; Odani T; Iwasaki S; Murata T; Sato K Bioorg Med Chem; 2021 Mar; 34():116034. PubMed ID: 33548803 [TBL] [Abstract][Full Text] [Related]
20. Design and synthesis of tetrahydropyridopyrimidine derivatives as dual GPR119 and DPP-4 modulators. Fang Y; Zhang S; Wu W; Liu Y; Yang J; Li Y; Li M; Dong H; Jin Y; Liu R; Yang Z Bioorg Chem; 2020 Jan; 94():103390. PubMed ID: 31662212 [TBL] [Abstract][Full Text] [Related] [Next] [New Search]