These tools will no longer be maintained as of December 31, 2024. Archived website can be found here. PubMed4Hh GitHub repository can be found here. Contact NLM Customer Service if you have questions.


BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

449 related articles for article (PubMed ID: 23029106)

  • 1. A novel small molecule FL118 that selectively inhibits survivin, Mcl-1, XIAP and cIAP2 in a p53-independent manner, shows superior antitumor activity.
    Ling X; Cao S; Cheng Q; Keefe JT; Rustum YM; Li F
    PLoS One; 2012; 7(9):e45571. PubMed ID: 23029106
    [TBL] [Abstract][Full Text] [Related]  

  • 2. Antitumor activity of FL118, a survivin, Mcl-1, XIAP, and cIAP2 selective inhibitor, is highly dependent on its primary structure and steric configuration.
    Zhao J; Ling X; Cao S; Liu X; Wan S; Jiang T; Li F
    Mol Pharm; 2014 Feb; 11(2):457-67. PubMed ID: 24329001
    [TBL] [Abstract][Full Text] [Related]  

  • 3. An ABCG2 non-substrate anticancer agent FL118 targets drug-resistant cancer stem-like cells and overcomes treatment resistance of human pancreatic cancer.
    Ling X; Wu W; Fan C; Xu C; Liao J; Rich LJ; Huang RY; Repasky EA; Wang X; Li F
    J Exp Clin Cancer Res; 2018 Oct; 37(1):240. PubMed ID: 30285798
    [TBL] [Abstract][Full Text] [Related]  

  • 4. Design, Synthesis, and In Vitro/In Vivo Anti-Cancer Activities of Novel (20
    Dai X; Wu G; Zhang Y; Zhang X; Yin R; Qi X; Li J; Jiang T
    Int J Mol Sci; 2020 Nov; 21(22):. PubMed ID: 33187360
    [TBL] [Abstract][Full Text] [Related]  

  • 5. FL118 induces p53-dependent senescence in colorectal cancer cells by promoting degradation of MdmX.
    Ling X; Xu C; Fan C; Zhong K; Li F; Wang X
    Cancer Res; 2014 Dec; 74(24):7487-97. PubMed ID: 25512388
    [TBL] [Abstract][Full Text] [Related]  

  • 6. FL118, a novel camptothecin derivative, is insensitive to ABCG2 expression and shows improved efficacy in comparison with irinotecan in colon and lung cancer models with ABCG2-induced resistance.
    Westover D; Ling X; Lam H; Welch J; Jin C; Gongora C; Del Rio M; Wani M; Li F
    Mol Cancer; 2015 Apr; 14():92. PubMed ID: 25928015
    [TBL] [Abstract][Full Text] [Related]  

  • 7. Topoisomerase I (Top1): a major target of FL118 for its antitumor efficacy or mainly involved in its side effects of hematopoietic toxicity?
    Li F; Ling X; Harris DL; Liao J; Wang Y; Westover D; Jiang G; Xu B; Boland PM; Jin C
    Am J Cancer Res; 2017; 7(2):370-382. PubMed ID: 28337384
    [TBL] [Abstract][Full Text] [Related]  

  • 8. Anticancer drug FL118 is more than a survivin inhibitor: where is the Achilles' heel of cancer?
    Li F
    Am J Cancer Res; 2014; 4(3):304-11. PubMed ID: 24959385
    [TBL] [Abstract][Full Text] [Related]  

  • 9. An intravenous (i.v.) route-compatible formulation of FL118, a survivin, Mcl-1, XIAP, and cIAP2 selective inhibitor, improves FL118 antitumor efficacy and therapeutic index (TI).
    Ling X; Li F
    Am J Transl Res; 2013; 5(2):139-54. PubMed ID: 23573360
    [TBL] [Abstract][Full Text] [Related]  

  • 10. FL118, acting as a 'molecular glue degrader', binds to dephosphorylates and degrades the oncoprotein DDX5 (p68) to control c-Myc, survivin and mutant Kras against colorectal and pancreatic cancer with high efficacy.
    Ling X; Wu W; Aljahdali IAM; Liao J; Santha S; Fountzilas C; Boland PM; Li F
    Clin Transl Med; 2022 May; 12(5):e881. PubMed ID: 35604033
    [TBL] [Abstract][Full Text] [Related]  

  • 11. Discovery of survivin inhibitors and beyond: FL118 as a proof of concept.
    Li F
    Int Rev Cell Mol Biol; 2013; 305():217-52. PubMed ID: 23890383
    [TBL] [Abstract][Full Text] [Related]  

  • 12. FL118 inhibits viability and induces apoptosis of colorectal cancer cells via inactivating the CIP2A/PP2A axis.
    Lin X; Gao M; Zhang A; Tong J; Zhang X; Su Q; Yang Z; Gao H; Jiang G
    Life Sci; 2019 Dec; 239():117074. PubMed ID: 31751585
    [TBL] [Abstract][Full Text] [Related]  

  • 13. Synergistic effect of oxymatrine and angiogenesis inhibitor NM-3 on modulating apoptosis in human gastric cancer cells.
    Song MQ; Zhu JS; Chen JL; Wang L; Da W; Zhu L; Zhang WP
    World J Gastroenterol; 2007 Mar; 13(12):1788-93. PubMed ID: 17465467
    [TBL] [Abstract][Full Text] [Related]  

  • 14. Kras mutation subtypes distinctly affect colorectal cancer cell sensitivity to FL118, a novel inhibitor of survivin, Mcl-1, XIAP, cIAP2 and MdmX.
    Thangaiyan R; Aljahdali IA; Lent-Moore KY; Liao J; Ling X; Li F
    Am J Transl Res; 2021; 13(7):7458-7474. PubMed ID: 34377229
    [TBL] [Abstract][Full Text] [Related]  

  • 15. Preclinical assesement of survivin and XIAP as prognostic biomarkers and therapeutic targets in gastroenteropancreatic neuroendocrine neoplasia.
    Dizdar L; Oesterwind KA; Riemer JC; Werner TA; Mersch S; Möhlendick B; Schütte SC; Verde PE; Raba K; Topp SA; Stoecklein NH; Esposito I; Knoefel WT; Krieg A
    Oncotarget; 2017 Jan; 8(5):8369-8382. PubMed ID: 28039474
    [TBL] [Abstract][Full Text] [Related]  

  • 16. p53-Independent apoptosis by benzyl isothiocyanate in human breast cancer cells is mediated by suppression of XIAP expression.
    Kim SH; Singh SV
    Cancer Prev Res (Phila); 2010 Jun; 3(6):718-26. PubMed ID: 20484174
    [TBL] [Abstract][Full Text] [Related]  

  • 17. Hydroxycamptothecin induces apoptosis and inhibits tumor growth in colon cancer by the downregulation of survivin and XIAP expression.
    Fei B; Chi AL; Weng Y
    World J Surg Oncol; 2013 May; 11():120. PubMed ID: 23721525
    [TBL] [Abstract][Full Text] [Related]  

  • 18. FL118, a novel camptothecin analogue, suppressed migration and invasion of human breast cancer cells by inhibiting epithelial-mesenchymal transition via the Wnt/β-catenin signaling pathway.
    Yang Z; Ji L; Jiang G; Liu R; Liu Z; Yang Y; Ma Q; Zhao H
    Biosci Trends; 2018; 12(1):40-46. PubMed ID: 29553100
    [TBL] [Abstract][Full Text] [Related]  

  • 19. Biological Potential and Mechanism of Prodigiosin from
    Li D; Liu J; Wang X; Kong D; Du W; Li H; Hse CY; Shupe T; Zhou D; Zhao K
    Int J Mol Sci; 2018 Nov; 19(11):. PubMed ID: 30400387
    [TBL] [Abstract][Full Text] [Related]  

  • 20. Topotecan triggers apoptosis in p53-deficient cells by forcing degradation of XIAP and survivin thereby activating caspase-3-mediated Bid cleavage.
    Tomicic MT; Christmann M; Kaina B
    J Pharmacol Exp Ther; 2010 Jan; 332(1):316-25. PubMed ID: 19812371
    [TBL] [Abstract][Full Text] [Related]  

    [Next]    [New Search]
    of 23.