BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

133 related articles for article (PubMed ID: 23025719)

  • 1. Application of structure-based drug design and parallel chemistry to identify selective, brain penetrant, in vivo active phosphodiesterase 9A inhibitors.
    Claffey MM; Helal CJ; Verhoest PR; Kang Z; Fors KS; Jung S; Zhong J; Bundesmann MW; Hou X; Lui S; Kleiman RJ; Vanase-Frawley M; Schmidt AW; Menniti F; Schmidt CJ; Hoffman WE; Hajos M; McDowell L; O'Connor RE; Macdougall-Murphy M; Fonseca KR; Becker SL; Nelson FR; Liras S
    J Med Chem; 2012 Nov; 55(21):9055-68. PubMed ID: 23025719
    [TBL] [Abstract][Full Text] [Related]  

  • 2. Design and discovery of 6-[(3S,4S)-4-methyl-1-(pyrimidin-2-ylmethyl)pyrrolidin-3-yl]-1-(tetrahydro-2H-pyran-4-yl)-1,5-dihydro-4H-pyrazolo[3,4-d]pyrimidin-4-one (PF-04447943), a selective brain penetrant PDE9A inhibitor for the treatment of cognitive disorders.
    Verhoest PR; Fonseca KR; Hou X; Proulx-Lafrance C; Corman M; Helal CJ; Claffey MM; Tuttle JB; Coffman KJ; Liu S; Nelson F; Kleiman RJ; Menniti FS; Schmidt CJ; Vanase-Frawley M; Liras S
    J Med Chem; 2012 Nov; 55(21):9045-54. PubMed ID: 22780914
    [TBL] [Abstract][Full Text] [Related]  

  • 3. Molecular dynamics-based discovery of novel phosphodiesterase-9A inhibitors with non-pyrazolopyrimidinone scaffolds.
    Li Z; Lu X; Feng LJ; Gu Y; Li X; Wu Y; Luo HB
    Mol Biosyst; 2015 Jan; 11(1):115-25. PubMed ID: 25328054
    [TBL] [Abstract][Full Text] [Related]  

  • 4. A novel series of potent and selective PDE5 inhibitors with potential for high and dose-independent oral bioavailability.
    Allerton CM; Barber CG; Beaumont KC; Brown DG; Cole SM; Ellis D; Lane CA; Maw GN; Mount NM; Rawson DJ; Robinson CM; Street SD; Summerhill NW
    J Med Chem; 2006 Jun; 49(12):3581-94. PubMed ID: 16759100
    [TBL] [Abstract][Full Text] [Related]  

  • 5. Identification of a brain penetrant PDE9A inhibitor utilizing prospective design and chemical enablement as a rapid lead optimization strategy.
    Verhoest PR; Proulx-Lafrance C; Corman M; Chenard L; Helal CJ; Hou X; Kleiman R; Liu S; Marr E; Menniti FS; Schmidt CJ; Vanase-Frawley M; Schmidt AW; Williams RD; Nelson FR; Fonseca KR; Liras S
    J Med Chem; 2009 Dec; 52(24):7946-9. PubMed ID: 19919087
    [TBL] [Abstract][Full Text] [Related]  

  • 6. The Novel Phosphodiesterase 9A Inhibitor BI 409306 Increases Cyclic Guanosine Monophosphate Levels in the Brain, Promotes Synaptic Plasticity, and Enhances Memory Function in Rodents.
    Rosenbrock H; Giovannini R; Schänzle G; Koros E; Runge F; Fuchs H; Marti A; Reymann KG; Schröder UH; Fedele E; Dorner-Ciossek C
    J Pharmacol Exp Ther; 2019 Dec; 371(3):633-641. PubMed ID: 31578258
    [No Abstract]   [Full Text] [Related]  

  • 7. Phosphodiesterase 9: insights from protein structure and role in therapeutics.
    Singh N; Patra S
    Life Sci; 2014 Jun; 106(1-2):1-11. PubMed ID: 24746902
    [TBL] [Abstract][Full Text] [Related]  

  • 8. The selective phosphodiesterase 9 (PDE9) inhibitor PF-04447943 (6-[(3S,4S)-4-methyl-1-(pyrimidin-2-ylmethyl)pyrrolidin-3-yl]-1-(tetrahydro-2H-pyran-4-yl)-1,5-dihydro-4H-pyrazolo[3,4-d]pyrimidin-4-one) enhances synaptic plasticity and cognitive function in rodents.
    Hutson PH; Finger EN; Magliaro BC; Smith SM; Converso A; Sanderson PE; Mullins D; Hyde LA; Eschle BK; Turnbull Z; Sloan H; Guzzi M; Zhang X; Wang A; Rindgen D; Mazzola R; Vivian JA; Eddins D; Uslaner JM; Bednar R; Gambone C; Le-Mair W; Marino MJ; Sachs N; Xu G; Parmentier-Batteur S
    Neuropharmacology; 2011 Sep; 61(4):665-76. PubMed ID: 21619887
    [TBL] [Abstract][Full Text] [Related]  

  • 9. Structure-based discovery of highly selective phosphodiesterase-9A inhibitors and implications for inhibitor design.
    Meng F; Hou J; Shao YX; Wu PY; Huang M; Zhu X; Cai Y; Li Z; Xu J; Liu P; Luo HB; Wan Y; Ke H
    J Med Chem; 2012 Oct; 55(19):8549-58. PubMed ID: 22985069
    [TBL] [Abstract][Full Text] [Related]  

  • 10. Synthesis and evaluation of polycyclic pyrazolo[3,4-d]pyrimidines as PDE1 and PDE5 cGMP phosphodiesterase inhibitors.
    Xia Y; Chackalamannil S; Czarniecki M; Tsai H; Vaccaro H; Cleven R; Cook J; Fawzi A; Watkins R; Zhang H
    J Med Chem; 1997 Dec; 40(26):4372-7. PubMed ID: 9435906
    [TBL] [Abstract][Full Text] [Related]  

  • 11. The discovery of potent, selective, and orally bioavailable PDE9 inhibitors as potential hypoglycemic agents.
    Deninno MP; Andrews M; Bell AS; Chen Y; Eller-Zarbo C; Eshelby N; Etienne JB; Moore DE; Palmer MJ; Visser MS; Yu LJ; Zavadoski WJ; Michael Gibbs E
    Bioorg Med Chem Lett; 2009 May; 19(9):2537-41. PubMed ID: 19339180
    [TBL] [Abstract][Full Text] [Related]  

  • 12. Insight into binding of phosphodiesterase-9A selective inhibitors by crystal structures and mutagenesis.
    Wang H; Luo X; Ye M; Hou J; Robinson H; Ke H
    J Med Chem; 2010 Feb; 53(4):1726-31. PubMed ID: 20121115
    [TBL] [Abstract][Full Text] [Related]  

  • 13. Potent and selective pyrazolo[1,5-a]pyrimidine based inhibitors of B-Raf(V600E) kinase with favorable physicochemical and pharmacokinetic properties.
    Ren L; Laird ER; Buckmelter AJ; Dinkel V; Gloor SL; Grina J; Newhouse B; Rasor K; Hastings G; Gradl SN; Rudolph J
    Bioorg Med Chem Lett; 2012 Jan; 22(2):1165-8. PubMed ID: 22196124
    [TBL] [Abstract][Full Text] [Related]  

  • 14. Structural determinants for inhibitor specificity and selectivity in PDE2A using the wheat germ in vitro translation system.
    Iffland A; Kohls D; Low S; Luan J; Zhang Y; Kothe M; Cao Q; Kamath AV; Ding YH; Ellenberger T
    Biochemistry; 2005 Jun; 44(23):8312-25. PubMed ID: 15938621
    [TBL] [Abstract][Full Text] [Related]  

  • 15. Discovery of a phosphodiesterase 9A inhibitor as a potential hypoglycemic agent.
    Shao YX; Huang M; Cui W; Feng LJ; Wu Y; Cai Y; Li Z; Zhu X; Liu P; Wan Y; Ke H; Luo HB
    J Med Chem; 2014 Dec; 57(24):10304-13. PubMed ID: 25432025
    [TBL] [Abstract][Full Text] [Related]  

  • 16. Design, synthesis and evaluation of pyrazolopyrimidinone derivatives as novel PDE9A inhibitors for treatment of Alzheimer's disease.
    Zhang P; Jiang MY; Le ML; Zhang B; Zhou Q; Wu Y; Zhang C; Luo HB
    Bioorg Med Chem Lett; 2020 Jul; 30(14):127254. PubMed ID: 32527553
    [TBL] [Abstract][Full Text] [Related]  

  • 17. C33(S), a novel PDE9A inhibitor, protects against rat cardiac hypertrophy through upregulating cGMP signaling.
    Wang PX; Li ZM; Cai SD; Li JY; He P; Huang Y; Feng GS; Luo HB; Chen SR; Liu PQ
    Acta Pharmacol Sin; 2017 Sep; 38(9):1257-1268. PubMed ID: 28649129
    [TBL] [Abstract][Full Text] [Related]  

  • 18. Dual M3 antagonists-PDE4 inhibitors. Part 2: Synthesis and SAR of 3-substituted azetidinyl derivatives.
    Provins L; Christophe B; Danhaive P; Dulieu J; Gillard M; Quéré L; Stebbins K
    Bioorg Med Chem Lett; 2007 Jun; 17(11):3077-80. PubMed ID: 17398090
    [TBL] [Abstract][Full Text] [Related]  

  • 19. Phosphodiesterase 9A regulates central cGMP and modulates responses to cholinergic and monoaminergic perturbation in vivo.
    Kleiman RJ; Chapin DS; Christoffersen C; Freeman J; Fonseca KR; Geoghegan KF; Grimwood S; Guanowsky V; Hajós M; Harms JF; Helal CJ; Hoffmann WE; Kocan GP; Majchrzak MJ; McGinnis D; McLean S; Menniti FS; Nelson F; Roof R; Schmidt AW; Seymour PA; Stephenson DT; Tingley FD; Vanase-Frawley M; Verhoest PR; Schmidt CJ
    J Pharmacol Exp Ther; 2012 May; 341(2):396-409. PubMed ID: 22328573
    [TBL] [Abstract][Full Text] [Related]  

  • 20. Use of structure-based design to discover a potent, selective, in vivo active phosphodiesterase 10A inhibitor lead series for the treatment of schizophrenia.
    Helal CJ; Kang Z; Hou X; Pandit J; Chappie TA; Humphrey JM; Marr ES; Fennell KF; Chenard LK; Fox C; Schmidt CJ; Williams RD; Chapin DS; Siuciak J; Lebel L; Menniti F; Cianfrogna J; Fonseca KR; Nelson FR; O'Connor R; MacDougall M; McDowell L; Liras S
    J Med Chem; 2011 Jul; 54(13):4536-47. PubMed ID: 21650160
    [TBL] [Abstract][Full Text] [Related]  

    [Next]    [New Search]
    of 7.